SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1uyp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1uyp BETA-FRUCTOSIDASE
(Thermotoga
maritima) 		4 / 8 SER A 401
HIS A   7
SER A 389
PHE A 393
 None
 1.17A 1eqbA-1uypA:
undetectable
1eqbB-1uypA:
undetectable		 1eqbA-1uypA:
21.81
1eqbB-1uypA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1uyp BETA-FRUCTOSIDASE
(Thermotoga
maritima) 		4 / 8 PHE A 393
SER A 401
HIS A   7
SER A 389
 None
 1.15A 1eqbA-1uypA:
undetectable
1eqbB-1uypA:
undetectable		 1eqbA-1uypA:
21.81
1eqbB-1uypA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1uyp BETA-FRUCTOSIDASE
(Thermotoga
maritima) 		4 / 8 SER A 401
HIS A   7
SER A 389
PHE A 393
 None
 1.18A 1eqbC-1uypA:
undetectable
1eqbD-1uypA:
undetectable		 1eqbC-1uypA:
21.81
1eqbD-1uypA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1uyp BETA-FRUCTOSIDASE
(Thermotoga
maritima) 		4 / 8 PHE A 393
SER A 401
HIS A   7
SER A 389
 None
 1.15A 1eqbC-1uypA:
undetectable
1eqbD-1uypA:
undetectable		 1eqbC-1uypA:
21.81
1eqbD-1uypA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 1uyp BETA-FRUCTOSIDASE
(Thermotoga
maritima) 		5 / 12 SER A 364
VAL A 363
TYR A 266
GLY A 362
PRO A 406
 None
 1.35A 1fdsA-1uypA:
undetectable		 1fdsA-1uypA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 1uyp BETA-FRUCTOSIDASE
(Thermotoga
maritima) 		4 / 8 GLY A  47
ASP A 138
THR A  90
ASP A  17
 None
GOL  A1437 (-2.9A)
None
GOL  A1437 (-2.8A)
 0.84A 1m4iA-1uypA:
undetectable		 1m4iA-1uypA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U1J_A_C2FA773_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 1uyp BETA-FRUCTOSIDASE
(Thermotoga
maritima) 		4 / 8 ARG A 337
SER A 361
ARG A 360
VAL A 345
 None
 1.23A 1u1jA-1uypA:
undetectable		 1u1jA-1uypA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1uyp BETA-FRUCTOSIDASE
(Thermotoga
maritima) 		3 / 3 GLU A 426
GLU A 325
LEU A 413
 None
 0.75A 1v8bB-1uypA:
undetectable		 1v8bB-1uypA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_A_ACTA1397_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 1uyp BETA-FRUCTOSIDASE
(Thermotoga
maritima) 		3 / 3 PRO A  10
GLY A  13
TYR A  34
 None
 0.75A 2vouA-1uypA:
undetectable		 2vouA-1uypA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_B_ACTB1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 1uyp BETA-FRUCTOSIDASE
(Thermotoga
maritima) 		3 / 3 PRO A  10
GLY A  13
TYR A  34
 None
 0.68A 2vouB-1uypA:
undetectable		 2vouB-1uypA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_C_ACTC1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 1uyp BETA-FRUCTOSIDASE
(Thermotoga
maritima) 		3 / 3 PRO A  10
GLY A  13
TYR A  34
 None
 0.67A 2vouC-1uypA:
undetectable		 2vouC-1uypA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_2
(PHOSPHOLIPASE A2)		 1uyp BETA-FRUCTOSIDASE
(Thermotoga
maritima) 		4 / 6 VAL A 251
VAL A 252
PHE A 215
ARG A 250
 None
None
None
SO4  A1434 (-4.0A)
 1.19A 3bjwF-1uypA:
undetectable		 3bjwF-1uypA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFL_A_5CHA693_1
(LACTOTRANSFERRIN)		 1uyp BETA-FRUCTOSIDASE
(Thermotoga
maritima) 		4 / 4 THR A 263
VAL A 276
GLY A  13
THR A  12
 None
 0.86A 3cflA-1uypA:
undetectable		 3cflA-1uypA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B304_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 1uyp BETA-FRUCTOSIDASE
(Thermotoga
maritima) 		4 / 5 ASN A 418
THR A 348
SER A 414
ARG A 337
 None
 1.46A 3hlwB-1uypA:
0.0		 3hlwB-1uypA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECLA600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1uyp BETA-FRUCTOSIDASE
(Thermotoga
maritima) 		4 / 8 TYR A  92
THR A  90
GLY A 153
THR A 208
 SO4  A1433 ( 4.8A)
None
None
None
 0.76A 3jusA-1uypA:
undetectable		 3jusA-1uypA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1uyp BETA-FRUCTOSIDASE
(Thermotoga
maritima) 		4 / 8 TYR A  92
THR A  90
GLY A 153
THR A 208
 SO4  A1433 ( 4.8A)
None
None
None
 0.76A 3jusA-1uypA:
undetectable		 3jusA-1uypA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECLB600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1uyp BETA-FRUCTOSIDASE
(Thermotoga
maritima) 		4 / 8 TYR A  92
THR A  90
GLY A 153
THR A 208
 SO4  A1433 ( 4.8A)
None
None
None
 0.75A 3jusB-1uypA:
undetectable		 3jusB-1uypA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 1uyp BETA-FRUCTOSIDASE
(Thermotoga
maritima) 		4 / 7 TYR A 324
LEU A 279
PHE A 392
VAL A 356
 None
 1.15A 3jwqC-1uypA:
undetectable		 3jwqC-1uypA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_2
(ADENOSINE KINASE,
PUTATIVE)		 1uyp BETA-FRUCTOSIDASE
(Thermotoga
maritima) 		4 / 5 LEU A  60
ALA A  63
PHE A  31
ASN A 112
 None
 1.45A 3uq6A-1uypA:
undetectable		 3uq6A-1uypA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)		 1uyp BETA-FRUCTOSIDASE
(Thermotoga
maritima) 		4 / 4 LEU A  60
ALA A  63
PHE A  31
ASN A 112
 None
 1.37A 3vaqA-1uypA:
undetectable		 3vaqA-1uypA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)		 1uyp BETA-FRUCTOSIDASE
(Thermotoga
maritima) 		4 / 4 LEU A  60
ALA A  63
PHE A  31
ASN A 112
 None
 1.39A 3vasA-1uypA:
undetectable		 3vasA-1uypA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 1uyp BETA-FRUCTOSIDASE
(Thermotoga
maritima) 		4 / 7 ASP A  94
GLY A  42
THR A  70
PHE A  74
 SO4  A1433 (-3.0A)
SO4  A1433 (-3.5A)
None
GOL  A1437 (-3.9A)
 0.97A 3vnsA-1uypA:
undetectable		 3vnsA-1uypA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 1uyp BETA-FRUCTOSIDASE
(Thermotoga
maritima) 		4 / 6 ILE A 404
TRP A  14
TRP A 256
TRP A 273
 None
 1.39A 3welA-1uypA:
undetectable		 3welA-1uypA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEO_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 1uyp BETA-FRUCTOSIDASE
(Thermotoga
maritima) 		4 / 6 ILE A 404
TRP A  14
TRP A 256
TRP A 273
 None
 1.43A 3weoA-1uypA:
undetectable		 3weoA-1uypA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_2
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 1uyp BETA-FRUCTOSIDASE
(Thermotoga
maritima) 		3 / 3 LEU A 265
LEU A 257
ASN A 211
 SO4  A1435 (-4.2A)
None
None
 0.75A 4otwA-1uypA:
2.6		 4otwA-1uypA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		 1uyp BETA-FRUCTOSIDASE
(Thermotoga
maritima) 		4 / 8 SER A  77
GLY A  76
ILE A 189
SER A 154
 None
 0.74A 5alcL-1uypA:
undetectable		 5alcL-1uypA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_F_GFNF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1uyp BETA-FRUCTOSIDASE
(Thermotoga
maritima) 		4 / 7 ASP A 357
ARG A 360
GLY A 365
ARG A 369
 None
 0.85A 5btfA-1uypA:
undetectable
5btfB-1uypA:
undetectable
5btfC-1uypA:
undetectable		 5btfA-1uypA:
20.79
5btfB-1uypA:
22.07
5btfC-1uypA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 1uyp BETA-FRUCTOSIDASE
(Thermotoga
maritima) 		4 / 6 PHE A 239
GLU A 391
PHE A 393
VAL A 295
 None
 1.24A 5h4dA-1uypA:
undetectable		 5h4dA-1uypA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_B_P2EB1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 1uyp BETA-FRUCTOSIDASE
(Thermotoga
maritima) 		4 / 5 PRO A  36
VAL A  62
GLY A  76
VAL A  73
 None
 1.11A 6ak3B-1uypA:
undetectable		 6ak3B-1uypA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA414_0
(AROMATIC
PEROXYGENASE)		 1uyp BETA-FRUCTOSIDASE
(Thermotoga
maritima) 		4 / 5 PHE A 392
VAL A 420
MET A 338
VAL A 356
 None
 1.24A 6ekzA-1uypA:
undetectable		 6ekzA-1uypA:
10.22