SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1uw0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_H_DHIH3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 1uw0 DNA LIGASE III
(Homo
sapiens) 		3 / 3 LEU A  73
TRP A  79
GLY A  78
 None
 0.71A 3l35A-1uw0A:
undetectable
3l35H-1uw0A:
undetectable		 3l35A-1uw0A:
18.80
3l35H-1uw0A:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_K_DHIK3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 1uw0 DNA LIGASE III
(Homo
sapiens) 		3 / 3 LEU A  73
TRP A  79
GLY A  78
 None
 0.71A 3l35B-1uw0A:
undetectable
3l35K-1uw0A:
undetectable		 3l35B-1uw0A:
18.80
3l35K-1uw0A:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_C_ESTC600_1
(ESTROGEN RECEPTOR
BETA)		 1uw0 DNA LIGASE III
(Homo
sapiens) 		5 / 12 LEU A  76
ILE A  53
ILE A  90
HIS A  93
LEU A  97
 None
 1.22A 4j24C-1uw0A:
undetectable		 4j24C-1uw0A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 1uw0 DNA LIGASE III
(Homo
sapiens) 		5 / 12 LEU A  76
ILE A  53
ILE A  90
HIS A  93
LEU A  97
 None
 1.19A 4j26B-1uw0A:
undetectable		 4j26B-1uw0A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_2
(NEURAMINIDASE)		 1uw0 DNA LIGASE III
(Homo
sapiens) 		4 / 5 LEU A  82
ASP A   9
ARG A  31
ILE A  25
 None
 1.40A 4mwrA-1uw0A:
undetectable		 4mwrA-1uw0A:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 1uw0 DNA LIGASE III
(Homo
sapiens) 		5 / 12 HIS A  52
CYH A  18
LYS A  19
CYH A  21
ILE A  25
 ZN  A1118 (-3.1A)
ZN  A1118 (-2.2A)
None
ZN  A1118 (-2.3A)
None
 1.40A 4ynpA-1uw0A:
undetectable		 4ynpA-1uw0A:
19.46