SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1v59'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_2
(PROTEIN (HIV-1
PROTEASE))		 1v59 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 105
ALA A  21
GLY A 340
ILE A 341
 None
 0.73A 1d4sB-1v59A:
undetectable		 1d4sB-1v59A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1v59 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 324
VAL A 322
ALA A 333
GLY A  12
LEU A  45
 FAD  A 480 (-3.2A)
None
FAD  A 480 (-3.4A)
FAD  A 480 (-3.1A)
None
 1.01A 1kiaC-1v59A:
2.7		 1kiaC-1v59A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1v59 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 8 GLU A 295
ASP A 122
ILE A 297
ILE A 320
 None
 0.87A 1p7lD-1v59A:
undetectable		 1p7lD-1v59A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1v59 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 8 GLU A 295
ASP A 122
ILE A 297
ILE A 320
 None
 0.88A 1p7lC-1v59A:
undetectable		 1p7lC-1v59A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1v59 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 8 GLU A 295
ASP A 122
ILE A 297
ILE A 320
 None
 0.86A 1rg9B-1v59A:
undetectable		 1rg9B-1v59A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1v59 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 8 GLU A 295
ASP A 122
ILE A 297
ILE A 320
 None
 0.88A 1rg9A-1v59A:
undetectable		 1rg9A-1v59A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1v59 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 8 GLU A 295
ASP A 122
ILE A 297
ILE A 320
 None
 0.87A 1rg9D-1v59A:
undetectable		 1rg9D-1v59A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1v59 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 8 GLU A 295
ASP A 122
ILE A 297
ILE A 320
 None
 0.87A 1rg9C-1v59A:
undetectable		 1rg9C-1v59A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_0
(HEMK PROTEIN)		 1v59 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 425
ILE A 411
VAL A 362
SER A 361
GLU A 368
 None
 1.17A 1sg9A-1v59A:
3.3		 1sg9A-1v59A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_1
(POL POLYPROTEIN)		 1v59 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		5 / 8 ALA A  21
GLY A  13
GLY A  12
ILE A  11
ALA A 343
 None
FAD  A 480 ( 4.8A)
FAD  A 480 (-3.1A)
None
None
 1.23A 1sguA-1v59A:
undetectable		 1sguA-1v59A:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VID_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 1v59 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 5 SER A  59
GLU A 197
TYR A 364
SER A 173
 None
FAD  A 480 ( 4.8A)
FAD  A 480 (-4.4A)
FAD  A 480 (-3.9A)
 1.15A 1vidA-1v59A:
3.2		 1vidA-1v59A:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_B_SAMB1217_1
(CATECHOL
O-METHYLTRANSFERASE)		 1v59 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 6 SER A  59
GLU A 197
TYR A 364
SER A 173
 None
FAD  A 480 ( 4.8A)
FAD  A 480 (-4.4A)
FAD  A 480 (-3.9A)
 1.17A 2cl5B-1v59A:
2.9		 2cl5B-1v59A:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 1v59 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 193
GLY A 192
GLY A 190
ILE A 218
ALA A 220
 None
NAD  A 482 (-3.5A)
NAD  A 482 (-3.0A)
None
NAD  A 482 ( 3.7A)
 0.71A 2fk8A-1v59A:
2.7		 2fk8A-1v59A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)		 1v59 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 105
ALA A  21
GLY A 340
ILE A 341
 None
 0.80A 3spkB-1v59A:
undetectable		 3spkB-1v59A:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		 1v59 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 163
ILE A 261
THR A 245
VAL A 283
 None
None
None
NAD  A 482 (-4.0A)
 0.86A 3ua5A-1v59A:
undetectable		 3ua5A-1v59A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 1v59 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 105
ILE A  22
GLY A  17
ILE A 341
ALA A 342
 None
 1.00A 3uwlB-1v59A:
undetectable		 3uwlB-1v59A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 1v59 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		5 / 8 GLY A 190
GLY A 191
GLY A 199
LEU A 234
VAL A 209
 NAD  A 482 (-3.0A)
NAD  A 482 ( 4.6A)
None
None
None
 1.27A 3v1nA-1v59A:
undetectable		 3v1nA-1v59A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 1v59 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 5 LEU A  56
LEU A  55
LEU A 205
SER A 203
 None
 0.95A 3vhuA-1v59A:
0.0		 3vhuA-1v59A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_A_ACTA1002_0
(PUTATIVE
OXIDOREDUCTASE)		 1v59 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 6 GLY A 224
VAL A 226
ASP A 223
THR A 375
 None
 0.94A 3vqrA-1v59A:
11.1		 3vqrA-1v59A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_B_ACTB1002_0
(PUTATIVE
OXIDOREDUCTASE)		 1v59 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 5 GLY A 224
VAL A 226
ASP A 223
THR A 375
 None
 0.92A 3vqrB-1v59A:
13.0		 3vqrB-1v59A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1v59 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 8 GLU A 295
ASP A 122
ILE A 297
ILE A 320
 None
 0.93A 4ndnB-1v59A:
undetectable		 4ndnB-1v59A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_0
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 1v59 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  17
ALA A  20
PHE A 313
ALA A 342
VAL A 354
 None
 1.02A 4ryaA-1v59A:
undetectable		 4ryaA-1v59A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1v59 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 7 ILE A  10
GLU A  35
GLY A  14
GLY A  17
 None
FAD  A 480 (-2.5A)
FAD  A 480 (-3.4A)
None
 0.83A 5a06A-1v59A:
undetectable		 5a06A-1v59A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1v59 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 7 ILE A  10
GLU A  35
GLY A  14
GLY A  17
 None
FAD  A 480 (-2.5A)
FAD  A 480 (-3.4A)
None
 0.81A 5a06C-1v59A:
undetectable		 5a06C-1v59A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1v59 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 7 ILE A  10
GLU A  35
GLY A  14
GLY A  17
 None
FAD  A 480 (-2.5A)
FAD  A 480 (-3.4A)
None
 0.84A 5a06E-1v59A:
undetectable		 5a06E-1v59A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1v59 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 7 ILE A  10
GLU A  35
GLY A  14
GLY A  17
 None
FAD  A 480 (-2.5A)
FAD  A 480 (-3.4A)
None
 0.83A 5a06F-1v59A:
undetectable		 5a06F-1v59A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 1v59 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 5 SER A  59
GLU A 197
TYR A 364
SER A 173
 None
FAD  A 480 ( 4.8A)
FAD  A 480 (-4.4A)
FAD  A 480 (-3.9A)
 1.18A 5fhrA-1v59A:
3.2		 5fhrA-1v59A:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 1v59 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 105
ILE A  22
GLY A  17
ILE A 341
ALA A 342
 None
 0.98A 5j7wC-1v59A:
undetectable		 5j7wC-1v59A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_B_FLPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1v59 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		5 / 12 SER A  52
GLY A 175
ALA A 176
SER A 172
LEU A 280
 FAD  A 480 ( 3.7A)
None
None
None
None
 1.11A 5jvzB-1v59A:
undetectable		 5jvzB-1v59A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_A_BEZA507_0
(BETA-LACTAMASE VIM-2)		 1v59 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		3 / 3 THR A 124
HIS A 319
ASN A 148
 None
 0.82A 5n4tA-1v59A:
undetectable		 5n4tA-1v59A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJY_A_BEZA304_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 1v59 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		3 / 3 MET A 331
GLU A 156
ARG A 285
 None
None
FAD  A 480 (-3.8A)
 1.10A 5tjyA-1v59A:
undetectable		 5tjyA-1v59A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJZ_A_BEZA302_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 1v59 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		3 / 3 MET A 331
GLU A 156
ARG A 285
 None
None
FAD  A 480 (-3.8A)
 1.11A 5tjzA-1v59A:
4.1		 5tjzA-1v59A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 1v59 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 106
ALA A 152
GLY A  13
GLY A  41
ILE A 102
 None
None
FAD  A 480 ( 4.8A)
None
None
 1.17A 5ul4A-1v59A:
undetectable		 5ul4A-1v59A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		 1v59 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		3 / 3 TRP A 371
ILE A 193
GLU A 368
 None
 0.81A 6hcxA-1v59A:
undetectable		 6hcxA-1v59A:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 1v59 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 105
ILE A  22
GLY A  17
ILE A 341
ALA A 342
 None
 1.00A 6qxsD-1v59A:
undetectable		 6qxsD-1v59A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 1v59 DIHYDROLIPOAMIDE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 105
ILE A  22
GLY A  17
ILE A 341
ALA A 342
 None
 0.99A 6qyaD-1v59A:
undetectable		 6qyaD-1v59A:
21.29