SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1v2d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMY_A_AZMA400_1
(MURINE CARBONIC
ANHYDRASE V)		 1v2d GLUTAMINE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 11 VAL A 129
LEU A 145
LEU A 149
THR A 150
THR A 153
 None
 1.21A 1dmyA-1v2dA:
undetectable		 1dmyA-1v2dA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HMY_A_SAMA328_0
(HAEIII
METHYLTRANSFERASE)		 1v2d GLUTAMINE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 8 PHE A 275
GLU A 273
PRO A  40
LEU A 224
 None
 0.92A 1hmyA-1v2dA:
3.6		 1hmyA-1v2dA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_D_SAMD200_0
(METHIONINE REPRESSOR)		 1v2d GLUTAMINE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 12 GLY A  62
ARG A 223
LEU A 267
GLU A  73
ALA A  69
 None
 0.85A 1mjqC-1v2dA:
undetectable
1mjqD-1v2dA:
undetectable		 1mjqC-1v2dA:
14.61
1mjqD-1v2dA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_J_SAMJ200_0
(METHIONINE REPRESSOR)		 1v2d GLUTAMINE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 12 GLY A  62
ARG A 223
GLU A  73
ALA A  69
LEU A  70
 None
 1.16A 1mjqI-1v2dA:
undetectable
1mjqJ-1v2dA:
undetectable		 1mjqI-1v2dA:
14.61
1mjqJ-1v2dA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_J_SAMJ200_0
(METHIONINE REPRESSOR)		 1v2d GLUTAMINE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 12 GLY A  62
ARG A 223
LEU A 267
GLU A  73
ALA A  69
 None
 0.84A 1mjqI-1v2dA:
undetectable
1mjqJ-1v2dA:
undetectable		 1mjqI-1v2dA:
14.61
1mjqJ-1v2dA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1v2d GLUTAMINE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 10 LEU A  51
LEU A  43
GLY A 262
ALA A 261
LEU A  63
 None
 1.06A 1pxxA-1v2dA:
undetectable		 1pxxA-1v2dA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_C_DIFC2701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1v2d GLUTAMINE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 12 LEU A  51
LEU A  43
GLY A 262
ALA A 261
LEU A  63
 None
 1.05A 1pxxC-1v2dA:
undetectable		 1pxxC-1v2dA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		 1v2d GLUTAMINE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 12 ASN A 159
ASP A 191
GLU A 192
ARG A 205
PRO A 203
 PLP  A 510 (-3.3A)
PLP  A 510 (-2.7A)
None
None
None
 1.24A 1s14A-1v2dA:
undetectable		 1s14A-1v2dA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_B_T44B602_1
(TRANSTHYRETIN)		 1v2d GLUTAMINE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 7 LEU A  43
GLU A 265
ALA A 270
ALA A 220
 None
 0.96A 1sn0B-1v2dA:
undetectable
1sn0D-1v2dA:
undetectable		 1sn0B-1v2dA:
18.53
1sn0D-1v2dA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_2
(POL POLYPROTEIN)		 1v2d GLUTAMINE
AMINOTRANSFERASE
(Thermus
thermophilus) 		3 / 3 ASP A 195
VAL A 168
PRO A 304
 None
 0.68A 2avvA-1v2dA:
undetectable		 2avvA-1v2dA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2002_1
(SERUM ALBUMIN)		 1v2d GLUTAMINE
AMINOTRANSFERASE
(Thermus
thermophilus) 		6 / 11 ARG A 223
ALA A 220
LEU A  66
ALA A  69
GLU A  73
VAL A  83
 None
 1.40A 2bxeB-1v2dA:
undetectable		 2bxeB-1v2dA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_1
(HYPOTHETICAL PROTEIN
LMO1582)		 1v2d GLUTAMINE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 4 THR A 307
THR A 160
ASP A 191
ASP A 118
 None
None
PLP  A 510 (-2.7A)
None
 1.44A 2f8lA-1v2dA:
undetectable		 2f8lA-1v2dA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB2_A_IBPA3960_1
(LACTOTRANSFERRIN)		 1v2d GLUTAMINE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 4 GLY A  62
VAL A  82
GLY A  86
THR A  88
 None
None
PLP  A 510 (-3.4A)
PLP  A 510 (-3.6A)
 0.82A 3ib2A-1v2dA:
undetectable		 3ib2A-1v2dA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 1v2d GLUTAMINE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 12 ASN A 159
ASP A 191
GLU A 192
ARG A 205
PRO A 203
 PLP  A 510 (-3.3A)
PLP  A 510 (-2.7A)
None
None
None
 1.28A 3lpsA-1v2dA:
undetectable		 3lpsA-1v2dA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 1v2d GLUTAMINE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 12 LEU A  98
LEU A  95
LEU A  91
ILE A 234
ILE A 189
 None
 1.09A 4a7aB-1v2dA:
undetectable		 4a7aB-1v2dA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_2
(ADENOSINE KINASE)		 1v2d GLUTAMINE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 5 ASN A 159
LEU A 157
SER A 190
LEU A  94
 PLP  A 510 (-3.3A)
None
None
None
 1.24A 4n09C-1v2dA:
3.6		 4n09C-1v2dA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1v2d GLUTAMINE
AMINOTRANSFERASE
(Thermus
thermophilus) 		6 / 12 ILE A 189
GLY A  86
ALA A  87
LEU A  91
LEU A  94
LEU A  95
 None
PLP  A 510 (-3.4A)
PLP  A 510 (-3.3A)
None
None
None
 1.42A 4o1zA-1v2dA:
undetectable		 4o1zA-1v2dA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1v2d GLUTAMINE
AMINOTRANSFERASE
(Thermus
thermophilus) 		6 / 12 ILE A 189
GLY A 232
ALA A  87
LEU A  91
LEU A  94
LEU A  95
 None
None
PLP  A 510 (-3.3A)
None
None
None
 1.33A 4o1zA-1v2dA:
undetectable		 4o1zA-1v2dA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1v2d GLUTAMINE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 12 ILE A 189
VAL A 217
GLY A  86
LEU A  94
LEU A  95
 None
None
PLP  A 510 (-3.4A)
None
None
 0.93A 4o1zA-1v2dA:
undetectable		 4o1zA-1v2dA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 1v2d GLUTAMINE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 11 ASN A 159
ASP A 191
GLU A 192
ARG A 205
PRO A 203
 PLP  A 510 (-3.3A)
PLP  A 510 (-2.7A)
None
None
None
 1.46A 4urnA-1v2dA:
undetectable		 4urnA-1v2dA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_1
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 1v2d GLUTAMINE
AMINOTRANSFERASE
(Thermus
thermophilus) 		3 / 3 ARG A 152
LYS A 125
GLU A 104
 None
 0.83A 5d0yA-1v2dA:
0.0		 5d0yA-1v2dA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1v2d GLUTAMINE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 12 LEU A  51
LEU A  43
GLY A 262
ALA A 261
LEU A  63
 None
 1.07A 5ikqA-1v2dA:
undetectable		 5ikqA-1v2dA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_B_JMSB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1v2d GLUTAMINE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 12 LEU A  51
LEU A  43
GLY A 262
ALA A 261
LEU A  63
 None
 1.06A 5ikqB-1v2dA:
undetectable		 5ikqB-1v2dA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J6H_A_NCAA402_0
(H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, Q10 ALPHA
CHAIN)		 1v2d GLUTAMINE
AMINOTRANSFERASE
(Thermus
thermophilus) 		3 / 3 PRO A  78
ARG A  67
GLU A  68
 None
 0.82A 5j6hA-1v2dA:
undetectable		 5j6hA-1v2dA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQB_B_IBPB706_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 1v2d GLUTAMINE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 8 ALA A 360
LEU A 322
LEU A 294
MET A 297
LEU A 314
 None
 1.44A 5jqbA-1v2dA:
undetectable
5jqbB-1v2dA:
undetectable		 5jqbA-1v2dA:
20.62
5jqbB-1v2dA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_2
(ADENOSINE KINASE)		 1v2d GLUTAMINE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 4 ASN A 159
LEU A 157
SER A 190
LEU A  94
 PLP  A 510 (-3.3A)
None
None
None
 1.27A 5kb5A-1v2dA:
3.6		 5kb5A-1v2dA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NY7_A_NCAA303_0
(AMIDASE)		 1v2d GLUTAMINE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 6 ARG A 205
PRO A 203
THR A 160
GLU A 192
 None
 1.13A 5ny7A-1v2dA:
undetectable		 5ny7A-1v2dA:
27.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGQ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 1v2d GLUTAMINE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 9 ALA A  69
GLU A  73
LEU A  70
ARG A 223
GLY A  62
 None
 1.41A 5wgqA-1v2dA:
0.0		 5wgqA-1v2dA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FK2_A_SORA302_0
(GALECTIN-3)		 1v2d GLUTAMINE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 4 ARG A 223
GLU A 196
GLU A  73
ARG A 271
 None
 1.24A 6fk2A-1v2dA:
undetectable		 6fk2A-1v2dA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FK2_A_SORA302_0
(GALECTIN-3)		 1v2d GLUTAMINE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 4 ARG A 271
GLU A  73
GLU A 196
ARG A 223
 None
 1.07A 6fk2A-1v2dA:
undetectable		 6fk2A-1v2dA:
14.96