SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1uzr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE)		 1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		4 / 7 TYR A 110
PHE A  65
ILE A 194
GLY A 170
 None
 0.81A 11gsA-1uzrA:
undetectable		 11gsA-1uzrA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE)		 1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		4 / 7 TYR A 110
PHE A  65
ILE A 194
GLY A 170
 None
 0.81A 11gsB-1uzrA:
undetectable		 11gsB-1uzrA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_B_803B311_1
(ANTIGEN CD11A (P180))		 1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		4 / 7 VAL A  64
LEU A 251
VAL A 249
LEU A 183
 None
 0.88A 1cqpA-1uzrA:
undetectable
1cqpB-1uzrA:
undetectable		 1cqpA-1uzrA:
23.61
1cqpB-1uzrA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		3 / 3 THR A 219
LEU A 223
LEU A 230
 CIT  A1294 ( 3.6A)
CIT  A1294 (-4.5A)
None
 0.21A 1mz9C-1uzrA:
undetectable		 1mz9C-1uzrA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		 1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		5 / 10 GLY A 250
VAL A 249
LEU A  60
LEU A 173
TYR A 172
 None
 0.99A 1pbcA-1uzrA:
undetectable		 1pbcA-1uzrA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		4 / 4 ALA A 100
VAL A  81
ALA A  80
HIS A 200
 None
None
None
FE  A1293 (-3.2A)
 1.09A 1q23A-1uzrA:
undetectable		 1q23A-1uzrA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		4 / 4 ALA A 100
VAL A  81
ALA A  80
HIS A 200
 None
None
None
FE  A1293 (-3.2A)
 1.12A 1q23F-1uzrA:
undetectable		 1q23F-1uzrA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		4 / 4 ALA A 100
VAL A  81
ALA A  80
HIS A 200
 None
None
None
FE  A1293 (-3.2A)
 1.10A 1q23K-1uzrA:
undetectable		 1q23K-1uzrA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		3 / 3 VAL A  81
ALA A  80
HIS A 200
 None
None
FE  A1293 (-3.2A)
 0.76A 1q23L-1uzrA:
undetectable		 1q23L-1uzrA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_A_DAHA208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		8 / 11 ASP A  72
GLU A 103
HIS A 106
GLU A 163
TYR A 168
PHE A 171
ILE A 193
GLU A 197
 FE  A1292 (-2.5A)
FE  A1293 ( 2.3A)
FE  A1292 (-3.2A)
FE  A1293 (-2.0A)
None
None
None
FE  A1292 ( 2.1A)
 0.81A 1rnrA-1uzrA:
31.1		 1rnrA-1uzrA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_A_DAHA208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		8 / 11 ASP A  72
GLU A 103
HIS A 106
LEU A 162
GLU A 163
TYR A 168
PHE A 171
ILE A 193
 FE  A1292 (-2.5A)
FE  A1293 ( 2.3A)
FE  A1292 (-3.2A)
None
FE  A1293 (-2.0A)
None
None
None
 0.67A 1rnrA-1uzrA:
31.1		 1rnrA-1uzrA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_B_DAHB208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		10 / 12 ASP A  72
GLU A 103
HIS A 106
TYR A 110
LEU A 162
GLU A 163
TYR A 168
PHE A 171
ILE A 193
GLU A 197
 FE  A1292 (-2.5A)
FE  A1293 ( 2.3A)
FE  A1292 (-3.2A)
None
None
FE  A1293 (-2.0A)
None
None
None
FE  A1292 ( 2.1A)
 0.85A 1rnrB-1uzrA:
31.4		 1rnrB-1uzrA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_A_EAAA0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		4 / 8 TYR A 110
PHE A  65
ILE A 194
GLY A 170
 None
 0.81A 2gssA-1uzrA:
undetectable		 2gssA-1uzrA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_B_EAAB0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		4 / 8 TYR A 110
PHE A  65
ILE A 194
GLY A 170
 None
 0.80A 2gssB-1uzrA:
undetectable		 2gssB-1uzrA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_B_EV1B1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		4 / 8 VAL A  41
ILE A 113
TYR A 110
PHE A  65
 None
 0.61A 2weyB-1uzrA:
undetectable		 2weyB-1uzrA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA3_0
(FERROCHELATASE)		 1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		3 / 3 PRO A 152
LEU A 153
ARG A 220
 CIT  A1294 (-3.1A)
CIT  A1294 (-3.9A)
None
 0.84A 3aqiA-1uzrA:
undetectable		 3aqiA-1uzrA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GF2_A_SALA147_1
(146AA LONG
HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR)		 1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		4 / 4 TYR A 246
LEU A  60
ARG A  63
TYR A 241
 None
None
GOL  A1295 (-3.3A)
None
 1.29A 3gf2A-1uzrA:
0.6		 3gf2A-1uzrA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_A_EAAA212_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		4 / 7 TYR A 110
PHE A  65
ILE A 194
GLY A 170
 None
 0.87A 3gssA-1uzrA:
0.0		 3gssA-1uzrA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		4 / 7 TYR A 110
PHE A  65
ILE A 194
GLY A 170
 None
 0.87A 3gssB-1uzrA:
undetectable		 3gssB-1uzrA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		4 / 8 TYR A 110
PHE A  65
ILE A 194
GLY A 170
 None
 0.85A 3hjoA-1uzrA:
undetectable		 3hjoA-1uzrA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_A_EAAA210_1
(GLUTATHIONE
S-TRANSFERASE P)		 1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		4 / 8 TYR A 110
PHE A  65
ILE A 194
GLY A 170
 None
 0.81A 3n9jA-1uzrA:
undetectable		 3n9jA-1uzrA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_B_EAAB214_1
(GLUTATHIONE
S-TRANSFERASE P)		 1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		4 / 8 TYR A 110
PHE A  65
ILE A 194
GLY A 170
 None
 0.81A 3n9jB-1uzrA:
undetectable		 3n9jB-1uzrA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		3 / 3 TYR A 235
LEU A 223
LYS A 224
 None
CIT  A1294 (-4.5A)
None
 0.36A 3sueD-1uzrA:
undetectable		 3sueD-1uzrA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_A_GAIA407_0
(PROTEIN (ARGINASE))		 1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		4 / 6 ARG A 155
GLU A  92
LEU A  96
ASP A  86
 None
 1.22A 4cevA-1uzrA:
undetectable
4cevB-1uzrA:
undetectable		 4cevA-1uzrA:
21.32
4cevB-1uzrA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U14_A_0HKA2000_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M3)		 1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		5 / 12 ASP A  72
TYR A 110
SER A 109
ALA A 187
TRP A  36
 FE  A1292 (-2.5A)
None
None
None
None
 1.42A 4u14A-1uzrA:
2.3		 4u14A-1uzrA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		5 / 12 ASP A  72
TYR A 110
THR A 186
ALA A 187
TRP A  36
 FE  A1292 (-2.5A)
None
None
None
None
 1.36A 4u15A-1uzrA:
2.7		 4u15A-1uzrA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		4 / 5 THR A  77
GLY A  79
GLU A 197
HIS A 200
 None
None
FE  A1292 ( 2.1A)
FE  A1293 (-3.2A)
 1.15A 5c0oH-1uzrA:
undetectable		 5c0oH-1uzrA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		3 / 3 ALA A 266
ASN A 269
LEU A 270
 None
 0.51A 5i1nC-1uzrA:
undetectable		 5i1nC-1uzrA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_2
(CYTOCHROME P450 3A4)		 1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		4 / 7 LEU A  68
PHE A  65
THR A 186
THR A 242
 None
 0.97A 5vc0A-1uzrA:
undetectable		 5vc0A-1uzrA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		5 / 11 VAL A 143
SER A 146
LEU A 166
VAL A 157
TYR A 226
 None
 1.35A 6dryA-1uzrA:
undetectable		 6dryA-1uzrA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 143
SER A 146
LEU A 166
GLY A  79
TYR A 226
 None
 1.03A 6drzA-1uzrA:
2.8		 6drzA-1uzrA:
23.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6EBP_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		8 / 9 LEU A  68
THR A  69
ASP A  72
SER A 109
ILE A 113
PHE A 114
PHE A 171
ILE A 193
 None
None
FE  A1292 (-2.5A)
None
None
None
None
None
 0.51A 6ebpA-1uzrA:
41.3		 6ebpA-1uzrA:
42.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6EBP_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		8 / 10 PHE A  65
LEU A  68
THR A  69
ASP A  72
SER A 109
ILE A 113
PHE A 114
ILE A 193
 None
None
None
FE  A1292 (-2.5A)
None
None
None
None
 0.36A 6ebpB-1uzrA:
41.0		 6ebpB-1uzrA:
42.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6EBP_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		8 / 10 PHE A  65
LEU A  68
THR A  69
ASP A  72
SER A 109
ILE A 113
PHE A 171
ILE A 193
 None
None
None
FE  A1292 (-2.5A)
None
None
None
None
 0.44A 6ebpB-1uzrA:
41.0		 6ebpB-1uzrA:
42.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6EBP_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		9 / 10 PHE A  65
LEU A  68
THR A  69
ASP A  72
SER A 109
ILE A 113
PHE A 114
PHE A 171
ILE A 193
 None
None
None
FE  A1292 (-2.5A)
None
None
None
None
None
 0.49A 6ebpC-1uzrA:
41.1		 6ebpC-1uzrA:
42.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6EBP_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		9 / 10 PHE A  65
LEU A  68
THR A  69
ASP A  72
SER A 109
ILE A 113
PHE A 114
ILE A 190
ILE A 193
 None
None
None
FE  A1292 (-2.5A)
None
None
None
None
None
 0.45A 6ebpD-1uzrA:
40.9		 6ebpD-1uzrA:
42.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6EBZ_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		6 / 11 PHE A  65
LEU A  68
THR A  66
ILE A 113
PHE A 114
ILE A 190
 None
 1.48A 6ebzA-1uzrA:
41.3		 6ebzA-1uzrA:
42.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6EBZ_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		10 / 11 PHE A  65
LEU A  68
THR A  69
ASP A  72
SER A 109
ILE A 113
PHE A 114
PHE A 171
ILE A 190
ILE A 193
 None
None
None
FE  A1292 (-2.5A)
None
None
None
None
None
None
 0.52A 6ebzA-1uzrA:
41.3		 6ebzA-1uzrA:
42.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6EBZ_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		6 / 11 PHE A  65
LEU A  68
THR A  66
ILE A 113
PHE A 114
ILE A 190
 None
 1.46A 6ebzB-1uzrA:
41.4		 6ebzB-1uzrA:
42.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6EBZ_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		10 / 11 PHE A  65
LEU A  68
THR A  69
ASP A  72
SER A 109
ILE A 113
PHE A 114
PHE A 171
ILE A 190
ILE A 193
 None
None
None
FE  A1292 (-2.5A)
None
None
None
None
None
None
 0.51A 6ebzB-1uzrA:
41.4		 6ebzB-1uzrA:
42.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6EBZ_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		6 / 11 PHE A  65
LEU A  68
THR A  66
ILE A 113
PHE A 114
ILE A 190
 None
 1.49A 6ebzC-1uzrA:
41.4		 6ebzC-1uzrA:
42.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6EBZ_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		9 / 11 PHE A  65
LEU A  68
THR A  69
ASP A  72
ILE A 113
PHE A 114
PHE A 171
ILE A 190
ILE A 193
 None
None
None
FE  A1292 (-2.5A)
None
None
None
None
None
 0.54A 6ebzC-1uzrA:
41.4		 6ebzC-1uzrA:
42.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6EBZ_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		7 / 11 THR A  69
ASP A  72
SER A 109
ILE A 113
PHE A 114
PHE A 171
ILE A 193
 None
FE  A1292 (-2.5A)
None
None
None
None
None
 0.85A 6ebzC-1uzrA:
41.4		 6ebzC-1uzrA:
42.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6EBZ_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		9 / 11 PHE A  65
LEU A  68
THR A  69
ASP A  72
SER A 109
ILE A 113
PHE A 114
ILE A 190
ILE A 193
 None
None
None
FE  A1292 (-2.5A)
None
None
None
None
None
 0.46A 6ebzD-1uzrA:
41.0		 6ebzD-1uzrA:
42.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6EBZ_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		9 / 11 PHE A  65
LEU A  68
THR A  69
ASP A  72
SER A 109
ILE A 113
PHE A 171
ILE A 190
ILE A 193
 None
None
None
FE  A1292 (-2.5A)
None
None
None
None
None
 0.51A 6ebzD-1uzrA:
41.0		 6ebzD-1uzrA:
42.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_A_DAHA126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		6 / 11 PHE A  65
LEU A  68
THR A  66
ILE A 113
PHE A 114
ILE A 190
 None
 1.49A 6gp2A-1uzrA:
40.5		 6gp2A-1uzrA:
26.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_A_DAHA126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		8 / 11 PHE A  65
LEU A  68
THR A  69
ASP A  72
SER A 109
ILE A 113
ILE A 190
ILE A 193
 None
None
None
FE  A1292 (-2.5A)
None
None
None
None
 0.53A 6gp2A-1uzrA:
40.5		 6gp2A-1uzrA:
26.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_A_DAHA126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		8 / 11 PHE A  65
LEU A  68
THR A  69
ASP A  72
SER A 109
ILE A 113
PHE A 171
ILE A 193
 None
None
None
FE  A1292 (-2.5A)
None
None
None
None
 0.63A 6gp2A-1uzrA:
40.5		 6gp2A-1uzrA:
26.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_A_DAHA126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		8 / 11 PHE A  65
LEU A  68
THR A  69
SER A 109
ILE A 113
PHE A 114
ILE A 190
ILE A 193
 None
 0.44A 6gp2A-1uzrA:
40.5		 6gp2A-1uzrA:
26.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_A_DAHA126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		8 / 11 PHE A  65
LEU A  68
THR A  69
SER A 109
ILE A 113
PHE A 114
PHE A 171
ILE A 193
 None
 0.56A 6gp2A-1uzrA:
40.5		 6gp2A-1uzrA:
26.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_B_DAHB126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		7 / 11 LEU A  68
THR A  69
ASP A  72
SER A 109
ILE A 113
PHE A 171
ILE A 193
 None
None
FE  A1292 (-2.5A)
None
None
None
None
 0.66A 6gp2B-1uzrA:
40.3		 6gp2B-1uzrA:
26.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_B_DAHB126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		7 / 11 LEU A  68
THR A  69
SER A 109
ILE A 113
PHE A 114
PHE A 171
ILE A 193
 None
 0.59A 6gp2B-1uzrA:
40.3		 6gp2B-1uzrA:
26.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_B_DAHB126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		6 / 11 PHE A  65
LEU A  68
THR A  66
ILE A 113
PHE A 114
ILE A 190
 None
 1.48A 6gp2B-1uzrA:
40.3		 6gp2B-1uzrA:
26.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_B_DAHB126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		8 / 11 PHE A  65
LEU A  68
THR A  69
ASP A  72
SER A 109
ILE A 113
ILE A 190
ILE A 193
 None
None
None
FE  A1292 (-2.5A)
None
None
None
None
 0.53A 6gp2B-1uzrA:
40.3		 6gp2B-1uzrA:
26.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_B_DAHB126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT
(Mycobacterium
tuberculosis) 		8 / 11 PHE A  65
LEU A  68
THR A  69
SER A 109
ILE A 113
PHE A 114
ILE A 190
ILE A 193
 None
 0.42A 6gp2B-1uzrA:
40.3		 6gp2B-1uzrA:
26.00