SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1uvx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_B_ESTB354_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 1uvx GLOBIN LI637
(Chlamydomonas
moewusii) 		4 / 8 SER A 110
VAL A 108
LEU A  53
VAL A  12
 None
None
None
XE  A1125 ( 4.6A)
 1.09A 1fduB-1uvxA:
undetectable		 1fduB-1uvxA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_A_NIOA145_1
(LEGHEMOGLOBIN A)		 1uvx GLOBIN LI637
(Chlamydomonas
moewusii) 		4 / 8 PHE A  19
TYR A  20
ILE A  23
VAL A  83
 XE  A1126 ( 4.2A)
CYN  A1123 (-4.9A)
None
HEM  A1122 (-4.5A)
 0.80A 1fslA-1uvxA:
8.2		 1fslA-1uvxA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_B_NIOB145_1
(LEGHEMOGLOBIN A)		 1uvx GLOBIN LI637
(Chlamydomonas
moewusii) 		4 / 8 PHE A  19
TYR A  20
ILE A  23
VAL A  83
 XE  A1126 ( 4.2A)
CYN  A1123 (-4.9A)
None
HEM  A1122 (-4.5A)
 0.72A 1fslB-1uvxA:
8.5		 1fslB-1uvxA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_A_T44A128_1
(TRANSTHYRETIN)		 1uvx GLOBIN LI637
(Chlamydomonas
moewusii) 		4 / 4 LYS A   5
LEU A   2
ALA A   4
LEU A  53
 None
 1.32A 2roxA-1uvxA:
undetectable		 2roxA-1uvxA:
26.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_A_ECNA403_1
(FLAVOHEMOGLOBIN)		 1uvx GLOBIN LI637
(Chlamydomonas
moewusii) 		5 / 12 PHE A  19
TYR A  20
PHE A  33
VAL A  83
LEU A  87
 XE  A1126 ( 4.2A)
CYN  A1123 (-4.9A)
HEM  A1122 ( 4.1A)
HEM  A1122 (-4.5A)
XE  A1126 (-3.7A)
 0.88A 4g1bA-1uvxA:
10.1		 4g1bA-1uvxA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_C_ECNC403_1
(FLAVOHEMOGLOBIN)		 1uvx GLOBIN LI637
(Chlamydomonas
moewusii) 		5 / 9 PHE A  19
TYR A  20
LEU A  49
VAL A  83
LEU A  87
 XE  A1126 ( 4.2A)
CYN  A1123 (-4.9A)
XE  A1125 (-4.7A)
HEM  A1122 (-4.5A)
XE  A1126 (-3.7A)
 1.12A 4g1bC-1uvxA:
3.6		 4g1bC-1uvxA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_2
(ANCESTRAL STEROID
RECEPTOR 2)		 1uvx GLOBIN LI637
(Chlamydomonas
moewusii) 		4 / 8 ALA A  15
THR A 111
VAL A 115
PHE A  80
 XE  A1127 ( 3.9A)
HEM  A1122 (-4.3A)
HEM  A1122 (-4.9A)
HEM  A1122 (-3.7A)
 0.74A 4ltwA-1uvxA:
undetectable		 4ltwA-1uvxA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA602_1
(SERUM ALBUMIN)		 1uvx GLOBIN LI637
(Chlamydomonas
moewusii) 		4 / 8 LEU A  91
ASP A 100
ALA A 104
VAL A 107
 XE  A1127 (-4.8A)
None
None
None
 0.68A 4zbqA-1uvxA:
undetectable		 4zbqA-1uvxA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_B_DB8B800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 1uvx GLOBIN LI637
(Chlamydomonas
moewusii) 		5 / 10 ILE A 101
GLY A   7
LEU A   6
ALA A 104
ASP A 103
 None
None
XE  A1127 ( 3.8A)
None
None
 1.22A 5ajqB-1uvxA:
undetectable		 5ajqB-1uvxA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_A_6J3A201_0
(TRANSTHYRETIN)		 1uvx GLOBIN LI637
(Chlamydomonas
moewusii) 		4 / 4 LYS A   5
LEU A   2
ALA A   4
LEU A  53
 None
 1.42A 6gnrA-1uvxA:
undetectable		 6gnrA-1uvxA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_B_6J3B201_0
(TRANSTHYRETIN)		 1uvx GLOBIN LI637
(Chlamydomonas
moewusii) 		4 / 4 LYS A   5
LEU A   2
ALA A   4
LEU A  53
 None
 1.43A 6gnrB-1uvxA:
undetectable		 6gnrB-1uvxA:
23.94