SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1uuf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_0
(ALCOHOL
DEHYDROGENASE)		 1uuf ZINC-TYPE ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN YAHK
(Escherichia
coli) 		5 / 11 CYH A  40
SER A  42
HIS A  62
SER A 116
CYH A 158
 ZN  A 402 (-2.3A)
ZN  A 402 ( 3.9A)
ZN  A 402 (-3.3A)
None
ZN  A 402 (-2.4A)
 1.05A 1ee2A-1uufA:
33.7		 1ee2A-1uufA:
28.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1uuf ZINC-TYPE ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN YAHK
(Escherichia
coli) 		4 / 8 GLN A 147
VAL A 153
GLY A  66
GLY A  85
 None
 0.75A 1f5lA-1uufA:
undetectable		 1f5lA-1uufA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_ACTA421_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 1uuf ZINC-TYPE ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN YAHK
(Escherichia
coli) 		5 / 8 GLY A 184
GLY A 187
GLY A 190
MET A 189
LEU A 186
 None
 1.20A 1qzzA-1uufA:
7.0		 1qzzA-1uufA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 1uuf ZINC-TYPE ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN YAHK
(Escherichia
coli) 		4 / 8 GLN A 147
VAL A 153
GLY A  66
GLY A  85
 None
 0.73A 2vinA-1uufA:
undetectable		 2vinA-1uufA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_1
(PROTEASE)		 1uuf ZINC-TYPE ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN YAHK
(Escherichia
coli) 		4 / 8 ALA A 219
ASP A 220
GLY A 179
THR A 205
 None
 0.86A 3el9A-1uufA:
undetectable		 3el9A-1uufA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1uuf ZINC-TYPE ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN YAHK
(Escherichia
coli) 		5 / 12 VAL A 336
VAL A 180
LEU A 242
ILE A 191
THR A 163
 None
 1.27A 3elzA-1uufA:
undetectable		 3elzA-1uufA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1uuf ZINC-TYPE ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN YAHK
(Escherichia
coli) 		5 / 10 ILE A  34
GLY A  81
TYR A  78
VAL A 140
LEU A 150
 None
 1.27A 3elzC-1uufA:
undetectable		 3elzC-1uufA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_1
(PROTEASE)		 1uuf ZINC-TYPE ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN YAHK
(Escherichia
coli) 		4 / 8 GLY A 218
ALA A 219
ASP A 220
LEU A 193
 None
 0.59A 3em6A-1uufA:
undetectable		 3em6A-1uufA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 1uuf ZINC-TYPE ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN YAHK
(Escherichia
coli) 		5 / 12 GLY A 182
GLY A 179
ALA A 219
PHE A 238
ASN A 243
 None
 1.21A 3qowA-1uufA:
6.2		 3qowA-1uufA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_D_CAMD502_0
(CAMPHOR
5-MONOOXYGENASE)		 1uuf ZINC-TYPE ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN YAHK
(Escherichia
coli) 		4 / 5 LEU A 193
GLY A 190
THR A 244
VAL A 267
 None
 0.97A 3wrkD-1uufA:
undetectable		 3wrkD-1uufA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 1uuf ZINC-TYPE ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN YAHK
(Escherichia
coli) 		5 / 11 ALA A 213
LEU A 217
GLY A 187
PHE A 240
GLY A 182
 None
 1.17A 3zosA-1uufA:
undetectable
3zosB-1uufA:
undetectable		 3zosA-1uufA:
22.25
3zosB-1uufA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_2
(HIV-1 PROTEASE)		 1uuf ZINC-TYPE ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN YAHK
(Escherichia
coli) 		4 / 8 GLY A 218
ALA A 219
ASP A 220
THR A 205
 None
 0.88A 4eyrB-1uufA:
undetectable		 4eyrB-1uufA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1uuf ZINC-TYPE ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN YAHK
(Escherichia
coli) 		4 / 6 GLY A 296
GLY A 295
GLU A 104
ILE A  89
 None
 0.83A 4fglD-1uufA:
4.3		 4fglD-1uufA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOY_A_CSCA214_1
(UNCHARACTERIZED
PROTEIN)		 1uuf ZINC-TYPE ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN YAHK
(Escherichia
coli) 		5 / 11 CYH A  40
GLY A  38
ILE A 342
TYR A 129
ARG A 330
 ZN  A 402 (-2.3A)
None
None
None
None
 1.37A 4koyA-1uufA:
0.0		 4koyA-1uufA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_B_ACTB403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1uuf ZINC-TYPE ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN YAHK
(Escherichia
coli) 		3 / 3 ARG A 287
ASP A 261
ARG A 286
 None
 0.70A 4wq4B-1uufA:
undetectable		 4wq4B-1uufA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_B_SAMB303_0
(CATECHOL
O-METHYLTRANSFERASE)		 1uuf ZINC-TYPE ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN YAHK
(Escherichia
coli) 		5 / 12 VAL A 267
GLY A 295
SER A 292
ILE A 297
GLN A 301
 None
 1.14A 4xueB-1uufA:
6.6		 4xueB-1uufA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z7F_C_FOLC201_0
(FOLATE ECF
TRANSPORTER)		 1uuf ZINC-TYPE ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN YAHK
(Escherichia
coli) 		5 / 12 ARG A 339
ALA A 314
THR A 163
THR A 300
LEU A 304
 None
 1.03A 4z7fC-1uufA:
undetectable		 4z7fC-1uufA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_A_SAMA601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 1uuf ZINC-TYPE ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN YAHK
(Escherichia
coli) 		5 / 12 GLY A 127
ILE A 133
HIS A 124
VAL A  90
VAL A 135
 None
 1.15A 5dpdA-1uufA:
4.2		 5dpdA-1uufA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 1uuf ZINC-TYPE ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN YAHK
(Escherichia
coli) 		5 / 12 ILE A  64
SER A 116
HIS A 124
GLY A 127
GLY A 128
 None
 1.04A 5l6eA-1uufA:
2.0		 5l6eA-1uufA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_I_BEZI1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 1uuf ZINC-TYPE ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN YAHK
(Escherichia
coli) 		3 / 3 SER A  10
TYR A   9
TYR A  56
 None
 0.40A 5lakA-1uufA:
0.0
5lakI-1uufA:
undetectable		 5lakA-1uufA:
20.51
5lakI-1uufA:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_J_BEZJ1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 1uuf ZINC-TYPE ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN YAHK
(Escherichia
coli) 		3 / 3 SER A  10
TYR A   9
TYR A  56
 None
 0.47A 5lakC-1uufA:
undetectable
5lakJ-1uufA:
undetectable		 5lakC-1uufA:
20.51
5lakJ-1uufA:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8H_B_478B401_1
(PROTEASE)		 1uuf ZINC-TYPE ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN YAHK
(Escherichia
coli) 		5 / 12 ILE A  20
VAL A  59
GLY A 128
ILE A  64
ILE A   3
 None
 0.90A 5t8hA-1uufA:
undetectable		 5t8hA-1uufA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 1uuf ZINC-TYPE ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN YAHK
(Escherichia
coli) 		5 / 12 GLY A 179
GLY A 187
GLY A 182
ALA A 214
ASP A 315
 None
 1.05A 6nj9K-1uufA:
5.3		 6nj9K-1uufA:
21.18