SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1uyv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXV_B_PNNB1001_0
(PENICILLIN ACYLASE)		 1uyv ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 7 MET A1564
SER A1732
PHE A1596
ALA A1623
 None
 1.11A 1fxvA-1uyvA:
undetectable
1fxvB-1uyvA:
undetectable		 1fxvA-1uyvA:
15.54
1fxvB-1uyvA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLB_A_NVPA999_1
(HIV-1 RT A-CHAIN)		 1uyv ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 8 LEU A1884
VAL A1891
GLY A1890
LEU A1860
 None
 0.85A 1jlbA-1uyvA:
undetectable		 1jlbA-1uyvA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1uyv ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 ILE A2136
LEU A2139
VAL A2143
 None
 0.30A 1mz9B-1uyvA:
undetectable		 1mz9B-1uyvA:
5.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_B_SAMB301_0
(HEMK PROTEIN)		 1uyv ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 PHE A1861
ILE A1820
GLY A1886
GLU A1575
ALA A1882
 None
 0.99A 1nv8B-1uyvA:
undetectable		 1nv8B-1uyvA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 1uyv ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 PHE A1861
ILE A1820
GLY A1886
GLU A1575
ALA A1882
 None
 0.99A 1sg9B-1uyvA:
4.0		 1sg9B-1uyvA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		 1uyv ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 8 LEU A1860
GLY A1859
LEU A1950
PRO A1835
 None
 0.95A 1ya4A-1uyvA:
undetectable		 1ya4A-1uyvA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A7Q_A_CFBA328_2
(DEOXYCYTIDINE KINASE)		 1uyv ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 4 ILE A1887
ASP A1825
LEU A1860
ARG A2127
 None
 1.30A 2a7qA-1uyvA:
0.5		 2a7qA-1uyvA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1uyv ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 5 ASP A1601
GLY A1626
ALA A1712
ILE A1711
 None
 0.89A 2aofA-1uyvA:
undetectable		 2aofA-1uyvA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		 1uyv ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 6 ASN A1587
ASN A1624
ILE A1755
THR A1726
 None
 1.13A 2hkkA-1uyvA:
undetectable		 2hkkA-1uyvA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_1
(ESTROGEN RECEPTOR)		 1uyv ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A1908
ASP A1906
LEU A1766
GLY A1758
LEU A1777
 None
 1.10A 2jfaB-1uyvA:
undetectable		 2jfaB-1uyvA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 1uyv ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 GLU A1541
ASP A1588
TYR A1507
 None
 0.87A 2yvlB-1uyvA:
undetectable		 2yvlB-1uyvA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB2_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1uyv ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 LEU A1739
LEU A1742
ARG A1717
 None
 0.66A 3hcnB-1uyvA:
undetectable		 3hcnB-1uyvA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_A_ACRA720_1
(ALPHA-AMYLASE, SUSG)		 1uyv ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 7 TYR A1988
GLU A2114
TRP A2115
LEU A1950
 None
 1.24A 3k8mA-1uyvA:
undetectable		 3k8mA-1uyvA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_C_9PLC1_1
(CYTOCHROME P450 2A13)		 1uyv ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 7 PHE A1596
PHE A1604
ALA A1712
THR A1715
 None
 1.01A 3t3sC-1uyvA:
undetectable		 3t3sC-1uyvA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_E_9PLE1_1
(CYTOCHROME P450 2A13)		 1uyv ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 8 PHE A1596
PHE A1604
ALA A1712
THR A1715
 None
 0.94A 3t3sE-1uyvA:
undetectable		 3t3sE-1uyvA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1uyv ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 4 PRO A1984
LEU A2126
ILE A1887
ARG A2127
 None
 1.45A 3w1wA-1uyvA:
undetectable		 3w1wA-1uyvA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACHG301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1uyv ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 8 TYR A1988
TYR A2015
ARG A2125
LEU A2126
 None
 1.17A 3wipG-1uyvA:
undetectable
3wipH-1uyvA:
undetectable		 3wipG-1uyvA:
14.27
3wipH-1uyvA:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_J_ACHJ301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1uyv ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 8 ARG A2125
LEU A2126
TYR A1988
TYR A2015
 None
 1.24A 3wipF-1uyvA:
undetectable
3wipJ-1uyvA:
undetectable		 3wipF-1uyvA:
14.27
3wipJ-1uyvA:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1475_0
(MJ0495-LIKE PROTEIN)		 1uyv ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 8 ILE A1949
ILE A1892
PHE A1939
SER A1865
GLY A1880
 None
 1.45A 4ac9C-1uyvA:
3.9		 4ac9C-1uyvA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1uyv ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 MET A1564
ASP A1601
GLY A1734
SER A1732
ILE A1735
 None
 1.44A 4djeA-1uyvA:
2.3		 4djeA-1uyvA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		 1uyv ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A1978
VAL A2003
ILE A1949
ILE A1936
ALA A1935
 None
 1.03A 4ltwA-1uyvA:
undetectable		 4ltwA-1uyvA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_A_ML1A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1uyv ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 8 PHE A1604
GLY A1736
ASN A1587
ILE A1754
 None
 0.94A 4qoiA-1uyvA:
2.7
4qoiB-1uyvA:
undetectable		 4qoiA-1uyvA:
14.98
4qoiB-1uyvA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB401_0
(PROTON-GATED ION
CHANNEL)		 1uyv ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 6 PHE A2123
ARG A2127
ILE A1820
GLU A1822
 None
 1.23A 4zzcB-1uyvA:
undetectable
4zzcC-1uyvA:
undetectable		 4zzcB-1uyvA:
19.05
4zzcC-1uyvA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_DIFA601_1
(SERUM ALBUMIN)		 1uyv ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 9 LEU A1739
ASN A1605
VAL A1607
ARG A1618
GLU A1600
 None
 1.11A 5dbyA-1uyvA:
0.0		 5dbyA-1uyvA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1uyv ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 HIS A1925
SER A1928
SER A1871
GLY A1872
ALA A1874
 None
 1.25A 5l5zV-1uyvA:
undetectable
5l5zb-1uyvA:
undetectable		 5l5zV-1uyvA:
15.92
5l5zb-1uyvA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1uyv ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 HIS A1925
SER A1928
SER A1871
GLY A1872
ALA A1874
 None
 1.25A 5l5zH-1uyvA:
undetectable
5l5zN-1uyvA:
undetectable		 5l5zH-1uyvA:
15.92
5l5zN-1uyvA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_A_Z80A401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1uyv ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 11 ILE A1619
ILE A1803
VAL A1584
ASP A1796
ALA A1518
 None
 0.92A 5lg3A-1uyvA:
undetectable		 5lg3A-1uyvA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_E_Z80E401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1uyv ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A1619
ILE A1803
VAL A1584
ASP A1796
ALA A1518
 None
 0.91A 5lg3E-1uyvA:
undetectable		 5lg3E-1uyvA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PHH_A_LDPA414_1
(LYSINE-SPECIFIC
DEMETHYLASE 4D)		 1uyv ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 6 ALA A1737
LEU A1739
TYR A1620
SER A1732
 None
 1.15A 5phhA-1uyvA:
undetectable		 5phhA-1uyvA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA303_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1uyv ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 GLU A1609
TYR A1610
ARG A1614
 None
 0.65A 5uunA-1uyvA:
undetectable		 5uunA-1uyvA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1uyv ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 GLU A1609
TYR A1610
ARG A1614
 None
 0.59A 5uunB-1uyvA:
undetectable		 5uunB-1uyvA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA901_0
(MRNA CAPPING ENZYME
P5)		 1uyv ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 11 VAL A1879
GLY A1880
ASP A1938
ALA A1935
LEU A1870
 None
 0.96A 5x6yA-1uyvA:
3.2		 5x6yA-1uyvA:
21.95