SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1uz5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_D_SAMD200_0
(METHIONINE REPRESSOR)		 1uz5 402AA LONG
HYPOTHETICAL
MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 ALA A 184
PHE A 225
GLY A 223
LEU A 239
ALA A 243
 None
 1.11A 1mjqC-1uz5A:
undetectable
1mjqD-1uz5A:
undetectable		 1mjqC-1uz5A:
14.25
1mjqD-1uz5A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_J_SAMJ200_0
(METHIONINE REPRESSOR)		 1uz5 402AA LONG
HYPOTHETICAL
MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 ALA A 184
PHE A 225
GLY A 223
LEU A 239
ALA A 243
 None
 1.11A 1mjqI-1uz5A:
undetectable
1mjqJ-1uz5A:
undetectable		 1mjqI-1uz5A:
14.25
1mjqJ-1uz5A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1uz5 402AA LONG
HYPOTHETICAL
MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN
(Pyrococcus
horikoshii) 		4 / 6 ARG A 158
ARG A 325
ILE A  37
ALA A 322
 None
SO4  A1404 (-3.2A)
None
None
 0.78A 1wmqA-1uz5A:
undetectable		 1wmqA-1uz5A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1uz5 402AA LONG
HYPOTHETICAL
MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN
(Pyrococcus
horikoshii) 		4 / 6 ARG A 158
ARG A 325
ILE A  37
ALA A 322
 None
SO4  A1404 (-3.2A)
None
None
 0.78A 1wmqB-1uz5A:
undetectable		 1wmqB-1uz5A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1uz5 402AA LONG
HYPOTHETICAL
MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN
(Pyrococcus
horikoshii) 		4 / 6 ARG A 158
ARG A 325
ILE A  37
ALA A 322
 None
SO4  A1404 (-3.2A)
None
None
 0.77A 1wpuA-1uz5A:
undetectable		 1wpuA-1uz5A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1uz5 402AA LONG
HYPOTHETICAL
MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN
(Pyrococcus
horikoshii) 		4 / 6 ARG A 158
ARG A 325
ILE A  37
ALA A 322
 None
SO4  A1404 (-3.2A)
None
None
 0.77A 1wpuB-1uz5A:
undetectable		 1wpuB-1uz5A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1uz5 402AA LONG
HYPOTHETICAL
MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN
(Pyrococcus
horikoshii) 		4 / 6 ARG A 158
ARG A 325
ILE A  37
ALA A 322
 None
SO4  A1404 (-3.2A)
None
None
 0.76A 1wrqA-1uz5A:
undetectable		 1wrqA-1uz5A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1uz5 402AA LONG
HYPOTHETICAL
MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN
(Pyrococcus
horikoshii) 		4 / 6 ARG A 158
ARG A 325
ILE A  37
ALA A 322
 None
SO4  A1404 (-3.2A)
None
None
 0.78A 1wrqB-1uz5A:
undetectable		 1wrqB-1uz5A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1uz5 402AA LONG
HYPOTHETICAL
MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN
(Pyrococcus
horikoshii) 		4 / 5 LEU A   9
GLY A 299
ALA A  12
ILE A 279
 None
 0.83A 2aohB-1uz5A:
undetectable		 2aohB-1uz5A:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_1
(POL POLYPROTEIN)		 1uz5 402AA LONG
HYPOTHETICAL
MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 ASP A 206
GLY A 209
GLY A 255
GLY A 302
ILE A 192
 None
 0.84A 2avsA-1uz5A:
undetectable		 2avsA-1uz5A:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_1
(POL POLYPROTEIN)		 1uz5 402AA LONG
HYPOTHETICAL
MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 ASP A 206
GLY A 209
GLY A 255
GLY A 302
ILE A 192
 None
 0.88A 2avvD-1uz5A:
undetectable		 2avvD-1uz5A:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_A_PXLA1003_1
(PYRIDOXINE KINASE)		 1uz5 402AA LONG
HYPOTHETICAL
MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN
(Pyrococcus
horikoshii) 		4 / 8 VAL A 379
VAL A 394
LEU A 350
PRO A 361
 None
 0.82A 2ddwA-1uz5A:
undetectable		 2ddwA-1uz5A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_1
(PROTEASE)		 1uz5 402AA LONG
HYPOTHETICAL
MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN
(Pyrococcus
horikoshii) 		5 / 10 ALA A  99
VAL A  83
GLY A 109
ALA A  54
ILE A 101
 None
 0.95A 3ekpC-1uz5A:
undetectable		 3ekpC-1uz5A:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_2
(PROTEASE)		 1uz5 402AA LONG
HYPOTHETICAL
MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN
(Pyrococcus
horikoshii) 		5 / 9 ALA A  99
VAL A  83
GLY A 109
ALA A  54
ILE A 101
 None
 1.02A 3ektB-1uz5A:
undetectable		 3ektB-1uz5A:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_0
(REPRESSOR PROTEIN
MPHR(A))		 1uz5 402AA LONG
HYPOTHETICAL
MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN
(Pyrococcus
horikoshii) 		6 / 12 LEU A 271
GLY A 290
LEU A 319
ILE A 240
VAL A 315
ILE A 216
 None
 1.03A 3frqB-1uz5A:
undetectable		 3frqB-1uz5A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1uz5 402AA LONG
HYPOTHETICAL
MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN
(Pyrococcus
horikoshii) 		4 / 6 VAL A 251
LEU A   9
ILE A 329
LEU A 300
 None
 0.94A 3kk6A-1uz5A:
undetectable		 3kk6A-1uz5A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1uz5 402AA LONG
HYPOTHETICAL
MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 GLY A 278
ASN A 310
GLY A 284
LEU A   9
ILE A 281
 None
None
SO4  A1406 (-4.1A)
None
None
 1.09A 3ku1G-1uz5A:
undetectable		 3ku1G-1uz5A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1uz5 402AA LONG
HYPOTHETICAL
MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN
(Pyrococcus
horikoshii) 		3 / 3 VAL A 251
SER A 253
LEU A 212
 None
 0.76A 3n8xA-1uz5A:
undetectable		 3n8xA-1uz5A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1uz5 402AA LONG
HYPOTHETICAL
MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 ASP A  65
ILE A 101
GLY A 109
ALA A  98
ALA A  99
 None
 1.06A 3sueA-1uz5A:
undetectable		 3sueA-1uz5A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_1
(ADENOSINE KINASE)		 1uz5 402AA LONG
HYPOTHETICAL
MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 LEU A 300
GLY A 223
ALA A 215
ASN A 217
VAL A 185
 None
 0.96A 4dc3A-1uz5A:
undetectable		 4dc3A-1uz5A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND4_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 1uz5 402AA LONG
HYPOTHETICAL
MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 VAL A 394
GLU A 395
LEU A 358
ALA A 334
LEU A 398
 None
 1.09A 5nd4B-1uz5A:
undetectable		 5nd4B-1uz5A:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_C_08JC602_1
(CYTOCHROME P450 3A4)		 1uz5 402AA LONG
HYPOTHETICAL
MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN
(Pyrococcus
horikoshii) 		4 / 7 ALA A  63
THR A  66
ILE A 129
LEU A  77
 None
 0.68A 5te8C-1uz5A:
undetectable		 5te8C-1uz5A:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_2
(CYTOCHROME P450 3A5)		 1uz5 402AA LONG
HYPOTHETICAL
MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN
(Pyrococcus
horikoshii) 		3 / 3 ARG A 321
PHE A 399
LEU A 219
 None
 0.70A 5veuA-1uz5A:
undetectable		 5veuA-1uz5A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA402_0
(CYCLIN-G-ASSOCIATED
KINASE)		 1uz5 402AA LONG
HYPOTHETICAL
MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN
(Pyrococcus
horikoshii) 		5 / 11 ASP A 232
SER A 235
ILE A 252
THR A 188
ILE A 268
 None
 1.13A 5y80A-1uz5A:
0.0		 5y80A-1uz5A:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA402_0
(CYCLIN-G-ASSOCIATED
KINASE)		 1uz5 402AA LONG
HYPOTHETICAL
MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN
(Pyrococcus
horikoshii) 		5 / 11 ASP A 232
VAL A 250
ILE A 252
THR A 188
ILE A 268
 None
 1.23A 5y80A-1uz5A:
0.0		 5y80A-1uz5A:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		 1uz5 402AA LONG
HYPOTHETICAL
MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 GLY A 254
GLY A 302
GLY A 290
ASN A 310
PRO A 283
 None
None
None
None
SO4  A1406 (-4.4A)
 0.94A 6gngB-1uz5A:
undetectable		 6gngB-1uz5A:
23.14