SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1v4n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3003_0
(BETA-CARBONIC
ANHYDRASE)		 1v4n 271AA LONG
HYPOTHETICAL
5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE
(Sulfurisphaera
tokodaii) 		4 / 8 TYR A 101
ASP A 159
VAL A 107
GLY A 161
 None
 0.92A 1ekjA-1v4nA:
undetectable
1ekjB-1v4nA:
2.7		 1ekjA-1v4nA:
22.70
1ekjB-1v4nA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 1v4n 271AA LONG
HYPOTHETICAL
5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE
(Sulfurisphaera
tokodaii) 		4 / 6 TYR A 101
ASP A 159
VAL A 107
GLY A 161
 None
 0.94A 1ekjC-1v4nA:
undetectable
1ekjD-1v4nA:
undetectable		 1ekjC-1v4nA:
22.70
1ekjD-1v4nA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)		 1v4n 271AA LONG
HYPOTHETICAL
5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE
(Sulfurisphaera
tokodaii) 		4 / 6 ASP A 159
VAL A 107
GLY A 161
TYR A 101
 None
 0.93A 1ekjC-1v4nA:
undetectable
1ekjD-1v4nA:
undetectable		 1ekjC-1v4nA:
22.70
1ekjD-1v4nA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_A_EAAA224_1
(GLUTATHIONE
TRANSFERASE)		 1v4n 271AA LONG
HYPOTHETICAL
5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE
(Sulfurisphaera
tokodaii) 		5 / 12 GLY A  16
LEU A  19
LEU A 244
VAL A 240
ALA A  93
 None
 1.09A 1gseA-1v4nA:
undetectable		 1gseA-1v4nA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA156_1
(CALMODULIN)		 1v4n 271AA LONG
HYPOTHETICAL
5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE
(Sulfurisphaera
tokodaii) 		5 / 8 ILE A  13
ILE A 248
GLU A 246
VAL A 247
ILE A  89
 None
 1.44A 1linA-1v4nA:
undetectable		 1linA-1v4nA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1v4n 271AA LONG
HYPOTHETICAL
5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE
(Sulfurisphaera
tokodaii) 		5 / 10 GLY A  95
PHE A 171
GLY A 190
MET A 191
THR A 214
 None
 0.46A 1pwyE-1v4nA:
24.7		 1pwyE-1v4nA:
26.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_0
(HEMK PROTEIN)		 1v4n 271AA LONG
HYPOTHETICAL
5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE
(Sulfurisphaera
tokodaii) 		5 / 12 ILE A  77
VAL A  91
SER A  92
ASN A  76
PRO A  58
 None
 1.25A 1sg9A-1v4nA:
undetectable		 1sg9A-1v4nA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1v4n 271AA LONG
HYPOTHETICAL
5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE
(Sulfurisphaera
tokodaii) 		5 / 10 GLY A  95
PHE A 171
GLY A 190
MET A 191
THR A 214
 None
 0.38A 1v3qE-1v4nA:
25.1		 1v3qE-1v4nA:
26.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 1v4n 271AA LONG
HYPOTHETICAL
5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE
(Sulfurisphaera
tokodaii) 		5 / 12 ALA A  93
GLY A  95
GLY A 190
MET A 191
VAL A 229
 None
 0.39A 3f8wA-1v4nA:
26.4		 3f8wA-1v4nA:
26.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 1v4n 271AA LONG
HYPOTHETICAL
5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE
(Sulfurisphaera
tokodaii) 		5 / 12 ALA A  93
GLY A  95
GLY A 190
MET A 191
VAL A 229
 None
 0.34A 3f8wC-1v4nA:
26.5		 3f8wC-1v4nA:
26.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 1v4n 271AA LONG
HYPOTHETICAL
5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE
(Sulfurisphaera
tokodaii) 		5 / 12 HIS A  60
ALA A  93
GLY A  95
GLY A 190
VAL A 229
 None
 0.99A 3f8wC-1v4nA:
26.5		 3f8wC-1v4nA:
26.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK2_X_LDPX433_1
(6-HYDROXY-L-NICOTINE
OXIDASE)		 1v4n 271AA LONG
HYPOTHETICAL
5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE
(Sulfurisphaera
tokodaii) 		4 / 7 TYR A 245
LEU A 142
LEU A 244
PHE A  56
 None
 1.19A 3nk2X-1v4nA:
undetectable		 3nk2X-1v4nA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOV_A_KOVA204_1
(UNCHARACTERIZED
PROTEIN)		 1v4n 271AA LONG
HYPOTHETICAL
5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE
(Sulfurisphaera
tokodaii) 		5 / 12 PRO A 137
GLY A 161
ILE A 188
PHE A 112
LEU A 193
 None
 1.47A 4kovA-1v4nA:
undetectable		 4kovA-1v4nA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LZR_A_LOCA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1v4n 271AA LONG
HYPOTHETICAL
5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE
(Sulfurisphaera
tokodaii) 		4 / 8 LEU A  49
LEU A  25
TYR A  20
ILE A  13
 None
 0.90A 4lzrA-1v4nA:
undetectable		 4lzrA-1v4nA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_E_ACTE403_0
(PROTON-GATED ION
CHANNEL)		 1v4n 271AA LONG
HYPOTHETICAL
5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE
(Sulfurisphaera
tokodaii) 		3 / 3 ARG A  59
TYR A 207
GLU A 196
 None
 0.48A 4zzbE-1v4nA:
undetectable		 4zzbE-1v4nA:
23.15