SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1uun'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_1
(TRANSTHYRETIN)		 1uun MSPA
(Mycolicibacteriu
m
smegmatis) 		4 / 7 LEU A  62
ALA A 164
LEU A 166
THR A 176
 None
 0.61A 1dvxA-1uunA:
undetectable		 1dvxA-1uunA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_2
(TRANSTHYRETIN)		 1uun MSPA
(Mycolicibacteriu
m
smegmatis) 		4 / 7 LEU A  62
ALA A 164
LEU A 166
THR A 176
 None
 0.60A 1dvxB-1uunA:
3.1		 1dvxB-1uunA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_1
(TRANSTHYRETIN)		 1uun MSPA
(Mycolicibacteriu
m
smegmatis) 		4 / 6 LEU A  62
ALA A 164
LEU A 166
THR A 176
 None
 0.63A 1ictB-1uunA:
undetectable		 1ictB-1uunA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_A_9CRA131_1
(TRANSTHYRETIN)		 1uun MSPA
(Mycolicibacteriu
m
smegmatis) 		4 / 6 LEU A  62
ALA A 164
LEU A 166
THR A 176
 None
 0.57A 1tyrA-1uunA:
3.6		 1tyrA-1uunA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 1uun MSPA
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ASP A   3
ASN A   4
THR A  17
 None
 0.63A 2pymB-1uunA:
undetectable		 2pymB-1uunA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 1uun MSPA
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ASP A   3
ASN A   4
THR A  17
 None
 0.53A 2q63B-1uunA:
undetectable		 2q63B-1uunA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_B_T44B128_1
(TRANSTHYRETIN)		 1uun MSPA
(Mycolicibacteriu
m
smegmatis) 		4 / 6 LEU A  62
ALA A 164
LEU A 166
THR A 176
 None
 0.66A 2roxB-1uunA:
undetectable		 2roxB-1uunA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1uun MSPA
(Mycolicibacteriu
m
smegmatis) 		4 / 5 THR A 176
THR A 130
HIS A  42
LEU A  25
 None
 1.29A 2zj0A-1uunA:
undetectable		 2zj0A-1uunA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_A_DIFA1_1
(TRANSTHYRETIN)		 1uun MSPA
(Mycolicibacteriu
m
smegmatis) 		4 / 6 LEU A  62
ALA A 164
LEU A 166
THR A 176
 None
 0.65A 3cfqA-1uunA:
3.2		 3cfqA-1uunA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_B_DIFB1_1
(TRANSTHYRETIN)		 1uun MSPA
(Mycolicibacteriu
m
smegmatis) 		4 / 7 LEU A  62
ALA A 164
LEU A 166
THR A 176
 None
 0.70A 3cfqA-1uunA:
3.2
3cfqB-1uunA:
undetectable		 3cfqA-1uunA:
24.04
3cfqB-1uunA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_A_1FLA502_1
(TRANSTHYRETIN)		 1uun MSPA
(Mycolicibacteriu
m
smegmatis) 		4 / 7 LEU A  62
ALA A 164
LEU A 166
THR A 176
 None
 0.65A 3d2tA-1uunA:
3.2		 3d2tA-1uunA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		 1uun MSPA
(Mycolicibacteriu
m
smegmatis) 		4 / 6 LEU A  62
ALA A 164
LEU A 166
THR A 176
 None
 0.63A 4d7bB-1uunA:
undetectable		 4d7bB-1uunA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		 1uun MSPA
(Mycolicibacteriu
m
smegmatis) 		4 / 7 LEU A  62
ALA A 164
LEU A 166
THR A 176
 None
 0.64A 4d7bA-1uunA:
undetectable		 4d7bA-1uunA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_A_1FLA201_1
(TRANSTHYRETIN)		 1uun MSPA
(Mycolicibacteriu
m
smegmatis) 		4 / 6 LEU A  62
ALA A 164
LEU A 166
THR A 176
 None
 0.59A 4i89A-1uunA:
3.1		 4i89A-1uunA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_B_IMNB201_1
(TRANSTHYRETIN)		 1uun MSPA
(Mycolicibacteriu
m
smegmatis) 		4 / 6 LEU A  62
ALA A 164
LEU A 166
THR A 176
 None
 0.76A 4ikiB-1uunA:
3.2		 4ikiB-1uunA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_A_SUZA201_1
(TRANSTHYRETIN)		 1uun MSPA
(Mycolicibacteriu
m
smegmatis) 		4 / 7 LEU A  62
ALA A 164
LEU A 166
THR A 176
 None
 0.77A 4ikjA-1uunA:
3.0
4ikjB-1uunA:
3.1		 4ikjA-1uunA:
22.83
4ikjB-1uunA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_A_SUZA201_1
(TRANSTHYRETIN)		 1uun MSPA
(Mycolicibacteriu
m
smegmatis) 		5 / 8 LEU A  62
ALA A 164
LEU A 166
THR A 176
SER A   7
 None
 1.49A 4ikkA-1uunA:
undetectable
4ikkB-1uunA:
undetectable		 4ikkA-1uunA:
22.83
4ikkB-1uunA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_B_SUZB201_1
(TRANSTHYRETIN)		 1uun MSPA
(Mycolicibacteriu
m
smegmatis) 		4 / 7 LEU A  62
ALA A 164
LEU A 166
THR A 176
 None
 0.74A 4ikkA-1uunA:
undetectable
4ikkB-1uunA:
undetectable		 4ikkA-1uunA:
22.83
4ikkB-1uunA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_B_SUZB201_1
(TRANSTHYRETIN)		 1uun MSPA
(Mycolicibacteriu
m
smegmatis) 		4 / 8 LEU A  62
ALA A 164
LEU A 166
THR A 176
 None
 0.76A 4iklA-1uunA:
3.1
4iklB-1uunA:
3.1		 4iklA-1uunA:
22.83
4iklB-1uunA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_A_ADNA501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 1uun MSPA
(Mycolicibacteriu
m
smegmatis) 		4 / 5 THR A 176
THR A 130
HIS A  42
LEU A  25
 None
 1.33A 4lvcA-1uunA:
undetectable		 4lvcA-1uunA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_C_ADNC501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 1uun MSPA
(Mycolicibacteriu
m
smegmatis) 		4 / 5 THR A 176
THR A 130
HIS A  42
LEU A  25
 None
 1.33A 4lvcC-1uunA:
undetectable		 4lvcC-1uunA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 1uun MSPA
(Mycolicibacteriu
m
smegmatis) 		3 / 3 SER A  43
ALA A 143
VAL A 142
 None
 0.68A 4o2bC-1uunA:
undetectable		 4o2bC-1uunA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		 1uun MSPA
(Mycolicibacteriu
m
smegmatis) 		4 / 7 LEU A  62
ALA A 164
LEU A 166
THR A 176
 None
 0.74A 4pwjB-1uunA:
undetectable		 4pwjB-1uunA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1uun MSPA
(Mycolicibacteriu
m
smegmatis) 		3 / 3 SER A  43
ALA A 143
VAL A 142
 None
 0.60A 4x1iA-1uunA:
undetectable		 4x1iA-1uunA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		 1uun MSPA
(Mycolicibacteriu
m
smegmatis) 		4 / 6 LEU A  62
ALA A 164
LEU A 166
THR A 176
 None
 0.61A 5bojA-1uunA:
3.2		 5bojA-1uunA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		 1uun MSPA
(Mycolicibacteriu
m
smegmatis) 		4 / 7 LEU A  62
ALA A 164
LEU A 166
THR A 176
 None
 0.60A 5bojB-1uunA:
undetectable		 5bojB-1uunA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		 1uun MSPA
(Mycolicibacteriu
m
smegmatis) 		4 / 6 LEU A  62
ALA A 164
LEU A 166
THR A 176
 None
 0.62A 5l4iA-1uunA:
undetectable		 5l4iA-1uunA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		 1uun MSPA
(Mycolicibacteriu
m
smegmatis) 		4 / 6 LEU A  62
ALA A 164
LEU A 166
THR A 176
 None
 0.59A 5l4iB-1uunA:
3.1		 5l4iB-1uunA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_A_ADNA501_2
(-)		 1uun MSPA
(Mycolicibacteriu
m
smegmatis) 		4 / 5 THR A 176
THR A 130
HIS A  42
LEU A  25
 None
 1.33A 6gbnA-1uunA:
undetectable		 6gbnA-1uunA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_D_ADND501_2
(-)		 1uun MSPA
(Mycolicibacteriu
m
smegmatis) 		4 / 5 THR A 176
THR A 130
HIS A  42
LEU A  25
 None
 1.30A 6gbnD-1uunA:
undetectable		 6gbnD-1uunA:
18.73