SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1uv4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA2001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 1uv4 ARABINAN-ENDO
1,5-ALPHA-L-ARABINAS
E
(Bacillus
subtilis) 		4 / 6 TRP A 152
GLY A 181
ASN A 210
PRO A 178
 None
 1.01A 1dedA-1uv4A:
undetectable		 1dedA-1uv4A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA2001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 1uv4 ARABINAN-ENDO
1,5-ALPHA-L-ARABINAS
E
(Bacillus
subtilis) 		4 / 6 TRP A 152
GLY A 182
ASN A 210
PRO A 178
 None
 1.40A 1dedA-1uv4A:
undetectable		 1dedA-1uv4A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 1uv4 ARABINAN-ENDO
1,5-ALPHA-L-ARABINAS
E
(Bacillus
subtilis) 		4 / 8 GLY A  36
SER A  90
ASP A 133
ASP A  14
 None
 0.83A 1m4iA-1uv4A:
undetectable		 1m4iA-1uv4A:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 1uv4 ARABINAN-ENDO
1,5-ALPHA-L-ARABINAS
E
(Bacillus
subtilis) 		5 / 11 GLY A 154
SER A 173
ILE A 174
LEU A 198
VAL A 200
 None
EDO  A1296 (-2.7A)
None
None
None
 0.93A 2kawA-1uv4A:
undetectable		 2kawA-1uv4A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 1uv4 ARABINAN-ENDO
1,5-ALPHA-L-ARABINAS
E
(Bacillus
subtilis) 		3 / 3 ILE A  78
ILE A  54
LEU A 160
 None
 0.53A 2prgA-1uv4A:
undetectable		 2prgA-1uv4A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_2
(GLUCOSYLTRANSFERASE-
SI)		 1uv4 ARABINAN-ENDO
1,5-ALPHA-L-ARABINAS
E
(Bacillus
subtilis) 		3 / 3 LEU A  27
TRP A  86
TYR A  89
 None
 0.99A 3aicA-1uv4A:
undetectable		 3aicA-1uv4A:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_2
(GLUCOSYLTRANSFERASE-
SI)		 1uv4 ARABINAN-ENDO
1,5-ALPHA-L-ARABINAS
E
(Bacillus
subtilis) 		3 / 3 LEU A  27
TRP A  86
TYR A  89
 None
 1.01A 3aicB-1uv4A:
undetectable		 3aicB-1uv4A:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_2
(GLUCOSYLTRANSFERASE-
SI)		 1uv4 ARABINAN-ENDO
1,5-ALPHA-L-ARABINAS
E
(Bacillus
subtilis) 		3 / 3 LEU A  27
TRP A  86
TYR A  89
 None
 1.00A 3aicG-1uv4A:
undetectable		 3aicG-1uv4A:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 1uv4 ARABINAN-ENDO
1,5-ALPHA-L-ARABINAS
E
(Bacillus
subtilis) 		3 / 4 SER A   8
GLY A 255
GLU A 135
 None
None
CA  A1294 (-2.9A)
 0.69A 3raeA-1uv4A:
undetectable
3raeC-1uv4A:
undetectable		 3raeA-1uv4A:
19.56
3raeC-1uv4A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 1uv4 ARABINAN-ENDO
1,5-ALPHA-L-ARABINAS
E
(Bacillus
subtilis) 		3 / 3 TYR A  80
LEU A  40
LYS A  41
 None
 0.64A 3sueD-1uv4A:
undetectable		 3sueD-1uv4A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_D_NCTD501_1
(CYTOCHROME P450 2A6)		 1uv4 ARABINAN-ENDO
1,5-ALPHA-L-ARABINAS
E
(Bacillus
subtilis) 		4 / 7 ASN A 128
ILE A 121
LEU A 171
PHE A 148
 EDO  A1296 ( 4.1A)
None
EDO  A1296 (-4.2A)
None
 0.86A 4ejjD-1uv4A:
undetectable		 4ejjD-1uv4A:
19.14