SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1uxi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_1
(PROTEIN (ADENOSINE
KINASE))		 1uxi MALATE DEHYDROGENASE
(Chloroflexus
aurantiacus) 		5 / 12 ASP A 123
GLY A 266
GLY A 173
ALA A 298
ASP A 148
 None
 0.92A 1bx4A-1uxiA:
6.3		 1bx4A-1uxiA:
22.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 1uxi MALATE DEHYDROGENASE
(Chloroflexus
aurantiacus) 		5 / 9 GLY A   9
ASP A  33
ILE A  34
TYR A  65
ILE A  98
 NAD  A1310 (-3.5A)
NAD  A1310 (-3.0A)
NAD  A1310 (-3.8A)
None
NAD  A1310 (-4.1A)
 0.87A 1cetA-1uxiA:
42.1		 1cetA-1uxiA:
42.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FB7_A_ROCA100_1
(HIV-1 PROTEASE)		 1uxi MALATE DEHYDROGENASE
(Chloroflexus
aurantiacus) 		5 / 12 ALA A 169
VAL A 146
GLY A 145
THR A 209
VAL A 206
 None
 1.02A 1fb7A-1uxiA:
undetectable		 1fb7A-1uxiA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_1
(N,N-DIMETHYLGLYCINE
OXIDASE)		 1uxi MALATE DEHYDROGENASE
(Chloroflexus
aurantiacus) 		3 / 3 ASP A 262
THR A 255
GLU A 138
 None
 0.86A 1pj7A-1uxiA:
6.1		 1pj7A-1uxiA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_C_URFC2081_1
(URIDINE
PHOSPHORYLASE)		 1uxi MALATE DEHYDROGENASE
(Chloroflexus
aurantiacus) 		4 / 7 GLY A 214
ARG A  88
ILE A 216
VAL A 217
 FUM  A1311 ( 4.8A)
FUM  A1311 (-4.0A)
None
None
 0.88A 1rxcC-1uxiA:
undetectable		 1rxcC-1uxiA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)		 1uxi MALATE DEHYDROGENASE
(Chloroflexus
aurantiacus) 		3 / 3 ASP A  90
GLU A 178
ARG A 151
 None
None
FUM  A1311 (-2.8A)
 0.68A 1wopA-1uxiA:
0.0		 1wopA-1uxiA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_CCSB417_0
(ESTROGEN RECEPTOR)		 1uxi MALATE DEHYDROGENASE
(Chloroflexus
aurantiacus) 		3 / 3 GLN A 257
LYS A 278
VAL A 276
 None
 0.93A 2jfaB-1uxiA:
undetectable		 2jfaB-1uxiA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_B_ACTB1463_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 1uxi MALATE DEHYDROGENASE
(Chloroflexus
aurantiacus) 		4 / 7 VAL A 167
ILE A 156
ALA A 160
VAL A 162
 None
 0.45A 2xrzB-1uxiA:
undetectable		 2xrzB-1uxiA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_A_LEIA16_0
(COIL SER L16D-PEN)		 1uxi MALATE DEHYDROGENASE
(Chloroflexus
aurantiacus) 		4 / 6 GLN A 235
GLU A 238
LYS A  24
LEU A  26
 None
 0.48A 3h5gA-1uxiA:
undetectable
3h5gC-1uxiA:
undetectable		 3h5gA-1uxiA:
6.47
3h5gC-1uxiA:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_C_LEIC16_0
(COIL SER L16D-PEN)		 1uxi MALATE DEHYDROGENASE
(Chloroflexus
aurantiacus) 		4 / 6 LYS A  24
LEU A  26
GLN A 235
GLU A 238
 None
 1.12A 3h5gB-1uxiA:
undetectable
3h5gC-1uxiA:
undetectable		 3h5gB-1uxiA:
6.47
3h5gC-1uxiA:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 1uxi MALATE DEHYDROGENASE
(Chloroflexus
aurantiacus) 		5 / 11 SER A   6
THR A  68
GLY A  61
THR A  60
ASP A  28
 None
 1.24A 3mg0H-1uxiA:
undetectable
3mg0I-1uxiA:
undetectable		 3mg0H-1uxiA:
21.97
3mg0I-1uxiA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_A_OBNA1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1uxi MALATE DEHYDROGENASE
(Chloroflexus
aurantiacus) 		5 / 11 GLN A  40
PRO A  39
ASP A  33
ALA A 101
ILE A  98
 None
None
NAD  A1310 (-3.0A)
NAD  A1310 ( 4.4A)
NAD  A1310 (-4.1A)
 1.29A 3n23A-1uxiA:
undetectable		 3n23A-1uxiA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_A_ADNA353_1
(ADENOSINE KINASE)		 1uxi MALATE DEHYDROGENASE
(Chloroflexus
aurantiacus) 		5 / 12 ASP A 123
GLY A 174
GLY A 176
GLY A 145
ASP A 148
 None
 0.95A 3uboA-1uxiA:
6.3		 3uboA-1uxiA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_A_UEGA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1uxi MALATE DEHYDROGENASE
(Chloroflexus
aurantiacus) 		5 / 11 GLY A 274
ALA A 239
GLY A 272
VAL A 114
VAL A 269
 None
 1.22A 4c5lA-1uxiA:
3.6		 4c5lA-1uxiA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1uxi MALATE DEHYDROGENASE
(Chloroflexus
aurantiacus) 		5 / 9 GLY A 274
ALA A 239
GLY A 272
VAL A 114
VAL A 269
 None
 1.21A 4c5lB-1uxiA:
undetectable		 4c5lB-1uxiA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_C_UEGC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1uxi MALATE DEHYDROGENASE
(Chloroflexus
aurantiacus) 		5 / 10 GLY A 274
ALA A 239
GLY A 272
VAL A 114
VAL A 269
 None
 1.24A 4c5lC-1uxiA:
4.6		 4c5lC-1uxiA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1uxi MALATE DEHYDROGENASE
(Chloroflexus
aurantiacus) 		5 / 10 GLY A 274
ALA A 239
GLY A 272
VAL A 114
VAL A 269
 None
 1.23A 4c5lD-1uxiA:
4.3		 4c5lD-1uxiA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1uxi MALATE DEHYDROGENASE
(Chloroflexus
aurantiacus) 		5 / 10 GLY A 274
ALA A 239
GLY A 272
VAL A 114
VAL A 269
 None
 1.19A 4c5nB-1uxiA:
4.6		 4c5nB-1uxiA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1uxi MALATE DEHYDROGENASE
(Chloroflexus
aurantiacus) 		5 / 10 GLY A 274
ALA A 239
GLY A 272
VAL A 114
VAL A 269
 None
 1.23A 4c5nD-1uxiA:
4.7		 4c5nD-1uxiA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 1uxi MALATE DEHYDROGENASE
(Chloroflexus
aurantiacus) 		4 / 8 LEU A  21
THR A 233
ILE A 116
VAL A 114
 None
 0.94A 4eq4B-1uxiA:
undetectable		 4eq4B-1uxiA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_D_MIXD101_1
(DNA TOPOISOMERASE
2-BETA)		 1uxi MALATE DEHYDROGENASE
(Chloroflexus
aurantiacus) 		4 / 6 ARG A  88
GLY A 174
GLN A 143
MET A 236
 FUM  A1311 (-4.0A)
None
NAD  A1310 (-3.7A)
None
 1.14A 4g0vB-1uxiA:
undetectable		 4g0vB-1uxiA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MGH_A_ACTA1320_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 1uxi MALATE DEHYDROGENASE
(Chloroflexus
aurantiacus) 		4 / 5 VAL A 267
LEU A 254
ILE A 279
LEU A 280
 None
 0.81A 4mghA-1uxiA:
2.7		 4mghA-1uxiA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQD_A_GAIA1005_0
(THIOSULFATE
DEHYDROGENASE)		 1uxi MALATE DEHYDROGENASE
(Chloroflexus
aurantiacus) 		4 / 4 ARG A  88
ARG A  82
GLY A 212
ARG A 151
 FUM  A1311 (-4.0A)
FUM  A1311 (-3.6A)
None
FUM  A1311 (-2.8A)
 0.99A 4wqdA-1uxiA:
0.0		 4wqdA-1uxiA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 1uxi MALATE DEHYDROGENASE
(Chloroflexus
aurantiacus) 		5 / 12 VAL A 140
LEU A 303
ASP A 123
ALA A 130
SER A 133
 None
 1.31A 5hnzB-1uxiA:
5.8		 5hnzB-1uxiA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V3C_A_AMHA402_1
(QUEUINE
TRNA-RIBOSYLTRANSFER
ASE)		 1uxi MALATE DEHYDROGENASE
(Chloroflexus
aurantiacus) 		5 / 9 ASP A 148
GLY A 173
GLY A 174
ALA A 298
VAL A 299
 None
 1.43A 5v3cA-1uxiA:
2.0		 5v3cA-1uxiA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1uxi MALATE DEHYDROGENASE
(Chloroflexus
aurantiacus) 		5 / 10 VAL A  13
GLY A  14
LEU A 147
ILE A 116
THR A  77
 NAD  A1310 (-3.6A)
None
NAD  A1310 ( 4.0A)
None
None
 1.04A 5vm8B-1uxiA:
3.5		 5vm8B-1uxiA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_C_RFPC502_1
(RIFAMPIN
MONOOXYGENASE)		 1uxi MALATE DEHYDROGENASE
(Chloroflexus
aurantiacus) 		5 / 12 VAL A 276
VAL A 269
GLY A 174
VAL A 299
GLY A 256
 None
 1.15A 6brdC-1uxiA:
4.5		 6brdC-1uxiA:
13.77