SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1v4p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_0
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 1v4p ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 ASP A  47
LEU A 144
ALA A  27
ARG A  48
ILE A  43
 None
 1.18A 2ejtA-1v4pA:
undetectable		 2ejtA-1v4pA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0P_A_ADNA1607_1
(ALCALIGIN
BIOSYNTHESIS PROTEIN)		 1v4p ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 8 GLY A  40
ILE A  43
ALA A  11
HIS A   9
 None
None
None
ZN  A1001 (-3.2A)
 0.90A 2x0pA-1v4pA:
undetectable		 2x0pA-1v4pA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_2
(PROTEASE)		 1v4p ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		3 / 3 ARG A 133
VAL A  35
THR A   8
 None
 0.80A 3ndtA-1v4pA:
undetectable		 3ndtA-1v4pA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_D_C2FD1200_0
(GLYCINE
N-METHYLTRANSFERASE)		 1v4p ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 HIS A 147
LEU A  12
HIS A  13
THR A   8
TYR A  34
 None
None
ZN  A1001 (-3.2A)
None
None
 1.37A 3thrA-1v4pA:
0.0
3thrB-1v4pA:
0.0
3thrC-1v4pA:
undetectable
3thrD-1v4pA:
0.0		 3thrA-1v4pA:
18.31
3thrB-1v4pA:
18.31
3thrC-1v4pA:
18.31
3thrD-1v4pA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6V_E_RBFE201_1
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E)		 1v4p ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 5 HIS A 147
VAL A 135
GLU A 145
VAL A  41
 None
 1.18A 4p6vB-1v4pA:
undetectable
4p6vE-1v4pA:
0.7		 4p6vB-1v4pA:
17.00
4p6vE-1v4pA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XR4_B_AG2B511_1
(HOMOSPERMIDINE
SYNTHASE)		 1v4p ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		3 / 3 VAL A  44
PHE A 137
ARG A  48
 None
 0.84A 4xr4B-1v4pA:
undetectable		 4xr4B-1v4pA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_B_AG2B501_1
(ARGININE/AGMATINE
ANTIPORTER)		 1v4p ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 6 ILE A  43
GLY A  17
ASN A 112
ILE A 146
 None
 0.84A 5j4nB-1v4pA:
undetectable		 5j4nB-1v4pA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_1
(PROTEASE)		 1v4p ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 ALA A  18
GLY A  24
LEU A  42
PRO A  50
ILE A  58
 None
 1.08A 6dgxB-1v4pA:
undetectable		 6dgxB-1v4pA:
20.62