SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1v4g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_CCSB381_0
(ESTROGEN RECEPTOR)		 1v4g GLUTAMATE--CYSTEINE
LIGASE
(Escherichia
coli) 		3 / 3 GLU A 369
ALA A 371
SER A 247
 None
 0.61A 1errB-1v4gA:
undetectable		 1errB-1v4gA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1502_0
(FERROCHELATASE)		 1v4g GLUTAMATE--CYSTEINE
LIGASE
(Escherichia
coli) 		4 / 8 LEU A 413
VAL A 193
GLY A 191
TRP A 192
 None
 1.03A 1hrkA-1v4gA:
undetectable		 1hrkA-1v4gA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2502_0
(FERROCHELATASE)		 1v4g GLUTAMATE--CYSTEINE
LIGASE
(Escherichia
coli) 		4 / 8 LEU A 413
VAL A 193
GLY A 191
TRP A 192
 None
 1.02A 1hrkB-1v4gA:
undetectable		 1hrkB-1v4gA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1v4g GLUTAMATE--CYSTEINE
LIGASE
(Escherichia
coli) 		3 / 3 LEU A 402
VAL A 405
LEU A 409
 None
 0.52A 1mz9B-1v4gA:
undetectable		 1mz9B-1v4gA:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1v4g GLUTAMATE--CYSTEINE
LIGASE
(Escherichia
coli) 		3 / 3 LEU A 413
VAL A 416
LEU A 420
 None
 0.50A 1mz9B-1v4gA:
undetectable		 1mz9B-1v4gA:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NB9_A_RBFA401_1
(HYPOTHETICAL PROTEIN
FLJ11149)		 1v4g GLUTAMATE--CYSTEINE
LIGASE
(Escherichia
coli) 		5 / 9 THR A 419
ILE A  22
VAL A 355
ARG A  24
ASP A 351
 None
 1.35A 1nb9A-1v4gA:
0.0		 1nb9A-1v4gA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 1v4g GLUTAMATE--CYSTEINE
LIGASE
(Escherichia
coli) 		4 / 8 LEU A 299
GLU A 296
TYR A 259
ILE A 251
 None
 0.82A 1qvtA-1v4gA:
0.0		 1qvtA-1v4gA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_1
(HEMK PROTEIN)		 1v4g GLUTAMATE--CYSTEINE
LIGASE
(Escherichia
coli) 		4 / 4 THR A 145
GLY A  37
ASP A  36
ALA A  40
 None
 1.26A 1sg9A-1v4gA:
undetectable		 1sg9A-1v4gA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_1
(VP39)		 1v4g GLUTAMATE--CYSTEINE
LIGASE
(Escherichia
coli) 		3 / 3 ASP A 412
ARG A 415
ASP A   4
 None
 0.74A 1vptA-1v4gA:
undetectable		 1vptA-1v4gA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_C_ADNC433_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v4g GLUTAMATE--CYSTEINE
LIGASE
(Escherichia
coli) 		5 / 12 THR A 129
ASP A 506
LEU A  52
GLY A 120
PHE A 510
 None
 1.16A 1xwfC-1v4gA:
undetectable		 1xwfC-1v4gA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_A_NCAA1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 1v4g GLUTAMATE--CYSTEINE
LIGASE
(Escherichia
coli) 		4 / 7 SER A 338
PHE A 447
ARG A 450
GLN A 346
 None
 1.17A 2c8aA-1v4gA:
undetectable		 2c8aA-1v4gA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 1v4g GLUTAMATE--CYSTEINE
LIGASE
(Escherichia
coli) 		5 / 12 TYR A 196
GLY A 199
LEU A 452
ILE A 381
ALA A 231
 None
 0.96A 2fk8A-1v4gA:
undetectable		 2fk8A-1v4gA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LBD_A_REAA500_1
(RETINOIC ACID
RECEPTOR GAMMA)		 1v4g GLUTAMATE--CYSTEINE
LIGASE
(Escherichia
coli) 		5 / 12 LEU A 197
ILE A 194
PHE A 353
GLY A 384
LEU A 391
 None
 1.21A 2lbdA-1v4gA:
undetectable		 2lbdA-1v4gA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_C_SNLC3001_1
(MINERALOCORTICOID
RECEPTOR)		 1v4g GLUTAMATE--CYSTEINE
LIGASE
(Escherichia
coli) 		5 / 12 LEU A 409
ALA A 417
GLN A 418
LEU A 359
PHE A 349
 None
 1.46A 2oaxC-1v4gA:
undetectable		 2oaxC-1v4gA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		 1v4g GLUTAMATE--CYSTEINE
LIGASE
(Escherichia
coli) 		3 / 3 LEU A 483
LEU A  48
PHE A  82
 None
 0.69A 2pgrA-1v4gA:
undetectable		 2pgrA-1v4gA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_E_ASDE1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1v4g GLUTAMATE--CYSTEINE
LIGASE
(Escherichia
coli) 		5 / 9 LEU A 420
LEU A  12
LEU A 359
ALA A 358
PHE A 159
 None
 1.27A 2vcvE-1v4gA:
undetectable		 2vcvE-1v4gA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_F_ASDF1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1v4g GLUTAMATE--CYSTEINE
LIGASE
(Escherichia
coli) 		4 / 8 LEU A 420
LEU A 359
ALA A 358
PHE A 159
 None
 0.90A 2vcvF-1v4gA:
undetectable		 2vcvF-1v4gA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_I_ASDI1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1v4g GLUTAMATE--CYSTEINE
LIGASE
(Escherichia
coli) 		5 / 9 LEU A 420
LEU A  12
LEU A 359
ALA A 358
PHE A 159
 None
 1.23A 2vcvI-1v4gA:
undetectable		 2vcvI-1v4gA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_P_ASDP1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1v4g GLUTAMATE--CYSTEINE
LIGASE
(Escherichia
coli) 		4 / 8 LEU A 420
LEU A 359
ALA A 358
PHE A 159
 None
 0.84A 2vcvP-1v4gA:
undetectable		 2vcvP-1v4gA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 1v4g GLUTAMATE--CYSTEINE
LIGASE
(Escherichia
coli) 		5 / 11 ILE A 194
PHE A 353
ILE A   2
PRO A   3
VAL A 193
 None
 1.23A 2w3aA-1v4gA:
undetectable		 2w3aA-1v4gA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)		 1v4g GLUTAMATE--CYSTEINE
LIGASE
(Escherichia
coli) 		4 / 6 GLU A  29
MET A  83
PHE A  68
ILE A  69
 None
 1.43A 2w98B-1v4gA:
undetectable		 2w98B-1v4gA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1414_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 1v4g GLUTAMATE--CYSTEINE
LIGASE
(Escherichia
coli) 		4 / 8 LEU A 299
ILE A 251
LEU A 249
LEU A 293
 None
 0.80A 2xfhA-1v4gA:
undetectable		 2xfhA-1v4gA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF0_A_PAUA314_0
(PANTOTHENATE KINASE)		 1v4g GLUTAMATE--CYSTEINE
LIGASE
(Escherichia
coli) 		4 / 8 VAL A 432
ASP A 343
LEU A  80
TYR A 151
 None
 1.04A 3af0A-1v4gA:
undetectable		 3af0A-1v4gA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1v4g GLUTAMATE--CYSTEINE
LIGASE
(Escherichia
coli) 		5 / 12 PHE A 488
VAL A 342
LEU A  26
ILE A 340
THR A  70
 None
 1.19A 3em0B-1v4gA:
undetectable		 3em0B-1v4gA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1v4g GLUTAMATE--CYSTEINE
LIGASE
(Escherichia
coli) 		4 / 8 ILE A   2
PRO A   3
VAL A 193
GLY A 191
 None
 0.83A 3em0B-1v4gA:
undetectable		 3em0B-1v4gA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCP_B_CHDB4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1v4g GLUTAMATE--CYSTEINE
LIGASE
(Escherichia
coli) 		3 / 3 GLY A  37
PRO A 105
LEU A  31
 None
 0.63A 3hcpB-1v4gA:
undetectable		 3hcpB-1v4gA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1v4g GLUTAMATE--CYSTEINE
LIGASE
(Escherichia
coli) 		4 / 7 ARG A 450
ALA A 449
ILE A 451
GLY A 199
 None
 0.83A 3v4tH-1v4gA:
undetectable		 3v4tH-1v4gA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_A_SAMA801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 1v4g GLUTAMATE--CYSTEINE
LIGASE
(Escherichia
coli) 		5 / 12 GLY A 148
SER A 147
THR A  30
SER A 331
LEU A 350
 None
 1.04A 3v8vA-1v4gA:
undetectable		 3v8vA-1v4gA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WFA_A_EDTA802_0
(ALPHA-GLUCOSIDASE)		 1v4g GLUTAMATE--CYSTEINE
LIGASE
(Escherichia
coli) 		4 / 5 ASN A 289
TYR A 274
TYR A 131
ARG A 138
 None
 1.47A 3wfaA-1v4gA:
0.0
3wfaB-1v4gA:
0.0		 3wfaA-1v4gA:
21.27
3wfaB-1v4gA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WFA_B_EDTB802_0
(ALPHA-GLUCOSIDASE)		 1v4g GLUTAMATE--CYSTEINE
LIGASE
(Escherichia
coli) 		4 / 6 TYR A 131
ARG A 138
ASN A 289
TYR A 274
 None
 1.47A 3wfaA-1v4gA:
0.0
3wfaB-1v4gA:
0.0		 3wfaA-1v4gA:
21.27
3wfaB-1v4gA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_A_P1BA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 1v4g GLUTAMATE--CYSTEINE
LIGASE
(Escherichia
coli) 		5 / 12 PRO A 305
LEU A 370
ILE A 251
ILE A 184
TYR A 188
 None
 1.29A 4a79A-1v4gA:
undetectable		 4a79A-1v4gA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_B_P1BB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 1v4g GLUTAMATE--CYSTEINE
LIGASE
(Escherichia
coli) 		5 / 12 PRO A 305
LEU A 370
ILE A 251
ILE A 184
TYR A 188
 None
 1.29A 4a79B-1v4gA:
undetectable		 4a79B-1v4gA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1v4g GLUTAMATE--CYSTEINE
LIGASE
(Escherichia
coli) 		4 / 6 ILE A  57
PHE A  82
HIS A 150
VAL A 347
 None
 1.19A 4a97I-1v4gA:
undetectable		 4a97I-1v4gA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_1
(METHYLTRANSFERASE
NSUN4)		 1v4g GLUTAMATE--CYSTEINE
LIGASE
(Escherichia
coli) 		3 / 3 ASP A 412
ARG A 415
ASP A   4
 None
 0.80A 4fp9D-1v4gA:
undetectable		 4fp9D-1v4gA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_1
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 1v4g GLUTAMATE--CYSTEINE
LIGASE
(Escherichia
coli) 		3 / 3 ASP A 412
ARG A 415
ASP A   4
 None
 0.79A 4fzvA-1v4gA:
undetectable		 4fzvA-1v4gA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_ACTA402_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 1v4g GLUTAMATE--CYSTEINE
LIGASE
(Escherichia
coli) 		3 / 3 LYS A 128
TYR A 131
ARG A 132
 None
 1.22A 4gc9A-1v4gA:
undetectable		 4gc9A-1v4gA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NNR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2)		 1v4g GLUTAMATE--CYSTEINE
LIGASE
(Escherichia
coli) 		5 / 12 TYR A 151
PHE A 153
VAL A 355
TYR A 429
PRO A  16
 None
 1.35A 4nnrA-1v4gA:
undetectable
4nnrB-1v4gA:
undetectable		 4nnrA-1v4gA:
14.59
4nnrB-1v4gA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 1v4g GLUTAMATE--CYSTEINE
LIGASE
(Escherichia
coli) 		4 / 5 PHE A  82
HIS A  87
LEU A 475
PRO A 339
 None
 1.45A 4o8zA-1v4gA:
undetectable		 4o8zA-1v4gA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 1v4g GLUTAMATE--CYSTEINE
LIGASE
(Escherichia
coli) 		4 / 7 THR A  42
ALA A  64
ALA A 117
MET A  94
 None
 0.94A 4qw0K-1v4gA:
undetectable		 4qw0K-1v4gA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 1v4g GLUTAMATE--CYSTEINE
LIGASE
(Escherichia
coli) 		4 / 7 THR A  42
ALA A  64
ALA A 117
MET A  94
 None
 0.94A 4qw0Y-1v4gA:
undetectable		 4qw0Y-1v4gA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_K_CHDK103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1v4g GLUTAMATE--CYSTEINE
LIGASE
(Escherichia
coli) 		5 / 11 GLU A  97
LEU A  39
LEU A  31
LEU A  65
ARG A 132
 None
 0.98A 4wg0I-1v4gA:
undetectable
4wg0J-1v4gA:
undetectable
4wg0K-1v4gA:
undetectable		 4wg0I-1v4gA:
3.18
4wg0J-1v4gA:
3.18
4wg0K-1v4gA:
3.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1v4g GLUTAMATE--CYSTEINE
LIGASE
(Escherichia
coli) 		4 / 4 GLY A 148
LEU A 350
PHE A 349
ILE A 194
 None
 0.74A 4xv2A-1v4gA:
0.9		 4xv2A-1v4gA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 1v4g GLUTAMATE--CYSTEINE
LIGASE
(Escherichia
coli) 		3 / 3 ASN A 186
LEU A 155
PHE A 181
 None
 0.75A 5dsgA-1v4gA:
undetectable		 5dsgA-1v4gA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 1v4g GLUTAMATE--CYSTEINE
LIGASE
(Escherichia
coli) 		3 / 3 ALA A 470
ASN A 473
LEU A 474
 None
 0.43A 5i1nC-1v4gA:
undetectable		 5i1nC-1v4gA:
5.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 1v4g GLUTAMATE--CYSTEINE
LIGASE
(Escherichia
coli) 		3 / 3 ALA A 470
ASN A 473
LEU A 474
 None
 0.38A 5i1oC-1v4gA:
undetectable		 5i1oC-1v4gA:
5.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_H_DVAH9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 1v4g GLUTAMATE--CYSTEINE
LIGASE
(Escherichia
coli) 		3 / 3 ALA A 470
ASN A 473
LEU A 474
 None
 0.50A 5i1oA-1v4gA:
undetectable		 5i1oA-1v4gA:
5.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 1v4g GLUTAMATE--CYSTEINE
LIGASE
(Escherichia
coli) 		3 / 3 ALA A 470
ASN A 473
LEU A 474
 None
 0.34A 5i1pA-1v4gA:
undetectable		 5i1pA-1v4gA:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 1v4g GLUTAMATE--CYSTEINE
LIGASE
(Escherichia
coli) 		3 / 3 ALA A 470
ASN A 473
LEU A 474
 None
 0.43A 5i1pD-1v4gA:
undetectable		 5i1pD-1v4gA:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMD_C_6UBC1304_1
(ION TRANSPORT
PROTEIN)		 1v4g GLUTAMATE--CYSTEINE
LIGASE
(Escherichia
coli) 		4 / 5 TYR A 326
ILE A 327
LEU A  26
GLY A  25
 None
 0.97A 5kmdC-1v4gA:
undetectable
5kmdD-1v4gA:
undetectable		 5kmdC-1v4gA:
19.92
5kmdD-1v4gA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1v4g GLUTAMATE--CYSTEINE
LIGASE
(Escherichia
coli) 		4 / 8 GLU A  29
PHE A 198
PHE A 447
LEU A 436
 None
 0.91A 5y2tB-1v4gA:
undetectable		 5y2tB-1v4gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW2_A_ACTA511_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 1v4g GLUTAMATE--CYSTEINE
LIGASE
(Escherichia
coli) 		3 / 3 ARG A 235
ILE A 146
SER A 103
 None
 0.81A 5zw2A-1v4gA:
undetectable		 5zw2A-1v4gA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW2_A_ACTA511_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 1v4g GLUTAMATE--CYSTEINE
LIGASE
(Escherichia
coli) 		3 / 3 ARG A 235
ILE A 146
SER A 147
 None
 0.81A 5zw2A-1v4gA:
undetectable		 5zw2A-1v4gA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1v4g GLUTAMATE--CYSTEINE
LIGASE
(Escherichia
coli) 		4 / 6 GLY A 125
ARG A 498
SER A 495
SER A  50
 None
 1.09A 6jogA-1v4gA:
undetectable		 6jogA-1v4gA:
16.63