SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1v4a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1503_0
(FERROCHELATASE)		 1v4a GLUTAMATE-AMMONIA-LI
GASE
ADENYLYLTRANSFERASE
(Escherichia
coli) 		3 / 3 LEU A  19
PRO A  20
LEU A  23
 None
 0.54A 1hrkA-1v4aA:
undetectable		 1hrkA-1v4aA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 1v4a GLUTAMATE-AMMONIA-LI
GASE
ADENYLYLTRANSFERASE
(Escherichia
coli) 		4 / 6 VAL A 236
VAL A 222
ILE A 157
ARG A 201
 None
 1.13A 1iepA-1v4aA:
undetectable		 1iepA-1v4aA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_ACTB294_0
(GLYCINE
N-METHYLTRANSFERASE)		 1v4a GLUTAMATE-AMMONIA-LI
GASE
ADENYLYLTRANSFERASE
(Escherichia
coli) 		4 / 6 ALA A 129
TYR A 220
ILE A 127
LEU A  90
 None
 1.04A 1xvaA-1v4aA:
undetectable
1xvaB-1v4aA:
undetectable		 1xvaA-1v4aA:
20.31
1xvaB-1v4aA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_B_DIFB1_1
(TRANSTHYRETIN)		 1v4a GLUTAMATE-AMMONIA-LI
GASE
ADENYLYLTRANSFERASE
(Escherichia
coli) 		4 / 7 LEU A 359
ALA A 355
LEU A 361
THR A 352
 None
 0.98A 3cfqA-1v4aA:
undetectable
3cfqB-1v4aA:
undetectable		 3cfqA-1v4aA:
13.35
3cfqB-1v4aA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_0
(NEURAMINIDASE)		 1v4a GLUTAMATE-AMMONIA-LI
GASE
ADENYLYLTRANSFERASE
(Escherichia
coli) 		5 / 12 GLU A 113
LEU A 350
ARG A 371
ARG A 379
ALA A 108
 None
 1.29A 3k37A-1v4aA:
undetectable		 3k37A-1v4aA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_0
(NEURAMINIDASE)		 1v4a GLUTAMATE-AMMONIA-LI
GASE
ADENYLYLTRANSFERASE
(Escherichia
coli) 		5 / 12 GLU A 113
LEU A 350
ARG A 371
ARG A 379
ALA A 108
 None
 1.29A 3k37B-1v4aA:
undetectable		 3k37B-1v4aA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 1v4a GLUTAMATE-AMMONIA-LI
GASE
ADENYLYLTRANSFERASE
(Escherichia
coli) 		5 / 12 LYS A 300
GLY A 321
ALA A 320
ALA A 373
VAL A 428
 None
 1.06A 3nvkF-1v4aA:
0.9
3nvkJ-1v4aA:
undetectable		 3nvkF-1v4aA:
21.89
3nvkJ-1v4aA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		 1v4a GLUTAMATE-AMMONIA-LI
GASE
ADENYLYLTRANSFERASE
(Escherichia
coli) 		5 / 11 ILE A 177
ILE A 263
PHE A 239
ALA A 272
GLU A 274
 None
 0.88A 3tmzA-1v4aA:
undetectable		 3tmzA-1v4aA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB502_1
(HEMOLYTIC LECTIN
CEL-III)		 1v4a GLUTAMATE-AMMONIA-LI
GASE
ADENYLYLTRANSFERASE
(Escherichia
coli) 		4 / 6 GLY A 230
LEU A 237
TYR A 245
GLU A 254
 None
 1.05A 3w9tB-1v4aA:
undetectable		 3w9tB-1v4aA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE502_1
(HEMOLYTIC LECTIN
CEL-III)		 1v4a GLUTAMATE-AMMONIA-LI
GASE
ADENYLYLTRANSFERASE
(Escherichia
coli) 		4 / 6 GLY A 230
LEU A 237
TYR A 245
GLU A 254
 None
 1.05A 3w9tE-1v4aA:
undetectable		 3w9tE-1v4aA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF503_1
(HEMOLYTIC LECTIN
CEL-III)		 1v4a GLUTAMATE-AMMONIA-LI
GASE
ADENYLYLTRANSFERASE
(Escherichia
coli) 		4 / 6 GLY A 230
LEU A 237
TYR A 245
GLU A 254
 None
 1.06A 3w9tF-1v4aA:
undetectable		 3w9tF-1v4aA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B9Z_A_ACRA1818_2
(ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B)		 1v4a GLUTAMATE-AMMONIA-LI
GASE
ADENYLYLTRANSFERASE
(Escherichia
coli) 		4 / 5 PHE A 411
PHE A 376
TRP A 414
GLN A 416
 None
 1.45A 4b9zA-1v4aA:
0.0		 4b9zA-1v4aA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		 1v4a GLUTAMATE-AMMONIA-LI
GASE
ADENYLYLTRANSFERASE
(Escherichia
coli) 		4 / 7 LEU A 359
ALA A 355
LEU A 361
THR A 352
 None
 0.94A 4d7bA-1v4aA:
undetectable		 4d7bA-1v4aA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFU_B_KANB402_1
(APH(2')-ID)		 1v4a GLUTAMATE-AMMONIA-LI
GASE
ADENYLYLTRANSFERASE
(Escherichia
coli) 		5 / 12 ASP A 173
SER A 172
ASP A 223
GLU A 381
GLU A 327
 None
 1.45A 4dfuB-1v4aA:
0.8		 4dfuB-1v4aA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_B_SUZB201_1
(TRANSTHYRETIN)		 1v4a GLUTAMATE-AMMONIA-LI
GASE
ADENYLYLTRANSFERASE
(Escherichia
coli) 		4 / 8 LEU A 359
ALA A 355
LEU A 361
THR A 352
 None
 0.99A 4ikjA-1v4aA:
undetectable
4ikjB-1v4aA:
undetectable		 4ikjA-1v4aA:
13.57
4ikjB-1v4aA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_B_SUZB201_1
(TRANSTHYRETIN)		 1v4a GLUTAMATE-AMMONIA-LI
GASE
ADENYLYLTRANSFERASE
(Escherichia
coli) 		4 / 7 LEU A 359
ALA A 355
LEU A 361
THR A 352
 None
 0.99A 4ikkA-1v4aA:
undetectable
4ikkB-1v4aA:
undetectable		 4ikkA-1v4aA:
13.57
4ikkB-1v4aA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1v4a GLUTAMATE-AMMONIA-LI
GASE
ADENYLYLTRANSFERASE
(Escherichia
coli) 		4 / 7 GLU A 381
THR A 392
LEU A 417
SER A 386
 None
 1.04A 4pfjA-1v4aA:
undetectable		 4pfjA-1v4aA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_D_QI9D602_0
(CYTOCHROME P450 2D6)		 1v4a GLUTAMATE-AMMONIA-LI
GASE
ADENYLYLTRANSFERASE
(Escherichia
coli) 		4 / 7 LEU A  56
SER A  34
VAL A  46
PHE A  41
 None
 0.95A 4wnvD-1v4aA:
0.1		 4wnvD-1v4aA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_A_4LEA401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1v4a GLUTAMATE-AMMONIA-LI
GASE
ADENYLYLTRANSFERASE
(Escherichia
coli) 		5 / 8 LEU A  90
LEU A 210
LEU A 206
LEU A 134
LEU A  86
 None
 1.15A 4z90A-1v4aA:
3.0
4z90B-1v4aA:
3.1
4z90C-1v4aA:
3.1
4z90D-1v4aA:
3.1
4z90E-1v4aA:
3.1		 4z90A-1v4aA:
21.62
4z90B-1v4aA:
21.62
4z90C-1v4aA:
21.62
4z90D-1v4aA:
21.62
4z90E-1v4aA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_A_4LEA401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1v4a GLUTAMATE-AMMONIA-LI
GASE
ADENYLYLTRANSFERASE
(Escherichia
coli) 		5 / 8 LEU A 134
LEU A  86
LEU A  90
LEU A 210
LEU A 206
 None
 1.14A 4z90A-1v4aA:
3.0
4z90B-1v4aA:
3.1
4z90C-1v4aA:
3.1
4z90D-1v4aA:
3.1
4z90E-1v4aA:
3.1		 4z90A-1v4aA:
21.62
4z90B-1v4aA:
21.62
4z90C-1v4aA:
21.62
4z90D-1v4aA:
21.62
4z90E-1v4aA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1v4a GLUTAMATE-AMMONIA-LI
GASE
ADENYLYLTRANSFERASE
(Escherichia
coli) 		5 / 8 LEU A  77
ALA A 130
LEU A  90
MET A  87
GLY A  85
 None
 1.27A 4zauA-1v4aA:
undetectable		 4zauA-1v4aA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQE_C_NMYC600_1
(BIFUNCTIONAL AAC/APH)		 1v4a GLUTAMATE-AMMONIA-LI
GASE
ADENYLYLTRANSFERASE
(Escherichia
coli) 		5 / 12 ASP A 173
SER A 172
ASP A 223
GLU A 381
GLU A 327
 None
 1.35A 5iqeC-1v4aA:
0.9		 5iqeC-1v4aA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDZ_A_ADNA905_1
(ATP-CITRATE SYNTHASE)		 1v4a GLUTAMATE-AMMONIA-LI
GASE
ADENYLYLTRANSFERASE
(Escherichia
coli) 		4 / 6 ARG A  94
ASP A 211
ARG A 221
ASP A 173
 None
 1.17A 5tdzA-1v4aA:
undetectable		 5tdzA-1v4aA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_2
(CYTOCHROME P450 3A5)		 1v4a GLUTAMATE-AMMONIA-LI
GASE
ADENYLYLTRANSFERASE
(Escherichia
coli) 		3 / 3 ARG A 262
PHE A 282
LEU A 275
 None
 0.65A 5veuA-1v4aA:
undetectable		 5veuA-1v4aA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_G_CHDG401_0
(BILE SALT HYDROLASE)		 1v4a GLUTAMATE-AMMONIA-LI
GASE
ADENYLYLTRANSFERASE
(Escherichia
coli) 		5 / 10 ILE A 329
LEU A 362
LEU A 359
ALA A 355
GLU A 113
 None
 1.22A 5y7pG-1v4aA:
undetectable		 5y7pG-1v4aA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_D_HISD402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1v4a GLUTAMATE-AMMONIA-LI
GASE
ADENYLYLTRANSFERASE
(Escherichia
coli) 		4 / 8 LEU A   8
GLN A   9
THR A  14
LEU A 400
 None
 0.81A 6czmD-1v4aA:
undetectable
6czmF-1v4aA:
undetectable		 6czmD-1v4aA:
22.30
6czmF-1v4aA:
22.30