SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1uwv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_B_DEXB2999_1
(GLUCOCORTICOID
RECEPTOR)		 1uwv 23S RRNA
(URACIL-5-)-METHYLTR
ANSFERASE RUMA
(Escherichia
coli) 		5 / 12 GLY A  28
GLN A  92
LEU A  99
THR A  38
PHE A  40
 None
 1.39A 1p93B-1uwvA:
undetectable		 1p93B-1uwvA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_A_CHDA459_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 1uwv 23S RRNA
(URACIL-5-)-METHYLTR
ANSFERASE RUMA
(Escherichia
coli) 		4 / 6 ASP A 292
LEU A 361
VAL A 360
ILE A 384
 None
 0.90A 1s9qA-1uwvA:
undetectable		 1s9qA-1uwvA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2L8M_A_CAMA415_0
(CAMPHOR
5-MONOOXYGENASE)		 1uwv 23S RRNA
(URACIL-5-)-METHYLTR
ANSFERASE RUMA
(Escherichia
coli) 		5 / 9 LEU A 279
VAL A 284
VAL A 311
ASP A 292
VAL A 290
 None
 1.33A 2l8mA-1uwvA:
undetectable		 2l8mA-1uwvA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_A_GW6A1_1
(GLUCOCORTICOID
RECEPTOR)		 1uwv 23S RRNA
(URACIL-5-)-METHYLTR
ANSFERASE RUMA
(Escherichia
coli) 		5 / 12 GLY A  28
GLN A  92
LEU A  99
THR A  38
PHE A  40
 None
 1.48A 3cldA-1uwvA:
0.0		 3cldA-1uwvA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_A_ADNA438_1
(ADENOSYLHOMOCYSTEINA
SE)		 1uwv 23S RRNA
(URACIL-5-)-METHYLTR
ANSFERASE RUMA
(Escherichia
coli) 		5 / 12 THR A 306
ASN A 271
LEU A 256
LEU A 254
GLY A 253
 None
 1.10A 3g1uA-1uwvA:
6.6		 3g1uA-1uwvA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_B_KANB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1uwv 23S RRNA
(URACIL-5-)-METHYLTR
ANSFERASE RUMA
(Escherichia
coli) 		3 / 3 ALA A 409
ARG A 383
LYS A 359
 None
 1.04A 3kp5B-1uwvA:
0.8		 3kp5B-1uwvA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1uwv 23S RRNA
(URACIL-5-)-METHYLTR
ANSFERASE RUMA
(Escherichia
coli) 		5 / 8 ILE A 164
ARG A 128
LEU A 165
VAL A 159
GLY A 147
 SF4  A1432 (-3.9A)
None
None
SF4  A1432 ( 4.7A)
None
 1.49A 3w1wA-1uwvA:
undetectable		 3w1wA-1uwvA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_1
(METHYLTRANSFERASE
WBDD)		 1uwv 23S RRNA
(URACIL-5-)-METHYLTR
ANSFERASE RUMA
(Escherichia
coli) 		3 / 3 ARG A 366
ASP A  25
GLN A  29
 None
 0.71A 4azsA-1uwvA:
12.2		 4azsA-1uwvA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_2
(ESTROGEN RECEPTOR)		 1uwv 23S RRNA
(URACIL-5-)-METHYLTR
ANSFERASE RUMA
(Escherichia
coli) 		4 / 5 LEU A 239
MET A 203
LEU A 230
HIS A 207
 None
 1.31A 4xi3B-1uwvA:
undetectable		 4xi3B-1uwvA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_3
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1uwv 23S RRNA
(URACIL-5-)-METHYLTR
ANSFERASE RUMA
(Escherichia
coli) 		5 / 12 ASP A 292
PHE A 294
VAL A 372
ILE A 376
PHE A 357
 None
 1.07A 5b8iC-1uwvA:
undetectable		 5b8iC-1uwvA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_A_REAA602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 1uwv 23S RRNA
(URACIL-5-)-METHYLTR
ANSFERASE RUMA
(Escherichia
coli) 		5 / 12 GLY A 190
ARG A 206
LEU A 135
MET A 146
CYH A 179
 None
PO4  A1435 (-4.2A)
None
None
None
 1.18A 5fhzA-1uwvA:
2.3		 5fhzA-1uwvA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HUA_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 1uwv 23S RRNA
(URACIL-5-)-METHYLTR
ANSFERASE RUMA
(Escherichia
coli) 		5 / 11 ASP A 292
PHE A 294
VAL A 372
ILE A 376
PHE A 357
 None
 1.10A 5huaA-1uwvA:
undetectable		 5huaA-1uwvA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 1uwv 23S RRNA
(URACIL-5-)-METHYLTR
ANSFERASE RUMA
(Escherichia
coli) 		4 / 7 PHE A 258
ALA A 197
GLN A 196
GLN A 326
 None
 1.11A 6b89A-1uwvA:
1.1		 6b89A-1uwvA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_E_HISE402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1uwv 23S RRNA
(URACIL-5-)-METHYLTR
ANSFERASE RUMA
(Escherichia
coli) 		5 / 9 LEU A 219
GLY A 181
LEU A 183
VAL A 176
CYH A 179
 None
 1.22A 6czmD-1uwvA:
undetectable
6czmE-1uwvA:
undetectable		 6czmD-1uwvA:
23.82
6czmE-1uwvA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_F_HISF402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1uwv 23S RRNA
(URACIL-5-)-METHYLTR
ANSFERASE RUMA
(Escherichia
coli) 		5 / 10 LEU A 219
GLY A 181
LEU A 183
VAL A 176
CYH A 179
 None
 1.22A 6czmE-1uwvA:
undetectable
6czmF-1uwvA:
undetectable		 6czmE-1uwvA:
23.82
6czmF-1uwvA:
23.82