SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1usy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_2
(PROTEIN (HIV-1
PROTEASE))		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		4 / 8 ALA C 251
ILE C 238
VAL C 109
ILE C 113
 None
 0.63A 1d4yB-1usyC:
undetectable		 1d4yB-1usyC:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		5 / 12 ILE C 154
LEU C 197
PRO C 198
VAL C 201
ILE C 179
 None
 0.99A 1df7A-1usyC:
undetectable		 1df7A-1usyC:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_0
(ALCOHOL
DEHYDROGENASE)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		5 / 11 LEU C 110
LEU C 192
LEU C 237
VAL C 127
ILE C 223
 None
 1.10A 1ee2A-1usyC:
undetectable		 1ee2A-1usyC:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_1
(ALCOHOL
DEHYDROGENASE)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		5 / 11 LEU C 110
LEU C 192
LEU C 237
VAL C 127
ILE C 223
 None
 1.10A 1ee2B-1usyC:
undetectable		 1ee2B-1usyC:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HMY_A_SAMA328_0
(HAEIII
METHYLTRANSFERASE)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Thermotoga
maritima) 		4 / 8 ILE E  81
THR E  83
PRO E   7
LEU E  11
 None
 0.84A 1hmyA-1usyE:
undetectable		 1hmyA-1usyE:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_2
(HIV-1 PROTEASE)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		5 / 9 ALA C 251
VAL C 114
ILE C 238
VAL C 109
ILE C 113
 None
 0.71A 1hpvB-1usyC:
undetectable		 1hpvB-1usyC:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_A_HISA450_0
(HISTIDYL-TRNA
SYNTHETASE)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		6 / 10 THR C  55
TYR C  75
GLN C  92
GLU C  96
TYR C 234
GLY C 253
 None
 0.84A 1httA-1usyC:
16.7		 1httA-1usyC:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_A_HISA450_0
(HISTIDYL-TRNA
SYNTHETASE)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		5 / 10 THR C  55
TYR C  75
GLU C  96
TYR C 234
GLY C 254
 None
 1.25A 1httA-1usyC:
16.7		 1httA-1usyC:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		7 / 12 THR C  55
GLN C  92
GLU C  96
TYR C 234
GLY C 253
TYR C 256
GLY C 265
 None
 0.61A 1httB-1usyC:
12.0		 1httB-1usyC:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		5 / 12 GLN C  92
GLU C  96
TYR C 234
TYR C 256
GLY C 265
 None
 1.29A 1httC-1usyC:
16.3		 1httC-1usyC:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		7 / 12 THR C  55
GLN C  92
GLU C  96
TYR C 234
GLY C 253
TYR C 256
GLY C 265
 None
 0.57A 1httC-1usyC:
16.3		 1httC-1usyC:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		6 / 12 THR C  55
GLN C  92
GLU C  96
TYR C 234
GLY C 253
GLY C 265
 None
 0.63A 1httD-1usyC:
16.3		 1httD-1usyC:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		4 / 7 LEU C 103
SER C 102
ASP C 105
PHE C 211
 None
 0.94A 1ismB-1usyC:
undetectable		 1ismB-1usyC:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NB9_A_RBFA401_1
(HYPOTHETICAL PROTEIN
FLJ11149)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Thermotoga
maritima) 		5 / 9 ILE E 169
SER E  86
GLU E 150
LEU E  11
ASP E  66
 None
None
PO4  E1202 (-4.6A)
None
None
 1.01A 1nb9A-1usyE:
undetectable		 1nb9A-1usyE:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T3R_A_017A1200_2
(PROTEASE RETROPEPSIN)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		5 / 11 ALA C 251
VAL C 114
ILE C 238
VAL C 109
ILE C 113
 None
 0.67A 1t3rB-1usyC:
undetectable		 1t3rB-1usyC:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F80_B_017B301_1
(POL POLYPROTEIN)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		5 / 12 ALA C 251
VAL C 114
ILE C 238
VAL C 109
ILE C 113
 None
 0.66A 2f80A-1usyC:
undetectable		 2f80A-1usyC:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F80_B_017B301_2
(POL POLYPROTEIN)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		5 / 12 ALA C 251
VAL C 114
ILE C 238
VAL C 109
ILE C 113
 None
 0.60A 2f80B-1usyC:
undetectable		 2f80B-1usyC:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F81_A_017A302_1
(POL POLYPROTEIN)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		5 / 12 ALA C 251
VAL C 114
ILE C 238
VAL C 109
ILE C 113
 None
 0.72A 2f81A-1usyC:
undetectable		 2f81A-1usyC:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACHA546_0
(ACETYLCHOLINESTERASE)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		4 / 8 TYR C  75
GLU C  96
TYR C 234
GLY C 265
 None
 1.05A 2ha4A-1usyC:
undetectable		 2ha4A-1usyC:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_1
(PROTEASE)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		5 / 12 ALA C 251
VAL C 114
ILE C 238
VAL C 109
ILE C 113
 None
 0.73A 2ienA-1usyC:
undetectable		 2ienA-1usyC:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4K_A_DR7A301_2
(PROTEASE)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		5 / 12 ALA C 251
VAL C 114
ILE C 238
VAL C 109
ILE C 113
 None
 0.62A 2o4kB-1usyC:
undetectable		 2o4kB-1usyC:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_2
(PROTEASE)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		5 / 9 ALA C 251
VAL C 114
ILE C 238
VAL C 109
ILE C 113
 None
 0.79A 2o4pB-1usyC:
undetectable		 2o4pB-1usyC:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4S_A_AB1A400_1
(PROTEASE)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		5 / 12 ALA C 251
VAL C 114
ILE C 238
VAL C 109
ILE C 113
 None
 0.58A 2o4sA-1usyC:
undetectable		 2o4sA-1usyC:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		5 / 12 ALA C 251
VAL C 114
ILE C 238
VAL C 109
ILE C 113
 None
 0.56A 2pymA-1usyC:
undetectable		 2pymA-1usyC:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		5 / 12 ALA C 251
VAL C 114
ILE C 238
VAL C 109
ILE C 113
 None
 0.54A 2pymB-1usyC:
undetectable		 2pymB-1usyC:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		5 / 12 ALA C 251
VAL C 114
ILE C 238
VAL C 109
ILE C 113
 None
 0.58A 2pynA-1usyC:
undetectable		 2pynA-1usyC:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		5 / 12 ALA C 251
VAL C 114
ILE C 238
VAL C 109
ILE C 113
 None
 0.58A 2pynB-1usyC:
undetectable		 2pynB-1usyC:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_1
(PROTEASE)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		5 / 9 ALA C 251
VAL C 114
ILE C 238
VAL C 109
ILE C 113
 None
 0.64A 2q5kA-1usyC:
undetectable		 2q5kA-1usyC:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		5 / 12 ALA C 251
VAL C 114
ILE C 238
VAL C 109
ILE C 113
 None
 0.57A 2q63A-1usyC:
undetectable		 2q63A-1usyC:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		5 / 12 ALA C 251
VAL C 114
ILE C 238
VAL C 109
ILE C 113
 None
 0.57A 2q63B-1usyC:
undetectable		 2q63B-1usyC:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_3
(PROTEASE RETROPEPSIN)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		5 / 12 ALA C 251
VAL C 114
ILE C 238
VAL C 109
ILE C 113
 None
 0.67A 2q64B-1usyC:
undetectable		 2q64B-1usyC:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		5 / 12 ALA C 251
VAL C 114
ILE C 238
VAL C 109
ILE C 113
 None
 0.58A 2qakB-1usyC:
undetectable		 2qakB-1usyC:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHC_B_AB1B9001_1
(PROTEASE RETROPEPSIN)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		5 / 11 ALA C 251
VAL C 114
ILE C 238
VAL C 109
ILE C 113
 None
 0.57A 2qhcA-1usyC:
undetectable		 2qhcA-1usyC:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHC_B_AB1B9001_2
(PROTEASE RETROPEPSIN)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		5 / 12 ALA C 251
VAL C 114
ILE C 238
VAL C 109
ILE C 113
 None
 0.53A 2qhcB-1usyC:
undetectable		 2qhcB-1usyC:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_2
(HIV-1 PROTEASE)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		5 / 12 ALA C 251
VAL C 114
ILE C 238
VAL C 109
ILE C 113
 None
 0.52A 2z54B-1usyC:
undetectable		 2z54B-1usyC:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		4 / 5 ARG C 186
MET C 195
THR C 194
LEU C 192
 None
 1.41A 3ag4J-1usyC:
undetectable		 3ag4J-1usyC:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_1
(PROTEASE
(RETROPEPSIN))		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		5 / 12 ALA C 251
VAL C 114
ILE C 238
VAL C 109
ILE C 113
 None
 0.63A 3bvbA-1usyC:
undetectable		 3bvbA-1usyC:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_2
(PROTEASE
(RETROPEPSIN))		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		5 / 12 ALA C 251
VAL C 114
ILE C 238
VAL C 109
ILE C 113
 None
 0.71A 3bvbB-1usyC:
undetectable		 3bvbB-1usyC:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYW_A_017A201_2
(HIV-1 PROTEASE)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		5 / 12 ALA C 251
VAL C 114
ILE C 238
VAL C 109
ILE C 113
 None
 0.73A 3cywB-1usyC:
undetectable		 3cywB-1usyC:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D20_A_017A201_1
(HIV-1 PROTEASE)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		5 / 12 ALA C 251
VAL C 114
ILE C 238
VAL C 109
ILE C 113
 None
 0.72A 3d20A-1usyC:
undetectable		 3d20A-1usyC:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_2
(PROTEASE)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		5 / 9 ALA C 251
VAL C 114
ILE C 238
VAL C 109
ILE C 113
 None
 0.68A 3ekvB-1usyC:
undetectable		 3ekvB-1usyC:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_2
(PROTEASE)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		5 / 11 ALA C 251
VAL C 114
ILE C 238
VAL C 109
ILE C 113
 None
 0.70A 3ekxB-1usyC:
undetectable		 3ekxB-1usyC:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL1_A_DR7A100_2
(PROTEASE)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		5 / 12 ALA C 251
VAL C 114
ILE C 238
VAL C 109
ILE C 113
 None
 0.69A 3el1B-1usyC:
undetectable		 3el1B-1usyC:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JVY_B_017B401_1
(GAG-POL POLYPROTEIN)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		5 / 12 ALA C 251
VAL C 114
ILE C 238
VAL C 109
ILE C 113
 None
 0.61A 3jvyA-1usyC:
undetectable		 3jvyA-1usyC:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JVY_B_017B401_2
(GAG-POL POLYPROTEIN)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		5 / 12 ALA C 251
VAL C 114
ILE C 238
VAL C 109
ILE C 113
 None
 0.64A 3jvyB-1usyC:
undetectable		 3jvyB-1usyC:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW2_A_017A401_1
(GAG-POL POLYPROTEIN)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		5 / 12 ALA C 251
VAL C 114
ILE C 238
VAL C 109
ILE C 113
 None
 0.61A 3jw2A-1usyC:
undetectable		 3jw2A-1usyC:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW2_A_017A401_2
(GAG-POL POLYPROTEIN)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		5 / 12 ALA C 251
VAL C 114
ILE C 238
VAL C 109
ILE C 113
 None
 0.65A 3jw2B-1usyC:
undetectable		 3jw2B-1usyC:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_3
(HIV-1 PROTEASE)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		5 / 12 ALA C 251
VAL C 114
ILE C 238
VAL C 109
ILE C 113
 None
 0.62A 3k4vB-1usyC:
undetectable		 3k4vB-1usyC:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		4 / 8 GLY C 266
PHE C  10
PHE C  12
PHE C 120
 None
 0.88A 3ko0D-1usyC:
undetectable
3ko0E-1usyC:
undetectable		 3ko0D-1usyC:
16.79
3ko0E-1usyC:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ201_1
(PROTEIN S100-A4)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		4 / 8 PHE C  12
PHE C 120
GLY C 266
PHE C  10
 None
 0.93A 3ko0B-1usyC:
undetectable
3ko0J-1usyC:
undetectable		 3ko0B-1usyC:
16.79
3ko0J-1usyC:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL201_1
(PROTEIN S100-A4)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		4 / 7 GLY C 266
PHE C  10
PHE C  12
PHE C 120
 None
 0.80A 3ko0L-1usyC:
undetectable
3ko0N-1usyC:
undetectable		 3ko0L-1usyC:
16.79
3ko0N-1usyC:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM201_1
(PROTEIN S100-A4)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		4 / 7 GLY C 266
PHE C  10
PHE C  12
PHE C 120
 None
 0.97A 3ko0M-1usyC:
0.0
3ko0P-1usyC:
undetectable		 3ko0M-1usyC:
16.79
3ko0P-1usyC:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT201_1
(PROTEIN S100-A4)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		4 / 7 PHE C  12
PHE C 120
GLY C 266
PHE C  10
 None
 0.91A 3ko0R-1usyC:
undetectable
3ko0T-1usyC:
undetectable		 3ko0R-1usyC:
16.79
3ko0T-1usyC:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZS_A_017A200_1
(HIV-1 PROTEASE)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		5 / 12 ALA C 251
VAL C 114
ILE C 238
VAL C 109
ILE C 113
 None
 0.65A 3lzsA-1usyC:
undetectable		 3lzsA-1usyC:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZS_A_017A200_2
(HIV-1 PROTEASE)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		5 / 12 ALA C 251
VAL C 114
ILE C 238
VAL C 109
ILE C 113
 None
 0.72A 3lzsB-1usyC:
undetectable		 3lzsB-1usyC:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_2
(HIV-1 PROTEASE)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		5 / 12 ALA C 251
VAL C 114
ILE C 238
VAL C 109
ILE C 113
 None
 0.68A 3lzuB-1usyC:
undetectable		 3lzuB-1usyC:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_2
(HIV-1 PROTEASE)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		5 / 11 ALA C 251
VAL C 114
ILE C 238
VAL C 109
ILE C 113
 None
 0.73A 3lzvB-1usyC:
undetectable		 3lzvB-1usyC:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MWS_B_017B201_2
(HIV-1 PROTEASE)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		5 / 12 ALA C 251
VAL C 114
ILE C 238
VAL C 109
ILE C 113
 None
 0.67A 3mwsB-1usyC:
undetectable		 3mwsB-1usyC:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_D_ROCD100_2
(PROTEASE)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		5 / 12 ALA C 251
VAL C 114
ILE C 238
VAL C 109
ILE C 113
 None
 0.66A 3ndtD-1usyC:
undetectable		 3ndtD-1usyC:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_1
(PROTEASE)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		5 / 10 ALA C 251
VAL C 114
ILE C 238
VAL C 109
ILE C 113
 None
 0.63A 3nu6A-1usyC:
undetectable		 3nu6A-1usyC:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_1
(PROTEASE)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		4 / 8 ALA C 251
VAL C 114
ILE C 238
VAL C 109
 None
 0.67A 3nu9A-1usyC:
undetectable		 3nu9A-1usyC:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OY4_B_017B200_1
(HIV-1 PROTEASE)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		5 / 11 ALA C 251
VAL C 114
ILE C 238
VAL C 109
ILE C 113
 None
 0.74A 3oy4A-1usyC:
undetectable		 3oy4A-1usyC:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKW_B_017B401_2
(PROTEASE)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		5 / 12 ALA C 251
VAL C 114
ILE C 238
VAL C 109
ILE C 113
 None
 0.64A 3tkwB-1usyC:
undetectable		 3tkwB-1usyC:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_3
(PROTEASE)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		5 / 12 ALA C 251
VAL C 114
ILE C 238
VAL C 109
ILE C 113
 None
 0.54A 3tl9B-1usyC:
undetectable		 3tl9B-1usyC:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Thermotoga
maritima) 		4 / 5 LEU E   4
THR E  22
ILE E 198
VAL E 197
 None
 0.90A 3wriA-1usyE:
undetectable		 3wriA-1usyE:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Thermotoga
maritima) 		4 / 5 LEU E   4
THR E  22
ILE E 198
VAL E 197
 None
 0.90A 3wriB-1usyE:
undetectable		 3wriB-1usyE:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		4 / 7 GLY C 236
THR C 132
ILE C 238
THR C  55
 None
 0.85A 4acaC-1usyC:
undetectable		 4acaC-1usyC:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_1
(ASPARTYL PROTEASE)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		5 / 12 ALA C 251
VAL C 114
ILE C 238
VAL C 109
ILE C 113
 None
 0.71A 4dqbA-1usyC:
undetectable		 4dqbA-1usyC:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_1
(ASPARTYL PROTEASE)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		5 / 10 ALA C 251
VAL C 114
ILE C 238
VAL C 109
ILE C 113
 None
 0.69A 4dqcA-1usyC:
undetectable		 4dqcA-1usyC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_1
(ASPARTYL PROTEASE)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		5 / 11 ALA C 251
VAL C 114
ILE C 238
VAL C 109
ILE C 113
 None
 0.66A 4dqeA-1usyC:
undetectable		 4dqeA-1usyC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQF_B_017B101_1
(ASPARTYL PROTEASE)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		5 / 12 ALA C 251
VAL C 114
ILE C 238
VAL C 109
ILE C 113
 None
 0.70A 4dqfA-1usyC:
undetectable		 4dqfA-1usyC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQH_B_017B101_1
(WILD-TYPE HIV-1
PROTEASE DIMER)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		5 / 11 ALA C 251
VAL C 114
ILE C 238
VAL C 109
ILE C 113
 None
 0.70A 4dqhA-1usyC:
undetectable		 4dqhA-1usyC:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_1
(HIV-1 PROTEASE)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		5 / 12 ALA C 251
VAL C 114
ILE C 238
VAL C 109
ILE C 113
 None
 0.64A 4jecA-1usyC:
undetectable		 4jecA-1usyC:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_1
(PROTEASE)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		4 / 8 ALA C 251
VAL C 114
VAL C 109
ILE C 113
 None
 0.65A 4ll3A-1usyC:
undetectable		 4ll3A-1usyC:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1W_A_017A104_2
(ASPARTYL PROTEASE)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		5 / 10 ALA C 251
VAL C 114
ILE C 238
VAL C 109
ILE C 113
 None
 0.76A 4q1wB-1usyC:
undetectable		 4q1wB-1usyC:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_2
(PROTEASE)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		5 / 11 ALA C 251
VAL C 114
ILE C 238
VAL C 109
ILE C 113
 None
 0.85A 4qgiB-1usyC:
undetectable		 4qgiB-1usyC:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_A_HQEA503_1
(CATALASE)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Thermotoga
maritima) 		5 / 9 ILE E   6
PHE E 190
LEU E   4
LEU E 194
PHE E  79
 None
 1.46A 4qopA-1usyE:
undetectable		 4qopA-1usyE:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_B_HQEB503_1
(CATALASE)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Thermotoga
maritima) 		5 / 9 ILE E   6
PHE E 190
LEU E   4
LEU E 194
PHE E  79
 None
 1.45A 4qopB-1usyE:
undetectable		 4qopB-1usyE:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		5 / 7 THR C  55
GLU C  96
GLY C 253
TYR C 256
GLY C 265
 None
 0.50A 4rdxA-1usyC:
19.8		 4rdxA-1usyC:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		5 / 7 THR C  55
GLU C  96
TYR C 234
TYR C 256
GLY C 265
 None
 0.89A 4rdxA-1usyC:
19.8		 4rdxA-1usyC:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		5 / 7 THR C  55
TYR C 234
GLY C 266
TYR C 256
GLY C 265
 None
 1.35A 4rdxA-1usyC:
19.8		 4rdxA-1usyC:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		7 / 12 THR C  55
GLN C  92
GLU C  96
TYR C 234
GLY C 253
TYR C 256
GLY C 265
 None
 0.63A 5e3iA-1usyC:
9.0		 5e3iA-1usyC:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		5 / 11 GLN C  92
GLU C  96
TYR C 234
TYR C 256
GLY C 265
 None
 1.34A 5e3iB-1usyC:
17.5		 5e3iB-1usyC:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		7 / 11 THR C  55
GLN C  92
GLU C  96
TYR C 234
GLY C 253
TYR C 256
GLY C 265
 None
 0.64A 5e3iB-1usyC:
17.5		 5e3iB-1usyC:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA405_0
(THIOREDOXIN
REDUCTASE)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Thermotoga
maritima) 		3 / 3 GLY E  64
LEU E  68
HIS E 172
 None
None
HIS  E1205 (-3.4A)
 0.60A 5u63A-1usyE:
undetectable		 5u63A-1usyE:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_B_ACTB405_0
(THIOREDOXIN
REDUCTASE)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Thermotoga
maritima) 		3 / 3 GLY E  64
LEU E  68
HIS E 172
 None
None
HIS  E1205 (-3.4A)
 0.57A 5u63B-1usyE:
undetectable		 5u63B-1usyE:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_2
(CYTOCHROME P450 3A4)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		4 / 7 ILE C 113
LEU C 212
PHE C 211
THR C 218
 None
 1.04A 5vc0A-1usyC:
undetectable		 5vc0A-1usyC:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_2
(CYTOCHROME P450 3A4)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		4 / 7 ILE C 113
LEU C 249
THR C 230
THR C 244
 None
 1.00A 5vc0A-1usyC:
undetectable		 5vc0A-1usyC:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		4 / 5 ARG C 186
MET C 195
THR C 194
LEU C 192
 None
 1.40A 5x19J-1usyC:
undetectable		 5x19J-1usyC:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		4 / 5 ARG C 186
MET C 195
THR C 194
LEU C 192
 None
 1.42A 5x1bJ-1usyC:
undetectable		 5x1bJ-1usyC:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		4 / 5 ARG C 186
MET C 195
THR C 194
LEU C 192
 None
 1.39A 5x1fW-1usyC:
0.0		 5x1fW-1usyC:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIL_B_TPVB201_1
(HIV-1 PROTEASE)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		5 / 12 ALA C 251
VAL C 114
ILE C 238
VAL C 109
ILE C 113
 None
 0.85A 6dilB-1usyC:
undetectable		 6dilB-1usyC:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ1_B_AB1B201_0
(HIV-1 PROTEASE)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		5 / 12 ALA C 251
VAL C 114
ILE C 238
VAL C 109
ILE C 113
 None
 0.60A 6dj1A-1usyC:
undetectable		 6dj1A-1usyC:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_0
(HIV-1 PROTEASE)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		5 / 10 ALA C 251
VAL C 114
ILE C 238
VAL C 109
ILE C 113
 None
 0.66A 6dj2A-1usyC:
undetectable		 6dj2A-1usyC:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		5 / 10 VAL C 109
LEU C 110
SER C 106
PHE C 239
GLY C  94
 None
 1.20A 6eu9B-1usyC:
0.0		 6eu9B-1usyC:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FZB_B_SRYB301_1
(STREPTOMYCIN
3''-ADENYLYLTRANSFER
ASE)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		5 / 12 LEU C 197
ASP C 196
ASP C 182
ILE C 179
THR C 226
 None
 1.38A 6fzbB-1usyC:
0.0		 6fzbB-1usyC:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_A_LLLA301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		4 / 6 ASP C  53
TYR C  75
GLU C  96
GLU C 261
 None
 1.48A 6mn5A-1usyC:
undetectable		 6mn5A-1usyC:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_C_LLLC301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT
(Thermotoga
maritima) 		4 / 6 ASP C  53
TYR C  75
GLU C  96
GLU C 261
 None
 1.37A 6mn5C-1usyC:
undetectable		 6mn5C-1usyC:
14.96