SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1uwy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_B_RTLB501_0
(RETINOL DEHYDRATASE)		 1uwy CARBOXYPEPTIDASE M
(Homo
sapiens) 		5 / 12 ILE A 288
LEU A  76
LEU A  75
HIS A 295
LEU A  83
 None
 1.22A 1fmlB-1uwyA:
undetectable		 1fmlB-1uwyA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 1uwy CARBOXYPEPTIDASE M
(Homo
sapiens) 		3 / 3 ARG A  47
GLY A  88
ASP A  87
 NAG  A1403 (-3.6A)
NAG  A1404 ( 4.7A)
None
 0.43A 1kf6A-1uwyA:
undetectable
1kf6B-1uwyA:
undetectable		 1kf6A-1uwyA:
19.87
1kf6B-1uwyA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1uwy CARBOXYPEPTIDASE M
(Homo
sapiens) 		4 / 8 SER A 197
ASN A 185
GLN A 249
PHE A 183
 None
 1.28A 1p6kA-1uwyA:
undetectable		 1p6kA-1uwyA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1uwy CARBOXYPEPTIDASE M
(Homo
sapiens) 		4 / 8 SER A 197
ASN A 185
GLN A 249
PHE A 183
 None
 1.29A 1p6kB-1uwyA:
undetectable		 1p6kB-1uwyA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1uwy CARBOXYPEPTIDASE M
(Homo
sapiens) 		4 / 8 SER A 197
ASN A 185
GLN A 249
PHE A 183
 None
 1.30A 1rs6A-1uwyA:
undetectable		 1rs6A-1uwyA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1uwy CARBOXYPEPTIDASE M
(Homo
sapiens) 		4 / 8 SER A 197
ASN A 185
GLN A 249
PHE A 183
 None
 1.25A 1rs6B-1uwyA:
undetectable		 1rs6B-1uwyA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1uwy CARBOXYPEPTIDASE M
(Homo
sapiens) 		4 / 8 SER A 197
ASN A 185
GLN A 249
PHE A 183
 None
 1.30A 1rs7B-1uwyA:
undetectable		 1rs7B-1uwyA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 1uwy CARBOXYPEPTIDASE M
(Homo
sapiens) 		3 / 3 LYS A 372
ILE A 361
THR A 357
 None
 0.74A 1rx3A-1uwyA:
undetectable		 1rx3A-1uwyA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 1uwy CARBOXYPEPTIDASE M
(Homo
sapiens) 		4 / 8 THR A 100
GLY A  46
ILE A 102
VAL A  45
 None
 0.94A 1rxcB-1uwyA:
3.8		 1rxcB-1uwyA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_E_URFE2031_1
(URIDINE
PHOSPHORYLASE)		 1uwy CARBOXYPEPTIDASE M
(Homo
sapiens) 		4 / 8 THR A 100
GLY A  46
ILE A 102
VAL A  45
 None
 0.98A 1rxcE-1uwyA:
3.9		 1rxcE-1uwyA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_I_URFI2041_1
(URIDINE
PHOSPHORYLASE)		 1uwy CARBOXYPEPTIDASE M
(Homo
sapiens) 		4 / 8 THR A 100
GLY A  46
ILE A 102
VAL A  45
 None
 0.97A 1rxcI-1uwyA:
4.0		 1rxcI-1uwyA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_K_URFK2061_1
(URIDINE
PHOSPHORYLASE)		 1uwy CARBOXYPEPTIDASE M
(Homo
sapiens) 		4 / 8 THR A 100
GLY A  46
ILE A 102
VAL A  45
 None
 0.92A 1rxcK-1uwyA:
4.7		 1rxcK-1uwyA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		 1uwy CARBOXYPEPTIDASE M
(Homo
sapiens) 		5 / 12 GLY A  32
VAL A 157
SER A 107
LEU A  28
HIS A  29
 None
 1.32A 1ya4B-1uwyA:
3.0		 1ya4B-1uwyA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1uwy CARBOXYPEPTIDASE M
(Homo
sapiens) 		4 / 8 SER A 197
ASN A 185
GLN A 249
PHE A 183
 None
 1.26A 1zzqA-1uwyA:
undetectable		 1zzqA-1uwyA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1uwy CARBOXYPEPTIDASE M
(Homo
sapiens) 		4 / 8 SER A 197
ASN A 185
GLN A 249
PHE A 183
 None
 1.23A 1zzqB-1uwyA:
undetectable		 1zzqB-1uwyA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1uwy CARBOXYPEPTIDASE M
(Homo
sapiens) 		4 / 8 SER A 197
ASN A 185
GLN A 249
PHE A 183
 None
 1.25A 1zzuA-1uwyA:
undetectable		 1zzuA-1uwyA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1uwy CARBOXYPEPTIDASE M
(Homo
sapiens) 		4 / 8 SER A 197
ASN A 185
GLN A 249
PHE A 183
 None
 1.29A 1zzuB-1uwyA:
undetectable		 1zzuB-1uwyA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DM6_A_IMNA1401_1
(NADP-DEPENDENT
LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE)		 1uwy CARBOXYPEPTIDASE M
(Homo
sapiens) 		5 / 10 TYR A  82
ILE A 102
PRO A 106
ILE A 104
TYR A  61
 None
 1.17A 2dm6A-1uwyA:
undetectable
2dm6B-1uwyA:
undetectable		 2dm6A-1uwyA:
21.76
2dm6B-1uwyA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6002_0
(PANTOTHENATE KINASE)		 1uwy CARBOXYPEPTIDASE M
(Homo
sapiens) 		4 / 8 TYR A 335
GLY A 300
ASP A 374
ILE A  54
 None
 0.87A 2f9wA-1uwyA:
undetectable
2f9wB-1uwyA:
undetectable		 2f9wA-1uwyA:
20.14
2f9wB-1uwyA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA6_A_SCKA902_1
(ACETYLCHOLINESTERASE)		 1uwy CARBOXYPEPTIDASE M
(Homo
sapiens) 		5 / 10 GLU A 153
ASN A 109
GLU A  12
LEU A  15
LEU A  28
 None
 1.26A 2ha6A-1uwyA:
3.0		 2ha6A-1uwyA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA6_B_SCKB952_1
(ACETYLCHOLINESTERASE)		 1uwy CARBOXYPEPTIDASE M
(Homo
sapiens) 		5 / 10 GLU A 153
ASN A 109
GLU A  12
LEU A  15
LEU A  28
 None
 1.26A 2ha6B-1uwyA:
3.2		 2ha6B-1uwyA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HZQ_A_STRA300_1
(APOLIPOPROTEIN D)		 1uwy CARBOXYPEPTIDASE M
(Homo
sapiens) 		4 / 7 THR A 199
ALA A 170
TYR A 290
LEU A 168
 None
 1.11A 2hzqA-1uwyA:
undetectable		 2hzqA-1uwyA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KI5_A_AC2A1_1
(PROTEIN (THYMIDINE
KINASE))		 1uwy CARBOXYPEPTIDASE M
(Homo
sapiens) 		5 / 12 GLU A  58
ILE A  56
GLN A 301
TYR A 331
ARG A 101
 None
 1.06A 2ki5A-1uwyA:
0.0		 2ki5A-1uwyA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OBV_A_SAMA501_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1)		 1uwy CARBOXYPEPTIDASE M
(Homo
sapiens) 		4 / 8 HIS A 322
SER A 197
PHE A 183
ASP A 201
 None
 1.20A 2obvA-1uwyA:
undetectable		 2obvA-1uwyA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 1uwy CARBOXYPEPTIDASE M
(Homo
sapiens) 		4 / 5 SER A 197
GLY A 186
HIS A 322
ASP A 250
 None
 0.91A 2oxtB-1uwyA:
undetectable		 2oxtB-1uwyA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS4_A_AZMA702_1
(CARBONIC ANHYDRASE 2)		 1uwy CARBOXYPEPTIDASE M
(Homo
sapiens) 		4 / 7 VAL A  71
TYR A   5
LYS A 275
GLU A 274
 None
 1.20A 3hs4A-1uwyA:
undetectable		 3hs4A-1uwyA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA358_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 1uwy CARBOXYPEPTIDASE M
(Homo
sapiens) 		3 / 3 HIS A  66
HIS A 173
MET A  65
 ZN  A1405 (-3.2A)
ZN  A1405 (-3.1A)
None
 1.00A 3mihA-1uwyA:
undetectable		 3mihA-1uwyA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 1uwy CARBOXYPEPTIDASE M
(Homo
sapiens) 		4 / 8 SER A 197
ASN A 185
GLN A 249
PHE A 183
 None
 1.26A 3n62B-1uwyA:
undetectable		 3n62B-1uwyA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 1uwy CARBOXYPEPTIDASE M
(Homo
sapiens) 		4 / 8 SER A 197
ASN A 185
GLN A 249
PHE A 183
 None
 1.19A 3n66B-1uwyA:
undetectable		 3n66B-1uwyA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 1uwy CARBOXYPEPTIDASE M
(Homo
sapiens) 		5 / 12 ALA A  63
LEU A 263
GLY A 174
TYR A 270
LEU A 276
 None
 1.03A 3tm4A-1uwyA:
undetectable		 3tm4A-1uwyA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 1uwy CARBOXYPEPTIDASE M
(Homo
sapiens) 		5 / 12 ALA A  63
LEU A 263
GLY A 174
TYR A 270
LEU A 276
 None
 0.99A 3tm4B-1uwyA:
undetectable		 3tm4B-1uwyA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_D_CAMD502_0
(CAMPHOR
5-MONOOXYGENASE)		 1uwy CARBOXYPEPTIDASE M
(Homo
sapiens) 		4 / 5 LEU A 244
GLY A 238
THR A 236
VAL A 178
 None
 1.00A 3wrkD-1uwyA:
undetectable		 3wrkD-1uwyA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_E_URFE1301_1
(URIDINE
PHOSPHORYLASE)		 1uwy CARBOXYPEPTIDASE M
(Homo
sapiens) 		4 / 8 THR A 100
GLY A  46
ILE A 102
VAL A  45
 None
 0.99A 4e1vE-1uwyA:
5.1		 4e1vE-1uwyA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FJP_A_NPSA711_1
(LACTOTRANSFERRIN)		 1uwy CARBOXYPEPTIDASE M
(Homo
sapiens) 		4 / 6 GLY A 112
PRO A 110
ASN A 109
GLY A  37
 None
 0.91A 4fjpA-1uwyA:
undetectable		 4fjpA-1uwyA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 1uwy CARBOXYPEPTIDASE M
(Homo
sapiens) 		3 / 3 LYS A 372
ILE A 361
THR A 357
 None
 0.78A 4gh8A-1uwyA:
undetectable		 4gh8A-1uwyA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB806_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1uwy CARBOXYPEPTIDASE M
(Homo
sapiens) 		4 / 7 SER A 197
ASN A 185
GLN A 249
PHE A 183
 None
 1.12A 4kcnB-1uwyA:
undetectable		 4kcnB-1uwyA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_1
(PROTEASE)		 1uwy CARBOXYPEPTIDASE M
(Homo
sapiens) 		4 / 8 VAL A 317
GLY A 297
VAL A 315
ILE A 345
 None
 0.64A 4ll3A-1uwyA:
undetectable		 4ll3A-1uwyA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1uwy CARBOXYPEPTIDASE M
(Homo
sapiens) 		4 / 7 HIS A 322
SER A 197
PHE A 183
ASP A 201
 None
 1.28A 4ndnC-1uwyA:
undetectable		 4ndnC-1uwyA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 1uwy CARBOXYPEPTIDASE M
(Homo
sapiens) 		5 / 12 ALA A 176
GLY A 175
ASN A 227
ASN A 230
PHE A 231
 None
 1.31A 4obwD-1uwyA:
undetectable		 4obwD-1uwyA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODJ_A_SAMA500_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 1uwy CARBOXYPEPTIDASE M
(Homo
sapiens) 		4 / 7 HIS A 322
SER A 197
PHE A 183
ASP A 201
 None
 1.21A 4odjA-1uwyA:
undetectable		 4odjA-1uwyA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE0_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1uwy CARBOXYPEPTIDASE M
(Homo
sapiens) 		5 / 9 TYR A 212
ILE A 288
PHE A  59
LEU A 172
LEU A 265
 None
 1.25A 4ze0A-1uwyA:
undetectable		 4ze0A-1uwyA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1uwy CARBOXYPEPTIDASE M
(Homo
sapiens) 		4 / 7 HIS A 322
SER A 197
PHE A 183
ASP A 201
 None
 1.24A 5a1iA-1uwyA:
undetectable		 5a1iA-1uwyA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KLA_A_ACTA1505_0
(MATERNAL PROTEIN
PUMILIO)		 1uwy CARBOXYPEPTIDASE M
(Homo
sapiens) 		3 / 3 HIS A 103
LYS A  60
PHE A 166
 None
 1.42A 5klaA-1uwyA:
undetectable		 5klaA-1uwyA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_1
(PAVINE
N-METHYLTRANSFERASE)		 1uwy CARBOXYPEPTIDASE M
(Homo
sapiens) 		4 / 5 SER A 197
ASN A 136
GLN A 249
ASP A 134
 None
 1.41A 5kpcA-1uwyA:
undetectable		 5kpcA-1uwyA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_1
(PAVINE
N-METHYLTRANSFERASE)		 1uwy CARBOXYPEPTIDASE M
(Homo
sapiens) 		4 / 5 SER A 240
ASN A 136
GLN A 249
ASP A 134
 None
 1.45A 5kpcA-1uwyA:
undetectable		 5kpcA-1uwyA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_A_NCTA402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 1uwy CARBOXYPEPTIDASE M
(Homo
sapiens) 		4 / 8 TRP A 160
THR A 163
CYH A 258
LEU A 161
 None
 1.35A 5kxiA-1uwyA:
undetectable
5kxiB-1uwyA:
0.0		 5kxiA-1uwyA:
22.05
5kxiB-1uwyA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 1uwy CARBOXYPEPTIDASE M
(Homo
sapiens) 		4 / 8 TRP A 160
THR A 163
CYH A 258
LEU A 161
 None
 1.34A 5kxiD-1uwyA:
undetectable
5kxiE-1uwyA:
undetectable		 5kxiD-1uwyA:
22.05
5kxiE-1uwyA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNW_D_GCSD302_1
(25 KDA PROTEIN
ELICITOR)		 1uwy CARBOXYPEPTIDASE M
(Homo
sapiens) 		4 / 7 ASP A 250
GLY A 247
ASP A 184
ASN A 252
 None
 0.97A 5nnwD-1uwyA:
0.0		 5nnwD-1uwyA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)		 1uwy CARBOXYPEPTIDASE M
(Homo
sapiens) 		4 / 7 ASP A 250
GLY A 247
ASP A 184
ASN A 252
 None
 0.91A 5no9D-1uwyA:
undetectable		 5no9D-1uwyA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 1uwy CARBOXYPEPTIDASE M
(Homo
sapiens) 		3 / 3 TRP A 241
MET A 229
ASN A 230
 None
 1.41A 5uc1B-1uwyA:
undetectable		 5uc1B-1uwyA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		 1uwy CARBOXYPEPTIDASE M
(Homo
sapiens) 		3 / 3 TRP A 241
MET A 229
ASN A 230
 None
 1.46A 5uc1A-1uwyA:
undetectable		 5uc1A-1uwyA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 1uwy CARBOXYPEPTIDASE M
(Homo
sapiens) 		4 / 5 LEU A 263
LEU A 265
MET A  65
GLN A 249
 None
 1.22A 5uc3A-1uwyA:
undetectable		 5uc3A-1uwyA:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1uwy CARBOXYPEPTIDASE M
(Homo
sapiens) 		4 / 8 SER A 197
ASN A 185
GLN A 249
PHE A 183
 None
 1.11A 5vunB-1uwyA:
undetectable		 5vunB-1uwyA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W3J_B_TA1B502_1
(TUBULIN BETA CHAIN)		 1uwy CARBOXYPEPTIDASE M
(Homo
sapiens) 		4 / 8 ASP A 374
HIS A 355
GLN A 301
GLY A 332
 None
 0.85A 5w3jB-1uwyA:
3.8		 5w3jB-1uwyA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1uwy CARBOXYPEPTIDASE M
(Homo
sapiens) 		4 / 8 SER A 197
ASN A 185
GLN A 249
PHE A 183
 None
 1.15A 6auuB-1uwyA:
undetectable		 6auuB-1uwyA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA814_0
(UNCHARACTERIZED
PROTEIN)		 1uwy CARBOXYPEPTIDASE M
(Homo
sapiens) 		4 / 5 GLN A 249
ASN A 171
THR A 262
LEU A 263
 None
 1.43A 6d8pA-1uwyA:
2.1		 6d8pA-1uwyA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ELI_A_T27A701_1
(REVERSE
TRANSCRIPTASE)		 1uwy CARBOXYPEPTIDASE M
(Homo
sapiens) 		5 / 12 VAL A 167
PRO A 182
PHE A 205
LEU A 208
TYR A 290
 None
 1.39A 6eliA-1uwyA:
undetectable		 6eliA-1uwyA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G6R_A_SAMA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1uwy CARBOXYPEPTIDASE M
(Homo
sapiens) 		4 / 7 HIS A 322
SER A 197
PHE A 183
ASP A 201
 None
 1.25A 6g6rA-1uwyA:
undetectable		 6g6rA-1uwyA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_D_LLLD301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1uwy CARBOXYPEPTIDASE M
(Homo
sapiens) 		4 / 6 ASP A  68
ARG A 127
GLU A 128
ASP A 134
 None
ZN  A1405 ( 4.8A)
None
None
 1.34A 6mn5D-1uwyA:
undetectable		 6mn5D-1uwyA:
12.62