SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1v3t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_F_ACTF3008_0
(BETA-CARBONIC
ANHYDRASE)		 1v3t LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE/PROSTAGLANDIN
15-KETO REDUCTASE
(Cavia
porcellus) 		4 / 8 ASP A 212
VAL A 139
GLY A 142
GLY A 141
 None
 0.75A 1ekjE-1v3tA:
undetectable
1ekjF-1v3tA:
undetectable		 1ekjE-1v3tA:
21.56
1ekjF-1v3tA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1v3t LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE/PROSTAGLANDIN
15-KETO REDUCTASE
(Cavia
porcellus) 		5 / 12 TYR A 181
GLY A 152
ALA A 153
SER A 156
GLY A 159
 None
NAP  A1350 (-3.3A)
NAP  A1350 (-3.4A)
None
None
 0.92A 1fe2A-1v3tA:
undetectable		 1fe2A-1v3tA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_0
(AMINOMETHYLTRANSFERA
SE)		 1v3t LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE/PROSTAGLANDIN
15-KETO REDUCTASE
(Cavia
porcellus) 		5 / 12 LEU A 164
ILE A 296
VAL A 291
TYR A 130
LEU A 134
 None
 1.13A 1wsvA-1v3tA:
undetectable		 1wsvA-1v3tA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_B_THHB4001_0
(AMINOMETHYLTRANSFERA
SE)		 1v3t LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE/PROSTAGLANDIN
15-KETO REDUCTASE
(Cavia
porcellus) 		5 / 12 LEU A 164
ILE A 296
VAL A 291
TYR A 130
LEU A 134
 None
 1.19A 1wsvB-1v3tA:
undetectable		 1wsvB-1v3tA:
24.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DM6_A_IMNA1401_1
(NADP-DEPENDENT
LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE)		 1v3t LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE/PROSTAGLANDIN
15-KETO REDUCTASE
(Cavia
porcellus) 		5 / 10 TYR A  49
ILE A  52
ALA A  53
TYR A 245
ILE A 271
 None
None
None
NAP  A1350 (-4.8A)
NAP  A1350 (-4.6A)
 0.38A 2dm6A-1v3tA:
53.9
2dm6B-1v3tA:
54.5		 2dm6A-1v3tA:
100.00
2dm6B-1v3tA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 1v3t LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE/PROSTAGLANDIN
15-KETO REDUCTASE
(Cavia
porcellus) 		5 / 8 TYR A 181
GLY A 159
GLY A 155
ALA A 151
ALA A 150
 None
 1.38A 2ej3C-1v3tA:
undetectable		 2ej3C-1v3tA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_1
(MINERALOCORTICOID
RECEPTOR)		 1v3t LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE/PROSTAGLANDIN
15-KETO REDUCTASE
(Cavia
porcellus) 		5 / 12 ASN A 217
ALA A 149
LEU A 317
THR A 128
PHE A 215
 NAP  A1350 (-3.9A)
NAP  A1350 ( 4.0A)
None
NAP  A1350 (-3.1A)
None
 1.27A 2oaxF-1v3tA:
undetectable		 2oaxF-1v3tA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1v3t LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE/PROSTAGLANDIN
15-KETO REDUCTASE
(Cavia
porcellus) 		3 / 3 SER A 148
GLY A 219
GLY A 240
 None
None
NAP  A1350 (-3.4A)
 0.48A 3bogA-1v3tA:
undetectable
3bogC-1v3tA:
undetectable		 3bogA-1v3tA:
undetectable
3bogC-1v3tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_1
(MODIFICATION
METHYLASE HHAI)		 1v3t LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE/PROSTAGLANDIN
15-KETO REDUCTASE
(Cavia
porcellus) 		3 / 3 GLU A 300
SER A  45
VAL A  46
 None
 0.80A 3eeoA-1v3tA:
5.5		 3eeoA-1v3tA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		 1v3t LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE/PROSTAGLANDIN
15-KETO REDUCTASE
(Cavia
porcellus) 		5 / 12 LEU A 133
GLY A 132
LEU A 134
ILE A 161
ALA A 283
 None
 0.96A 3gwvA-1v3tA:
undetectable		 3gwvA-1v3tA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWW_A_SFXA801_1
(TRANSPORTER)		 1v3t LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE/PROSTAGLANDIN
15-KETO REDUCTASE
(Cavia
porcellus) 		5 / 12 LEU A 133
GLY A 132
LEU A 134
ILE A 161
ALA A 283
 None
 0.94A 3gwwA-1v3tA:
undetectable		 3gwwA-1v3tA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_A_LEIA16_0
(COIL SER L16D-PEN)		 1v3t LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE/PROSTAGLANDIN
15-KETO REDUCTASE
(Cavia
porcellus) 		4 / 6 GLN A 229
LEU A 227
LYS A 263
LEU A 265
 None
 0.83A 3h5gA-1v3tA:
undetectable
3h5gC-1v3tA:
undetectable		 3h5gA-1v3tA:
6.79
3h5gC-1v3tA:
6.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 1v3t LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE/PROSTAGLANDIN
15-KETO REDUCTASE
(Cavia
porcellus) 		5 / 12 GLY A 323
GLY A 319
LEU A 317
SER A 243
ALA A 149
 None
NAP  A1350 (-3.6A)
None
NAP  A1350 (-4.8A)
NAP  A1350 ( 4.0A)
 1.05A 3kkzB-1v3tA:
6.5		 3kkzB-1v3tA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)		 1v3t LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE/PROSTAGLANDIN
15-KETO REDUCTASE
(Cavia
porcellus) 		5 / 12 GLY A 123
GLY A 120
ALA A 283
LEU A 127
SER A  45
 None
 1.07A 3p2kD-1v3tA:
4.4		 3p2kD-1v3tA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)		 1v3t LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE/PROSTAGLANDIN
15-KETO REDUCTASE
(Cavia
porcellus) 		5 / 12 ILE A 296
LEU A 287
GLY A 152
GLY A 155
THR A 121
 None
None
NAP  A1350 (-3.3A)
None
None
 1.00A 3vaqA-1v3tA:
5.0		 3vaqA-1v3tA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)		 1v3t LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE/PROSTAGLANDIN
15-KETO REDUCTASE
(Cavia
porcellus) 		5 / 12 ILE A 296
LEU A 287
GLY A 152
GLY A 155
THR A 121
 None
None
NAP  A1350 (-3.3A)
None
None
 1.01A 3vasA-1v3tA:
5.8		 3vasA-1v3tA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 1v3t LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE/PROSTAGLANDIN
15-KETO REDUCTASE
(Cavia
porcellus) 		5 / 12 PRO A 252
PRO A 255
LEU A 227
ILE A 267
ALA A 241
 None
 1.11A 4a83A-1v3tA:
undetectable		 4a83A-1v3tA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1v3t LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE/PROSTAGLANDIN
15-KETO REDUCTASE
(Cavia
porcellus) 		5 / 12 TYR A 181
GLY A 152
ALA A 153
SER A 156
GLY A 159
 None
NAP  A1350 (-3.3A)
NAP  A1350 (-3.4A)
None
None
 0.85A 4e1gA-1v3tA:
undetectable		 4e1gA-1v3tA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1v3t LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE/PROSTAGLANDIN
15-KETO REDUCTASE
(Cavia
porcellus) 		5 / 12 TYR A 181
GLY A 152
ALA A 153
SER A 156
GLY A 159
 None
NAP  A1350 (-3.3A)
NAP  A1350 (-3.4A)
None
None
 0.87A 4e1gB-1v3tA:
undetectable		 4e1gB-1v3tA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 1v3t LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE/PROSTAGLANDIN
15-KETO REDUCTASE
(Cavia
porcellus) 		5 / 12 TYR A 214
ALA A 172
GLY A 171
ASN A 217
GLY A 174
 None
None
None
NAP  A1350 (-3.9A)
NAP  A1350 (-3.2A)
 0.89A 4obwA-1v3tA:
7.2		 4obwA-1v3tA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 1v3t LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE/PROSTAGLANDIN
15-KETO REDUCTASE
(Cavia
porcellus) 		5 / 12 TYR A 214
ALA A 172
GLY A 171
ASN A 217
GLY A 174
 None
None
None
NAP  A1350 (-3.9A)
NAP  A1350 (-3.2A)
 0.89A 4obwB-1v3tA:
6.4		 4obwB-1v3tA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 1v3t LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE/PROSTAGLANDIN
15-KETO REDUCTASE
(Cavia
porcellus) 		5 / 12 TYR A 214
ALA A 172
GLY A 171
ASN A 217
GLY A 174
 None
None
None
NAP  A1350 (-3.9A)
NAP  A1350 (-3.2A)
 0.88A 4obwD-1v3tA:
5.6		 4obwD-1v3tA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA602_1
(SERUM ALBUMIN)		 1v3t LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE/PROSTAGLANDIN
15-KETO REDUCTASE
(Cavia
porcellus) 		4 / 8 LYS A 282
ALA A 283
LEU A 287
LEU A 127
 None
 0.65A 4po0A-1v3tA:
undetectable		 4po0A-1v3tA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_B_DESB600_1
(ESTROGEN RECEPTOR)		 1v3t LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE/PROSTAGLANDIN
15-KETO REDUCTASE
(Cavia
porcellus) 		5 / 11 LEU A 223
GLU A 221
LEU A 199
ARG A 247
MET A 230
 None
 1.35A 4zn7B-1v3tA:
undetectable		 4zn7B-1v3tA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_D95A816_0
(GEPHYRIN)		 1v3t LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE/PROSTAGLANDIN
15-KETO REDUCTASE
(Cavia
porcellus) 		5 / 11 PHE A 313
ILE A 314
LEU A 317
ARG A  51
MET A  64
 None
 1.46A 6fgcA-1v3tA:
0.9		 6fgcA-1v3tA:
13.82