SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1v4u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TBF_A_VIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1v4u HEMOGLOBIN BETA
CHAIN
(Thunnus
thynnus) 		5 / 9 LEU B  68
LEU B 110
VAL B 137
ALA B 140
LEU B  88
 None
None
None
None
HEM  B 147 (-4.9A)
 1.11A 1tbfA-1v4uB:
undetectable		 1tbfA-1v4uB:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1v4u HEMOGLOBIN BETA
CHAIN
(Thunnus
thynnus) 		3 / 3 GLU B  83
GLU B  87
LEU B 141
 None
None
HEM  B 147 (-4.9A)
 0.74A 1v8bB-1v4uB:
undetectable		 1v8bB-1v4uB:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		 1v4u HEMOGLOBIN ALPHA
CHAIN
HEMOGLOBIN BETA
CHAIN
(Thunnus
thynnus) 		5 / 12 HIS A 124
HIS A 105
VAL B  67
LEU B 110
THR B 111
 None
None
HEM  B 147 (-3.8A)
None
None
 1.14A 1z9yA-1v4uA:
undetectable		 1z9yA-1v4uA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)		 1v4u HEMOGLOBIN ALPHA
CHAIN
(Thunnus
thynnus) 		5 / 12 SER A 104
ILE A 107
PHE A 130
ALA A 132
ALA A 139
 HEM  A 144 ( 4.9A)
None
None
None
None
 1.12A 2j0dA-1v4uA:
undetectable		 2j0dA-1v4uA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)		 1v4u HEMOGLOBIN ALPHA
CHAIN
(Thunnus
thynnus) 		4 / 8 ILE A  25
LEU A  14
VAL A  11
LEU A 127
 None
 0.88A 2w98B-1v4uA:
undetectable		 2w98B-1v4uA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 1v4u HEMOGLOBIN BETA
CHAIN
(Thunnus
thynnus) 		5 / 10 LEU B 134
LEU B  71
VAL B  75
ILE B 114
LEU B  18
 None
HEM  B 147 ( 4.7A)
None
None
None
 1.12A 3jw5B-1v4uB:
undetectable		 3jw5B-1v4uB:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 1v4u HEMOGLOBIN ALPHA
CHAIN
(Thunnus
thynnus) 		5 / 8 GLY A  66
GLY A  67
GLY A  26
ILE A 107
LEU A 103
 None
HEM  A 144 ( 4.2A)
None
None
HEM  A 144 (-4.4A)
 1.42A 3v1nA-1v4uA:
undetectable		 3v1nA-1v4uA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_C_NCTC501_1
(CYTOCHROME P450 2A13)		 1v4u HEMOGLOBIN BETA
CHAIN
(Thunnus
thynnus) 		4 / 7 PHE B 130
PHE B 122
LEU B  68
LEU B  18
 None
 0.89A 4ejgC-1v4uB:
undetectable		 4ejgC-1v4uB:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_B_LURB201_1
(TRANSTHYRETIN)		 1v4u HEMOGLOBIN BETA
CHAIN
(Thunnus
thynnus) 		4 / 8 GLU B  83
ALA B 140
LEU B  88
VAL B 136
 None
None
HEM  B 147 (-4.9A)
None
 0.94A 4iizB-1v4uB:
undetectable		 4iizB-1v4uB:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 1v4u HEMOGLOBIN ALPHA
CHAIN
(Thunnus
thynnus) 		3 / 3 HIS A 105
VAL A  68
LEU A 131
 None
 0.77A 4m2vA-1v4uA:
undetectable		 4m2vA-1v4uA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 1v4u HEMOGLOBIN ALPHA
CHAIN
(Thunnus
thynnus) 		5 / 12 VAL A  64
PHE A 130
VAL A 111
LEU A 131
VAL A 134
 HEM  A 144 (-3.8A)
None
None
None
None
 1.06A 5tudD-1v4uA:
2.3		 5tudD-1v4uA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 1v4u HEMOGLOBIN ALPHA
CHAIN
(Thunnus
thynnus) 		3 / 3 LYS A  12
LEU A  78
ASP A  76
 None
 0.84A 5zv2A-1v4uA:
undetectable		 5zv2A-1v4uA:
20.15