SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1uw4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1872_0
(FPRA)		 1uw4 UPF3X
(Homo
sapiens) 		4 / 5 SER A  51
ASN A 100
ALA A 139
ASP A  78
 None
 1.25A 1lqtA-1uw4A:
undetectable
1lqtB-1uw4A:
undetectable		 1lqtA-1uw4A:
12.38
1lqtB-1uw4A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1429_0
(FPRA)		 1uw4 UPF3X
(Homo
sapiens) 		4 / 5 SER A  51
ASN A 100
ALA A 139
ASP A  78
 None
 1.23A 1lquA-1uw4A:
undetectable
1lquB-1uw4A:
undetectable		 1lquA-1uw4A:
12.38
1lquB-1uw4A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_2
(LIVER
CARBOXYLESTERASE I)		 1uw4 REGULATOR OF
NONSENSE TRANSCRIPTS
2
(Homo
sapiens) 		3 / 3 PHE B 945
LEU B 926
MET B 975
 None
 0.85A 1mx1D-1uw4B:
undetectable		 1mx1D-1uw4B:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 1uw4 REGULATOR OF
NONSENSE TRANSCRIPTS
2
(Homo
sapiens) 		3 / 3 ARG B 776
ILE B 816
TRP B 817
 None
 1.09A 1nodB-1uw4B:
undetectable		 1nodB-1uw4B:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_C_CHDC3271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 1uw4 UPF3X
(Homo
sapiens) 		4 / 7 LYS A  64
LEU A  67
GLN A  68
LEU A  58
 None
 1.10A 1v55C-1uw4A:
undetectable
1v55J-1uw4A:
undetectable		 1v55C-1uw4A:
15.13
1v55J-1uw4A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_A_STRA401_1
(MINERALOCORTICOID
RECEPTOR)		 1uw4 REGULATOR OF
NONSENSE TRANSCRIPTS
2
(Homo
sapiens) 		5 / 12 LEU B 830
ASN B 829
LEU B 831
ALA B 828
LEU B 779
 None
 1.26A 2aa6A-1uw4B:
undetectable		 2aa6A-1uw4B:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_A_PXLA1003_1
(PYRIDOXINE KINASE)		 1uw4 REGULATOR OF
NONSENSE TRANSCRIPTS
2
(Homo
sapiens) 		4 / 8 VAL B 775
VAL B 809
LEU B 771
PRO B 799
 None
 1.01A 2ddwA-1uw4B:
undetectable		 2ddwA-1uw4B:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_P_CHDP310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1uw4 UPF3X
(Homo
sapiens) 		4 / 7 LYS A  64
LEU A  67
GLN A  68
LEU A  58
 None
 1.09A 2dysP-1uw4A:
undetectable
2dysW-1uw4A:
undetectable		 2dysP-1uw4A:
15.13
2dysW-1uw4A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1uw4 UPF3X
(Homo
sapiens) 		4 / 7 LYS A  64
LEU A  67
GLN A  68
LEU A  58
 None
 1.09A 2eimC-1uw4A:
undetectable
2eimJ-1uw4A:
undetectable		 2eimC-1uw4A:
15.13
2eimJ-1uw4A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 1uw4 REGULATOR OF
NONSENSE TRANSCRIPTS
2
(Homo
sapiens) 		3 / 3 ARG B 776
ILE B 816
TRP B 817
 None
 1.08A 2nodB-1uw4B:
undetectable		 2nodB-1uw4B:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		 1uw4 REGULATOR OF
NONSENSE TRANSCRIPTS
2
UPF3X
(Homo
sapiens) 		3 / 3 LEU B 910
LEU A  89
PHE B 899
 None
 0.67A 2pgrA-1uw4B:
undetectable		 2pgrA-1uw4B:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 1uw4 REGULATOR OF
NONSENSE TRANSCRIPTS
2
(Homo
sapiens) 		3 / 3 ASN B 865
ARG B 868
ASP B 911
 None
 0.98A 2qe6A-1uw4B:
undetectable		 2qe6A-1uw4B:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 1uw4 REGULATOR OF
NONSENSE TRANSCRIPTS
2
(Homo
sapiens) 		3 / 3 ASN B 865
ARG B 868
ASP B 911
 None
 0.98A 2qe6B-1uw4B:
undetectable		 2qe6B-1uw4B:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_1
(PUTATIVE
MODIFICATION
METHYLASE)		 1uw4 UPF3X
REGULATOR OF
NONSENSE TRANSCRIPTS
2
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ASP B 840
THR A  63
GLU A  81
 None
 0.73A 2zifB-1uw4B:
undetectable		 2zifB-1uw4B:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_B_SAMB402_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 1uw4 UPF3X
REGULATOR OF
NONSENSE TRANSCRIPTS
2
(Homo
sapiens;
Homo
sapiens) 		5 / 12 PHE A 136
PHE A  83
GLY B 848
ILE B 843
ASP B 840
 None
 1.30A 2zznB-1uw4A:
undetectable		 2zznB-1uw4A:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 1uw4 REGULATOR OF
NONSENSE TRANSCRIPTS
2
(Homo
sapiens) 		4 / 4 ARG B 984
GLN B 950
PHE B 949
LEU B 942
 None
 1.33A 3abkC-1uw4B:
1.1		 3abkC-1uw4B:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1uw4 REGULATOR OF
NONSENSE TRANSCRIPTS
2
(Homo
sapiens) 		4 / 5 ARG B 984
GLN B 950
PHE B 949
LEU B 942
 None
 1.36A 3ablC-1uw4B:
undetectable
3ablJ-1uw4B:
undetectable		 3ablC-1uw4B:
20.20
3ablJ-1uw4B:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E6T_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1uw4 REGULATOR OF
NONSENSE TRANSCRIPTS
2
(Homo
sapiens) 		3 / 3 ARG B 776
ILE B 816
TRP B 817
 None
 1.03A 3e6tB-1uw4B:
undetectable		 3e6tB-1uw4B:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW4_A_TICA600_1
(CYTOCHROME P450 2B4)		 1uw4 REGULATOR OF
NONSENSE TRANSCRIPTS
2
(Homo
sapiens) 		5 / 11 ILE B 853
ALA B 872
GLU B 877
ILE B 889
VAL B 884
 None
 0.97A 3kw4A-1uw4B:
undetectable		 3kw4A-1uw4B:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1uw4 REGULATOR OF
NONSENSE TRANSCRIPTS
2
(Homo
sapiens) 		3 / 3 ARG B 776
ILE B 816
TRP B 817
 None
 1.14A 3nw2A-1uw4B:
undetectable		 3nw2A-1uw4B:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUN_A_CCSA165_0
(LYSOZYME)		 1uw4 UPF3X
(Homo
sapiens) 		3 / 3 ASN A 100
ALA A 139
LYS A  52
 None
 1.03A 3runA-1uw4A:
undetectable		 3runA-1uw4A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA609_0
(GBAA_1210 PROTEIN)		 1uw4 REGULATOR OF
NONSENSE TRANSCRIPTS
2
(Homo
sapiens) 		3 / 3 LYS B 806
VAL B 841
HIS B 844
 None
 1.19A 3tj7A-1uw4B:
undetectable		 3tj7A-1uw4B:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1uw4 UPF3X
(Homo
sapiens) 		4 / 6 VAL A 131
VAL A  53
ILE A  99
LEU A  67
 None
 0.92A 4l1wB-1uw4A:
undetectable		 4l1wB-1uw4A:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_A_BEZA1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 1uw4 REGULATOR OF
NONSENSE TRANSCRIPTS
2
(Homo
sapiens) 		4 / 6 GLY B 900
SER B 908
VAL B 901
HIS B 915
 None
 0.82A 5ewuA-1uw4B:
3.5		 5ewuA-1uw4B:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_B_BEZB1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 1uw4 REGULATOR OF
NONSENSE TRANSCRIPTS
2
(Homo
sapiens) 		4 / 6 GLY B 900
SER B 908
VAL B 901
HIS B 915
 None
 0.83A 5ewuB-1uw4B:
1.9		 5ewuB-1uw4B:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 1uw4 REGULATOR OF
NONSENSE TRANSCRIPTS
2
(Homo
sapiens) 		3 / 3 ARG B 984
PHE B 949
LEU B 942
 None
 0.94A 5x1bC-1uw4B:
undetectable		 5x1bC-1uw4B:
20.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BEO_A_DHIA4_0
((DPR)PY(DHI)PKDL(DGN
))		 1uw4 UPF3X
(Homo
sapiens) 		3 / 3 TYR A  94
PRO A  59
LEU A  58
 None
 0.88A 6beoA-1uw4A:
undetectable		 6beoA-1uw4A:
50.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 1uw4 REGULATOR OF
NONSENSE TRANSCRIPTS
2
(Homo
sapiens) 		4 / 4 ARG B 984
GLN B 950
PHE B 949
LEU B 942
 None
 1.47A 6nmfC-1uw4B:
1.1		 6nmfC-1uw4B:
20.20