SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1uz4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EA1_A_TPFA470_1
(CYTOCHROME P450
51-LIKE RV0764C)		 1uz4 MAN5A
(Cellvibrio
mixtus) 		4 / 8 TYR A 182
PHE A 172
PHE A 102
THR A  99
 None
 1.11A 1ea1A-1uz4A:
0.0		 1ea1A-1uz4A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_2_T442129_1
(TRANSTHYRETIN)		 1uz4 MAN5A
(Cellvibrio
mixtus) 		4 / 6 GLU A  57
THR A 108
ALA A  54
LEU A  52
 None
 1.08A 1etb2-1uz4A:
undetectable		 1etb2-1uz4A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_B_DVAB6_0
(MINI-GRAMICIDIN A)		 1uz4 MAN5A
(Cellvibrio
mixtus) 		3 / 3 ALA A 240
VAL A 235
TRP A 234
 None
 0.89A 1kqeB-1uz4A:
undetectable
1kqeD-1uz4A:
undetectable		 1kqeB-1uz4A:
2.42
1kqeD-1uz4A:
2.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1868_0
(FPRA)		 1uz4 MAN5A
(Cellvibrio
mixtus) 		3 / 3 ALA A 314
HIS A 315
VAL A 318
 None
 0.42A 1lqtB-1uz4A:
undetectable		 1lqtB-1uz4A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1425_0
(FPRA)		 1uz4 MAN5A
(Cellvibrio
mixtus) 		3 / 3 ALA A 314
HIS A 315
VAL A 318
 None
 0.39A 1lquB-1uz4A:
undetectable		 1lquB-1uz4A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_A_SALA710_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1uz4 MAN5A
(Cellvibrio
mixtus) 		4 / 7 VAL A 127
LEU A  79
ALA A  50
LEU A 113
 None
 0.82A 1pthA-1uz4A:
undetectable		 1pthA-1uz4A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_B_SALB711_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1uz4 MAN5A
(Cellvibrio
mixtus) 		4 / 7 VAL A 127
LEU A  79
ALA A  50
LEU A 113
 None
 0.82A 1pthB-1uz4A:
undetectable		 1pthB-1uz4A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC439_0
(ADP-RIBOSYL CYCLASE)		 1uz4 MAN5A
(Cellvibrio
mixtus) 		3 / 3 TRP A  47
PHE A 397
TRP A 391
 None
GOL  A1435 (-4.2A)
None
 0.84A 1r15C-1uz4A:
undetectable		 1r15C-1uz4A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF469_0
(ADP-RIBOSYL CYCLASE)		 1uz4 MAN5A
(Cellvibrio
mixtus) 		3 / 3 TRP A  47
PHE A 397
TRP A 391
 None
GOL  A1435 (-4.2A)
None
 0.82A 1r15F-1uz4A:
undetectable		 1r15F-1uz4A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_G_NCAG479_0
(ADP-RIBOSYL CYCLASE)		 1uz4 MAN5A
(Cellvibrio
mixtus) 		3 / 3 TRP A  47
PHE A 397
TRP A 391
 None
GOL  A1435 (-4.2A)
None
 0.83A 1r15G-1uz4A:
undetectable		 1r15G-1uz4A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_H_NCAH489_0
(ADP-RIBOSYL CYCLASE)		 1uz4 MAN5A
(Cellvibrio
mixtus) 		3 / 3 TRP A  47
PHE A 397
TRP A 391
 None
GOL  A1435 (-4.2A)
None
 0.82A 1r15H-1uz4A:
undetectable		 1r15H-1uz4A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U1J_A_C2FA773_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 1uz4 MAN5A
(Cellvibrio
mixtus) 		4 / 8 ARG A 383
ASN A 388
ARG A 335
TRP A 390
 None
 1.29A 1u1jA-1uz4A:
11.8		 1u1jA-1uz4A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA501_0
(FERROCHELATASE)		 1uz4 MAN5A
(Cellvibrio
mixtus) 		5 / 11 MET A  46
LEU A 117
LEU A 116
LEU A  68
ILE A 207
 None
 1.32A 2qd3A-1uz4A:
undetectable		 2qd3A-1uz4A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA503_0
(CHORISMATE SYNTHASE)		 1uz4 MAN5A
(Cellvibrio
mixtus) 		4 / 5 GLN A 111
THR A 108
ALA A  54
ARG A  61
 None
 1.40A 2qhfA-1uz4A:
undetectable		 2qhfA-1uz4A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_1
(AAC(6')-IB)		 1uz4 MAN5A
(Cellvibrio
mixtus) 		5 / 12 GLY A 382
TYR A  48
VAL A  44
ASP A 415
ASP A 413
 None
 1.45A 2vqyA-1uz4A:
0.0		 2vqyA-1uz4A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_B_CTCB1385_0
(TETX2 PROTEIN)		 1uz4 MAN5A
(Cellvibrio
mixtus) 		4 / 8 ARG A  63
GLY A 394
PRO A 402
GLY A 399
 GOL  A1435 (-4.6A)
GOL  A1435 ( 4.6A)
None
None
 0.84A 2y6rB-1uz4A:
undetectable		 2y6rB-1uz4A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1uz4 MAN5A
(Cellvibrio
mixtus) 		4 / 6 LEU A  79
VAL A 127
LEU A  64
ASP A 114
 None
 0.81A 3cs9D-1uz4A:
undetectable		 3cs9D-1uz4A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1uz4 MAN5A
(Cellvibrio
mixtus) 		5 / 12 ASN A  45
VAL A 127
LEU A 129
TYR A 279
GLN A 211
 None
 1.43A 3elzC-1uz4A:
undetectable		 3elzC-1uz4A:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1uz4 MAN5A
(Cellvibrio
mixtus) 		3 / 3 ASN A 374
MET A 312
PHE A 331
 None
 1.12A 3g4lD-1uz4A:
undetectable		 3g4lD-1uz4A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1uz4 MAN5A
(Cellvibrio
mixtus) 		4 / 7 ARG A 174
PRO A 216
SER A 255
GLY A 219
 None
 1.09A 3hcnA-1uz4A:
undetectable		 3hcnA-1uz4A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA310_1
(BETA-LACTAMASE)		 1uz4 MAN5A
(Cellvibrio
mixtus) 		4 / 8 ALA A  83
TRP A  47
GLY A 399
PRO A 401
 None
None
None
IFL  A1432 (-4.6A)
 0.92A 3ny4A-1uz4A:
undetectable		 3ny4A-1uz4A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3M_A_DLUA398_1
(PFV INTEGRASE)		 1uz4 MAN5A
(Cellvibrio
mixtus) 		4 / 8 ASP A 400
GLY A 410
TYR A  48
ARG A  63
 None
None
None
GOL  A1435 (-4.6A)
 0.97A 3s3mA-1uz4A:
undetectable		 3s3mA-1uz4A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_B_08JB2_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1uz4 MAN5A
(Cellvibrio
mixtus) 		4 / 7 VAL A  25
LEU A 250
ASN A  78
ILE A  41
 None
 0.99A 3u5kB-1uz4A:
undetectable		 3u5kB-1uz4A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_C_TYLC1184_1
(BROMODOMAIN
CONTAINING 2)		 1uz4 MAN5A
(Cellvibrio
mixtus) 		4 / 5 VAL A  25
LEU A 250
ASN A  78
ILE A  41
 None
 0.93A 4a9jC-1uz4A:
undetectable		 4a9jC-1uz4A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1103_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1uz4 MAN5A
(Cellvibrio
mixtus) 		4 / 5 ARG A 313
MET A 312
HIS A 315
LEU A 326
 None
 1.49A 4g5jA-1uz4A:
0.0		 4g5jA-1uz4A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_C_SVRC301_1
(NUCLEOCAPSID PROTEIN)		 1uz4 MAN5A
(Cellvibrio
mixtus) 		4 / 8 GLY A 380
ASN A 379
ARG A 335
ILE A 419
 None
 0.97A 4j4vC-1uz4A:
undetectable		 4j4vC-1uz4A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		 1uz4 MAN5A
(Cellvibrio
mixtus) 		5 / 12 LEU A 280
PHE A 268
ALA A 314
ASP A 264
MET A 265
 None
 1.45A 4j7xA-1uz4A:
2.6		 4j7xA-1uz4A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0U_A_ADNA501_1
(AURORA KINASE A)		 1uz4 MAN5A
(Cellvibrio
mixtus) 		5 / 6 VAL A  81
ALA A  49
LEU A  68
THR A 206
LEU A 120
 None
 1.36A 4o0uA-1uz4A:
undetectable		 4o0uA-1uz4A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_F_MFXF2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1uz4 MAN5A
(Cellvibrio
mixtus) 		4 / 6 ARG A 192
SER A 195
ASP A 106
GLU A  57
 None
 0.97A 5cdqA-1uz4A:
undetectable
5cdqC-1uz4A:
undetectable
5cdqD-1uz4A:
undetectable		 5cdqA-1uz4A:
19.42
5cdqC-1uz4A:
19.42
5cdqD-1uz4A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_W_MFXW2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1uz4 MAN5A
(Cellvibrio
mixtus) 		4 / 5 ARG A 192
SER A 195
ASP A 106
GLU A  57
 None
 1.00A 5cdqR-1uz4A:
0.0
5cdqT-1uz4A:
0.0
5cdqU-1uz4A:
1.6		 5cdqR-1uz4A:
19.42
5cdqT-1uz4A:
19.42
5cdqU-1uz4A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1uz4 MAN5A
(Cellvibrio
mixtus) 		5 / 12 VAL A 127
LEU A  79
ALA A 377
ALA A  50
LEU A 113
 None
 0.84A 5kirA-1uz4A:
undetectable		 5kirA-1uz4A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_E_Z80E401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1uz4 MAN5A
(Cellvibrio
mixtus) 		5 / 12 ILE A 375
VAL A  44
GLU A  67
ASN A  70
ILE A  74
 None
 1.03A 5lg3E-1uz4A:
undetectable		 5lg3E-1uz4A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_J_Z80J401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1uz4 MAN5A
(Cellvibrio
mixtus) 		5 / 12 ILE A 375
VAL A  44
GLU A  67
ASN A  70
ILE A  74
 None
 1.08A 5lg3J-1uz4A:
undetectable		 5lg3J-1uz4A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 1uz4 MAN5A
(Cellvibrio
mixtus) 		4 / 7 LEU A 116
ILE A  74
TRP A 378
MET A  46
 None
 1.17A 5ljcA-1uz4A:
undetectable		 5ljcA-1uz4A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1uz4 MAN5A
(Cellvibrio
mixtus) 		3 / 3 THR A 206
MET A 208
HIS A 249
 None
 0.86A 5uunA-1uz4A:
undetectable		 5uunA-1uz4A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1uz4 MAN5A
(Cellvibrio
mixtus) 		4 / 7 VAL A 153
PRO A 156
SER A 169
THR A 142
 None
 1.02A 5vkqA-1uz4A:
0.0
5vkqD-1uz4A:
0.0		 5vkqA-1uz4A:
13.22
5vkqD-1uz4A:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_1
(REGULATORY PROTEIN
TETR)		 1uz4 MAN5A
(Cellvibrio
mixtus) 		4 / 7 GLY A 382
GLN A 403
ASP A 400
ASP A 415
 None
IFL  A1432 ( 3.6A)
None
None
 1.13A 5vlmE-1uz4A:
undetectable		 5vlmE-1uz4A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JMJ_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1uz4 MAN5A
(Cellvibrio
mixtus) 		4 / 5 GLY A 257
HIS A 272
SER A 252
SER A 253
 None
 0.73A 6jmjA-1uz4A:
undetectable		 6jmjA-1uz4A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1uz4 MAN5A
(Cellvibrio
mixtus) 		4 / 7 GLY A 257
HIS A 272
SER A 252
SER A 253
 None
 0.69A 6jnhA-1uz4A:
2.3		 6jnhA-1uz4A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1uz4 MAN5A
(Cellvibrio
mixtus) 		4 / 6 GLY A 257
HIS A 272
SER A 252
SER A 253
 None
 0.71A 6jogA-1uz4A:
2.4		 6jogA-1uz4A:
17.19