SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1v43'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWI_A_CAMA418_0
(CYTOCHROME P450-CAM)		 1v43 SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		4 / 8 LEU A 335
VAL A 336
VAL A 352
VAL A 354
 None
 0.96A 1iwiA-1v43A:
undetectable		 1iwiA-1v43A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT4_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 1v43 SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 LEU A 164
ALA A 152
ALA A 156
VAL A 194
TYR A 198
 None
 1.12A 1kt4A-1v43A:
0.0		 1kt4A-1v43A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_1
(PROTEASE)		 1v43 SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		5 / 10 ALA A 206
ASP A 202
VAL A 215
GLY A 244
ILE A 213
 None
 0.89A 1muiA-1v43A:
undetectable		 1muiA-1v43A:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1v43 SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		4 / 6 ARG A 212
TYR A  70
ASP A  75
GLU A  39
 None
 1.31A 1rjdA-1v43A:
2.2		 1rjdA-1v43A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1v43 SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		4 / 6 ARG A 212
TYR A  70
ASP A  75
GLU A  39
 None
 1.31A 1rjdB-1v43A:
undetectable		 1rjdB-1v43A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1v43 SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		4 / 6 ARG A 212
TYR A  70
ASP A  75
GLU A  39
 None
 1.32A 1rjdC-1v43A:
2.7		 1rjdC-1v43A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 1v43 SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		4 / 5 ALA A 127
TYR A 102
ILE A 105
ASP A 120
 None
 1.21A 1upfA-1v43A:
undetectable		 1upfA-1v43A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_C_URFC999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 1v43 SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		4 / 5 ALA A 127
TYR A 102
ILE A 105
ASP A 120
 None
 0.97A 1upfC-1v43A:
undetectable		 1upfC-1v43A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 1v43 SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		5 / 8 ILE A 361
PHE A 287
ARG A 310
MET A 294
THR A 295
 None
 1.45A 1v55N-1v43A:
undetectable
1v55W-1v43A:
undetectable		 1v55N-1v43A:
21.39
1v55W-1v43A:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_2
(RETINOIC ACID
RECEPTOR, BETA)		 1v43 SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		3 / 3 LEU A 260
PHE A 287
ARG A 310
 None
 0.69A 1xdkB-1v43A:
undetectable		 1xdkB-1v43A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_2
(RETINOIC ACID
RECEPTOR, BETA)		 1v43 SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		3 / 3 LEU A 260
PHE A 287
ARG A 310
 None
 0.69A 1xdkF-1v43A:
undetectable		 1xdkF-1v43A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		 1v43 SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		4 / 8 ARG A 150
LEU A 130
LEU A 164
VAL A  89
 None
 1.01A 2bdmA-1v43A:
undetectable		 2bdmA-1v43A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA501_0
(FERROCHELATASE)		 1v43 SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		5 / 11 LEU A  55
LEU A  43
ARG A  84
ILE A  86
VAL A  13
 None
 1.34A 2qd3A-1v43A:
undetectable		 2qd3A-1v43A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z97_A_CAMA422_0
(CYTOCHROME P450-CAM)		 1v43 SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		4 / 6 LEU A 335
VAL A 336
VAL A 352
VAL A 354
 None
 0.98A 2z97A-1v43A:
undetectable		 2z97A-1v43A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB7_A_NCAA901_0
(PROSTAGLANDIN
REDUCTASE 2)		 1v43 SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		4 / 5 ILE A 197
MET A 216
LEU A  15
LEU A  33
 None
 0.96A 2zb7A-1v43A:
undetectable		 2zb7A-1v43A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 1v43 SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 THR A  26
GLY A  50
LEU A  15
ASN A  32
GLU A  62
 None
 1.13A 2zw9B-1v43A:
undetectable		 2zw9B-1v43A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1v43 SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		4 / 5 ILE A 361
ARG A 310
MET A 294
THR A 295
 None
 1.41A 3abkN-1v43A:
undetectable
3abkW-1v43A:
undetectable		 3abkN-1v43A:
21.39
3abkW-1v43A:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1v43 SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		5 / 8 ILE A 361
PHE A 287
ARG A 310
MET A 294
THR A 295
 None
 1.49A 3abmN-1v43A:
undetectable
3abmW-1v43A:
undetectable		 3abmN-1v43A:
21.39
3abmW-1v43A:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1v43 SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		5 / 7 ILE A 361
PHE A 287
ARG A 310
MET A 294
THR A 295
 None
 1.45A 3ag4N-1v43A:
undetectable
3ag4W-1v43A:
undetectable		 3ag4N-1v43A:
21.39
3ag4W-1v43A:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 1v43 SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		5 / 8 ILE A 361
PHE A 287
ARG A 310
MET A 294
THR A 295
 None
 1.46A 3asoN-1v43A:
undetectable
3asoW-1v43A:
undetectable		 3asoN-1v43A:
21.39
3asoW-1v43A:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KT0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 1v43 SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		5 / 11 PHE A 331
GLY A 262
ARG A 263
GLY A 332
LEU A 321
 None
 0.99A 4kt0A-1v43A:
undetectable
4kt0J-1v43A:
undetectable		 4kt0A-1v43A:
19.55
4kt0J-1v43A:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYK_A_OAQA302_0
(SULFOTRANSFERASE)		 1v43 SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 PRO A 161
ILE A  58
LEU A 164
VAL A  11
LEU A  15
 None
 1.23A 5bykA-1v43A:
undetectable		 5bykA-1v43A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CU6_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 1v43 SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		4 / 6 TYR A 102
ILE A 132
VAL A 123
ALA A 127
 None
 0.80A 5cu6A-1v43A:
undetectable		 5cu6A-1v43A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1v43 SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		5 / 7 ILE A 361
PHE A 287
ARG A 310
MET A 294
THR A 295
 None
 1.34A 5iy5N-1v43A:
undetectable
5iy5W-1v43A:
undetectable		 5iy5N-1v43A:
21.39
5iy5W-1v43A:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)		 1v43 SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 VAL A  76
ASP A  75
THR A  53
GLY A  67
LEU A  18
 None
 1.22A 5ogcB-1v43A:
undetectable		 5ogcB-1v43A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_2
(PROTEIN CYP51)		 1v43 SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		4 / 6 PRO A 246
LEU A 327
PHE A 317
LEU A 335
 None
 1.10A 5tl8A-1v43A:
undetectable		 5tl8A-1v43A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1v43 SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		5 / 9 GLY A 262
VAL A 253
GLU A 252
ASP A 333
GLY A 264
 None
 1.12A 5zniA-1v43A:
undetectable		 5zniA-1v43A:
14.58