SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ut9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_B_TESB904_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 1ut9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Ruminiclostridiu
m
thermocellum) 		4 / 7 VAL A 690
ILE A 689
GLU A 570
TRP A 399
 None
 1.06A 1j96B-1ut9A:
undetectable		 1j96B-1ut9A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB8_0
(GRAMICIDIN A)		 1ut9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Ruminiclostridiu
m
thermocellum) 		4 / 5 VAL A 391
GLY A 394
VAL A 392
TRP A 800
 None
 1.29A 1tkqB-1ut9A:
undetectable		 1tkqB-1ut9A:
3.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB8_0
(GRAMICIDIN A)		 1ut9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Ruminiclostridiu
m
thermocellum) 		4 / 5 VAL A 391
GLY A 395
VAL A 392
TRP A 800
 None
 1.31A 1tkqB-1ut9A:
undetectable		 1tkqB-1ut9A:
3.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1ut9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Ruminiclostridiu
m
thermocellum) 		4 / 7 GLY A 394
GLY A 385
PHE A 318
PHE A 319
 None
 0.80A 2qwxA-1ut9A:
undetectable
2qwxB-1ut9A:
undetectable		 2qwxA-1ut9A:
18.33
2qwxB-1ut9A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1ut9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Ruminiclostridiu
m
thermocellum) 		4 / 5 LEU A 476
THR A 788
THR A 474
HIS A 387
 None
 1.13A 2zj0C-1ut9A:
undetectable		 2zj0C-1ut9A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_B_ADNB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1ut9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Ruminiclostridiu
m
thermocellum) 		4 / 5 LEU A 476
THR A 788
THR A 474
HIS A 387
 None
 1.16A 3ce6B-1ut9A:
undetectable		 3ce6B-1ut9A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I45_A_NIOA500_1
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN)		 1ut9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Ruminiclostridiu
m
thermocellum) 		4 / 8 SER A 587
LEU A 584
TYR A 565
LEU A 627
 None
 1.00A 3i45A-1ut9A:
undetectable		 3i45A-1ut9A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3007_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1ut9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Ruminiclostridiu
m
thermocellum) 		5 / 9 ASN A 499
THR A 503
ALA A 501
LEU A 504
ALA A 529
 None
 1.46A 3kp6B-1ut9A:
undetectable		 3kp6B-1ut9A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_A_VIBA223_1
(THIAMINE
PYROPHOSPHOKINASE)		 1ut9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Ruminiclostridiu
m
thermocellum) 		4 / 7 TYR A 268
SER A 235
ASN A 234
THR A 256
 None
 0.81A 3lm8A-1ut9A:
undetectable
3lm8C-1ut9A:
undetectable		 3lm8A-1ut9A:
17.02
3lm8C-1ut9A:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 1ut9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Ruminiclostridiu
m
thermocellum) 		4 / 8 SER A 680
GLN A 687
PHE A 683
ASN A 681
 None
 1.32A 3n66B-1ut9A:
undetectable		 3n66B-1ut9A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_2
(P38A)		 1ut9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Ruminiclostridiu
m
thermocellum) 		3 / 3 GLU A 406
LEU A 629
LEU A 634
 None
 0.68A 3ohtA-1ut9A:
undetectable		 3ohtA-1ut9A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_2
(P38A)		 1ut9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Ruminiclostridiu
m
thermocellum) 		3 / 3 GLU A 406
LEU A 629
LEU A 634
 None
 0.65A 3ohtB-1ut9A:
undetectable		 3ohtB-1ut9A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 1ut9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Ruminiclostridiu
m
thermocellum) 		3 / 3 ARG A 472
PHE A 471
PRO A 486
 None
 0.77A 3zoaB-1ut9A:
undetectable		 3zoaB-1ut9A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA502_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 1ut9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Ruminiclostridiu
m
thermocellum) 		4 / 8 TYR A 221
LEU A 272
VAL A 214
VAL A 216
 None
 0.88A 4em2A-1ut9A:
undetectable		 4em2A-1ut9A:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_1
(HIV-1 PROTEASE)		 1ut9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Ruminiclostridiu
m
thermocellum) 		4 / 7 LEU A 476
ASP A 383
ILE A 757
THR A 742
 None
 0.90A 4eyrA-1ut9A:
undetectable		 4eyrA-1ut9A:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1ut9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Ruminiclostridiu
m
thermocellum) 		4 / 8 ASP A 671
ASP A 264
GLU A 766
GLU A 672
 None
 1.00A 4feuD-1ut9A:
undetectable		 4feuD-1ut9A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1ut9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Ruminiclostridiu
m
thermocellum) 		4 / 7 ASP A 264
ASN A 656
GLU A 655
GLU A 670
 None
 1.21A 4fewB-1ut9A:
undetectable		 4fewB-1ut9A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_1
(METHYLTRANSFERASE
NSUN4)		 1ut9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Ruminiclostridiu
m
thermocellum) 		3 / 3 ASP A 483
ARG A 487
ASP A 386
 None
 0.82A 4fp9D-1ut9A:
undetectable		 4fp9D-1ut9A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_1
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 1ut9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Ruminiclostridiu
m
thermocellum) 		3 / 3 ASP A 483
ARG A 487
ASP A 386
 None
 0.85A 4fzvA-1ut9A:
undetectable		 4fzvA-1ut9A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_2
(NEURAMINIDASE)		 1ut9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Ruminiclostridiu
m
thermocellum) 		4 / 5 ARG A 340
TRP A 741
ILE A 796
ASN A 799
 None
 1.32A 4i00A-1ut9A:
undetectable		 4i00A-1ut9A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA506_0
(RNA POLYMERASE
3D-POL)		 1ut9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Ruminiclostridiu
m
thermocellum) 		3 / 3 VAL A 573
GLY A 576
LYS A 581
 None
 0.59A 4k50A-1ut9A:
undetectable		 4k50A-1ut9A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE504_0
(RNA POLYMERASE
3D-POL)		 1ut9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Ruminiclostridiu
m
thermocellum) 		3 / 3 VAL A 573
GLY A 576
LYS A 581
 None
 0.67A 4k50E-1ut9A:
1.1		 4k50E-1ut9A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI504_0
(RNA POLYMERASE
3D-POL)		 1ut9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Ruminiclostridiu
m
thermocellum) 		3 / 3 VAL A 573
GLY A 576
LYS A 581
 None
 0.58A 4k50I-1ut9A:
1.0		 4k50I-1ut9A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_B_ACTB401_0
(3C-LIKE PROTEINASE)		 1ut9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Ruminiclostridiu
m
thermocellum) 		3 / 3 ARG A 487
ASP A 353
TYR A 382
 None
 0.91A 4yo9B-1ut9A:
undetectable		 4yo9B-1ut9A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DGR_A_GCSA602_1
(PUTATIVE
ENDOGLUCANASE-RELATE
D PROTEIN)		 1ut9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ASP A 383
ALA A 384
ASP A 386
TYR A 390
GLU A 795
 None
 0.68A 5dgrA-1ut9A:
28.1		 5dgrA-1ut9A:
25.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1ut9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Ruminiclostridiu
m
thermocellum) 		4 / 4 ASN A 794
ILE A 711
TYR A 713
PHE A 683
 None
 1.41A 5igvA-1ut9A:
0.0		 5igvA-1ut9A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 1ut9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Ruminiclostridiu
m
thermocellum) 		5 / 12 THR A 453
GLU A 524
ILE A 444
ALA A 508
ALA A 526
 None
 1.09A 5kvaA-1ut9A:
undetectable		 5kvaA-1ut9A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 1ut9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Ruminiclostridiu
m
thermocellum) 		5 / 12 THR A 453
GLU A 524
ILE A 444
ALA A 508
ALA A 526
 None
 1.11A 5kvaB-1ut9A:
undetectable		 5kvaB-1ut9A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_1
(TETRACYCLINE
DESTRUCTASE TET(50))		 1ut9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Ruminiclostridiu
m
thermocellum) 		4 / 5 ASP A 696
ARG A 407
ARG A 411
LEU A 222
 None
 1.26A 5tuiB-1ut9A:
0.0		 5tuiB-1ut9A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_I_PACI1_0
(SERINE PROTEASE NS3
SERINE PROTEASE
SUBUNIT NS2B
PEPTIDE
PAC-DLY-DLY-DAR)		 1ut9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Ruminiclostridiu
m
thermocellum) 		3 / 3 VAL A 392
TYR A 555
GLU A 563
 None
 0.77A 5zmqD-1ut9A:
undetectable
5zmqE-1ut9A:
undetectable		 5zmqD-1ut9A:
15.69
5zmqE-1ut9A:
6.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1ut9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Ruminiclostridiu
m
thermocellum) 		4 / 8 SER A 680
GLN A 687
PHE A 683
ASN A 681
 None
 1.34A 6auuB-1ut9A:
undetectable		 6auuB-1ut9A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DCH_A_ACTA401_0
(SCOE PROTEIN)		 1ut9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Ruminiclostridiu
m
thermocellum) 		4 / 5 THR A 295
ASP A 721
HIS A 299
ARG A 215
 None
 1.15A 6dchA-1ut9A:
undetectable		 6dchA-1ut9A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_A_GM4A301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 1ut9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Ruminiclostridiu
m
thermocellum) 		5 / 11 VAL A 392
ALA A 495
ASP A 607
GLU A 606
ALA A 541
 None
 1.20A 6dk1A-1ut9A:
undetectable		 6dk1A-1ut9A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_C_GM4C301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 1ut9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Ruminiclostridiu
m
thermocellum) 		5 / 11 VAL A 392
ALA A 495
ASP A 607
GLU A 606
ALA A 541
 None
 1.22A 6dk1C-1ut9A:
undetectable		 6dk1C-1ut9A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H0F_B_Y70B502_0
(IKAROS (IKZF1)
PROTEIN CEREBLON)		 1ut9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Ruminiclostridiu
m
thermocellum) 		5 / 12 GLU A 563
TRP A 566
TRP A 399
ASN A 393
GLY A 395
 None
 1.49A 6h0fB-1ut9A:
0.0
6h0fC-1ut9A:
0.0		 6h0fB-1ut9A:
8.05
6h0fC-1ut9A:
5.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H0F_E_Y70E502_0
(IKAROS (IKZF1)
PROTEIN CEREBLON)		 1ut9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Ruminiclostridiu
m
thermocellum) 		5 / 12 GLU A 563
TRP A 566
TRP A 399
ASN A 393
GLY A 395
 None
 1.48A 6h0fE-1ut9A:
0.0
6h0fF-1ut9A:
0.0		 6h0fE-1ut9A:
8.05
6h0fF-1ut9A:
5.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H0F_H_Y70H502_0
(IKAROS (IKZF1)
PROTEIN CEREBLON)		 1ut9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Ruminiclostridiu
m
thermocellum) 		5 / 12 GLU A 563
TRP A 566
TRP A 399
ASN A 393
GLY A 395
 None
 1.47A 6h0fH-1ut9A:
0.0
6h0fI-1ut9A:
0.0		 6h0fH-1ut9A:
8.05
6h0fI-1ut9A:
5.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H0F_K_Y70K502_0
(IKAROS (IKZF1)
PROTEIN CEREBLON)		 1ut9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Ruminiclostridiu
m
thermocellum) 		5 / 12 GLU A 563
TRP A 566
TRP A 399
ASN A 393
GLY A 395
 None
 1.49A 6h0fK-1ut9A:
0.0
6h0fL-1ut9A:
0.0		 6h0fK-1ut9A:
8.05
6h0fL-1ut9A:
5.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1ut9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Ruminiclostridiu
m
thermocellum) 		4 / 7 VAL A 725
ILE A 796
GLY A 395
ALA A 802
 None
 0.83A 6hd6B-1ut9A:
undetectable		 6hd6B-1ut9A:
10.48