SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1uxt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NB9_A_RBFA401_1
(HYPOTHETICAL PROTEIN
FLJ11149)		 1uxt GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(NADP+)
(Thermoproteus
tenax) 		5 / 9 VAL A 479
ARG A 122
LEU A  83
ILE A 183
ASP A 129
 None
 1.38A 1nb9A-1uxtA:
undetectable		 1nb9A-1uxtA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1uxt GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(NADP+)
(Thermoproteus
tenax) 		3 / 3 GLU A 473
GLU A 480
LEU A 158
 None
 0.73A 1v8bA-1uxtA:
5.1		 1v8bA-1uxtA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1uxt GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(NADP+)
(Thermoproteus
tenax) 		3 / 3 GLU A 473
GLU A 480
LEU A 158
 None
 0.74A 1v8bB-1uxtA:
4.9		 1v8bB-1uxtA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_A_ADNA2001_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 1uxt GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(NADP+)
(Thermoproteus
tenax) 		4 / 7 ARG A  72
ALA A 187
PRO A 213
ALA A 216
 G1P  A1502 (-3.3A)
None
None
None
 0.95A 2ejfA-1uxtA:
undetectable		 2ejfA-1uxtA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J5M_A_ACTA1321_0
(CHLOROPEROXIDASE)		 1uxt GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(NADP+)
(Thermoproteus
tenax) 		4 / 6 LEU A 409
ILE A 435
VAL A 427
ALA A 438
 None
 0.93A 2j5mA-1uxtA:
0.0		 2j5mA-1uxtA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCU_A_TYLA3001_1
(LACTOTRANSFERRIN)		 1uxt GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(NADP+)
(Thermoproteus
tenax) 		3 / 3 LEU A 208
TYR A  22
GLY A  28
 None
 0.61A 2ocuA-1uxtA:
undetectable		 2ocuA-1uxtA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		 1uxt GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(NADP+)
(Thermoproteus
tenax) 		3 / 3 LEU A   5
LEU A 219
PHE A  97
 None
 0.68A 2pgrA-1uxtA:
undetectable		 2pgrA-1uxtA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 1uxt GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(NADP+)
(Thermoproteus
tenax) 		5 / 12 ILE A 217
VAL A 188
ALA A  24
LEU A  23
VAL A 204
 None
 1.01A 3fpjA-1uxtA:
4.8		 3fpjA-1uxtA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_1
(HIV-1 PROTEASE)		 1uxt GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(NADP+)
(Thermoproteus
tenax) 		5 / 9 LEU A 158
ASP A 234
GLY A 255
VAL A 252
VAL A 161
 None
NA  A1504 ( 4.9A)
NA  A1504 (-4.4A)
None
None
 0.94A 3oxvA-1uxtA:
undetectable		 3oxvA-1uxtA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_2
(ADENOSINE KINASE)		 1uxt GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(NADP+)
(Thermoproteus
tenax) 		4 / 5 SER A 322
ILE A 289
GLY A 365
PRO A 376
 None
 1.00A 3uboB-1uxtA:
3.2		 3uboB-1uxtA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_A_SAMA801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 1uxt GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(NADP+)
(Thermoproteus
tenax) 		5 / 12 GLY A 266
THR A 245
ASP A 268
VAL A 400
LEU A 402
 NAD  A1503 (-4.7A)
None
None
None
None
 1.04A 3v8vA-1uxtA:
5.2		 3v8vA-1uxtA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A81_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 1uxt GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(NADP+)
(Thermoproteus
tenax) 		5 / 12 ILE A 435
GLY A 429
ASP A 275
VAL A 406
ASN A 417
 None
 1.23A 4a81A-1uxtA:
undetectable		 4a81A-1uxtA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		 1uxt GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(NADP+)
(Thermoproteus
tenax) 		4 / 7 ARG A 320
GLY A 288
TYR A 290
SER A 291
 None
 0.98A 4cp3A-1uxtA:
undetectable
4cp3B-1uxtA:
undetectable		 4cp3A-1uxtA:
12.25
4cp3B-1uxtA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTK_C_SAMC1263_0
(POLYPROTEIN)		 1uxt GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(NADP+)
(Thermoproteus
tenax) 		6 / 12 SER A 468
GLY A 464
GLY A 267
GLY A 422
GLU A 395
ASP A 424
 None
None
None
None
NAD  A1503 (-2.9A)
None
 1.18A 4ctkC-1uxtA:
undetectable		 4ctkC-1uxtA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1uxt GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(NADP+)
(Thermoproteus
tenax) 		4 / 8 ASP A 173
ASP A 298
ASP A 424
GLU A 115
 NAD  A1503 ( 4.8A)
None
None
None
 0.88A 4feuD-1uxtA:
undetectable		 4feuD-1uxtA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_D_SVRD301_1
(NUCLEOCAPSID PROTEIN)		 1uxt GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(NADP+)
(Thermoproteus
tenax) 		5 / 11 GLY A  67
ALA A 237
PRO A 213
PHE A 212
ILE A 217
 None
 1.38A 4j4vD-1uxtA:
undetectable
4j4vE-1uxtA:
undetectable		 4j4vD-1uxtA:
20.00
4j4vE-1uxtA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA205_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 1uxt GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(NADP+)
(Thermoproteus
tenax) 		5 / 12 PRO A 453
ASN A 450
ALA A 276
GLY A 429
LEU A 273
 None
 1.35A 4oadA-1uxtA:
undetectable		 4oadA-1uxtA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB301_1
(CHITOSANASE)		 1uxt GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(NADP+)
(Thermoproteus
tenax) 		3 / 3 GLY A 337
PRO A 338
GLN A 295
 None
 0.46A 4oltB-1uxtA:
0.0		 4oltB-1uxtA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB305_1
(CHITOSANASE)		 1uxt GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(NADP+)
(Thermoproteus
tenax) 		3 / 3 GLY A 337
PRO A 338
GLN A 295
 None
 0.35A 4qwpB-1uxtA:
0.0		 4qwpB-1uxtA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_B_LOCB502_1
(TUBULIN BETA CHAIN)		 1uxt GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(NADP+)
(Thermoproteus
tenax) 		5 / 12 LEU A 409
LEU A 304
ALA A 412
ALA A 425
ILE A 447
 None
 1.13A 4x1yB-1uxtA:
undetectable		 4x1yB-1uxtA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_2
(ESTROGEN RECEPTOR)		 1uxt GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(NADP+)
(Thermoproteus
tenax) 		3 / 3 LEU A  83
ASP A  88
ILE A 475
 None
 0.61A 4xi3D-1uxtA:
undetectable		 4xi3D-1uxtA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1uxt GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(NADP+)
(Thermoproteus
tenax) 		4 / 5 VAL A 444
TYR A 180
ILE A 183
PRO A 461
 None
 1.11A 4ze1A-1uxtA:
0.2		 4ze1A-1uxtA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_2
(PROTEASE E35D-APV)		 1uxt GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(NADP+)
(Thermoproteus
tenax) 		5 / 9 LEU A 219
GLY A  28
GLY A   8
ILE A  10
VAL A 204
 None
 1.02A 5kr0B-1uxtA:
undetectable		 5kr0B-1uxtA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VYH_A_FOLA409_0
(S PROTEIN)		 1uxt GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(NADP+)
(Thermoproteus
tenax) 		5 / 10 PRO A 170
PRO A 199
ALA A 118
GLY A 456
ILE A 457
 None
 1.25A 5vyhA-1uxtA:
undetectable		 5vyhA-1uxtA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA605_0
(ALPHA-AMYLASE)		 1uxt GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(NADP+)
(Thermoproteus
tenax) 		4 / 8 TYR A 421
GLY A 464
ASP A 268
ASP A 298
 None
 0.73A 6ag0A-1uxtA:
undetectable		 6ag0A-1uxtA:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC605_0
(ALPHA-AMYLASE)		 1uxt GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(NADP+)
(Thermoproteus
tenax) 		4 / 8 TYR A 421
GLY A 464
ASP A 268
ASP A 298
 None
 0.66A 6ag0C-1uxtA:
undetectable		 6ag0C-1uxtA:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1uxt GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(NADP+)
(Thermoproteus
tenax) 		5 / 12 ILE A 340
THR A 165
VAL A 190
SER A 244
GLU A 395
 None
None
None
NAD  A1503 (-2.5A)
NAD  A1503 (-2.9A)
 1.27A 6bzoC-1uxtA:
0.0		 6bzoC-1uxtA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 1uxt GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(NADP+)
(Thermoproteus
tenax) 		4 / 6 ALA A 111
SER A 291
GLY A 294
ILE A 340
 None
 0.86A 6f8cA-1uxtA:
undetectable		 6f8cA-1uxtA:
10.38