SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1v40'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE)		 1v40 GLUTATHIONE-REQUIRIN
G PROSTAGLANDIN D
SYNTHASE
(Homo
sapiens) 		4 / 7 TYR A   8
PHE A   9
GLY A  13
ARG A  14
 None
O16  A3201 (-3.0A)
O16  A3201 ( 3.7A)
O16  A3201 ( 3.8A)
 0.38A 11gsB-1v40A:
24.5		 11gsB-1v40A:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB503_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1v40 GLUTATHIONE-REQUIRIN
G PROSTAGLANDIN D
SYNTHASE
(Homo
sapiens) 		4 / 6 ARG A  19
ALA A  15
ILE A  53
PRO A  52
 None
None
None
GSH  A3200 ( 4.5A)
 1.26A 1oniB-1v40A:
undetectable
1oniC-1v40A:
undetectable		 1oniB-1v40A:
19.10
1oniC-1v40A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1301_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 1v40 GLUTATHIONE-REQUIRIN
G PROSTAGLANDIN D
SYNTHASE
(Homo
sapiens) 		4 / 6 LEU A  25
PHE A  22
ALA A  23
LEU A  77
 None
 0.97A 1ukbA-1v40A:
undetectable		 1ukbA-1v40A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_A_EAAA0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 1v40 GLUTATHIONE-REQUIRIN
G PROSTAGLANDIN D
SYNTHASE
(Homo
sapiens) 		4 / 8 TYR A   8
PHE A   9
ARG A  14
TRP A  39
 None
O16  A3201 (-3.0A)
O16  A3201 ( 3.8A)
GSH  A3200 (-4.1A)
 0.68A 2gssA-1v40A:
24.5		 2gssA-1v40A:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_B_EAAB0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 1v40 GLUTATHIONE-REQUIRIN
G PROSTAGLANDIN D
SYNTHASE
(Homo
sapiens) 		4 / 8 TYR A   8
PHE A   9
ARG A  14
TRP A  39
 None
O16  A3201 (-3.0A)
O16  A3201 ( 3.8A)
GSH  A3200 (-4.1A)
 0.68A 2gssB-1v40A:
24.5		 2gssB-1v40A:
27.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VD0_B_D27B1200_0
(GLUTATHIONE-REQUIRIN
G PROSTAGLANDIN D
SYNTHASE)		 1v40 GLUTATHIONE-REQUIRIN
G PROSTAGLANDIN D
SYNTHASE
(Homo
sapiens) 		10 / 10 MET A  11
GLY A  13
ARG A  14
MET A  99
TRP A 104
ALA A 105
TYR A 152
CYH A 156
THR A 159
LEU A 199
 O16  A3201 ( 3.9A)
O16  A3201 ( 3.7A)
O16  A3201 ( 3.8A)
O16  A3201 (-4.7A)
O16  A3201 (-4.0A)
O16  A3201 (-3.0A)
O16  A3201 (-4.9A)
O16  A3201 (-3.6A)
O16  A3201 ( 4.8A)
O16  A3201 (-3.8A)
 0.65A 2vd0B-1v40A:
34.3		 2vd0B-1v40A:
99.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)		 1v40 GLUTATHIONE-REQUIRIN
G PROSTAGLANDIN D
SYNTHASE
(Homo
sapiens) 		5 / 12 LEU A   6
THR A   7
PRO A  47
GLY A  49
LEU A  46
 None
None
None
GOL  A3001 (-3.3A)
None
 1.31A 3j6pB-1v40A:
undetectable		 3j6pB-1v40A:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_A_EAAA210_1
(GLUTATHIONE
S-TRANSFERASE P)		 1v40 GLUTATHIONE-REQUIRIN
G PROSTAGLANDIN D
SYNTHASE
(Homo
sapiens) 		4 / 8 TYR A   8
PHE A   9
ARG A  14
TRP A  39
 None
O16  A3201 (-3.0A)
O16  A3201 ( 3.8A)
GSH  A3200 (-4.1A)
 0.70A 3n9jA-1v40A:
24.4		 3n9jA-1v40A:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_B_EAAB214_1
(GLUTATHIONE
S-TRANSFERASE P)		 1v40 GLUTATHIONE-REQUIRIN
G PROSTAGLANDIN D
SYNTHASE
(Homo
sapiens) 		4 / 8 TYR A   8
PHE A   9
GLY A  13
ARG A  14
 None
O16  A3201 (-3.0A)
O16  A3201 ( 3.7A)
O16  A3201 ( 3.8A)
 0.39A 3n9jB-1v40A:
24.4		 3n9jB-1v40A:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLH_A_T27A555_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1v40 GLUTATHIONE-REQUIRIN
G PROSTAGLANDIN D
SYNTHASE
(Homo
sapiens) 		5 / 12 PRO A  52
LEU A   6
TYR A   8
PRO A 195
TYR A  29
 GSH  A3200 ( 4.5A)
None
None
None
None
 1.36A 3qlhA-1v40A:
0.0		 3qlhA-1v40A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD507_1
(HEMOLYTIC LECTIN
CEL-III)		 1v40 GLUTATHIONE-REQUIRIN
G PROSTAGLANDIN D
SYNTHASE
(Homo
sapiens) 		4 / 5 GLU A  16
GLY A  13
TYR A 152
ASP A  96
 None
O16  A3201 ( 3.7A)
O16  A3201 (-4.9A)
O16  A3201 ( 4.8A)
 1.32A 3w9tD-1v40A:
undetectable		 3w9tD-1v40A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1476_0
(MJ0495-LIKE PROTEIN)		 1v40 GLUTATHIONE-REQUIRIN
G PROSTAGLANDIN D
SYNTHASE
(Homo
sapiens) 		4 / 5 ILE A  51
ALA A  15
HIS A  32
ARG A  33
 GSH  A3200 (-4.2A)
None
None
None
 0.86A 4ac9B-1v40A:
undetectable
4ac9C-1v40A:
undetectable		 4ac9B-1v40A:
19.29
4ac9C-1v40A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1v40 GLUTATHIONE-REQUIRIN
G PROSTAGLANDIN D
SYNTHASE
(Homo
sapiens) 		4 / 5 ILE A  51
ALA A  15
HIS A  32
ARG A  33
 GSH  A3200 (-4.2A)
None
None
None
 0.90A 4acaB-1v40A:
undetectable
4acaC-1v40A:
undetectable		 4acaB-1v40A:
19.29
4acaC-1v40A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_D_ACTD1113_0
(BLR5658 PROTEIN)		 1v40 GLUTATHIONE-REQUIRIN
G PROSTAGLANDIN D
SYNTHASE
(Homo
sapiens) 		4 / 4 TRP A 153
LEU A 168
LEU A 161
THR A 158
 None
 1.42A 4bboD-1v40A:
0.0		 4bboD-1v40A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1v40 GLUTATHIONE-REQUIRIN
G PROSTAGLANDIN D
SYNTHASE
(Homo
sapiens) 		4 / 8 SER A  64
ARG A  14
ILE A  17
TRP A 148
 GSH  A3200 (-2.5A)
O16  A3201 ( 3.8A)
None
None
 1.06A 4d39A-1v40A:
undetectable		 4d39A-1v40A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		 1v40 GLUTATHIONE-REQUIRIN
G PROSTAGLANDIN D
SYNTHASE
(Homo
sapiens) 		4 / 5 LEU A 135
ASP A 132
LEU A 141
THR A 176
 None
 1.27A 4wozF-1v40A:
undetectable
4wozH-1v40A:
undetectable		 4wozF-1v40A:
21.07
4wozH-1v40A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 1v40 GLUTATHIONE-REQUIRIN
G PROSTAGLANDIN D
SYNTHASE
(Homo
sapiens) 		5 / 12 ALA A  15
ILE A 184
ARG A  12
ILE A 155
LEU A  77
 None
 1.16A 5h8tA-1v40A:
undetectable		 5h8tA-1v40A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1v40 GLUTATHIONE-REQUIRIN
G PROSTAGLANDIN D
SYNTHASE
(Homo
sapiens) 		4 / 6 VAL A  88
LEU A  71
ILE A  27
PHE A  22
 None
 0.99A 5jw1A-1v40A:
undetectable		 5jw1A-1v40A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1v40 GLUTATHIONE-REQUIRIN
G PROSTAGLANDIN D
SYNTHASE
(Homo
sapiens) 		4 / 6 VAL A  92
LEU A  71
ILE A  27
PHE A  22
 None
 0.65A 5jw1A-1v40A:
undetectable		 5jw1A-1v40A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)		 1v40 GLUTATHIONE-REQUIRIN
G PROSTAGLANDIN D
SYNTHASE
(Homo
sapiens) 		5 / 12 LEU A   6
THR A   7
PRO A  47
GLY A  49
LEU A  46
 None
None
None
GOL  A3001 (-3.3A)
None
 1.23A 5ogcB-1v40A:
undetectable		 5ogcB-1v40A:
16.78