SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1uzn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1uzn 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 12 TYR A 153
ILE A  27
GLY A 139
ALA A 158
SER A 156
GLY A 184
 None
NAP  A1249 (-4.1A)
None
None
None
None
 1.12A 1kiaA-1uznA:
6.3		 1kiaA-1uznA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1uzn 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 TYR A 153
ILE A  27
GLY A 139
ALA A 158
GLY A 184
 None
NAP  A1249 (-4.1A)
None
None
None
 1.04A 1kiaB-1uznA:
6.3		 1kiaB-1uznA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1uzn 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 TYR A 153
ILE A  27
GLY A 139
ALA A 158
GLY A 184
 None
NAP  A1249 (-4.1A)
None
None
None
 1.04A 1kiaC-1uznA:
6.9		 1kiaC-1uznA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1uzn 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 TYR A 153
ILE A  27
GLY A 139
ALA A 158
SER A 156
 None
NAP  A1249 (-4.1A)
None
None
None
 1.14A 1nbhA-1uznA:
6.9		 1nbhA-1uznA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1uzn 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 12 TYR A 153
ILE A  27
GLY A 139
ALA A 158
SER A 156
GLY A 184
 None
NAP  A1249 (-4.1A)
None
None
None
None
 1.14A 1nbhB-1uznA:
5.8		 1nbhB-1uznA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1uzn 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 TYR A 153
ILE A  27
GLY A 139
ALA A 158
SER A 156
 None
NAP  A1249 (-4.1A)
None
None
None
 1.15A 1nbhC-1uznA:
5.8		 1nbhC-1uznA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1uzn 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 TYR A 153
ILE A  27
GLY A 139
ALA A 158
SER A 156
 None
NAP  A1249 (-4.1A)
None
None
None
 1.15A 1nbhD-1uznA:
3.2		 1nbhD-1uznA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1uzn 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 12 TYR A 153
ILE A  27
GLY A 139
ALA A 158
SER A 156
GLY A 184
 None
NAP  A1249 (-4.1A)
None
None
None
None
 1.12A 1nbiA-1uznA:
6.5		 1nbiA-1uznA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1uzn 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 12 TYR A 153
ILE A  27
GLY A 139
ALA A 158
SER A 156
GLY A 184
 None
NAP  A1249 (-4.1A)
None
None
None
None
 1.12A 1nbiB-1uznA:
6.7		 1nbiB-1uznA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1uzn 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 TYR A 153
GLY A 139
ALA A 158
SER A 156
GLY A 184
 None
 1.18A 1nbiC-1uznA:
4.0		 1nbiC-1uznA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1uzn 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 TYR A 153
GLY A 139
ALA A 158
SER A 156
GLY A 184
 None
 1.17A 1nbiD-1uznA:
6.1		 1nbiD-1uznA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1uzn 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Mycobacterium
tuberculosis) 		4 / 5 GLY A 242
ILE A 206
TRP A 145
VAL A 141
 None
 1.17A 1rs7A-1uznA:
undetectable		 1rs7A-1uznA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1uzn 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  22
ARG A  47
ASP A  61
ASN A  88
ALA A 111
 NAP  A1249 (-3.2A)
NAP  A1249 (-3.6A)
NAP  A1249 (-3.7A)
None
NAP  A1249 (-3.6A)
 1.05A 2bm9B-1uznA:
4.9		 2bm9B-1uznA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1uzn 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 12 GLY A  22
ARG A  47
ASP A  61
ASN A  88
ALA A  89
ALA A 111
 NAP  A1249 (-3.2A)
NAP  A1249 (-3.6A)
NAP  A1249 (-3.7A)
None
NAP  A1249 (-3.7A)
NAP  A1249 (-3.6A)
 1.18A 2bm9E-1uznA:
5.2		 2bm9E-1uznA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1uzn 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  22
ARG A  47
ASP A  61
ALA A  89
ALA A 111
 NAP  A1249 (-3.2A)
NAP  A1249 (-3.6A)
NAP  A1249 (-3.7A)
NAP  A1249 (-3.7A)
NAP  A1249 (-3.6A)
 1.03A 2br4C-1uznA:
5.3		 2br4C-1uznA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1uzn 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  22
ARG A  47
ASP A  61
ALA A  89
ALA A 111
 NAP  A1249 (-3.2A)
NAP  A1249 (-3.6A)
NAP  A1249 (-3.7A)
NAP  A1249 (-3.7A)
NAP  A1249 (-3.6A)
 0.97A 2br4F-1uznA:
5.2		 2br4F-1uznA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1004_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 1uzn 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Mycobacterium
tuberculosis) 		4 / 7 VAL A  68
SER A  65
ARG A 118
THR A 114
 None
 1.09A 2f78B-1uznA:
undetectable		 2f78B-1uznA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 1uzn 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  23
ILE A  27
ALA A  43
LEU A  85
VAL A  84
 None
NAP  A1249 (-4.1A)
None
None
None
 0.92A 2yqzB-1uznA:
6.1		 2yqzB-1uznA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 1uzn 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Mycobacterium
tuberculosis) 		4 / 8 ILE A 138
ASN A 112
SER A 156
SER A 140
 None
 1.14A 2zw9B-1uznA:
5.3		 2zw9B-1uznA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_1
(PROTEASE)		 1uzn 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 11 GLY A 115
ALA A 116
ILE A 138
GLY A  90
LEU A  91
 None
None
None
NAP  A1249 (-4.2A)
NAP  A1249 (-4.4A)
 0.87A 3em4A-1uznA:
undetectable		 3em4A-1uznA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_2
(HIV-1 PROTEASE)		 1uzn 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 11 ASN A  88
VAL A  86
ILE A  31
GLY A 219
ILE A 136
 None
 0.96A 3lzvB-1uznA:
undetectable		 3lzvB-1uznA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 1uzn 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 224
PHE A 223
SER A 226
ILE A 237
ALA A 235
 None
 1.06A 3mdtB-1uznA:
undetectable		 3mdtB-1uznA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_2
(ADENOSINE KINASE)		 1uzn 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Mycobacterium
tuberculosis) 		4 / 5 SER A 140
ILE A  27
TYR A 153
GLY A 184
 None
NAP  A1249 (-4.1A)
None
None
 0.94A 3uboB-1uznA:
6.6		 3uboB-1uznA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_1
(HIV-1 PROTEASE)		 1uzn 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Mycobacterium
tuberculosis) 		6 / 11 GLY A  90
ALA A  89
VAL A  44
GLY A  23
GLY A  28
ILE A  27
 NAP  A1249 (-4.2A)
NAP  A1249 (-3.7A)
None
None
None
NAP  A1249 (-4.1A)
 1.38A 3ufnA-1uznA:
undetectable		 3ufnA-1uznA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1uzn 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Mycobacterium
tuberculosis) 		4 / 5 TYR A 153
VAL A 108
SER A  92
GLY A  90
 None
None
None
NAP  A1249 (-4.2A)
 1.26A 3v4tA-1uznA:
0.0
3v4tD-1uznA:
0.0		 3v4tA-1uznA:
23.26
3v4tD-1uznA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA802_1
(CATALASE-PEROXIDASE)		 1uzn 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Mycobacterium
tuberculosis) 		4 / 8 LEU A 203
ILE A 206
GLY A 184
ILE A 186
 None
 0.89A 3wxoA-1uznA:
undetectable		 3wxoA-1uznA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1uzn 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Mycobacterium
tuberculosis) 		4 / 5 GLY A 242
ILE A 206
TRP A 145
VAL A 141
 None
 1.21A 4d33B-1uznA:
undetectable		 4d33B-1uznA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1uzn 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 GLN A  79
LEU A  35
GLU A  76
ILE A 136
ARG A 122
 None
 0.98A 4hytA-1uznA:
4.2		 4hytA-1uznA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_C_OBNC2004_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1uzn 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 GLN A  79
LEU A  35
GLU A  76
ILE A 136
ARG A 122
 None
 0.99A 4hytC-1uznA:
2.2		 4hytC-1uznA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 1uzn 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Mycobacterium
tuberculosis) 		4 / 6 LEU A  55
LEU A  19
VAL A  20
PHE A  56
 None
 1.20A 4uswA-1uznA:
undetectable		 4uswA-1uznA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_A_PZAA1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 1uzn 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Mycobacterium
tuberculosis) 		4 / 7 VAL A 236
ALA A 182
GLY A 143
ARG A 165
 None
 0.89A 5fpdA-1uznA:
1.9		 5fpdA-1uznA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_B_PZAB1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 1uzn 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Mycobacterium
tuberculosis) 		4 / 7 VAL A 236
ALA A 182
GLY A 143
ARG A 165
 None
 0.91A 5fpdB-1uznA:
undetectable		 5fpdB-1uznA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_C_AC2C301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1uzn 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 11 SER A 142
GLY A 184
ALA A 202
SER A 140
ILE A 186
 None
 1.07A 5i3cC-1uznA:
2.2		 5i3cC-1uznA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1uzn 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 VAL A  42
LEU A  55
VAL A  20
GLY A  28
ILE A  31
 None
 0.99A 5vopA-1uznA:
2.5		 5vopA-1uznA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 1uzn 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  26
ALA A  30
ASN A  24
SER A  49
GLU A  59
 NAP  A1249 (-3.4A)
None
NAP  A1249 (-3.3A)
NAP  A1249 ( 4.4A)
None
 1.17A 6bqgA-1uznA:
undetectable		 6bqgA-1uznA:
16.46