SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1v2a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		 1v2a GLUTATHIONE
TRANSFERASE GST1-6
(Anopheles
dirus) 		4 / 7 HIS A  59
TYR A  70
TYR A  75
LEU A  71
 None
 1.08A 1qzrA-1v2aA:
undetectable		 1qzrA-1v2aA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		 1v2a GLUTATHIONE
TRANSFERASE GST1-6
(Anopheles
dirus) 		4 / 7 HIS A  59
TYR A  70
TYR A  75
LEU A  71
 None
 1.10A 1qzrB-1v2aA:
undetectable		 1qzrB-1v2aA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)		 1v2a GLUTATHIONE
TRANSFERASE GST1-6
(Anopheles
dirus) 		4 / 6 VAL A  68
LEU A  96
CYH A 156
SER A  14
 None
 1.08A 3b6rB-1v2aA:
undetectable		 3b6rB-1v2aA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_A_IMNA201_1
(TRANSTHYRETIN)		 1v2a GLUTATHIONE
TRANSFERASE GST1-6
(Anopheles
dirus) 		3 / 3 LYS A  20
LEU A  17
ALA A  19
 None
 0.68A 4ikiA-1v2aA:
undetectable		 4ikiA-1v2aA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJQ_A_27RA401_1
(DNA POLYMERASE III
SUBUNIT BETA)		 1v2a GLUTATHIONE
TRANSFERASE GST1-6
(Anopheles
dirus) 		4 / 5 TYR A 104
THR A 162
PRO A  10
VAL A 198
 None
 1.29A 4mjqA-1v2aA:
undetectable		 4mjqA-1v2aA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB603_1
(SERUM ALBUMIN)		 1v2a GLUTATHIONE
TRANSFERASE GST1-6
(Anopheles
dirus) 		5 / 11 ARG A 185
LEU A  17
VAL A 198
LEU A   7
LEU A 158
 None
 1.27A 4or0B-1v2aA:
undetectable		 4or0B-1v2aA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 1v2a GLUTATHIONE
TRANSFERASE GST1-6
(Anopheles
dirus) 		3 / 3 PRO A  47
VAL A  60
HIS A  59
 None
 0.74A 4pevC-1v2aA:
1.7		 4pevC-1v2aA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_2
(CDL2.2)		 1v2a GLUTATHIONE
TRANSFERASE GST1-6
(Anopheles
dirus) 		5 / 12 LEU A  17
TRP A 180
LEU A 135
ILE A 107
LEU A 164
 None
 1.15A 5ienB-1v2aA:
0.0		 5ienB-1v2aA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U98_D_1KXD301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 1v2a GLUTATHIONE
TRANSFERASE GST1-6
(Anopheles
dirus) 		5 / 10 TYR A   5
TYR A   3
ILE A  67
SER A  14
ILE A 155
 None
 1.37A 5u98D-1v2aA:
undetectable		 5u98D-1v2aA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		 1v2a GLUTATHIONE
TRANSFERASE GST1-6
(Anopheles
dirus) 		4 / 6 ARG A 185
ALA A 199
THR A 202
ALA A 163
 None
 1.02A 6ma6A-1v2aA:
undetectable		 6ma6A-1v2aA:
25.20