SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1uxo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		 1uxo YDEN PROTEIN
(Bacillus
subtilis) 		5 / 12 ILE A   8
ALA A  69
THR A 113
LEU A  78
PHE A  99
 None
 1.04A 1og5B-1uxoA:
undetectable		 1og5B-1uxoA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_J_BEZJ5041_0
(CES1 PROTEIN)		 1uxo YDEN PROTEIN
(Bacillus
subtilis) 		4 / 4 GLY A  10
SER A  71
ILE A 139
HIS A 164
 None
 1.26A 1yajJ-1uxoA:
8.9		 1yajJ-1uxoA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 1uxo YDEN PROTEIN
(Bacillus
subtilis) 		5 / 12 ALA A 155
ILE A 122
LEU A  78
ILE A  93
TYR A 184
 None
 1.08A 2drcB-1uxoA:
undetectable		 2drcB-1uxoA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1121_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 1uxo YDEN PROTEIN
(Bacillus
subtilis) 		4 / 5 VAL A  96
SER A 134
VAL A 159
SER A  97
 None
 1.11A 2j9cA-1uxoA:
undetectable
2j9cB-1uxoA:
undetectable
2j9cC-1uxoA:
undetectable		 2j9cA-1uxoA:
18.75
2j9cB-1uxoA:
18.75
2j9cC-1uxoA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0P_A_ADNA1607_1
(ALCALIGIN
BIOSYNTHESIS PROTEIN)		 1uxo YDEN PROTEIN
(Bacillus
subtilis) 		4 / 8 GLY A  98
HIS A  70
ILE A  93
ALA A 133
 None
 0.92A 2x0pA-1uxoA:
undetectable		 2x0pA-1uxoA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		 1uxo YDEN PROTEIN
(Bacillus
subtilis) 		3 / 3 LEU A  78
ARG A 129
ILE A  77
 None
 0.66A 2xn5B-1uxoA:
undetectable		 2xn5B-1uxoA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)		 1uxo YDEN PROTEIN
(Bacillus
subtilis) 		4 / 8 HIS A 164
PHE A  20
PRO A  42
TRP A  50
 None
 1.26A 3v35A-1uxoA:
undetectable		 3v35A-1uxoA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1uxo YDEN PROTEIN
(Bacillus
subtilis) 		5 / 10 LEU A  37
ASP A  35
THR A  65
GLN A   4
THR A  60
 None
 1.07A 4n9uA-1uxoA:
undetectable		 4n9uA-1uxoA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1uxo YDEN PROTEIN
(Bacillus
subtilis) 		5 / 12 LEU A  37
ASP A  35
THR A  65
GLN A   4
THR A  60
 None
 1.06A 5cg5A-1uxoA:
undetectable		 5cg5A-1uxoA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1uxo YDEN PROTEIN
(Bacillus
subtilis) 		5 / 12 LEU A  37
ASP A  35
THR A  65
GLN A   4
THR A  60
 None
 1.07A 5cg6A-1uxoA:
undetectable		 5cg6A-1uxoA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1uxo YDEN PROTEIN
(Bacillus
subtilis) 		3 / 3 PHE A 142
ASP A 136
LEU A 106
 None
 0.60A 5uhbC-1uxoA:
undetectable		 5uhbC-1uxoA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1uxo YDEN PROTEIN
(Bacillus
subtilis) 		3 / 3 PHE A 142
ASP A 136
LEU A 106
 None
 0.56A 5uhcC-1uxoA:
undetectable		 5uhcC-1uxoA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUO_D_08HD501_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT GAMMA-2)		 1uxo YDEN PROTEIN
(Bacillus
subtilis) 		4 / 8 TYR A 184
PHE A 185
VAL A 177
TYR A 178
 None
 1.19A 6huoC-1uxoA:
undetectable
6huoD-1uxoA:
undetectable		 6huoC-1uxoA:
16.40
6huoD-1uxoA:
16.84