SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1v33'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HTU_A_BCZA801_1
(NEURAMINIDASE)		 1v33 DNA PRIMASE SMALL
SUBUNIT
(Pyrococcus
horikoshii) 		4 / 4 ARG A  11
ASP A  40
GLU A   5
ARG A   8
 None
 1.24A 2htuA-1v33A:
undetectable		 2htuA-1v33A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		 1v33 DNA PRIMASE SMALL
SUBUNIT
(Pyrococcus
horikoshii) 		4 / 7 SER A 271
ARG A 216
ILE A 124
PHE A 279
 None
 1.25A 2qb4A-1v33A:
undetectable		 2qb4A-1v33A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		 1v33 DNA PRIMASE SMALL
SUBUNIT
(Pyrococcus
horikoshii) 		4 / 6 SER A 271
ARG A 216
ILE A 124
PHE A 279
 None
 1.21A 2qeiA-1v33A:
undetectable		 2qeiA-1v33A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQ5_B_LDPB1197_1
(S-NORCOCLAURINE
SYNTHASE)		 1v33 DNA PRIMASE SMALL
SUBUNIT
(Pyrococcus
horikoshii) 		4 / 7 LEU A 267
LEU A 264
LEU A 222
PRO A 256
 None
 0.80A 2vq5B-1v33A:
undetectable		 2vq5B-1v33A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1v33 DNA PRIMASE SMALL
SUBUNIT
(Pyrococcus
horikoshii) 		5 / 12 SER A 146
ALA A 305
LEU A 291
VAL A  93
ILE A 152
 PO4  A 701 ( 3.9A)
None
None
None
None
 1.02A 3adxB-1v33A:
undetectable		 3adxB-1v33A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1v33 DNA PRIMASE SMALL
SUBUNIT
(Pyrococcus
horikoshii) 		3 / 3 VAL A 333
LYS A 330
HIS A 298
 None
None
PO4  A 701 (-3.8A)
 0.85A 3elzA-1v33A:
undetectable		 3elzA-1v33A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1v33 DNA PRIMASE SMALL
SUBUNIT
(Pyrococcus
horikoshii) 		4 / 7 PHE A 255
PHE A 268
LYS A 266
GLY A 226
 None
 1.09A 3em0B-1v33A:
0.0		 3em0B-1v33A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_F_9PLF1_1
(CYTOCHROME P450 2A13)		 1v33 DNA PRIMASE SMALL
SUBUNIT
(Pyrococcus
horikoshii) 		5 / 8 PHE A 196
PHE A 206
PHE A 268
ALA A 269
THR A 272
 None
 1.46A 3t3sF-1v33A:
undetectable		 3t3sF-1v33A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_ACTA303_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 1v33 DNA PRIMASE SMALL
SUBUNIT
(Pyrococcus
horikoshii) 		3 / 3 TYR A  72
HIS A 298
ARG A 292
 None
PO4  A 701 (-3.8A)
PO4  A 701 (-4.2A)
 1.02A 4htfA-1v33A:
undetectable		 4htfA-1v33A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_1
(NEURAMINIDASE)		 1v33 DNA PRIMASE SMALL
SUBUNIT
(Pyrococcus
horikoshii) 		3 / 3 ARG A  11
ASP A  40
ARG A   8
 None
 0.98A 4mx0A-1v33A:
undetectable		 4mx0A-1v33A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_A_ADNA301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 1v33 DNA PRIMASE SMALL
SUBUNIT
(Pyrococcus
horikoshii) 		5 / 9 PRO A 256
LEU A 264
GLY A 260
ILE A 242
SER A 234
 None
 1.21A 4x3mA-1v33A:
undetectable		 4x3mA-1v33A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_2
(ESTROGEN RECEPTOR)		 1v33 DNA PRIMASE SMALL
SUBUNIT
(Pyrococcus
horikoshii) 		4 / 6 LEU A 215
ASP A 120
ILE A 235
PRO A 102
 None
 1.02A 4xi3C-1v33A:
1.2		 4xi3C-1v33A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1v33 DNA PRIMASE SMALL
SUBUNIT
(Pyrococcus
horikoshii) 		4 / 9 SER A 146
ALA A 305
LEU A 291
ILE A 152
 PO4  A 701 ( 3.9A)
None
None
None
 0.86A 4xtaA-1v33A:
undetectable		 4xtaA-1v33A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z7F_C_FOLC201_0
(FOLATE ECF
TRANSPORTER)		 1v33 DNA PRIMASE SMALL
SUBUNIT
(Pyrococcus
horikoshii) 		5 / 12 ARG A 209
SER A 177
PHE A  94
THR A 284
LEU A  92
 None
 1.41A 4z7fC-1v33A:
undetectable		 4z7fC-1v33A:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1v33 DNA PRIMASE SMALL
SUBUNIT
(Pyrococcus
horikoshii) 		4 / 6 PHE A 173
SER A 177
ALA A 176
LEU A 171
 None
 0.97A 5dzkB-1v33A:
undetectable
5dzkP-1v33A:
undetectable		 5dzkB-1v33A:
20.44
5dzkP-1v33A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1v33 DNA PRIMASE SMALL
SUBUNIT
(Pyrococcus
horikoshii) 		4 / 7 PHE A 173
SER A 177
ALA A 176
LEU A 171
 None
 1.12A 5dzkD-1v33A:
undetectable
5dzkR-1v33A:
undetectable		 5dzkD-1v33A:
20.44
5dzkR-1v33A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1v33 DNA PRIMASE SMALL
SUBUNIT
(Pyrococcus
horikoshii) 		4 / 6 TYR A 307
ASP A 140
HIS A 142
ILE A 152
 None
 1.19A 5ih0A-1v33A:
undetectable		 5ih0A-1v33A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_0
(CYTOCHROME P450 1A1)		 1v33 DNA PRIMASE SMALL
SUBUNIT
(Pyrococcus
horikoshii) 		5 / 12 ILE A  63
LEU A 297
PHE A  14
ASP A  23
ILE A  56
 None
 1.44A 6dwnB-1v33A:
0.0		 6dwnB-1v33A:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1v33 DNA PRIMASE SMALL
SUBUNIT
(Pyrococcus
horikoshii) 		5 / 10 SER A  73
GLY A  38
PHE A  39
ILE A  24
ILE A  28
 None
 1.00A 6ebpD-1v33A:
undetectable		 6ebpD-1v33A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1v33 DNA PRIMASE SMALL
SUBUNIT
(Pyrococcus
horikoshii) 		5 / 11 SER A  73
GLY A  38
PHE A  39
ILE A  24
ILE A  28
 None
 1.02A 6ebzA-1v33A:
undetectable		 6ebzA-1v33A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1v33 DNA PRIMASE SMALL
SUBUNIT
(Pyrococcus
horikoshii) 		5 / 11 SER A  73
GLY A  38
PHE A  39
ILE A  24
ILE A  28
 None
 1.02A 6ebzB-1v33A:
undetectable		 6ebzB-1v33A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 1v33 DNA PRIMASE SMALL
SUBUNIT
(Pyrococcus
horikoshii) 		5 / 11 SER A  73
GLY A  38
PHE A  39
ILE A  24
ILE A  28
 None
 1.00A 6ebzD-1v33A:
undetectable		 6ebzD-1v33A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_A_DAHA126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 1v33 DNA PRIMASE SMALL
SUBUNIT
(Pyrococcus
horikoshii) 		5 / 11 SER A  73
GLY A  38
PHE A  39
ILE A  24
ILE A  28
 None
 1.06A 6gp2A-1v33A:
undetectable		 6gp2A-1v33A:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_B_DAHB126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 1v33 DNA PRIMASE SMALL
SUBUNIT
(Pyrococcus
horikoshii) 		5 / 11 SER A  73
GLY A  38
PHE A  39
ILE A  24
ILE A  28
 None
 1.04A 6gp2B-1v33A:
undetectable		 6gp2B-1v33A:
10.83