SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1uus'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DG5_A_TOPA201_1
(DIHYDROFOLATE
REDUCTASE)		 1uus STAT PROTEIN
(Dictyostelium
discoideum) 		5 / 11 ALA A 475
ILE A 409
PHE A 371
LEU A 424
PRO A 423
 None
 1.13A 1dg5A-1uusA:
undetectable		 1dg5A-1uusA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EUP_A_ASDA452_1
(CYTOCHROME P450ERYF)		 1uus STAT PROTEIN
(Dictyostelium
discoideum) 		4 / 8 PHE A 562
ILE A 543
LEU A 540
LEU A 516
 None
 0.89A 1eupA-1uusA:
0.2		 1eupA-1uusA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 1uus STAT PROTEIN
(Dictyostelium
discoideum) 		4 / 7 LYS A 330
LEU A 333
GLN A 334
PHE A 337
 None
 0.95A 1v55P-1uusA:
5.8
1v55W-1uusA:
undetectable		 1v55P-1uusA:
19.58
1v55W-1uusA:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1uus STAT PROTEIN
(Dictyostelium
discoideum) 		4 / 7 LYS A 330
LEU A 333
GLN A 334
PHE A 337
 None
 0.93A 2eijP-1uusA:
5.8
2eijW-1uusA:
undetectable		 2eijP-1uusA:
19.58
2eijW-1uusA:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 1uus STAT PROTEIN
(Dictyostelium
discoideum) 		4 / 6 LEU A 343
PHE A 398
ASP A 463
GLU A 346
 None
 1.32A 2vn1B-1uusA:
0.0		 2vn1B-1uusA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1414_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 1uus STAT PROTEIN
(Dictyostelium
discoideum) 		4 / 8 LEU A 340
LEU A 298
THR A 261
LEU A 262
 None
 0.81A 2xfhA-1uusA:
undetectable		 2xfhA-1uusA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1uus STAT PROTEIN
(Dictyostelium
discoideum) 		4 / 7 LYS A 330
LEU A 333
GLN A 334
PHE A 337
 None
 0.99A 2zxwC-1uusA:
5.7
2zxwJ-1uusA:
undetectable		 2zxwC-1uusA:
19.58
2zxwJ-1uusA:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 1uus STAT PROTEIN
(Dictyostelium
discoideum) 		4 / 8 LYS A 330
LEU A 333
GLN A 334
PHE A 337
 None
 0.91A 3asoC-1uusA:
5.8
3asoJ-1uusA:
undetectable		 3asoC-1uusA:
19.58
3asoJ-1uusA:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 1uus STAT PROTEIN
(Dictyostelium
discoideum) 		4 / 5 ILE A 522
PRO A 372
PHE A 371
PRO A 370
 None
 1.31A 3bjwC-1uusA:
undetectable		 3bjwC-1uusA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_2
(DIHYDROFOLATE
REDUCTASE)		 1uus STAT PROTEIN
(Dictyostelium
discoideum) 		4 / 4 ILE A 588
PHE A 651
ILE A 611
THR A 581
 None
 1.12A 3ia4A-1uusA:
undetectable		 3ia4A-1uusA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 1uus STAT PROTEIN
(Dictyostelium
discoideum) 		3 / 3 GLY A 490
TRP A 488
VAL A 374
 None
 0.72A 3n62B-1uusA:
undetectable		 3n62B-1uusA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N65_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 1uus STAT PROTEIN
(Dictyostelium
discoideum) 		3 / 3 GLY A 490
TRP A 488
VAL A 374
 None
 0.74A 3n65B-1uusA:
undetectable		 3n65B-1uusA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 1uus STAT PROTEIN
(Dictyostelium
discoideum) 		3 / 3 GLY A 490
TRP A 488
VAL A 374
 None
 0.71A 3n66B-1uusA:
undetectable		 3n66B-1uusA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3O_A_DLUA399_1
(PFV INTEGRASE)		 1uus STAT PROTEIN
(Dictyostelium
discoideum) 		4 / 7 ASP A 322
PRO A 320
GLN A 517
GLU A 319
 None
 1.25A 3s3oA-1uusA:
undetectable		 3s3oA-1uusA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SNF_A_ACTA110_0
(PROTEIN P-30)		 1uus STAT PROTEIN
(Dictyostelium
discoideum) 		4 / 5 ILE A 579
THR A 572
SER A 569
PHE A 613
 None
 1.19A 3snfA-1uusA:
undetectable		 3snfA-1uusA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1uus STAT PROTEIN
(Dictyostelium
discoideum) 		4 / 4 PRO A 287
LEU A 288
ILE A 350
ARG A 395
 None
 1.19A 4f4dA-1uusA:
undetectable		 4f4dA-1uusA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G8Z_X_TOPX301_1
(DIHYDROFOLATE
REDUCTASE)		 1uus STAT PROTEIN
(Dictyostelium
discoideum) 		5 / 10 ILE A 588
LEU A 686
PHE A 651
ILE A 611
THR A 581
 None
 1.17A 4g8zX-1uusA:
undetectable		 4g8zX-1uusA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 1uus STAT PROTEIN
(Dictyostelium
discoideum) 		5 / 10 PHE A 398
THR A 392
LEU A 436
VAL A 471
ILE A 461
 None
 1.19A 4jx1B-1uusA:
undetectable		 4jx1B-1uusA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFJ_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 1uus STAT PROTEIN
(Dictyostelium
discoideum) 		6 / 12 ILE A 409
ALA A 475
LEU A 366
PHE A 457
LEU A 424
VAL A 453
 None
 1.42A 4kfjB-1uusA:
undetectable		 4kfjB-1uusA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 1uus STAT PROTEIN
(Dictyostelium
discoideum) 		3 / 3 SER A 473
ALA A 363
VAL A 362
 None
 0.56A 4o2bA-1uusA:
undetectable		 4o2bA-1uusA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 1uus STAT PROTEIN
(Dictyostelium
discoideum) 		3 / 3 SER A 473
ALA A 363
VAL A 362
 None
 0.64A 4o2bC-1uusA:
undetectable		 4o2bC-1uusA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 2)		 1uus STAT PROTEIN
(Dictyostelium
discoideum) 		3 / 3 PHE A 609
THR A 644
LEU A 686
 None
 0.67A 4qztA-1uusA:
undetectable		 4qztA-1uusA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1uus STAT PROTEIN
(Dictyostelium
discoideum) 		3 / 3 PHE A 566
ILE A 543
ASP A 558
 None
 0.71A 5cswA-1uusA:
undetectable		 5cswA-1uusA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1uus STAT PROTEIN
(Dictyostelium
discoideum) 		3 / 3 ARG A 612
ILE A 588
PHE A 621
 None
 0.65A 5kirA-1uusA:
undetectable		 5kirA-1uusA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1uus STAT PROTEIN
(Dictyostelium
discoideum) 		3 / 3 GLY A 490
TRP A 488
VAL A 374
 None
 0.71A 5vuoB-1uusA:
undetectable		 5vuoB-1uusA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA901_0
(MRNA CAPPING ENZYME
P5)		 1uus STAT PROTEIN
(Dictyostelium
discoideum) 		5 / 11 ALA A 363
SER A 341
LEU A 342
ASN A 345
ASN A 361
 None
 1.21A 5x6yA-1uusA:
undetectable		 5x6yA-1uusA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 1uus STAT PROTEIN
(Dictyostelium
discoideum) 		5 / 7 PHE A 651
ILE A 579
PHE A 520
LEU A 573
ILE A 623
 None
 1.26A 6b5vA-1uusA:
1.4
6b5vB-1uusA:
3.5		 6b5vA-1uusA:
12.06
6b5vB-1uusA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_0
(NS3 PROTEASE)		 1uus STAT PROTEIN
(Dictyostelium
discoideum) 		5 / 12 PHE A 457
ILE A 461
GLY A 458
SER A 473
ALA A 363
 None
 1.11A 6c2mB-1uusA:
undetectable		 6c2mB-1uusA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1uus STAT PROTEIN
(Dictyostelium
discoideum) 		3 / 3 LEU A 343
ASN A 274
LEU A 288
 None
 0.60A 6exiA-1uusA:
undetectable		 6exiA-1uusA:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA821_0
(GEPHYRIN)		 1uus STAT PROTEIN
(Dictyostelium
discoideum) 		3 / 3 ARG A 551
PHE A 548
GLY A 549
 None
 0.74A 6fgdA-1uusA:
undetectable		 6fgdA-1uusA:
21.16