SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1uyw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H8S_A_AICA1000_1
(MUTANT AL2 6E7P9G)		 1uyw FAB ANTIBODY HEAVY
CHAIN
FAB ANTIBODY LIGHT
CHAIN
(Mus
musculus) 		6 / 12 TYR L  36
TYR L  94
PHE L  98
VAL H  37
ALA H  93
TRP H 103
 None
 0.52A 1h8sA-1uywL:
22.7		 1h8sA-1uywL:
45.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_G_BEZG3385_0
(CES1 PROTEIN)		 1uyw FAB ANTIBODY LIGHT
CHAIN
(Mus
musculus) 		3 / 3 SER L 177
VAL L 115
LEU L 136
 None
 0.71A 1yajG-1uywL:
undetectable		 1yajG-1uywL:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 1uyw FAB ANTIBODY LIGHT
CHAIN
(Mus
musculus) 		5 / 12 GLY L  91
ILE L   2
GLY L  89
PHE L  98
MET L   4
 None
 1.12A 3ps9A-1uywL:
undetectable		 3ps9A-1uywL:
15.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		 1uyw FAB ANTIBODY HEAVY
CHAIN
FAB ANTIBODY LIGHT
CHAIN
(Mus
musculus) 		4 / 7 TYR L  32
SER L  34
TYR L  36
TYR H 100
 None
 0.85A 5aclA-1uywL:
18.2		 5aclA-1uywL:
31.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		 1uyw FAB ANTIBODY LIGHT
CHAIN
(Mus
musculus) 		4 / 7 TYR L  32
SER L  34
TYR L  36
TYR L  49
 None
 0.54A 5aclA-1uywL:
18.2		 5aclA-1uywL:
31.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		 1uyw FAB ANTIBODY HEAVY
CHAIN
FAB ANTIBODY LIGHT
CHAIN
(Mus
musculus) 		4 / 8 SER L 116
THR L 114
SER L 174
THR H 182
 None
 0.99A 5l4eA-1uywL:
undetectable
5l4eB-1uywL:
3.3
5l4eC-1uywL:
undetectable
5l4eD-1uywL:
undetectable
5l4eE-1uywL:
3.3		 5l4eA-1uywL:
18.93
5l4eB-1uywL:
18.93
5l4eC-1uywL:
18.93
5l4eD-1uywL:
18.93
5l4eE-1uywL:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L94_A_TESA502_1
(CYTOCHROME P450)		 1uyw FAB ANTIBODY HEAVY
CHAIN
(Mus
musculus) 		5 / 8 VAL H 121
ALA H 118
THR H 204
VAL H 150
VAL H 197
 None
 1.47A 5l94A-1uywH:
undetectable		 5l94A-1uywH:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1T_A_SAMA605_0
(RADICAL SAM)		 1uyw FAB ANTIBODY HEAVY
CHAIN
FAB ANTIBODY LIGHT
CHAIN
(Mus
musculus;
Mus
musculus) 		5 / 12 LEU L 160
THR L 178
VAL L 133
SER L 131
THR H 117
 None
 1.39A 5v1tA-1uywL:
undetectable		 5v1tA-1uywL:
17.32