SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1uwi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A27_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 1uwi BETA-GALACTOSIDASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A  56
MET A  21
TYR A 448
VAL A  37
PHE A  17
 None
 1.35A 1a27A-1uwiA:
undetectable		 1a27A-1uwiA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G60_A_SAMA500_0
(ADENINE-SPECIFIC
METHYLTRANSFERASE
MBOIIA)		 1uwi BETA-GALACTOSIDASE
(Sulfolobus
solfataricus) 		5 / 12 ASN A  62
ASP A  28
PRO A 152
GLY A  16
ASN A 430
 None
 1.37A 1g60A-1uwiA:
undetectable		 1g60A-1uwiA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G60_B_SAMB501_0
(ADENINE-SPECIFIC
METHYLTRANSFERASE
MBOIIA)		 1uwi BETA-GALACTOSIDASE
(Sulfolobus
solfataricus) 		5 / 12 ASN A  62
ASP A  28
PRO A 152
GLY A  16
ASN A 430
 None
 1.39A 1g60B-1uwiA:
1.5		 1g60B-1uwiA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPK_A_ACAA80_1
(PLASMINOGEN)		 1uwi BETA-GALACTOSIDASE
(Sulfolobus
solfataricus) 		4 / 6 PRO A 482
ASP A 392
ASP A 395
TYR A 400
 None
 1.46A 1hpkA-1uwiA:
undetectable		 1hpkA-1uwiA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		 1uwi BETA-GALACTOSIDASE
(Sulfolobus
solfataricus) 		4 / 7 TYR A 401
HIS A 405
LEU A 368
TYR A 322
 None
 1.20A 1tuvA-1uwiA:
undetectable		 1tuvA-1uwiA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAK_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 1uwi BETA-GALACTOSIDASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A 343
VAL A 327
LEU A 337
GLY A 338
GLY A 339
 None
 0.92A 1uakA-1uwiA:
undetectable		 1uakA-1uwiA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_C_URFC999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 1uwi BETA-GALACTOSIDASE
(Sulfolobus
solfataricus) 		4 / 5 ALA A 292
TYR A 237
ILE A 240
ASP A 104
 None
 1.14A 1upfC-1uwiA:
2.5		 1upfC-1uwiA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VID_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 1uwi BETA-GALACTOSIDASE
(Sulfolobus
solfataricus) 		4 / 5 SER A 265
GLU A 362
TYR A 340
SER A 357
 None
 1.43A 1vidA-1uwiA:
0.0		 1vidA-1uwiA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMJ_A_ACRA1001_2
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 1uwi BETA-GALACTOSIDASE
(Sulfolobus
solfataricus) 		4 / 6 THR A 325
TYR A 262
TRP A 287
THR A 323
 None
 1.44A 2qmjA-1uwiA:
7.2		 2qmjA-1uwiA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_B_NBVB1504_1
(GLUCOSYLCERAMIDASE)		 1uwi BETA-GALACTOSIDASE
(Sulfolobus
solfataricus) 		5 / 11 ASN A 205
GLU A 206
TYR A 322
GLU A 387
TRP A 425
 None
 0.84A 2v3dB-1uwiA:
15.1		 2v3dB-1uwiA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1000_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1uwi BETA-GALACTOSIDASE
(Sulfolobus
solfataricus) 		5 / 10 THR A 386
ILE A 261
TYR A 262
PHE A 290
ILE A 317
 None
 1.15A 2y7pA-1uwiA:
undetectable		 2y7pA-1uwiA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVJ_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 1uwi BETA-GALACTOSIDASE
(Sulfolobus
solfataricus) 		4 / 6 SER A 265
GLU A 362
TYR A 340
SER A 357
 None
 1.40A 2zvjA-1uwiA:
0.0		 2zvjA-1uwiA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1200_1
(SERUM ALBUMIN)		 1uwi BETA-GALACTOSIDASE
(Sulfolobus
solfataricus) 		4 / 5 ILE A 145
TYR A 143
ARG A 420
GLY A 421
 None
 1.10A 3b9mA-1uwiA:
0.0		 3b9mA-1uwiA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_2
(PHOSPHOLIPASE A2)		 1uwi BETA-GALACTOSIDASE
(Sulfolobus
solfataricus) 		4 / 6 VAL A 403
GLY A  74
ARG A   9
LEU A 142
 None
 0.99A 3bjwE-1uwiA:
undetectable		 3bjwE-1uwiA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1uwi BETA-GALACTOSIDASE
(Sulfolobus
solfataricus) 		4 / 5 THR A 386
THR A 203
HIS A 243
LEU A 314
 None
 1.33A 3ce6A-1uwiA:
undetectable		 3ce6A-1uwiA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1uwi BETA-GALACTOSIDASE
(Sulfolobus
solfataricus) 		4 / 5 THR A 386
THR A 203
HIS A 243
LEU A 314
 None
 1.34A 3ce6C-1uwiA:
undetectable		 3ce6C-1uwiA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF202_1
(PROTEIN S100-A4)		 1uwi BETA-GALACTOSIDASE
(Sulfolobus
solfataricus) 		5 / 11 GLU A 362
LEU A 354
PHE A 363
PHE A 359
SER A 265
 None
 1.42A 3ko0E-1uwiA:
undetectable
3ko0F-1uwiA:
undetectable
3ko0G-1uwiA:
undetectable
3ko0H-1uwiA:
undetectable		 3ko0E-1uwiA:
11.96
3ko0F-1uwiA:
11.96
3ko0G-1uwiA:
11.96
3ko0H-1uwiA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU9_B_SPMB700_1
(POLYAMINE OXIDASE)		 1uwi BETA-GALACTOSIDASE
(Sulfolobus
solfataricus) 		4 / 7 GLU A  54
TYR A 431
PHE A  17
TYR A  34
 None
 1.34A 3ku9B-1uwiA:
undetectable		 3ku9B-1uwiA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TPX_E_ACTE204_0
(E3 UBIQUITIN-PROTEIN
LIGASE MDM2)		 1uwi BETA-GALACTOSIDASE
(Sulfolobus
solfataricus) 		3 / 3 LYS A 485
PRO A 486
LEU A 487
 None
 0.71A 3tpxE-1uwiA:
undetectable		 3tpxE-1uwiA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UGR_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 1uwi BETA-GALACTOSIDASE
(Sulfolobus
solfataricus) 		4 / 7 TYR A 322
ASN A 430
PRO A  57
TYR A 448
 None
 1.15A 3ugrA-1uwiA:
10.9		 3ugrA-1uwiA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 1uwi BETA-GALACTOSIDASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A 469
VAL A 419
TYR A 462
TYR A 422
ASN A 388
 None
 1.45A 4a83A-1uwiA:
0.0		 4a83A-1uwiA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOY_A_CSCA214_1
(UNCHARACTERIZED
PROTEIN)		 1uwi BETA-GALACTOSIDASE
(Sulfolobus
solfataricus) 		5 / 11 PRO A 223
TYR A 215
GLY A 211
ILE A 239
LEU A 153
 None
 1.22A 4koyA-1uwiA:
0.0		 4koyA-1uwiA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_A_ACTA603_0
(CHOLINE OXIDASE)		 1uwi BETA-GALACTOSIDASE
(Sulfolobus
solfataricus) 		3 / 3 ARG A 398
HIS A 424
SER A 458
 None
 0.78A 4mjwA-1uwiA:
undetectable
4mjwB-1uwiA:
undetectable		 4mjwA-1uwiA:
22.75
4mjwB-1uwiA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_B_ACTB603_0
(CHOLINE OXIDASE)		 1uwi BETA-GALACTOSIDASE
(Sulfolobus
solfataricus) 		3 / 3 SER A 458
ARG A 398
HIS A 424
 None
 0.74A 4mjwA-1uwiA:
undetectable
4mjwB-1uwiA:
undetectable		 4mjwA-1uwiA:
22.75
4mjwB-1uwiA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		 1uwi BETA-GALACTOSIDASE
(Sulfolobus
solfataricus) 		5 / 9 VAL A 409
TYR A 422
GLY A 469
PHE A   4
GLY A 421
 None
 1.26A 4mm5A-1uwiA:
undetectable		 4mm5A-1uwiA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA603_1
(TRANSPORTER)		 1uwi BETA-GALACTOSIDASE
(Sulfolobus
solfataricus) 		5 / 10 VAL A 409
TYR A 422
GLY A 469
PHE A   4
GLY A 421
 None
 1.32A 4mmcA-1uwiA:
undetectable		 4mmcA-1uwiA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_B_29QB603_1
(TRANSPORTER)		 1uwi BETA-GALACTOSIDASE
(Sulfolobus
solfataricus) 		5 / 9 VAL A 409
TYR A 422
GLY A 469
PHE A   4
GLY A 421
 None
 1.24A 4mmeB-1uwiA:
undetectable		 4mmeB-1uwiA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTS_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 1uwi BETA-GALACTOSIDASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A 389
GLY A 442
ASP A 429
TYR A 431
TYR A 322
 None
 1.25A 4rtsA-1uwiA:
undetectable		 4rtsA-1uwiA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_2
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 1uwi BETA-GALACTOSIDASE
(Sulfolobus
solfataricus) 		3 / 3 GLU A  83
TRP A  84
ASN A 147
 None
 0.70A 5dv4A-1uwiA:
undetectable		 5dv4A-1uwiA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 1uwi BETA-GALACTOSIDASE
(Sulfolobus
solfataricus) 		4 / 5 SER A 265
GLU A 362
TYR A 340
SER A 357
 None
 1.46A 5fhrA-1uwiA:
1.1		 5fhrA-1uwiA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 1uwi BETA-GALACTOSIDASE
(Sulfolobus
solfataricus) 		5 / 9 LEU A 231
LEU A 175
ARG A 233
MET A 236
ALA A 235
 None
 1.50A 5g44A-1uwiA:
undetectable		 5g44A-1uwiA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_J_EDTJ301_0
(TCRBETA CHAIN)		 1uwi BETA-GALACTOSIDASE
(Sulfolobus
solfataricus) 		4 / 5 TYR A 321
GLU A 362
GLY A 341
SER A 265
 None
 1.16A 5jhdJ-1uwiA:
0.0		 5jhdJ-1uwiA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L94_A_TESA502_1
(CYTOCHROME P450)		 1uwi BETA-GALACTOSIDASE
(Sulfolobus
solfataricus) 		5 / 8 VAL A 371
ALA A 417
VAL A 385
HIS A 405
VAL A 319
 None
 1.33A 5l94A-1uwiA:
undetectable		 5l94A-1uwiA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		 1uwi BETA-GALACTOSIDASE
(Sulfolobus
solfataricus) 		3 / 3 TRP A 151
MET A 204
ASN A 147
 None
 1.49A 5uc1A-1uwiA:
undetectable		 5uc1A-1uwiA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA307_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 1uwi BETA-GALACTOSIDASE
(Sulfolobus
solfataricus) 		4 / 5 ASP A 392
GLU A 345
ARG A 346
THR A 356
 None
 1.41A 5uxcA-1uwiA:
undetectable		 5uxcA-1uwiA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH6_A_017A104_0
(PROTEASE)		 1uwi BETA-GALACTOSIDASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A 312
ILE A 317
GLY A 259
VAL A 258
ILE A 293
 None
 0.96A 6dh6A-1uwiA:
undetectable		 6dh6A-1uwiA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_2
(-)		 1uwi BETA-GALACTOSIDASE
(Sulfolobus
solfataricus) 		4 / 5 ILE A 261
THR A 386
THR A 203
LEU A 314
 None
 0.96A 6f3mD-1uwiA:
undetectable		 6f3mD-1uwiA:
21.55