SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ux6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_A_DVAA8_0
(ACTINOMYCIN D)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
3 / 3 THR A1035
THR A1032
PRO A1034
None
0.81A 1a7yA-1ux6A:
undetectable
1a7yA-1ux6A:
4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB2_0
(ACTINOMYCIN D)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
3 / 3 THR A1032
PRO A1034
THR A1035
None
0.70A 1a7yB-1ux6A:
undetectable
1a7yB-1ux6A:
4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB8_0
(ACTINOMYCIN D)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
3 / 3 THR A1035
THR A1032
PRO A1034
None
0.87A 1a7yB-1ux6A:
undetectable
1a7yB-1ux6A:
4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC2_0
(ACTINOMYCIN D)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
3 / 3 THR A1032
PRO A1034
THR A1035
None
0.71A 1dscC-1ux6A:
undetectable
1dscC-1ux6A:
4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC8_0
(ACTINOMYCIN D)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
3 / 3 THR A1035
THR A1032
PRO A1034
None
0.70A 1dscC-1ux6A:
undetectable
1dscC-1ux6A:
4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_C_DVAC8_0
(ACTINOMYCIN D)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
3 / 3 THR A1035
THR A1032
PRO A1034
None
0.66A 1fjaC-1ux6A:
undetectable
1fjaC-1ux6A:
4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_D_DVAD8_0
(ACTINOMYCIN D)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
3 / 3 THR A1035
THR A1032
PRO A1034
None
0.66A 1fjaD-1ux6A:
undetectable
1fjaD-1ux6A:
4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE2_0
(ACTINOMYCIN D)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
3 / 3 THR A1032
PRO A1034
THR A1035
None
0.78A 1i3wE-1ux6A:
undetectable
1i3wE-1ux6A:
4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE8_0
(ACTINOMYCIN D)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
3 / 3 THR A1035
THR A1032
PRO A1034
None
0.83A 1i3wE-1ux6A:
undetectable
1i3wE-1ux6A:
4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_F_DVAF8_0
(ACTINOMYCIN D)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
3 / 3 THR A1035
THR A1032
PRO A1034
None
0.76A 1i3wF-1ux6A:
undetectable
1i3wF-1ux6A:
4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG2_0
(ACTINOMYCIN D)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
3 / 3 THR A1032
PRO A1034
THR A1035
None
0.82A 1i3wG-1ux6A:
undetectable
1i3wG-1ux6A:
4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG8_0
(ACTINOMYCIN D)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
3 / 3 THR A1035
THR A1032
PRO A1034
None
0.74A 1i3wG-1ux6A:
undetectable
1i3wG-1ux6A:
4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_H_DVAH8_0
(ACTINOMYCIN D)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
3 / 3 THR A1035
THR A1032
PRO A1034
None
0.76A 1i3wH-1ux6A:
undetectable
1i3wH-1ux6A:
4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD2_0
(ACTINOMYCIN D)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
3 / 3 THR A1032
PRO A1034
THR A1035
None
0.81A 1mnvD-1ux6A:
undetectable
1mnvD-1ux6A:
4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD8_0
(ACTINOMYCIN D)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
3 / 3 THR A1035
THR A1032
PRO A1034
None
0.76A 1mnvD-1ux6A:
undetectable
1mnvD-1ux6A:
4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OVF_B_DVAB2_0
(ACTINOMYCIN D)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
3 / 3 THR A1032
PRO A1034
THR A1035
None
0.76A 1ovfB-1ux6A:
undetectable
1ovfB-1ux6A:
4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_A_DVAA8_0
(ACTINOMYCIN X2)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
3 / 3 THR A1035
THR A1032
PRO A1034
None
0.80A 1qfiA-1ux6A:
undetectable
1qfiA-1ux6A:
4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF8_0
(7-AMINO-ACTINOMYCIN
D)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
3 / 3 THR A1035
THR A1032
PRO A1034
None
0.82A 1unjF-1ux6A:
undetectable
1unjF-1ux6A:
4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL2_0
(7-AMINO-ACTINOMYCIN
D)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
3 / 3 THR A1032
PRO A1034
THR A1035
None
0.81A 1unjL-1ux6A:
undetectable
1unjL-1ux6A:
4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL8_0
(7-AMINO-ACTINOMYCIN
D)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
3 / 3 THR A1035
THR A1032
PRO A1034
None
0.77A 1unjL-1ux6A:
undetectable
1unjL-1ux6A:
4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR2_0
(7-AMINO-ACTINOMYCIN
D)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
3 / 3 THR A1032
PRO A1034
THR A1035
None
0.81A 1unjR-1ux6A:
undetectable
1unjR-1ux6A:
4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR8_0
(7-AMINO-ACTINOMYCIN
D)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
3 / 3 THR A1035
THR A1032
PRO A1034
None
0.76A 1unjR-1ux6A:
undetectable
1unjR-1ux6A:
4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_W_DVAW8_0
(7-AMINO-ACTINOMYCIN
D)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
3 / 3 THR A1035
THR A1032
PRO A1034
None
0.80A 1unjW-1ux6A:
undetectable
1unjW-1ux6A:
4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX2_0
(7-AMINO-ACTINOMYCIN
D)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
3 / 3 THR A1032
PRO A1034
THR A1035
None
0.79A 1unjX-1ux6A:
undetectable
1unjX-1ux6A:
4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX8_0
(7-AMINO-ACTINOMYCIN
D)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
3 / 3 THR A1035
THR A1032
PRO A1034
None
0.78A 1unjX-1ux6A:
undetectable
1unjX-1ux6A:
4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE2_0
(7-AMINOACTINOMYCIN D)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
3 / 3 THR A1032
PRO A1034
THR A1035
None
0.83A 1unmE-1ux6A:
undetectable
1unmE-1ux6A:
4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE8_0
(7-AMINOACTINOMYCIN D)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
3 / 3 THR A1035
THR A1032
PRO A1034
None
0.75A 1unmE-1ux6A:
undetectable
1unmE-1ux6A:
4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF2_0
(7-AMINOACTINOMYCIN D)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
3 / 3 THR A1032
PRO A1034
THR A1035
None
0.70A 1unmF-1ux6A:
undetectable
1unmF-1ux6A:
4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF8_0
(7-AMINOACTINOMYCIN D)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
3 / 3 THR A1035
THR A1032
PRO A1034
None
0.69A 1unmF-1ux6A:
undetectable
1unmF-1ux6A:
4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC8_0
(N8-ACTINOMYCIN D)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
3 / 3 THR A1035
THR A1032
PRO A1034
None
0.70A 209dC-1ux6A:
undetectable
209dC-1ux6A:
4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_B_SALB1305_1
(LYSR-TYPE REGULATORY
PROTEIN)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
4 / 5 SER A 974
PRO A 946
GLY A 977
TRP A 959
None
1.46A 2y7kB-1ux6A:
undetectable
2y7kB-1ux6A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1001_1
(LYSR-TYPE REGULATORY
PROTEIN)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
4 / 6 SER A 974
PRO A 946
GLY A 977
TRP A 959
None
1.25A 2y7pA-1ux6A:
0.0
2y7pA-1ux6A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_C_GLYC73_0
(NONSTRUCTURAL
PROTEIN 1)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
4 / 4 ASP A 843
ASP A 832
SER A1013
ARG A1016
CA  A2010 (-3.1A)
CA  A2012 ( 2.8A)
None
None
1.45A 2z0aC-1ux6A:
undetectable
2z0aC-1ux6A:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
316D_C_DVAC2_0
(8-FLUORO-ACTINOMYCIN
D)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
3 / 3 THR A1032
PRO A1034
THR A1035
None
0.82A 316dC-1ux6A:
undetectable
316dC-1ux6A:
4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
4 / 5 GLN A 943
PHE A 942
LEU A1130
PHE A 985
None
1.47A 3ablC-1ux6A:
undetectable
3ablJ-1ux6A:
undetectable
3ablC-1ux6A:
19.50
3ablJ-1ux6A:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_2
(GENOME POLYPROTEIN)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
4 / 4 PHE A1007
TYR A1108
VAL A 969
LEU A 968
None
1.27A 3keeD-1ux6A:
0.0
3keeD-1ux6A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3O_A_DLUA399_1
(PFV INTEGRASE)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
4 / 7 ASP A 839
ASP A 830
TYR A1011
ARG A1129
CA  A2011 ( 2.1A)
CA  A2012 ( 2.9A)
None
None
1.27A 3s3oA-1ux6A:
undetectable
3s3oA-1ux6A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_1
(MNMC2)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
4 / 6 GLU A 984
ASP A 933
ASP A 847
ASN A 855
None
None
CA  A2010 ( 2.8A)
None
1.24A 3vywA-1ux6A:
undetectable
3vywA-1ux6A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_D_DVAD8_0
(VAL-GRAMICIDIN A)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
3 / 3 TRP A1022
VAL A1025
TRP A1084
None
0.91A 3zq8C-1ux6A:
undetectable
3zq8D-1ux6A:
undetectable
3zq8C-1ux6A:
4.41
3zq8D-1ux6A:
4.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
4 / 7 ASP A 933
ASP A 868
ASN A 855
ASP A 874
None
CA  A2007 ( 2.7A)
None
None
1.16A 4feuB-1ux6A:
undetectable
4feuB-1ux6A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
4 / 8 ASP A 874
ASP A 870
ASP A 890
ASN A 882
None
CA  A2007 ( 2.8A)
CA  A2005 ( 2.2A)
CA  A2006 (-2.8A)
1.19A 4feuF-1ux6A:
undetectable
4feuF-1ux6A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
4 / 8 ASP A 933
ASP A 868
ASN A 855
ASP A 874
None
CA  A2007 ( 2.7A)
None
None
1.17A 4feuF-1ux6A:
undetectable
4feuF-1ux6A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
4 / 7 ASP A 933
ASP A 868
ASN A 855
ASP A 874
None
CA  A2007 ( 2.7A)
None
None
1.18A 4fevB-1ux6A:
undetectable
4fevB-1ux6A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
4 / 7 ASP A 874
ASP A 870
ASP A 890
ASN A 882
None
CA  A2007 ( 2.8A)
CA  A2005 ( 2.2A)
CA  A2006 (-2.8A)
1.17A 4fevD-1ux6A:
undetectable
4fevD-1ux6A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
4 / 7 ASP A 933
ASP A 868
ASN A 855
ASP A 874
None
CA  A2007 ( 2.7A)
None
None
1.14A 4fevD-1ux6A:
undetectable
4fevD-1ux6A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
4 / 7 ASP A 874
ASP A 870
ASP A 890
ASN A 882
None
CA  A2007 ( 2.8A)
CA  A2005 ( 2.2A)
CA  A2006 (-2.8A)
1.18A 4fevF-1ux6A:
undetectable
4fevF-1ux6A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
4 / 7 ASP A 933
ASP A 868
ASN A 855
ASP A 874
None
CA  A2007 ( 2.7A)
None
None
1.16A 4fevF-1ux6A:
undetectable
4fevF-1ux6A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
4 / 7 ASP A 874
ASP A 870
ASP A 890
ASN A 882
None
CA  A2007 ( 2.8A)
CA  A2005 ( 2.2A)
CA  A2006 (-2.8A)
1.21A 4fewB-1ux6A:
undetectable
4fewB-1ux6A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
4 / 7 ASP A 933
ASP A 868
ASN A 855
ASP A 874
None
CA  A2007 ( 2.7A)
None
None
1.16A 4fewB-1ux6A:
undetectable
4fewB-1ux6A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
4 / 8 ASP A 874
ASP A 870
ASP A 890
ASN A 882
None
CA  A2007 ( 2.8A)
CA  A2005 ( 2.2A)
CA  A2006 (-2.8A)
1.16A 4fewD-1ux6A:
undetectable
4fewD-1ux6A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
4 / 8 ASP A 933
ASP A 868
ASN A 855
ASP A 874
None
CA  A2007 ( 2.7A)
None
None
1.15A 4fewD-1ux6A:
undetectable
4fewD-1ux6A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
4 / 8 ASP A 874
ASP A 870
ASP A 890
ASN A 882
None
CA  A2007 ( 2.8A)
CA  A2005 ( 2.2A)
CA  A2006 (-2.8A)
1.19A 4fewF-1ux6A:
undetectable
4fewF-1ux6A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
4 / 8 ASP A 933
ASP A 868
ASN A 855
ASP A 874
None
CA  A2007 ( 2.7A)
None
None
1.18A 4fewF-1ux6A:
undetectable
4fewF-1ux6A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEX_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
4 / 7 ASP A 874
ASP A 870
ASP A 890
ASN A 882
None
CA  A2007 ( 2.8A)
CA  A2005 ( 2.2A)
CA  A2006 (-2.8A)
1.19A 4fexB-1ux6A:
0.5
4fexB-1ux6A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEX_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
4 / 7 ASP A 933
ASP A 868
ASN A 855
ASP A 874
None
CA  A2007 ( 2.7A)
None
None
1.15A 4fexB-1ux6A:
0.5
4fexB-1ux6A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
4 / 8 ASP A 874
ASP A 870
ASP A 890
ASN A 882
None
CA  A2007 ( 2.8A)
CA  A2005 ( 2.2A)
CA  A2006 (-2.8A)
1.15A 4gkhB-1ux6A:
undetectable
4gkhB-1ux6A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
4 / 8 ASP A 933
ASP A 868
ASN A 855
ASP A 874
None
CA  A2007 ( 2.7A)
None
None
1.12A 4gkhB-1ux6A:
undetectable
4gkhB-1ux6A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
4 / 8 ASP A 933
ASP A 868
ASN A 855
ASP A 874
None
CA  A2007 ( 2.7A)
None
None
1.17A 4gkhD-1ux6A:
0.6
4gkhD-1ux6A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
4 / 8 ASP A 933
ASP A 868
ASN A 855
ASP A 874
None
CA  A2007 ( 2.7A)
None
None
1.14A 4gkhF-1ux6A:
undetectable
4gkhF-1ux6A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
4 / 7 ASP A 874
ASP A 870
ASP A 890
ASN A 882
None
CA  A2007 ( 2.8A)
CA  A2005 ( 2.2A)
CA  A2006 (-2.8A)
1.19A 4gkhG-1ux6A:
undetectable
4gkhG-1ux6A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
4 / 7 ASP A 933
ASP A 868
ASN A 855
ASP A 874
None
CA  A2007 ( 2.7A)
None
None
1.17A 4gkhG-1ux6A:
undetectable
4gkhG-1ux6A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_J_KANJ301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
4 / 6 ASP A 874
ASP A 870
ASP A 890
ASN A 882
None
CA  A2007 ( 2.8A)
CA  A2005 ( 2.2A)
CA  A2006 (-2.8A)
1.22A 4gkhJ-1ux6A:
undetectable
4gkhJ-1ux6A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_J_KANJ301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
4 / 6 ASP A 874
ASP A 870
ASP A 890
ASP A 879
None
CA  A2007 ( 2.8A)
CA  A2005 ( 2.2A)
CA  A2004 ( 3.1A)
1.33A 4gkhJ-1ux6A:
undetectable
4gkhJ-1ux6A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_J_KANJ301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
4 / 6 ASP A 933
ASP A 868
ASN A 855
ASP A 874
None
CA  A2007 ( 2.7A)
None
None
1.18A 4gkhJ-1ux6A:
undetectable
4gkhJ-1ux6A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
4 / 8 ASP A 874
ASP A 870
ASP A 890
ASN A 882
None
CA  A2007 ( 2.8A)
CA  A2005 ( 2.2A)
CA  A2006 (-2.8A)
1.17A 4gkiA-1ux6A:
undetectable
4gkiA-1ux6A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
4 / 8 ASP A 933
ASP A 868
ASN A 855
ASP A 874
None
CA  A2007 ( 2.7A)
None
None
1.16A 4gkiA-1ux6A:
undetectable
4gkiA-1ux6A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
4 / 8 ASP A 874
ASP A 870
ASP A 890
ASN A 882
None
CA  A2007 ( 2.8A)
CA  A2005 ( 2.2A)
CA  A2006 (-2.8A)
1.20A 4gkiC-1ux6A:
undetectable
4gkiC-1ux6A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
4 / 8 ASP A 933
ASP A 868
ASN A 855
ASP A 874
None
CA  A2007 ( 2.7A)
None
None
1.17A 4gkiC-1ux6A:
undetectable
4gkiC-1ux6A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTR_A_IBPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
4 / 8 VAL A1008
TYR A1011
LEU A1058
LEU A1062
None
1.07A 4jtrA-1ux6A:
undetectable
4jtrA-1ux6A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KSZ_A_CYSA620_0
(LACTOPEROXIDASE)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
3 / 3 ARG A1000
GLU A 999
PHE A1087
None
0.96A 4kszA-1ux6A:
undetectable
4kszA-1ux6A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
4 / 6 ASP A 917
ASN A 863
TYR A1147
ASP A 926
CA  A2002 ( 2.8A)
None
None
CA  A2001 ( 2.2A)
1.02A 4mdaA-1ux6A:
0.0
4mdaA-1ux6A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
4 / 5 ASN A 897
ALA A 911
GLY A 909
ASP A1151
CA  A2005 (-3.3A)
None
CA  A2003 ( 4.8A)
None
0.97A 4n48A-1ux6A:
undetectable
4n48A-1ux6A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTM_A_SAMA301_0
(DNA ADENINE
METHYLASE)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
5 / 12 GLY A1127
GLY A1128
GLY A 848
ILE A 844
PRO A 860
None
None
None
None
CA  A2009 ( 4.8A)
0.88A 4rtmA-1ux6A:
undetectable
4rtmA-1ux6A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
5 / 12 GLY A1053
PHE A1135
ALA A1061
GLN A1071
HIS A1057
None
1.35A 4wh5A-1ux6A:
0.0
4wh5A-1ux6A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQL_A_KANA203_1
(2''-AMINOGLYCOSIDE
NUCLEOTIDYLTRANSFERA
SE)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
5 / 9 ASP A 915
ASP A 919
ASP A 917
TYR A1147
GLU A1148
CA  A2002 (-3.1A)
CA  A2002 ( 2.7A)
CA  A2002 ( 2.8A)
None
None
1.37A 4wqlA-1ux6A:
0.0
4wqlA-1ux6A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_B_5OGB804_1
(HDAC6 PROTEIN)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
5 / 12 ASP A 938
PHE A 942
ASP A 983
LEU A1130
TYR A1147
None
1.50A 5eenB-1ux6A:
undetectable
5eenB-1ux6A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
4 / 5 GLY A1070
PRO A1034
THR A1068
THR A1051
None
1.10A 5h5fA-1ux6A:
undetectable
5h5fA-1ux6A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_B_SAMB301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
5 / 12 ASP A 975
PRO A 949
GLN A 970
GLY A 977
SER A1014
CA  A2016 (-3.4A)
None
None
None
None
1.31A 5hfjB-1ux6A:
undetectable
5hfjB-1ux6A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_G_SAMG301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
5 / 12 ASP A 975
PRO A 949
GLN A 970
GLY A 977
SER A1014
CA  A2016 (-3.4A)
None
None
None
None
1.37A 5hfjG-1ux6A:
undetectable
5hfjG-1ux6A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HSW_A_ACTA501_0
(ORF 37)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
4 / 5 SER A1013
SER A1014
SER A1015
SER A 829
None
0.94A 5hswA-1ux6A:
undetectable
5hswA-1ux6A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
4 / 5 ASP A 933
ASN A 931
ASP A 874
ASN A 855
None
1.47A 5vooA-1ux6A:
undetectable
5vooA-1ux6A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
4 / 5 ASP A 933
ASN A 931
ASP A 874
ASN A 855
None
1.49A 5vooB-1ux6A:
undetectable
5vooB-1ux6A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
4 / 5 ASP A 933
ASN A 931
ASP A 874
ASN A 855
None
1.48A 5vooC-1ux6A:
undetectable
5vooC-1ux6A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
4 / 5 ASP A 933
ASN A 931
ASP A 874
ASN A 855
None
1.46A 5vooD-1ux6A:
undetectable
5vooD-1ux6A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
4 / 5 ASP A 933
ASN A 931
ASP A 874
ASN A 855
None
1.49A 5vooE-1ux6A:
undetectable
5vooE-1ux6A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
4 / 4 ASP A 933
ASN A 931
ASP A 874
ASN A 855
None
1.47A 5vooF-1ux6A:
undetectable
5vooF-1ux6A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_F_ZOLF401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
4 / 5 ASP A 854
ASP A 845
GLN A 864
GLN A1012
CA  A2009 ( 2.3A)
CA  A2010 ( 2.7A)
CA  A2009 ( 4.9A)
None
1.41A 6g31F-1ux6A:
undetectable
6g31F-1ux6A:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_G_ZOLG401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)
1ux6 THROMBOSPONDIN-1
(Homo
sapiens)
4 / 7 ASP A 854
ASP A 845
GLN A 864
GLN A1012
CA  A2009 ( 2.3A)
CA  A2010 ( 2.7A)
CA  A2009 ( 4.9A)
None
1.49A 6g31G-1ux6A:
undetectable
6g31G-1ux6A:
10.92