SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1uwe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
316D_C_DVAC2_0
(8-FLUORO-ACTINOMYCIN
D)		 1uwe ANTIBODY 14D9
(Homo
sapiens;
Mus
musculus) 		3 / 3 THR H  33
PRO H  52
THR H  30
 None
 0.91A 316dC-1uweH:
undetectable		 316dC-1uweH:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA302_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 1uwe ANTIBODY 14D9
(Homo
sapiens;
Mus
musculus) 		4 / 6 LEU H 189
GLY H 190
ALA H 125
PRO H 126
 None
 0.51A 3huoA-1uweH:
undetectable		 3huoA-1uweH:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1uwe ANTIBODY 14D9
(Homo
sapiens;
Mus
musculus) 		5 / 11 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
 None
 0.86A 4qvnH-1uweH:
undetectable
4qvnI-1uweH:
0.3		 4qvnH-1uweH:
22.48
4qvnI-1uweH:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1uwe ANTIBODY 14D9
(Homo
sapiens;
Mus
musculus) 		5 / 10 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
 None
 0.86A 4qvnV-1uweH:
undetectable
4qvnW-1uweH:
undetectable		 4qvnV-1uweH:
22.48
4qvnW-1uweH:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1uwe ANTIBODY 14D9
(Homo
sapiens;
Mus
musculus) 		5 / 12 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
 None
 0.84A 4qvpH-1uweH:
undetectable
4qvpI-1uweH:
undetectable		 4qvpH-1uweH:
22.48
4qvpI-1uweH:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1uwe ANTIBODY 14D9
(Homo
sapiens;
Mus
musculus) 		5 / 12 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
 None
 0.84A 4qvpV-1uweH:
undetectable
4qvpW-1uweH:
undetectable		 4qvpV-1uweH:
22.48
4qvpW-1uweH:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1uwe ANTIBODY 14D9
(Homo
sapiens;
Mus
musculus) 		5 / 11 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
 None
 0.86A 4qvqH-1uweH:
undetectable
4qvqI-1uweH:
undetectable		 4qvqH-1uweH:
22.48
4qvqI-1uweH:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1uwe ANTIBODY 14D9
(Homo
sapiens;
Mus
musculus) 		5 / 11 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
 None
 0.85A 4qvqV-1uweH:
undetectable
4qvqW-1uweH:
undetectable		 4qvqV-1uweH:
22.48
4qvqW-1uweH:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 1uwe ANTIBODY 14D9
(Homo
sapiens;
Mus
musculus) 		5 / 11 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
 None
 0.88A 4qvvH-1uweH:
undetectable		 4qvvH-1uweH:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 1uwe ANTIBODY 14D9
(Homo
sapiens;
Mus
musculus) 		5 / 11 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
 None
 0.87A 4qvvV-1uweH:
undetectable		 4qvvV-1uweH:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 1uwe ANTIBODY 14D9
(Homo
sapiens;
Mus
musculus) 		5 / 11 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
 None
 0.87A 4qvyH-1uweH:
undetectable		 4qvyH-1uweH:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1uwe ANTIBODY 14D9
(Homo
sapiens;
Mus
musculus) 		5 / 12 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
 None
 0.87A 4qvyV-1uweH:
undetectable
4qvyW-1uweH:
undetectable		 4qvyV-1uweH:
22.48
4qvyW-1uweH:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1uwe ANTIBODY 14D9
(Homo
sapiens;
Mus
musculus) 		5 / 11 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
 None
 0.86A 4qw0H-1uweH:
undetectable
4qw0I-1uweH:
undetectable		 4qw0H-1uweH:
22.48
4qw0I-1uweH:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1uwe ANTIBODY 14D9
(Homo
sapiens;
Mus
musculus) 		5 / 11 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
 None
 0.86A 4qw0V-1uweH:
undetectable
4qw0W-1uweH:
undetectable		 4qw0V-1uweH:
22.48
4qw0W-1uweH:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1uwe ANTIBODY 14D9
(Homo
sapiens;
Mus
musculus) 		5 / 12 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
 None
 0.88A 4qw1H-1uweH:
undetectable
4qw1I-1uweH:
undetectable		 4qw1H-1uweH:
22.48
4qw1I-1uweH:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1uwe ANTIBODY 14D9
(Homo
sapiens;
Mus
musculus) 		5 / 12 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
 None
 0.87A 4qw1V-1uweH:
undetectable
4qw1W-1uweH:
undetectable		 4qw1V-1uweH:
22.48
4qw1W-1uweH:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1uwe ANTIBODY 14D9
(Homo
sapiens;
Mus
musculus) 		5 / 11 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
 None
 0.88A 4qwuH-1uweH:
0.0
4qwuI-1uweH:
undetectable		 4qwuH-1uweH:
22.48
4qwuI-1uweH:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1uwe ANTIBODY 14D9
(Homo
sapiens;
Mus
musculus) 		5 / 11 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
 None
 0.88A 4qwuV-1uweH:
0.0
4qwuW-1uweH:
undetectable		 4qwuV-1uweH:
22.48
4qwuW-1uweH:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1uwe ANTIBODY 14D9
(Homo
sapiens;
Mus
musculus) 		5 / 8 THR H 191
ASN H 155
VAL H 182
LEU H 138
GLY H 190
 None
 1.46A 4r3aA-1uweH:
undetectable		 4r3aA-1uweH:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA409_0
(FAD:PROTEIN FMN
TRANSFERASE)		 1uwe ANTIBODY 14D9
(Homo
sapiens;
Mus
musculus) 		4 / 5 VAL H  18
ILE H  20
VAL H 109
THR H 107
 None
 0.76A 4xdtA-1uweH:
undetectable		 4xdtA-1uweH:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1uwe ANTIBODY 14D9
(Homo
sapiens;
Mus
musculus) 		5 / 11 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
 None
 0.87A 5bxnH-1uweH:
undetectable
5bxnI-1uweH:
undetectable		 5bxnH-1uweH:
22.48
5bxnI-1uweH:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1uwe ANTIBODY 14D9
(Homo
sapiens;
Mus
musculus) 		5 / 12 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
 None
 0.86A 5cz7V-1uweH:
undetectable
5cz7W-1uweH:
undetectable		 5cz7V-1uweH:
22.48
5cz7W-1uweH:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 1uwe ANTIBODY 14D9
(Homo
sapiens;
Mus
musculus) 		5 / 11 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
 None
 0.85A 5d0xV-1uweH:
undetectable		 5d0xV-1uweH:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1uwe ANTIBODY 14D9
(Homo
sapiens;
Mus
musculus) 		5 / 12 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
 None
 0.83A 5l5fH-1uweH:
undetectable
5l5fI-1uweH:
undetectable		 5l5fH-1uweH:
22.48
5l5fI-1uweH:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1uwe ANTIBODY 14D9
(Homo
sapiens;
Mus
musculus) 		5 / 12 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
 None
 0.83A 5l5fV-1uweH:
undetectable
5l5fW-1uweH:
undetectable		 5l5fV-1uweH:
22.48
5l5fW-1uweH:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_H_BO2H301_0
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1uwe ANTIBODY 14D9
(Homo
sapiens;
Mus
musculus) 		5 / 12 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
 None
 0.96A 6hwdH-1uweH:
undetectable
6hwdI-1uweH:
undetectable		 6hwdH-1uweH:
19.78
6hwdI-1uweH:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_V_BO2V301_0
(PROTEASOME SUBUNIT
BETA TYPE-2)		 1uwe ANTIBODY 14D9
(Homo
sapiens;
Mus
musculus) 		5 / 11 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
 None
 0.96A 6hwdV-1uweH:
undetectable		 6hwdV-1uweH:
19.78