SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1uuo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 1uuo DIHYDROOROTATE
DEHYDROGENASE
(Rattus
rattus) 		4 / 6 ASN A 145
ASN A 212
ASN A 284
THR A 285
 ORO  A1399 ( 3.0A)
FMN  A1398 ( 3.0A)
ORO  A1399 ( 3.2A)
ORO  A1399 (-2.7A)
 0.66A 1h7xA-1uuoA:
31.0		 1h7xA-1uuoA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 1uuo DIHYDROOROTATE
DEHYDROGENASE
(Rattus
rattus) 		4 / 6 ASN A 145
ASN A 212
ASN A 284
THR A 285
 ORO  A1399 ( 3.0A)
FMN  A1398 ( 3.0A)
ORO  A1399 ( 3.2A)
ORO  A1399 (-2.7A)
 0.65A 1h7xB-1uuoA:
31.0		 1h7xB-1uuoA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 1uuo DIHYDROOROTATE
DEHYDROGENASE
(Rattus
rattus) 		4 / 6 ASN A 145
ASN A 212
ASN A 284
THR A 285
 ORO  A1399 ( 3.0A)
FMN  A1398 ( 3.0A)
ORO  A1399 ( 3.2A)
ORO  A1399 (-2.7A)
 0.66A 1h7xC-1uuoA:
31.0		 1h7xC-1uuoA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 1uuo DIHYDROOROTATE
DEHYDROGENASE
(Rattus
rattus) 		4 / 6 ASN A 145
ASN A 212
ASN A 284
THR A 285
 ORO  A1399 ( 3.0A)
FMN  A1398 ( 3.0A)
ORO  A1399 ( 3.2A)
ORO  A1399 (-2.7A)
 0.65A 1h7xD-1uuoA:
31.0		 1h7xD-1uuoA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		 1uuo DIHYDROOROTATE
DEHYDROGENASE
(Rattus
rattus) 		4 / 7 LEU A 343
GLY A 339
LEU A 378
PRO A  91
 None
 0.84A 1ya4B-1uuoA:
undetectable		 1ya4B-1uuoA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1uuo DIHYDROOROTATE
DEHYDROGENASE
(Rattus
rattus) 		5 / 12 ILE A 331
LEU A  84
GLY A 179
GLN A 168
ARG A 164
 None
 1.19A 2ogyA-1uuoA:
10.4		 2ogyA-1uuoA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMB_D_IPHD2002_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 1uuo DIHYDROOROTATE
DEHYDROGENASE
(Rattus
rattus) 		4 / 7 TYR A  38
HIS A  36
PRO A  44
TYR A  41
 None
 1.24A 2ombC-1uuoA:
undetectable
2ombD-1uuoA:
undetectable		 2ombC-1uuoA:
22.69
2ombD-1uuoA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_A_LDPA501_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 1uuo DIHYDROOROTATE
DEHYDROGENASE
(Rattus
rattus) 		4 / 7 GLY A 332
GLN A 354
PHE A 115
PHE A  88
 None
 0.87A 2qmzA-1uuoA:
undetectable
2qmzB-1uuoA:
undetectable		 2qmzA-1uuoA:
22.16
2qmzB-1uuoA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1uuo DIHYDROOROTATE
DEHYDROGENASE
(Rattus
rattus) 		4 / 7 GLY A 332
GLN A 354
PHE A 115
PHE A  88
 None
 0.97A 2qwxA-1uuoA:
undetectable
2qwxB-1uuoA:
undetectable		 2qwxA-1uuoA:
22.89
2qwxB-1uuoA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1uuo DIHYDROOROTATE
DEHYDROGENASE
(Rattus
rattus) 		4 / 7 GLY A 332
GLN A 354
PHE A 115
PHE A  88
 None
 1.00A 2qx4A-1uuoA:
undetectable
2qx4B-1uuoA:
undetectable		 2qx4A-1uuoA:
22.16
2qx4B-1uuoA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1uuo DIHYDROOROTATE
DEHYDROGENASE
(Rattus
rattus) 		4 / 6 GLY A 332
GLN A 354
PHE A 115
PHE A  88
 None
 0.92A 2qx6A-1uuoA:
undetectable
2qx6B-1uuoA:
undetectable		 2qx6A-1uuoA:
22.16
2qx6B-1uuoA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_B_X2NB1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 1uuo DIHYDROOROTATE
DEHYDROGENASE
(Rattus
rattus) 		5 / 12 MET A  43
ALA A  55
ALA A  59
THR A  63
LEU A 111
 BRF  A1397 (-4.1A)
BRF  A1397 (-3.2A)
BRF  A1397 (-3.5A)
BRF  A1397 ( 4.7A)
None
 1.07A 2x2nB-1uuoA:
undetectable		 2x2nB-1uuoA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_C_X2NC1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 1uuo DIHYDROOROTATE
DEHYDROGENASE
(Rattus
rattus) 		5 / 12 MET A  43
ALA A  55
ALA A  59
THR A  63
LEU A 111
 BRF  A1397 (-4.1A)
BRF  A1397 (-3.2A)
BRF  A1397 (-3.5A)
BRF  A1397 ( 4.7A)
None
 1.06A 2x2nC-1uuoA:
undetectable		 2x2nC-1uuoA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 1uuo DIHYDROOROTATE
DEHYDROGENASE
(Rattus
rattus) 		5 / 12 MET A  43
ALA A  55
ALA A  59
THR A  63
LEU A 111
 BRF  A1397 (-4.1A)
BRF  A1397 (-3.2A)
BRF  A1397 (-3.5A)
BRF  A1397 ( 4.7A)
None
 1.05A 2x2nD-1uuoA:
0.0		 2x2nD-1uuoA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 1uuo DIHYDROOROTATE
DEHYDROGENASE
(Rattus
rattus) 		5 / 11 VAL A 333
GLY A 334
LYS A 307
ILE A  94
ALA A  95
 FMN  A1398 (-4.5A)
FMN  A1398 (-3.6A)
None
None
FMN  A1398 (-3.4A)
 1.14A 2yy8A-1uuoA:
undetectable
2yy8B-1uuoA:
2.1		 2yy8A-1uuoA:
21.61
2yy8B-1uuoA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_E_RTLE177_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 1uuo DIHYDROOROTATE
DEHYDROGENASE
(Rattus
rattus) 		5 / 11 ALA A 193
ALA A 192
VAL A 213
LEU A 230
GLN A 225
 None
 1.28A 3bszE-1uuoA:
undetectable		 3bszE-1uuoA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU5_B_478B401_1
(PROTEASE)		 1uuo DIHYDROOROTATE
DEHYDROGENASE
(Rattus
rattus) 		6 / 12 LEU A 182
GLY A 203
ALA A 206
VAL A 118
VAL A 121
ILE A 180
 None
 1.35A 3nu5A-1uuoA:
undetectable		 3nu5A-1uuoA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1uuo DIHYDROOROTATE
DEHYDROGENASE
(Rattus
rattus) 		3 / 3 SER A 151
ASP A  99
ASP A 106
 None
 0.90A 3uj7A-1uuoA:
undetectable		 3uj7A-1uuoA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 1uuo DIHYDROOROTATE
DEHYDROGENASE
(Rattus
rattus) 		5 / 12 LEU A  67
PHE A  37
LEU A  42
TYR A  38
ALA A  55
 None
None
BRF  A1397 (-4.6A)
None
BRF  A1397 (-3.2A)
 1.09A 3vw7A-1uuoA:
undetectable		 3vw7A-1uuoA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_1
(PROTEASE)		 1uuo DIHYDROOROTATE
DEHYDROGENASE
(Rattus
rattus) 		5 / 9 LEU A 182
ALA A 206
ASP A 207
VAL A 118
ILE A 180
 None
 1.27A 3wsjA-1uuoA:
undetectable		 3wsjA-1uuoA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 1uuo DIHYDROOROTATE
DEHYDROGENASE
(Rattus
rattus) 		5 / 11 VAL A  60
ALA A 104
GLY A  97
VAL A 116
LEU A 108
 None
None
FMN  A1398 (-3.0A)
None
None
 1.16A 3zosA-1uuoA:
undetectable
3zosB-1uuoA:
undetectable		 3zosA-1uuoA:
22.51
3zosB-1uuoA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		 1uuo DIHYDROOROTATE
DEHYDROGENASE
(Rattus
rattus) 		5 / 11 GLY A 128
ALA A  96
GLY A  97
GLU A 117
ASN A 181
 None
FMN  A1398 (-3.7A)
FMN  A1398 (-3.0A)
None
FMN  A1398 (-3.2A)
 1.24A 4a6nA-1uuoA:
undetectable		 4a6nA-1uuoA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_1
(METHYLTRANSFERASE
WBDD)		 1uuo DIHYDROOROTATE
DEHYDROGENASE
(Rattus
rattus) 		3 / 3 GLN A 225
ASP A 264
GLN A 263
 None
 0.70A 4aztA-1uuoA:
1.2		 4aztA-1uuoA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_B_ASWB1301_1
(DNA TOPOISOMERASE
2-BETA)		 1uuo DIHYDROOROTATE
DEHYDROGENASE
(Rattus
rattus) 		4 / 7 ILE A 331
GLY A 335
ALA A  95
GLN A 340
 None
FMN  A1398 (-3.6A)
FMN  A1398 (-3.4A)
None
 0.93A 4g0uB-1uuoA:
undetectable		 4g0uB-1uuoA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 1uuo DIHYDROOROTATE
DEHYDROGENASE
(Rattus
rattus) 		6 / 10 PHE A  98
THR A  63
LEU A  68
VAL A 116
ASP A  99
ILE A  94
 None
BRF  A1397 ( 4.7A)
None
None
None
None
 1.32A 4jx1B-1uuoA:
undetectable		 4jx1B-1uuoA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1uuo DIHYDROOROTATE
DEHYDROGENASE
(Rattus
rattus) 		3 / 3 SER A 151
ASP A  99
ASP A 106
 None
 0.90A 4mwzA-1uuoA:
undetectable		 4mwzA-1uuoA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_B_ACTB201_0
(RETINOL-BINDING
PROTEIN 2)		 1uuo DIHYDROOROTATE
DEHYDROGENASE
(Rattus
rattus) 		4 / 5 TYR A 208
GLU A 117
LEU A 253
GLN A 354
 None
 1.37A 4qztB-1uuoA:
0.0		 4qztB-1uuoA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1uuo DIHYDROOROTATE
DEHYDROGENASE
(Rattus
rattus) 		4 / 5 ARG A 381
GLY A 382
GLU A 380
ARG A 395
 None
 0.97A 5cdqA-1uuoA:
undetectable
5cdqB-1uuoA:
0.3
5cdqC-1uuoA:
undetectable		 5cdqA-1uuoA:
21.46
5cdqB-1uuoA:
21.65
5cdqC-1uuoA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_F_MFXF2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1uuo DIHYDROOROTATE
DEHYDROGENASE
(Rattus
rattus) 		4 / 6 SER A 288
ASP A 311
ARG A 310
GLY A 334
 None
None
None
FMN  A1398 (-3.6A)
 0.90A 5cdqA-1uuoA:
undetectable
5cdqC-1uuoA:
undetectable
5cdqD-1uuoA:
undetectable		 5cdqA-1uuoA:
21.46
5cdqC-1uuoA:
21.46
5cdqD-1uuoA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_F_MFXF2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1uuo DIHYDROOROTATE
DEHYDROGENASE
(Rattus
rattus) 		4 / 6 SER A 288
ASP A 311
ARG A 310
GLY A 335
 None
None
None
FMN  A1398 (-3.6A)
 1.07A 5cdqA-1uuoA:
undetectable
5cdqC-1uuoA:
undetectable
5cdqD-1uuoA:
undetectable		 5cdqA-1uuoA:
21.46
5cdqC-1uuoA:
21.46
5cdqD-1uuoA:
21.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5K9D_A_ACTA405_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 1uuo DIHYDROOROTATE
DEHYDROGENASE
(Rattus
rattus) 		3 / 3 GLN A 168
THR A 172
ASP A 207
 None
 0.15A 5k9dA-1uuoA:
60.9		 5k9dA-1uuoA:
87.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5K9D_A_ACTA407_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 1uuo DIHYDROOROTATE
DEHYDROGENASE
(Rattus
rattus) 		4 / 5 ASP A 311
THR A 314
ARG A 318
GLU A 344
 None
 0.84A 5k9dA-1uuoA:
60.9		 5k9dA-1uuoA:
87.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5K9D_A_CE9A402_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 1uuo DIHYDROOROTATE
DEHYDROGENASE
(Rattus
rattus) 		10 / 12 MET A  43
ALA A  55
HIS A  56
LEU A  58
ALA A  59
THR A  63
PHE A  98
TYR A 356
LEU A 359
PRO A 364
 BRF  A1397 (-4.1A)
BRF  A1397 (-3.2A)
BRF  A1397 (-4.0A)
None
BRF  A1397 (-3.5A)
BRF  A1397 ( 4.7A)
None
FMN  A1398 ( 4.2A)
None
BRF  A1397 (-4.6A)
 0.64A 5k9dA-1uuoA:
60.9		 5k9dA-1uuoA:
87.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L94_A_TESA502_1
(CYTOCHROME P450)		 1uuo DIHYDROOROTATE
DEHYDROGENASE
(Rattus
rattus) 		5 / 8 VAL A 386
ILE A 346
ALA A 350
VAL A  83
VAL A  81
 None
 1.20A 5l94A-1uuoA:
undetectable		 5l94A-1uuoA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1uuo DIHYDROOROTATE
DEHYDROGENASE
(Rattus
rattus) 		5 / 9 GLY A 326
VAL A  83
ILE A 390
GLY A 391
PHE A 115
 None
 0.87A 5vkqC-1uuoA:
undetectable
5vkqD-1uuoA:
undetectable		 5vkqC-1uuoA:
12.80
5vkqD-1uuoA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AY4_A_TPFA506_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 1uuo DIHYDROOROTATE
DEHYDROGENASE
(Rattus
rattus) 		5 / 10 MET A  43
ALA A  55
ALA A  59
THR A  63
LEU A 111
 BRF  A1397 (-4.1A)
BRF  A1397 (-3.2A)
BRF  A1397 (-3.5A)
BRF  A1397 ( 4.7A)
None
 1.08A 6ay4A-1uuoA:
undetectable		 6ay4A-1uuoA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_1
(PROTEIN CYP51)		 1uuo DIHYDROOROTATE
DEHYDROGENASE
(Rattus
rattus) 		5 / 12 MET A  43
ALA A  55
ALA A  59
THR A  63
LEU A 111
 BRF  A1397 (-4.1A)
BRF  A1397 (-3.2A)
BRF  A1397 (-3.5A)
BRF  A1397 ( 4.7A)
None
 1.07A 6aycA-1uuoA:
undetectable		 6aycA-1uuoA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA902_0
(PROTEIN ARGONAUTE-2)		 1uuo DIHYDROOROTATE
DEHYDROGENASE
(Rattus
rattus) 		4 / 4 VAL A 353
ALA A  95
PHE A 115
PHE A 113
 None
FMN  A1398 (-3.4A)
None
None
 1.36A 6cbdA-1uuoA:
2.0		 6cbdA-1uuoA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		 1uuo DIHYDROOROTATE
DEHYDROGENASE
(Rattus
rattus) 		4 / 6 ARG A 162
ALA A 169
THR A 172
ALA A 206
 None
 1.14A 6ma6A-1uuoA:
undetectable		 6ma6A-1uuoA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_D_FFOD403_0
(THYMIDYLATE SYNTHASE)		 1uuo DIHYDROOROTATE
DEHYDROGENASE
(Rattus
rattus) 		5 / 10 ILE A  94
LEU A 171
LEU A 111
GLY A 112
ASN A  90
 None
 1.22A 6r2eD-1uuoA:
0.0		 6r2eD-1uuoA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 1uuo DIHYDROOROTATE
DEHYDROGENASE
(Rattus
rattus) 		5 / 11 ILE A  94
LEU A 171
LEU A 111
GLY A 112
ASN A  90
 None
 1.16A 6r2eF-1uuoA:
undetectable		 6r2eF-1uuoA:
24.17