SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1v4v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1503_0
(FERROCHELATASE)		 1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Thermus
thermophilus) 		3 / 3 LEU A 191
PRO A 192
LEU A 195
 None
 0.54A 1hrkA-1v4vA:
2.4		 1hrkA-1v4vA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		 1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Thermus
thermophilus) 		3 / 3 ASP A 148
PHE A 151
VAL A 361
 None
 0.72A 1kijB-1v4vA:
undetectable		 1kijB-1v4vA:
26.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_D_SAMD200_0
(METHIONINE REPRESSOR)		 1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Thermus
thermophilus) 		5 / 12 ALA A 358
GLY A 360
ALA A  27
LEU A  28
PRO A  36
 None
 1.06A 1mjqC-1v4vA:
undetectable
1mjqD-1v4vA:
undetectable		 1mjqC-1v4vA:
14.29
1mjqD-1v4vA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_J_SAMJ200_0
(METHIONINE REPRESSOR)		 1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Thermus
thermophilus) 		5 / 12 ALA A 358
GLY A 360
ALA A  27
LEU A  28
PRO A  36
 None
 1.06A 1mjqI-1v4vA:
undetectable
1mjqJ-1v4vA:
undetectable		 1mjqI-1v4vA:
14.29
1mjqJ-1v4vA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_0
(VITAMIN D3 RECEPTOR)		 1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Thermus
thermophilus) 		5 / 12 LEU A 331
LEU A 316
VAL A 324
LEU A 221
LEU A 217
 None
 1.17A 1s19A-1v4vA:
undetectable		 1s19A-1v4vA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KUH_A_HLTA150_1
(CALMODULIN)		 1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Thermus
thermophilus) 		4 / 6 LEU A  39
MET A  90
LEU A  37
GLU A  59
 None
 1.15A 2kuhA-1v4vA:
0.0		 2kuhA-1v4vA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Thermus
thermophilus) 		4 / 5 LEU A 156
VAL A  24
LEU A  96
ARG A 359
 None
 1.06A 2oiqA-1v4vA:
undetectable		 2oiqA-1v4vA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		 1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Thermus
thermophilus) 		3 / 3 LEU A 146
LEU A  87
PHE A 105
 None
 0.63A 2pgrA-1v4vA:
undetectable		 2pgrA-1v4vA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_A_RBFA200_1
(DODECIN)		 1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Thermus
thermophilus) 		4 / 8 ARG A  45
GLN A  67
ARG A  78
GLN A  82
 None
 1.21A 2vxaA-1v4vA:
undetectable
2vxaC-1v4vA:
undetectable
2vxaE-1v4vA:
undetectable		 2vxaA-1v4vA:
10.90
2vxaC-1v4vA:
10.90
2vxaE-1v4vA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_B_RBFB200_1
(DODECIN)		 1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Thermus
thermophilus) 		4 / 8 GLN A  67
ARG A  45
ARG A  78
GLN A  82
 None
 1.18A 2vxaA-1v4vA:
undetectable
2vxaB-1v4vA:
undetectable
2vxaK-1v4vA:
undetectable		 2vxaA-1v4vA:
10.90
2vxaB-1v4vA:
10.90
2vxaK-1v4vA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_C_RBFC200_1
(DODECIN)		 1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Thermus
thermophilus) 		4 / 8 GLN A  67
ARG A  45
ARG A  78
GLN A  82
 None
 1.21A 2vxaB-1v4vA:
undetectable
2vxaC-1v4vA:
undetectable
2vxaG-1v4vA:
undetectable		 2vxaB-1v4vA:
10.90
2vxaC-1v4vA:
10.90
2vxaG-1v4vA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_D_RBFD200_1
(DODECIN)		 1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Thermus
thermophilus) 		4 / 8 ARG A  45
GLN A  67
ARG A  78
GLN A  82
 None
 1.24A 2vxaD-1v4vA:
undetectable
2vxaF-1v4vA:
undetectable
2vxaI-1v4vA:
undetectable		 2vxaD-1v4vA:
10.90
2vxaF-1v4vA:
10.90
2vxaI-1v4vA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_E_RBFE200_1
(DODECIN)		 1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Thermus
thermophilus) 		4 / 8 GLN A  67
ARG A  45
ARG A  78
GLN A  82
 None
 1.19A 2vxaD-1v4vA:
undetectable
2vxaE-1v4vA:
undetectable
2vxaL-1v4vA:
undetectable		 2vxaD-1v4vA:
10.90
2vxaE-1v4vA:
10.90
2vxaL-1v4vA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_G_RBFG200_1
(DODECIN)		 1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Thermus
thermophilus) 		4 / 8 ARG A  78
GLN A  82
ARG A  45
GLN A  67
 None
 1.19A 2vxaF-1v4vA:
undetectable
2vxaG-1v4vA:
undetectable
2vxaI-1v4vA:
undetectable		 2vxaF-1v4vA:
10.90
2vxaG-1v4vA:
10.90
2vxaI-1v4vA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_H_RBFH200_1
(DODECIN)		 1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Thermus
thermophilus) 		4 / 8 ARG A  78
GLN A  82
GLN A  67
ARG A  45
 None
 1.21A 2vxaB-1v4vA:
0.0
2vxaG-1v4vA:
0.0
2vxaH-1v4vA:
0.0		 2vxaB-1v4vA:
10.90
2vxaG-1v4vA:
10.90
2vxaH-1v4vA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_I_RBFI200_1
(DODECIN)		 1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Thermus
thermophilus) 		4 / 8 GLN A  67
ARG A  45
ARG A  78
GLN A  82
 None
 1.17A 2vxaH-1v4vA:
undetectable
2vxaI-1v4vA:
undetectable
2vxaJ-1v4vA:
undetectable		 2vxaH-1v4vA:
10.90
2vxaI-1v4vA:
10.90
2vxaJ-1v4vA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_J_RBFJ200_1
(DODECIN)		 1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Thermus
thermophilus) 		4 / 8 ARG A  78
GLN A  82
ARG A  45
GLN A  67
 None
 1.20A 2vxaD-1v4vA:
undetectable
2vxaJ-1v4vA:
undetectable
2vxaL-1v4vA:
undetectable		 2vxaD-1v4vA:
10.90
2vxaJ-1v4vA:
10.90
2vxaL-1v4vA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_K_RBFK200_1
(DODECIN)		 1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Thermus
thermophilus) 		4 / 8 ARG A  78
GLN A  82
GLN A  67
ARG A  45
 None
 1.19A 2vxaH-1v4vA:
undetectable
2vxaJ-1v4vA:
undetectable
2vxaK-1v4vA:
undetectable		 2vxaH-1v4vA:
10.90
2vxaJ-1v4vA:
10.90
2vxaK-1v4vA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_L_RBFL200_1
(DODECIN)		 1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Thermus
thermophilus) 		4 / 8 ARG A  78
GLN A  82
GLN A  67
ARG A  45
 None
 1.19A 2vxaA-1v4vA:
undetectable
2vxaK-1v4vA:
undetectable
2vxaL-1v4vA:
undetectable		 2vxaA-1v4vA:
10.90
2vxaK-1v4vA:
10.90
2vxaL-1v4vA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_A_SAMA300_0
(PUTATIVE RRNA
METHYLASE)		 1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Thermus
thermophilus) 		5 / 12 GLY A 119
ASP A 144
ILE A 116
GLY A 115
LEU A  96
 None
 0.94A 3eeyA-1v4vA:
4.3		 3eeyA-1v4vA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_B_SAMB300_0
(PUTATIVE RRNA
METHYLASE)		 1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Thermus
thermophilus) 		5 / 12 GLY A 119
ASP A 144
ILE A 116
GLY A 115
LEU A  96
 None
 0.95A 3eeyB-1v4vA:
4.3		 3eeyB-1v4vA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_0
(PUTATIVE RRNA
METHYLASE)		 1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Thermus
thermophilus) 		5 / 12 GLY A 119
ASP A 144
ILE A 116
GLY A 115
LEU A  96
 None
 0.95A 3eeyC-1v4vA:
4.0		 3eeyC-1v4vA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_0
(PUTATIVE RRNA
METHYLASE)		 1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Thermus
thermophilus) 		5 / 12 GLY A 119
ASP A 144
ILE A 116
GLY A 115
LEU A  96
 None
 0.97A 3eeyD-1v4vA:
4.1		 3eeyD-1v4vA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_0
(PUTATIVE RRNA
METHYLASE)		 1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Thermus
thermophilus) 		5 / 12 GLY A 119
ASP A 144
ILE A 116
GLY A 115
LEU A  96
 None
 1.00A 3eeyE-1v4vA:
4.3		 3eeyE-1v4vA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_F_SAMF300_0
(PUTATIVE RRNA
METHYLASE)		 1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Thermus
thermophilus) 		5 / 12 GLY A 119
ASP A 144
ILE A 116
GLY A 115
LEU A  96
 None
 1.10A 3eeyF-1v4vA:
4.2		 3eeyF-1v4vA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_H_SAMH300_0
(PUTATIVE RRNA
METHYLASE)		 1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Thermus
thermophilus) 		5 / 12 GLY A 119
ASP A 144
ILE A 116
GLY A 115
LEU A  96
 None
 1.02A 3eeyH-1v4vA:
5.2		 3eeyH-1v4vA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_I_SAMI300_0
(PUTATIVE RRNA
METHYLASE)		 1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Thermus
thermophilus) 		5 / 12 GLY A 119
ASP A 144
ILE A 116
GLY A 115
LEU A  96
 None
 0.97A 3eeyI-1v4vA:
4.0		 3eeyI-1v4vA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_J_SAMJ300_0
(PUTATIVE RRNA
METHYLASE)		 1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Thermus
thermophilus) 		5 / 12 GLY A 119
ASP A 144
ILE A 116
GLY A 115
LEU A  96
 None
 1.02A 3eeyJ-1v4vA:
4.0		 3eeyJ-1v4vA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Thermus
thermophilus) 		4 / 5 PRO A  23
VAL A  24
THR A 101
GLY A  99
 None
 1.12A 3elzB-1v4vA:
undetectable		 3elzB-1v4vA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_1
(PUTATIVE REGULATORY
PROTEIN)		 1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Thermus
thermophilus) 		3 / 3 TYR A 348
MET A 268
LEU A 278
 GOL  A1500 (-3.9A)
None
None
 0.87A 3vw1D-1v4vA:
0.0		 3vw1D-1v4vA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Thermus
thermophilus) 		5 / 12 VAL A 294
LEU A 314
VAL A 327
LEU A 299
VAL A 324
 None
 1.14A 3w68B-1v4vA:
undetectable		 3w68B-1v4vA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_C_SAMC800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Thermus
thermophilus) 		5 / 11 ILE A 313
ALA A 290
GLY A 289
GLU A 288
GLY A 351
 None
None
None
GOL  A1500 (-4.9A)
None
 1.09A 4e47C-1v4vA:
undetectable		 4e47C-1v4vA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Thermus
thermophilus) 		5 / 11 ILE A 313
ALA A 290
GLY A 289
GLU A 288
GLY A 351
 None
None
None
GOL  A1500 (-4.9A)
None
 1.13A 4jdsA-1v4vA:
undetectable		 4jdsA-1v4vA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Thermus
thermophilus) 		5 / 11 ILE A 313
ALA A 290
GLY A 289
GLU A 288
GLY A 351
 None
None
None
GOL  A1500 (-4.9A)
None
 1.13A 4jdsB-1v4vA:
undetectable		 4jdsB-1v4vA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_C_SAMC401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Thermus
thermophilus) 		5 / 11 ILE A 313
ALA A 290
GLY A 289
GLU A 288
GLY A 351
 None
None
None
GOL  A1500 (-4.9A)
None
 1.11A 4jdsC-1v4vA:
undetectable		 4jdsC-1v4vA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)		 1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Thermus
thermophilus) 		4 / 7 VAL A 297
ALA A 317
LEU A 338
LEU A 221
 None
 0.79A 4l9iA-1v4vA:
undetectable		 4l9iA-1v4vA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		 1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Thermus
thermophilus) 		4 / 6 GLU A 122
ASP A 150
ASP A 144
GLU A 164
 None
 1.35A 4ntxA-1v4vA:
undetectable
4ntxC-1v4vA:
0.0		 4ntxA-1v4vA:
22.20
4ntxC-1v4vA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Thermus
thermophilus) 		4 / 8 THR A 177
GLU A  17
VAL A  38
LEU A  10
 None
 1.01A 4r38B-1v4vA:
undetectable		 4r38B-1v4vA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Thermus
thermophilus) 		5 / 11 ILE A 313
ALA A 290
GLY A 289
GLU A 288
GLY A 351
 None
None
None
GOL  A1500 (-4.9A)
None
 1.13A 5ayfA-1v4vA:
undetectable		 5ayfA-1v4vA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Thermus
thermophilus) 		3 / 3 ALA A 157
ASN A 160
LEU A 161
 None
 0.40A 5i1nB-1v4vA:
undetectable		 5i1nB-1v4vA:
7.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_H_DVAH9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Thermus
thermophilus) 		3 / 3 ALA A 157
ASN A 160
LEU A 161
 None
 0.46A 5i1oA-1v4vA:
undetectable		 5i1oA-1v4vA:
7.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFP_A_8W5A804_2
(GLUCOCORTICOID
RECEPTOR)		 1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Thermus
thermophilus) 		4 / 4 LEU A 292
MET A 268
ILE A 313
LEU A 278
 None
 1.36A 5nfpA-1v4vA:
undetectable		 5nfpA-1v4vA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_B_SAMB501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Thermus
thermophilus) 		5 / 9 LEU A  34
PRO A  36
ILE A  31
GLY A  30
ALA A 358
 None
 0.81A 5o96A-1v4vA:
3.9
5o96B-1v4vA:
3.6		 5o96A-1v4vA:
22.11
5o96B-1v4vA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_1
(RIBOFLAVIN LYASE)		 1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Thermus
thermophilus) 		5 / 12 ALA A 291
GLY A 284
GLY A 312
ALA A 344
VAL A 296
 GOL  A1500 ( 4.6A)
None
None
None
None
 0.99A 5w4zB-1v4vA:
0.7		 5w4zB-1v4vA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Thermus
thermophilus) 		5 / 12 ALA A  18
GLY A  42
ALA A  22
TYR A 265
PHE A  55
 None
 1.23A 5zvgA-1v4vA:
3.5		 5zvgA-1v4vA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Thermus
thermophilus) 		5 / 12 ALA A  18
GLY A  42
ALA A  22
TYR A 265
PHE A  55
 None
 1.21A 5zvgB-1v4vA:
undetectable		 5zvgB-1v4vA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_1
(PROTEASE)		 1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE
(Thermus
thermophilus) 		5 / 12 VAL A   9
ILE A  79
LEU A  37
VAL A  97
VAL A  95
 None
 1.01A 6dh0B-1v4vA:
undetectable		 6dh0B-1v4vA:
14.37