SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1v2x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IE4_B_T44B328_1 (TRANSTHYRETIN)	1v2x	TRNA (GM18) METHYLTRANSFERASE (Thermus thermophilus)	4 / 8	GLU A 28 ALA A 85 ALA A 118 THR A 24	None	0.92A	1ie4B-1v2xA: undetectable 1ie4D-1v2xA: undetectable	1ie4B-1v2xA: 20.50 1ie4D-1v2xA: 20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1P2Y_A_NCTA440_1 (CYTOCHROME P450-CAM)	1v2x	TRNA (GM18) METHYLTRANSFERASE (Thermus thermophilus)	4 / 7	LEU A 23 VAL A 48 GLY A 47 ILE A 39	None	0.77A	1p2yA-1v2xA: undetectable	1p2yA-1v2xA: 19.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1V2X_A_SAMA400_0 (TRNA (GM18) METHYLTRANSFERASE)	1v2x	TRNA (GM18) METHYLTRANSFERASE (Thermus thermophilus)	12 / 12	LEU A 101 PHE A 121 GLY A 122 TRP A 126 GLY A 127 LYS A 141 ILE A 142 MET A 144 SER A 150 LEU A 151 VAL A 153 ALA A 156	SAM A 400 ( 4.1A) SAM A 400 (-4.6A) SAM A 400 (-3.2A) None SAM A 400 (-3.8A) None SAM A 400 (-3.6A) SAM A 400 (-3.3A) SAM A 400 ( 3.7A) SAM A 400 (-4.0A) SAM A 400 (-3.9A) SAM A 400 (-3.5A)	0.00A	1v2xA-1v2xA: 37.7	1v2xA-1v2xA: 100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1X7P_A_SAMA301_0 (RRNA METHYLTRANSFERASE)	1v2x	TRNA (GM18) METHYLTRANSFERASE (Thermus thermophilus)	8 / 11	THR A 99 GLY A 122 GLY A 127 ILE A 142 MET A 144 SER A 150 LEU A 151 ALA A 156	SAM A 400 (-3.2A) SAM A 400 (-3.2A) SAM A 400 (-3.8A) SAM A 400 (-3.6A) SAM A 400 (-3.3A) SAM A 400 ( 3.7A) SAM A 400 (-4.0A) SAM A 400 (-3.5A)	0.71A	1x7pA-1v2xA: 19.2 1x7pB-1v2xA: 19.2	1x7pA-1v2xA: 25.34 1x7pB-1v2xA: 25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1X7P_B_SAMB302_0 (RRNA METHYLTRANSFERASE)	1v2x	TRNA (GM18) METHYLTRANSFERASE (Thermus thermophilus)	7 / 10	THR A 99 GLY A 122 GLY A 127 ILE A 142 MET A 144 LEU A 151 ALA A 156	SAM A 400 (-3.2A) SAM A 400 (-3.2A) SAM A 400 (-3.8A) SAM A 400 (-3.6A) SAM A 400 (-3.3A) SAM A 400 (-4.0A) SAM A 400 (-3.5A)	0.48A	1x7pA-1v2xA: 19.2 1x7pB-1v2xA: 19.2	1x7pA-1v2xA: 25.34 1x7pB-1v2xA: 25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BR4_D_SAMD301_1 (CEPHALOSPORIN HYDROXYLASE CMCI)	1v2x	TRNA (GM18) METHYLTRANSFERASE (Thermus thermophilus)	3 / 3	LYS A 90 ASP A 104 ASP A 137	None	0.94A	2br4D-1v2xA: 2.1	2br4D-1v2xA: 21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2F16_K_BO2K1402_1 (PROTEASOME COMPONENT PRE2 PROTEASOME COMPONENT C5)	1v2x	TRNA (GM18) METHYLTRANSFERASE (Thermus thermophilus)	5 / 10	ALA A 98 THR A 99 ALA A 100 ALA A 139 ALA A 132	None SAM A 400 (-3.2A) None None None	0.95A	2f16K-1v2xA: undetectable 2f16L-1v2xA: undetectable	2f16K-1v2xA: 22.75 2f16L-1v2xA: 20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2F16_Y_BO2Y1403_1 (PROTEASOME COMPONENT PRE2 PROTEASOME COMPONENT C5)	1v2x	TRNA (GM18) METHYLTRANSFERASE (Thermus thermophilus)	5 / 10	ALA A 98 THR A 99 ALA A 100 ALA A 139 ALA A 132	None SAM A 400 (-3.2A) None None None	0.94A	2f16Y-1v2xA: undetectable 2f16Z-1v2xA: undetectable	2f16Y-1v2xA: 22.75 2f16Z-1v2xA: 20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X45_A_HSMA1161_1 (ALLERGEN ARG R 1)	1v2x	TRNA (GM18) METHYLTRANSFERASE (Thermus thermophilus)	4 / 5	VAL A 119 TYR A 97 VAL A 111 ASP A 112	None	1.21A	2x45A-1v2xA: undetectable	2x45A-1v2xA: 19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X45_C_HSMC1161_1 (ALLERGEN ARG R 1)	1v2x	TRNA (GM18) METHYLTRANSFERASE (Thermus thermophilus)	4 / 5	VAL A 119 TYR A 97 VAL A 111 ASP A 112	None	1.16A	2x45C-1v2xA: undetectable	2x45C-1v2xA: 19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BPX_A_SALA257_1 (TRANSCRIPTIONAL REGULATOR)	1v2x	TRNA (GM18) METHYLTRANSFERASE (Thermus thermophilus)	4 / 8	ALA A 158 PHE A 121 ILE A 39 THR A 42	None SAM A 400 (-4.6A) None None	0.87A	3bpxA-1v2xA: 0.1 3bpxB-1v2xA: 0.0	3bpxA-1v2xA: 21.78 3bpxB-1v2xA: 21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DCM_X_SAMX5452_0 (UNCHARACTERIZED PROTEIN TM_1570)	1v2x	TRNA (GM18) METHYLTRANSFERASE (Thermus thermophilus)	7 / 11	THR A 99 GLY A 122 GLY A 127 ILE A 142 LEU A 151 VAL A 153 ALA A 156	SAM A 400 (-3.2A) SAM A 400 (-3.2A) SAM A 400 (-3.8A) SAM A 400 (-3.6A) SAM A 400 (-4.0A) SAM A 400 (-3.9A) SAM A 400 (-3.5A)	0.46A	3dcmX-1v2xA: 13.4	3dcmX-1v2xA: 25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3GYQ_A_SAMA270_0 (RRNA (ADENOSINE-2'-O-)-ME THYLTRANSFERASE)	1v2x	TRNA (GM18) METHYLTRANSFERASE (Thermus thermophilus)	5 / 12	GLY A 122 ILE A 142 MET A 144 SER A 150 LEU A 151	SAM A 400 (-3.2A) SAM A 400 (-3.6A) SAM A 400 (-3.3A) SAM A 400 ( 3.7A) SAM A 400 (-4.0A)	0.83A	3gyqA-1v2xA: 17.5 3gyqB-1v2xA: 17.8	3gyqA-1v2xA: 23.83 3gyqB-1v2xA: 23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3GYQ_B_SAMB270_0 (RRNA (ADENOSINE-2'-O-)-ME THYLTRANSFERASE)	1v2x	TRNA (GM18) METHYLTRANSFERASE (Thermus thermophilus)	6 / 11	GLY A 122 ILE A 142 MET A 144 SER A 150 LEU A 151 VAL A 153	SAM A 400 (-3.2A) SAM A 400 (-3.6A) SAM A 400 (-3.3A) SAM A 400 ( 3.7A) SAM A 400 (-4.0A) SAM A 400 (-3.9A)	0.52A	3gyqB-1v2xA: 17.8	3gyqB-1v2xA: 23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NK7_A_SAMA770_0 (23S RRNA METHYLTRANSFERASE)	1v2x	TRNA (GM18) METHYLTRANSFERASE (Thermus thermophilus)	7 / 12	ASN A 35 GLY A 122 GLY A 127 ILE A 142 MET A 144 ASN A 152 VAL A 153	PO4 A 201 (-3.4A) SAM A 400 (-3.2A) SAM A 400 (-3.8A) SAM A 400 (-3.6A) SAM A 400 (-3.3A) PO4 A 201 (-3.8A) SAM A 400 (-3.9A)	0.55A	3nk7A-1v2xA: 18.8	3nk7A-1v2xA: 23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NK7_A_SAMA770_0 (23S RRNA METHYLTRANSFERASE)	1v2x	TRNA (GM18) METHYLTRANSFERASE (Thermus thermophilus)	6 / 12	ASN A 35 GLY A 122 GLY A 127 ILE A 160 ASN A 152 VAL A 153	PO4 A 201 (-3.4A) SAM A 400 (-3.2A) SAM A 400 (-3.8A) None PO4 A 201 (-3.8A) SAM A 400 (-3.9A)	1.30A	3nk7A-1v2xA: 18.8	3nk7A-1v2xA: 23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NK7_A_SAMA770_0 (23S RRNA METHYLTRANSFERASE)	1v2x	TRNA (GM18) METHYLTRANSFERASE (Thermus thermophilus)	7 / 12	ASN A 35 GLY A 122 ILE A 142 MET A 144 SER A 150 ASN A 152 VAL A 153	PO4 A 201 (-3.4A) SAM A 400 (-3.2A) SAM A 400 (-3.6A) SAM A 400 (-3.3A) SAM A 400 ( 3.7A) PO4 A 201 (-3.8A) SAM A 400 (-3.9A)	0.49A	3nk7A-1v2xA: 18.8	3nk7A-1v2xA: 23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NK7_A_SAMA770_0 (23S RRNA METHYLTRANSFERASE)	1v2x	TRNA (GM18) METHYLTRANSFERASE (Thermus thermophilus)	5 / 12	GLU A 124 ILE A 142 MET A 144 SER A 150 ASN A 152	PO4 A 201 ( 4.6A) SAM A 400 (-3.6A) SAM A 400 (-3.3A) SAM A 400 ( 3.7A) PO4 A 201 (-3.8A)	1.05A	3nk7A-1v2xA: 18.8	3nk7A-1v2xA: 23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NK7_B_SAMB770_0 (23S RRNA METHYLTRANSFERASE)	1v2x	TRNA (GM18) METHYLTRANSFERASE (Thermus thermophilus)	9 / 12	ASN A 35 PHE A 121 GLY A 122 GLY A 127 ILE A 142 MET A 144 SER A 150 LEU A 151 VAL A 153	PO4 A 201 (-3.4A) SAM A 400 (-4.6A) SAM A 400 (-3.2A) SAM A 400 (-3.8A) SAM A 400 (-3.6A) SAM A 400 (-3.3A) SAM A 400 ( 3.7A) SAM A 400 (-4.0A) SAM A 400 (-3.9A)	0.60A	3nk7B-1v2xA: 18.8	3nk7B-1v2xA: 23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NK7_B_SAMB770_0 (23S RRNA METHYLTRANSFERASE)	1v2x	TRNA (GM18) METHYLTRANSFERASE (Thermus thermophilus)	7 / 12	GLY A 122 GLU A 124 GLY A 127 ILE A 142 MET A 144 SER A 150 LEU A 151	SAM A 400 (-3.2A) PO4 A 201 ( 4.6A) SAM A 400 (-3.8A) SAM A 400 (-3.6A) SAM A 400 (-3.3A) SAM A 400 ( 3.7A) SAM A 400 (-4.0A)	1.14A	3nk7B-1v2xA: 18.8	3nk7B-1v2xA: 23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NK7_B_SAMB770_0 (23S RRNA METHYLTRANSFERASE)	1v2x	TRNA (GM18) METHYLTRANSFERASE (Thermus thermophilus)	5 / 12	GLY A 122 ILE A 142 MET A 144 SER A 150 LEU A 151	SAM A 400 (-3.2A) SAM A 400 (-3.6A) SAM A 400 (-3.3A) SAM A 400 ( 3.7A) SAM A 400 (-4.0A)	0.89A	3nk7B-1v2xA: 18.8	3nk7B-1v2xA: 23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PO0_A_NPSA602_1 (SERUM ALBUMIN)	1v2x	TRNA (GM18) METHYLTRANSFERASE (Thermus thermophilus)	4 / 8	ALA A 85 LEU A 89 LEU A 26 GLU A 50	None	0.76A	4po0A-1v2xA: undetectable	4po0A-1v2xA: 15.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4X3M_A_ADNA301_1 (RNA 2'-O RIBOSE METHYLTRANSFERASE)	1v2x	TRNA (GM18) METHYLTRANSFERASE (Thermus thermophilus)	5 / 9	GLY A 122 ILE A 142 MET A 144 SER A 150 VAL A 153	SAM A 400 (-3.2A) SAM A 400 (-3.6A) SAM A 400 (-3.3A) SAM A 400 ( 3.7A) SAM A 400 (-3.9A)	0.43A	4x3mA-1v2xA: 18.7	4x3mA-1v2xA: 30.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4X3M_B_ADNB301_1 (RNA 2'-O RIBOSE METHYLTRANSFERASE)	1v2x	TRNA (GM18) METHYLTRANSFERASE (Thermus thermophilus)	6 / 9	GLY A 122 ILE A 142 MET A 144 SER A 150 LEU A 151 VAL A 153	SAM A 400 (-3.2A) SAM A 400 (-3.6A) SAM A 400 (-3.3A) SAM A 400 ( 3.7A) SAM A 400 (-4.0A) SAM A 400 (-3.9A)	0.41A	4x3mB-1v2xA: 16.9	4x3mB-1v2xA: 30.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5L0Z_A_SAMA304_0 (PROBABLE RNA METHYLTRANSFERASE, TRMH FAMILY)	1v2x	TRNA (GM18) METHYLTRANSFERASE (Thermus thermophilus)	8 / 12	THR A 99 LEU A 101 GLY A 122 GLY A 127 ILE A 142 SER A 150 LEU A 151 ALA A 156	SAM A 400 (-3.2A) SAM A 400 ( 4.1A) SAM A 400 (-3.2A) SAM A 400 (-3.8A) SAM A 400 (-3.6A) SAM A 400 ( 3.7A) SAM A 400 (-4.0A) SAM A 400 (-3.5A)	0.52A	5l0zA-1v2xA: 19.2	5l0zA-1v2xA: 23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5L0Z_B_SAMB304_0 (PROBABLE RNA METHYLTRANSFERASE, TRMH FAMILY)	1v2x	TRNA (GM18) METHYLTRANSFERASE (Thermus thermophilus)	7 / 10	THR A 99 GLY A 122 GLY A 127 ILE A 142 SER A 150 LEU A 151 ALA A 156	SAM A 400 (-3.2A) SAM A 400 (-3.2A) SAM A 400 (-3.8A) SAM A 400 (-3.6A) SAM A 400 ( 3.7A) SAM A 400 (-4.0A) SAM A 400 (-3.5A)	0.53A	5l0zB-1v2xA: 19.3	5l0zB-1v2xA: 23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5L0Z_B_SAMB304_0 (PROBABLE RNA METHYLTRANSFERASE, TRMH FAMILY)	1v2x	TRNA (GM18) METHYLTRANSFERASE (Thermus thermophilus)	7 / 10	THR A 99 LEU A 101 GLY A 122 GLY A 127 ILE A 142 LEU A 151 ALA A 156	SAM A 400 (-3.2A) SAM A 400 ( 4.1A) SAM A 400 (-3.2A) SAM A 400 (-3.8A) SAM A 400 (-3.6A) SAM A 400 (-4.0A) SAM A 400 (-3.5A)	0.68A	5l0zB-1v2xA: 19.3	5l0zB-1v2xA: 23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5L5Z_K_BO2K301_1 (PROTEASOME SUBUNIT BETA TYPE-5,PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6)	1v2x	TRNA (GM18) METHYLTRANSFERASE (Thermus thermophilus)	5 / 9	ALA A 98 THR A 99 ALA A 100 ALA A 139 ALA A 132	None SAM A 400 (-3.2A) None None None	0.98A	5l5zK-1v2xA: undetectable 5l5zL-1v2xA: undetectable	5l5zK-1v2xA: 20.87 5l5zL-1v2xA: 21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5L5Z_Y_BO2Y301_1 (PROTEASOME SUBUNIT BETA TYPE-5,PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6)	1v2x	TRNA (GM18) METHYLTRANSFERASE (Thermus thermophilus)	5 / 9	ALA A 98 THR A 99 ALA A 100 ALA A 139 ALA A 132	None SAM A 400 (-3.2A) None None None	0.99A	5l5zY-1v2xA: undetectable 5l5zZ-1v2xA: undetectable	5l5zY-1v2xA: 20.87 5l5zZ-1v2xA: 21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5M54_B_TA1B502_1 (TUBULIN BETA-2B CHAIN)	1v2x	TRNA (GM18) METHYLTRANSFERASE (Thermus thermophilus)	5 / 12	VAL A 74 ASP A 44 ALA A 51 ARG A 19 LEU A 23	None	1.49A	5m54B-1v2xA: undetectable	5m54B-1v2xA: 18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5O96_C_SAMC501_0 (RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE E)	1v2x	TRNA (GM18) METHYLTRANSFERASE (Thermus thermophilus)	4 / 7	GLY A 122 GLY A 127 LEU A 151 ALA A 156	SAM A 400 (-3.2A) SAM A 400 (-3.8A) SAM A 400 (-4.0A) SAM A 400 (-3.5A)	0.72A	5o96C-1v2xA: 12.1	5o96C-1v2xA: 22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6CDU_A_EY4A502_0 (CHIMERIC ALPHA1GABAA RECEPTOR)	1v2x	TRNA (GM18) METHYLTRANSFERASE (Thermus thermophilus)	4 / 7	ALA A 51 TYR A 75 GLN A 20 VAL A 48	None	0.90A	6cduA-1v2xA: undetectable 6cduE-1v2xA: undetectable	6cduA-1v2xA: 19.08 6cduE-1v2xA: 19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6CDU_H_EY4H500_0 (CHIMERIC ALPHA1GABAA RECEPTOR)	1v2x	TRNA (GM18) METHYLTRANSFERASE (Thermus thermophilus)	4 / 7	GLN A 20 VAL A 48 ALA A 51 TYR A 75	None	0.89A	6cduH-1v2xA: undetectable 6cduI-1v2xA: undetectable	6cduH-1v2xA: 19.08 6cduI-1v2xA: 19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_B_GMJB301_0 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	1v2x	TRNA (GM18) METHYLTRANSFERASE (Thermus thermophilus)	5 / 12	TYR A 113 ILE A 140 VAL A 128 THR A 117 LEU A 23	None	1.25A	6djzB-1v2xA: undetectable	6djzB-1v2xA: 23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HWD_K_BO2K301_0 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	1v2x	TRNA (GM18) METHYLTRANSFERASE (Thermus thermophilus)	5 / 11	ALA A 98 THR A 99 ALA A 100 ALA A 139 ALA A 132	None SAM A 400 (-3.2A) None None None	0.92A	6hwdK-1v2xA: undetectable 6hwdL-1v2xA: undetectable	6hwdK-1v2xA: 20.37 6hwdL-1v2xA: 16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HWD_Y_BO2Y301_0 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	1v2x	TRNA (GM18) METHYLTRANSFERASE (Thermus thermophilus)	5 / 11	ALA A 98 THR A 99 ALA A 100 ALA A 139 ALA A 132	None SAM A 400 (-3.2A) None None None	0.91A	6hwdY-1v2xA: undetectable 6hwdZ-1v2xA: undetectable	6hwdY-1v2xA: 20.37 6hwdZ-1v2xA: 16.38

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1IE4_B_T44B328_1","TRANSTHYRETIN;TRANSTHYRETIN","1v2x","TRNA (GM18) METHYLTRANSFERASE","Thermus thermophilus",4,"GLU A  28;ALA A  85;ALA A 118;THR A  24","None","0.92A","1ie4B-1v2xA:undetectable;1ie4D-1v2xA:undetectable","1ie4B-1v2xA:20.50;1ie4D-1v2xA:20.50"],["1P2Y_A_NCTA440_1","CYTOCHROME P450-CAM","1v2x","TRNA (GM18) METHYLTRANSFERASE","Thermus thermophilus",4,"LEU A  23;VAL A  48;GLY A  47;ILE A  39","None","0.77A","1p2yA-1v2xA:undetectable","1p2yA-1v2xA:19.11"],["1V2X_A_SAMA400_0","TRNA (GM18) METHYLTRANSFERASE","1v2x","TRNA (GM18) METHYLTRANSFERASE","Thermus thermophilus",12,"LEU A 101;PHE A 121;GLY A 122;TRP A 126;GLY A 127;LYS A 141;ILE A 142;MET A 144;SER A 150;LEU A 151;VAL A 153;ALA A 156","SAM A 400 ( 4.1A);SAM A 400 (-4.6A);SAM A 400 (-3.2A);None;SAM A 400 (-3.8A);None;SAM A 400 (-3.6A);SAM A 400 (-3.3A);SAM A 400 ( 3.7A);SAM A 400 (-4.0A);SAM A 400 (-3.9A);SAM A 400 (-3.5A)","0.00A","1v2xA-1v2xA:37.7","1v2xA-1v2xA:100.00"],["1X7P_A_SAMA301_0","RRNA METHYLTRANSFERASE","1v2x","TRNA (GM18) METHYLTRANSFERASE","Thermus thermophilus",8,"THR A  99;GLY A 122;GLY A 127;ILE A 142;MET A 144;SER A 150;LEU A 151;ALA A 156","SAM A 400 (-3.2A);SAM A 400 (-3.2A);SAM A 400 (-3.8A);SAM A 400 (-3.6A);SAM A 400 (-3.3A);SAM A 400 ( 3.7A);SAM A 400 (-4.0A);SAM A 400 (-3.5A)","0.71A","1x7pA-1v2xA:19.2;1x7pB-1v2xA:19.2","1x7pA-1v2xA:25.34;1x7pB-1v2xA:25.34"],["1X7P_B_SAMB302_0","RRNA METHYLTRANSFERASE","1v2x","TRNA (GM18) METHYLTRANSFERASE","Thermus thermophilus",7,"THR A  99;GLY A 122;GLY A 127;ILE A 142;MET A 144;LEU A 151;ALA A 156","SAM A 400 (-3.2A);SAM A 400 (-3.2A);SAM A 400 (-3.8A);SAM A 400 (-3.6A);SAM A 400 (-3.3A);SAM A 400 (-4.0A);SAM A 400 (-3.5A)","0.48A","1x7pA-1v2xA:19.2;1x7pB-1v2xA:19.2","1x7pA-1v2xA:25.34;1x7pB-1v2xA:25.34"],["2BR4_D_SAMD301_1","CEPHALOSPORIN HYDROXYLASE CMCI","1v2x","TRNA (GM18) METHYLTRANSFERASE","Thermus thermophilus",3,"LYS A  90;ASP A 104;ASP A 137","None","0.94A","2br4D-1v2xA:2.1","2br4D-1v2xA:21.14"],["2F16_K_BO2K1402_1","PROTEASOME COMPONENT PRE2;PROTEASOME COMPONENT C5","1v2x","TRNA (GM18) METHYLTRANSFERASE","Thermus thermophilus",5,"ALA A  98;THR A  99;ALA A 100;ALA A 139;ALA A 132","None;SAM A 400 (-3.2A);None;None;None","0.95A","2f16K-1v2xA:undetectable;2f16L-1v2xA:undetectable","2f16K-1v2xA:22.75;2f16L-1v2xA:20.17"],["2F16_Y_BO2Y1403_1","PROTEASOME COMPONENT PRE2;PROTEASOME COMPONENT C5","1v2x","TRNA (GM18) METHYLTRANSFERASE","Thermus thermophilus",5,"ALA A  98;THR A  99;ALA A 100;ALA A 139;ALA A 132","None;SAM A 400 (-3.2A);None;None;None","0.94A","2f16Y-1v2xA:undetectable;2f16Z-1v2xA:undetectable","2f16Y-1v2xA:22.75;2f16Z-1v2xA:20.17"],["2X45_A_HSMA1161_1","ALLERGEN ARG R 1","1v2x","TRNA (GM18) METHYLTRANSFERASE","Thermus thermophilus",4,"VAL A 119;TYR A  97;VAL A 111;ASP A 112","None","1.21A","2x45A-1v2xA:undetectable","2x45A-1v2xA:19.10"],["2X45_C_HSMC1161_1","ALLERGEN ARG R 1","1v2x","TRNA (GM18) METHYLTRANSFERASE","Thermus thermophilus",4,"VAL A 119;TYR A  97;VAL A 111;ASP A 112","None","1.16A","2x45C-1v2xA:undetectable","2x45C-1v2xA:19.10"],["3BPX_A_SALA257_1","TRANSCRIPTIONAL REGULATOR;TRANSCRIPTIONAL REGULATOR","1v2x","TRNA (GM18) METHYLTRANSFERASE","Thermus thermophilus",4,"ALA A 158;PHE A 121;ILE A  39;THR A  42","None;SAM A 400 (-4.6A);None;None","0.87A","3bpxA-1v2xA:0.1;3bpxB-1v2xA:0.0","3bpxA-1v2xA:21.78;3bpxB-1v2xA:21.78"],["3DCM_X_SAMX5452_0","UNCHARACTERIZED PROTEIN TM_1570","1v2x","TRNA (GM18) METHYLTRANSFERASE","Thermus thermophilus",7,"THR A  99;GLY A 122;GLY A 127;ILE A 142;LEU A 151;VAL A 153;ALA A 156","SAM A 400 (-3.2A);SAM A 400 (-3.2A);SAM A 400 (-3.8A);SAM A 400 (-3.6A);SAM A 400 (-4.0A);SAM A 400 (-3.9A);SAM A 400 (-3.5A)","0.46A","3dcmX-1v2xA:13.4","3dcmX-1v2xA:25.00"],["3GYQ_A_SAMA270_0","RRNA (ADENOSINE-2'-O-)-METHYLTRANSFERASE","1v2x","TRNA (GM18) METHYLTRANSFERASE","Thermus thermophilus",5,"GLY A 122;ILE A 142;MET A 144;SER A 150;LEU A 151","SAM A 400 (-3.2A);SAM A 400 (-3.6A);SAM A 400 (-3.3A);SAM A 400 ( 3.7A);SAM A 400 (-4.0A)","0.83A","3gyqA-1v2xA:17.5;3gyqB-1v2xA:17.8","3gyqA-1v2xA:23.83;3gyqB-1v2xA:23.83"],["3GYQ_B_SAMB270_0","RRNA (ADENOSINE-2'-O-)-METHYLTRANSFERASE","1v2x","TRNA (GM18) METHYLTRANSFERASE","Thermus thermophilus",6,"GLY A 122;ILE A 142;MET A 144;SER A 150;LEU A 151;VAL A 153","SAM A 400 (-3.2A);SAM A 400 (-3.6A);SAM A 400 (-3.3A);SAM A 400 ( 3.7A);SAM A 400 (-4.0A);SAM A 400 (-3.9A)","0.52A","3gyqB-1v2xA:17.8","3gyqB-1v2xA:23.83"],["3NK7_A_SAMA770_0","23S RRNA METHYLTRANSFERASE","1v2x","TRNA (GM18) METHYLTRANSFERASE","Thermus thermophilus",7,"ASN A  35;GLY A 122;GLY A 127;ILE A 142;MET A 144;ASN A 152;VAL A 153","PO4 A 201 (-3.4A);SAM A 400 (-3.2A);SAM A 400 (-3.8A);SAM A 400 (-3.6A);SAM A 400 (-3.3A);PO4 A 201 (-3.8A);SAM A 400 (-3.9A)","0.55A","3nk7A-1v2xA:18.8","3nk7A-1v2xA:23.49"],["3NK7_A_SAMA770_0","23S RRNA METHYLTRANSFERASE","1v2x","TRNA (GM18) METHYLTRANSFERASE","Thermus thermophilus",6,"ASN A  35;GLY A 122;GLY A 127;ILE A 160;ASN A 152;VAL A 153","PO4 A 201 (-3.4A);SAM A 400 (-3.2A);SAM A 400 (-3.8A);None;PO4 A 201 (-3.8A);SAM A 400 (-3.9A)","1.30A","3nk7A-1v2xA:18.8","3nk7A-1v2xA:23.49"],["3NK7_A_SAMA770_0","23S RRNA METHYLTRANSFERASE","1v2x","TRNA (GM18) METHYLTRANSFERASE","Thermus thermophilus",7,"ASN A  35;GLY A 122;ILE A 142;MET A 144;SER A 150;ASN A 152;VAL A 153","PO4 A 201 (-3.4A);SAM A 400 (-3.2A);SAM A 400 (-3.6A);SAM A 400 (-3.3A);SAM A 400 ( 3.7A);PO4 A 201 (-3.8A);SAM A 400 (-3.9A)","0.49A","3nk7A-1v2xA:18.8","3nk7A-1v2xA:23.49"],["3NK7_A_SAMA770_0","23S RRNA METHYLTRANSFERASE","1v2x","TRNA (GM18) METHYLTRANSFERASE","Thermus thermophilus",5,"GLU A 124;ILE A 142;MET A 144;SER A 150;ASN A 152","PO4 A 201 ( 4.6A);SAM A 400 (-3.6A);SAM A 400 (-3.3A);SAM A 400 ( 3.7A);PO4 A 201 (-3.8A)","1.05A","3nk7A-1v2xA:18.8","3nk7A-1v2xA:23.49"],["3NK7_B_SAMB770_0","23S RRNA METHYLTRANSFERASE","1v2x","TRNA (GM18) METHYLTRANSFERASE","Thermus thermophilus",9,"ASN A  35;PHE A 121;GLY A 122;GLY A 127;ILE A 142;MET A 144;SER A 150;LEU A 151;VAL A 153","PO4 A 201 (-3.4A);SAM A 400 (-4.6A);SAM A 400 (-3.2A);SAM A 400 (-3.8A);SAM A 400 (-3.6A);SAM A 400 (-3.3A);SAM A 400 ( 3.7A);SAM A 400 (-4.0A);SAM A 400 (-3.9A)","0.60A","3nk7B-1v2xA:18.8","3nk7B-1v2xA:23.49"],["3NK7_B_SAMB770_0","23S RRNA METHYLTRANSFERASE","1v2x","TRNA (GM18) METHYLTRANSFERASE","Thermus thermophilus",7,"GLY A 122;GLU A 124;GLY A 127;ILE A 142;MET A 144;SER A 150;LEU A 151","SAM A 400 (-3.2A);PO4 A 201 ( 4.6A);SAM A 400 (-3.8A);SAM A 400 (-3.6A);SAM A 400 (-3.3A);SAM A 400 ( 3.7A);SAM A 400 (-4.0A)","1.14A","3nk7B-1v2xA:18.8","3nk7B-1v2xA:23.49"],["3NK7_B_SAMB770_0","23S RRNA METHYLTRANSFERASE","1v2x","TRNA (GM18) METHYLTRANSFERASE","Thermus thermophilus",5,"GLY A 122;ILE A 142;MET A 144;SER A 150;LEU A 151","SAM A 400 (-3.2A);SAM A 400 (-3.6A);SAM A 400 (-3.3A);SAM A 400 ( 3.7A);SAM A 400 (-4.0A)","0.89A","3nk7B-1v2xA:18.8","3nk7B-1v2xA:23.49"],["4PO0_A_NPSA602_1","SERUM ALBUMIN","1v2x","TRNA (GM18) METHYLTRANSFERASE","Thermus thermophilus",4,"ALA A  85;LEU A  89;LEU A  26;GLU A  50","None","0.76A","4po0A-1v2xA:undetectable","4po0A-1v2xA:15.41"],["4X3M_A_ADNA301_1","RNA 2'-O RIBOSE METHYLTRANSFERASE","1v2x","TRNA (GM18) METHYLTRANSFERASE","Thermus thermophilus",5,"GLY A 122;ILE A 142;MET A 144;SER A 150;VAL A 153","SAM A 400 (-3.2A);SAM A 400 (-3.6A);SAM A 400 (-3.3A);SAM A 400 ( 3.7A);SAM A 400 (-3.9A)","0.43A","4x3mA-1v2xA:18.7","4x3mA-1v2xA:30.30"],["4X3M_B_ADNB301_1","RNA 2'-O RIBOSE METHYLTRANSFERASE","1v2x","TRNA (GM18) METHYLTRANSFERASE","Thermus thermophilus",6,"GLY A 122;ILE A 142;MET A 144;SER A 150;LEU A 151;VAL A 153","SAM A 400 (-3.2A);SAM A 400 (-3.6A);SAM A 400 (-3.3A);SAM A 400 ( 3.7A);SAM A 400 (-4.0A);SAM A 400 (-3.9A)","0.41A","4x3mB-1v2xA:16.9","4x3mB-1v2xA:30.30"],["5L0Z_A_SAMA304_0","PROBABLE RNA METHYLTRANSFERASE, TRMH FAMILY","1v2x","TRNA (GM18) METHYLTRANSFERASE","Thermus thermophilus",8,"THR A  99;LEU A 101;GLY A 122;GLY A 127;ILE A 142;SER A 150;LEU A 151;ALA A 156","SAM A 400 (-3.2A);SAM A 400 ( 4.1A);SAM A 400 (-3.2A);SAM A 400 (-3.8A);SAM A 400 (-3.6A);SAM A 400 ( 3.7A);SAM A 400 (-4.0A);SAM A 400 (-3.5A)","0.52A","5l0zA-1v2xA:19.2","5l0zA-1v2xA:23.30"],["5L0Z_B_SAMB304_0","PROBABLE RNA METHYLTRANSFERASE, TRMH FAMILY","1v2x","TRNA (GM18) METHYLTRANSFERASE","Thermus thermophilus",7,"THR A  99;GLY A 122;GLY A 127;ILE A 142;SER A 150;LEU A 151;ALA A 156","SAM A 400 (-3.2A);SAM A 400 (-3.2A);SAM A 400 (-3.8A);SAM A 400 (-3.6A);SAM A 400 ( 3.7A);SAM A 400 (-4.0A);SAM A 400 (-3.5A)","0.53A","5l0zB-1v2xA:19.3","5l0zB-1v2xA:23.30"],["5L0Z_B_SAMB304_0","PROBABLE RNA METHYLTRANSFERASE, TRMH FAMILY","1v2x","TRNA (GM18) METHYLTRANSFERASE","Thermus thermophilus",7,"THR A  99;LEU A 101;GLY A 122;GLY A 127;ILE A 142;LEU A 151;ALA A 156","SAM A 400 (-3.2A);SAM A 400 ( 4.1A);SAM A 400 (-3.2A);SAM A 400 (-3.8A);SAM A 400 (-3.6A);SAM A 400 (-4.0A);SAM A 400 (-3.5A)","0.68A","5l0zB-1v2xA:19.3","5l0zB-1v2xA:23.30"],["5L5Z_K_BO2K301_1","PROTEASOME SUBUNIT BETA TYPE-5,PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6","1v2x","TRNA (GM18) METHYLTRANSFERASE","Thermus thermophilus",5,"ALA A  98;THR A  99;ALA A 100;ALA A 139;ALA A 132","None;SAM A 400 (-3.2A);None;None;None","0.98A","5l5zK-1v2xA:undetectable;5l5zL-1v2xA:undetectable","5l5zK-1v2xA:20.87;5l5zL-1v2xA:21.98"],["5L5Z_Y_BO2Y301_1","PROTEASOME SUBUNIT BETA TYPE-5,PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6","1v2x","TRNA (GM18) METHYLTRANSFERASE","Thermus thermophilus",5,"ALA A  98;THR A  99;ALA A 100;ALA A 139;ALA A 132","None;SAM A 400 (-3.2A);None;None;None","0.99A","5l5zY-1v2xA:undetectable;5l5zZ-1v2xA:undetectable","5l5zY-1v2xA:20.87;5l5zZ-1v2xA:21.98"],["5M54_B_TA1B502_1","TUBULIN BETA-2B CHAIN","1v2x","TRNA (GM18) METHYLTRANSFERASE","Thermus thermophilus",5,"VAL A  74;ASP A  44;ALA A  51;ARG A  19;LEU A  23","None","1.49A","5m54B-1v2xA:undetectable","5m54B-1v2xA:18.20"],["5O96_C_SAMC501_0","RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE E","1v2x","TRNA (GM18) METHYLTRANSFERASE","Thermus thermophilus",4,"GLY A 122;GLY A 127;LEU A 151;ALA A 156","SAM A 400 (-3.2A);SAM A 400 (-3.8A);SAM A 400 (-4.0A);SAM A 400 (-3.5A)","0.72A","5o96C-1v2xA:12.1","5o96C-1v2xA:22.90"],["6CDU_A_EY4A502_0","CHIMERIC ALPHA1GABAA RECEPTOR","1v2x","TRNA (GM18) METHYLTRANSFERASE","Thermus thermophilus",4,"ALA A  51;TYR A  75;GLN A  20;VAL A  48","None","0.90A","6cduA-1v2xA:undetectable;6cduE-1v2xA:undetectable","6cduA-1v2xA:19.08;6cduE-1v2xA:19.08"],["6CDU_H_EY4H500_0","CHIMERIC ALPHA1GABAA RECEPTOR","1v2x","TRNA (GM18) METHYLTRANSFERASE","Thermus thermophilus",4,"GLN A  20;VAL A  48;ALA A  51;TYR A  75","None","0.89A","6cduH-1v2xA:undetectable;6cduI-1v2xA:undetectable","6cduH-1v2xA:19.08;6cduI-1v2xA:19.08"],["6DJZ_B_GMJB301_0","SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1","1v2x","TRNA (GM18) METHYLTRANSFERASE","Thermus thermophilus",5,"TYR A 113;ILE A 140;VAL A 128;THR A 117;LEU A  23","None","1.25A","6djzB-1v2xA:undetectable","6djzB-1v2xA:23.83"],["6HWD_K_BO2K301_0","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","1v2x","TRNA (GM18) METHYLTRANSFERASE","Thermus thermophilus",5,"ALA A  98;THR A  99;ALA A 100;ALA A 139;ALA A 132","None;SAM A 400 (-3.2A);None;None;None","0.92A","6hwdK-1v2xA:undetectable;6hwdL-1v2xA:undetectable","6hwdK-1v2xA:20.37;6hwdL-1v2xA:16.38"],["6HWD_Y_BO2Y301_0","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","1v2x","TRNA (GM18) METHYLTRANSFERASE","Thermus thermophilus",5,"ALA A  98;THR A  99;ALA A 100;ALA A 139;ALA A 132","None;SAM A 400 (-3.2A);None;None;None","0.91A","6hwdY-1v2xA:undetectable;6hwdZ-1v2xA:undetectable","6hwdY-1v2xA:20.37;6hwdZ-1v2xA:16.38"]]