SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1v5b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3003_1
(SERUM ALBUMIN)		 1v5b 3-ISOPROPYLMALATE
DEHYDROGENASE
(Bacillus
coagulans) 		4 / 6 PHE A 272
LYS A   4
ALA A  68
MET A 303
 None
 1.15A 1hk2A-1v5bA:
undetectable		 1hk2A-1v5bA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9J_H_TESH1010_1
(RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT HEAVY
CHAIN
RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT LIGHT
CHAIN)		 1v5b 3-ISOPROPYLMALATE
DEHYDROGENASE
(Bacillus
coagulans) 		5 / 11 SER A 196
SER A 197
GLY A 139
LEU A 160
VAL A 221
 None
 1.38A 1i9jH-1v5bA:
undetectable
1i9jL-1v5bA:
undetectable		 1i9jH-1v5bA:
20.27
1i9jL-1v5bA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_B_MTXB352_1
(PTERIDINE REDUCTASE
1)		 1v5b 3-ISOPROPYLMALATE
DEHYDROGENASE
(Bacillus
coagulans) 		5 / 12 ASP A 236
LEU A 177
LEU A 105
PRO A 107
TYR A 306
 None
 1.47A 1p33B-1v5bA:
undetectable		 1p33B-1v5bA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_C_MTXC353_1
(PTERIDINE REDUCTASE
1)		 1v5b 3-ISOPROPYLMALATE
DEHYDROGENASE
(Bacillus
coagulans) 		5 / 12 ASP A 236
LEU A 177
LEU A 105
PRO A 107
TYR A 306
 None
 1.50A 1p33C-1v5bA:
3.6		 1p33C-1v5bA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB504_1
(YKOF)		 1v5b 3-ISOPROPYLMALATE
DEHYDROGENASE
(Bacillus
coagulans) 		4 / 6 PRO A 107
PHE A 308
LEU A 304
SER A 307
 None
 1.00A 1sbrA-1v5bA:
undetectable
1sbrB-1v5bA:
undetectable		 1sbrA-1v5bA:
19.58
1sbrB-1v5bA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))		 1v5b 3-ISOPROPYLMALATE
DEHYDROGENASE
(Bacillus
coagulans) 		5 / 12 SER A 196
SER A 197
GLY A 139
LEU A 160
VAL A 221
 None
 1.27A 1vpoH-1v5bA:
undetectable
1vpoL-1v5bA:
undetectable		 1vpoH-1v5bA:
19.95
1vpoL-1v5bA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2888_0
(AMINOMETHYLTRANSFERA
SE)		 1v5b 3-ISOPROPYLMALATE
DEHYDROGENASE
(Bacillus
coagulans) 		5 / 10 LEU A 325
GLU A  16
ILE A  13
LEU A 294
MET A 261
 None
 1.03A 1wopA-1v5bA:
0.0		 1wopA-1v5bA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_B_P1ZB2001_1
(SERUM ALBUMIN)		 1v5b 3-ISOPROPYLMALATE
DEHYDROGENASE
(Bacillus
coagulans) 		5 / 9 GLU A  58
LEU A  71
LEU A  95
ALA A  47
ALA A  41
 None
 1.11A 2bxcB-1v5bA:
undetectable		 2bxcB-1v5bA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 1v5b 3-ISOPROPYLMALATE
DEHYDROGENASE
(Bacillus
coagulans) 		3 / 3 ALA A  21
THR A 296
PHE A  38
 None
 0.78A 2c6nB-1v5bA:
undetectable		 2c6nB-1v5bA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W13_A_ACTA1208_0
(ZINC
METALLOPROTEINASE
BAP1)		 1v5b 3-ISOPROPYLMALATE
DEHYDROGENASE
(Bacillus
coagulans) 		4 / 4 THR A 240
ARG A 134
GLU A 241
ASN A 242
 None
 1.25A 2w13A-1v5bA:
4.4		 2w13A-1v5bA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1v5b 3-ISOPROPYLMALATE
DEHYDROGENASE
(Bacillus
coagulans) 		5 / 12 ILE A 167
GLU A 241
SER A 266
ALA A 265
ILE A 170
 None
 1.20A 2xkwB-1v5bA:
undetectable		 2xkwB-1v5bA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_A_MIYA2001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1v5b 3-ISOPROPYLMALATE
DEHYDROGENASE
(Bacillus
coagulans) 		4 / 8 SER A 266
GLY A  91
ILE A  43
ALA A  47
 None
 0.89A 3aodA-1v5bA:
undetectable		 3aodA-1v5bA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 1v5b 3-ISOPROPYLMALATE
DEHYDROGENASE
(Bacillus
coagulans) 		4 / 8 ALA A  20
THR A 344
ILE A 345
THR A 348
 None
 0.75A 3bpxA-1v5bA:
undetectable
3bpxB-1v5bA:
undetectable		 3bpxA-1v5bA:
19.33
3bpxB-1v5bA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 1v5b 3-ISOPROPYLMALATE
DEHYDROGENASE
(Bacillus
coagulans) 		5 / 12 ALA A  73
PRO A  88
GLY A  44
GLY A  45
PRO A 277
 None
 0.98A 3m6vA-1v5bA:
undetectable		 3m6vA-1v5bA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 1v5b 3-ISOPROPYLMALATE
DEHYDROGENASE
(Bacillus
coagulans) 		5 / 12 ALA A  73
PRO A  88
GLY A  44
GLY A  45
PRO A 277
 None
 0.99A 3m6vB-1v5bA:
undetectable		 3m6vB-1v5bA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 1v5b 3-ISOPROPYLMALATE
DEHYDROGENASE
(Bacillus
coagulans) 		5 / 12 ALA A  73
PRO A  88
GLY A  44
GLY A  45
PRO A 277
 None
 0.99A 3m6wA-1v5bA:
undetectable		 3m6wA-1v5bA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1v5b 3-ISOPROPYLMALATE
DEHYDROGENASE
(Bacillus
coagulans) 		5 / 12 HIS A 279
GLY A 295
GLY A  72
ALA A 282
ASP A 284
 None
 1.10A 3sueC-1v5bA:
undetectable		 3sueC-1v5bA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1v5b 3-ISOPROPYLMALATE
DEHYDROGENASE
(Bacillus
coagulans) 		4 / 8 LEU A 251
LEU A 262
ILE A 229
VAL A 128
 None
 0.74A 4klaA-1v5bA:
undetectable		 4klaA-1v5bA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		 1v5b 3-ISOPROPYLMALATE
DEHYDROGENASE
(Bacillus
coagulans) 		4 / 4 ALA A  73
VAL A 278
GLY A 295
THR A 296
 None
 1.13A 4ubeA-1v5bA:
3.5		 4ubeA-1v5bA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 1v5b 3-ISOPROPYLMALATE
DEHYDROGENASE
(Bacillus
coagulans) 		5 / 9 LEU A 294
LEU A  25
SER A 299
LEU A 298
ILE A 317
 None
 1.09A 4ubsA-1v5bA:
undetectable		 4ubsA-1v5bA:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_A_ADNA301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 1v5b 3-ISOPROPYLMALATE
DEHYDROGENASE
(Bacillus
coagulans) 		5 / 9 LEU A 248
GLY A 245
SER A 187
VAL A 221
THR A 224
 None
 0.99A 4x3mA-1v5bA:
2.1		 4x3mA-1v5bA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1v5b 3-ISOPROPYLMALATE
DEHYDROGENASE
(Bacillus
coagulans) 		4 / 6 GLU A  89
GLY A  44
GLY A  45
ASP A  11
 None
 0.85A 5a06D-1v5bA:
undetectable		 5a06D-1v5bA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		 1v5b 3-ISOPROPYLMALATE
DEHYDROGENASE
(Bacillus
coagulans) 		4 / 7 PRO A  15
ILE A  22
PHE A  38
VAL A   7
 None
 0.78A 5bmvC-1v5bA:
undetectable		 5bmvC-1v5bA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_3
(PROTEASE)		 1v5b 3-ISOPROPYLMALATE
DEHYDROGENASE
(Bacillus
coagulans) 		3 / 3 ASP A 222
VAL A 188
LEU A 248
 None
 0.62A 5e5jB-1v5bA:
undetectable		 5e5jB-1v5bA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_B_CHDB401_0
(BILE SALT HYDROLASE)		 1v5b 3-ISOPROPYLMALATE
DEHYDROGENASE
(Bacillus
coagulans) 		5 / 10 LEU A  29
ILE A 352
LEU A 351
LEU A 298
ALA A 301
 None
 1.14A 5y7pB-1v5bA:
0.0		 5y7pB-1v5bA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_D_CHDD401_0
(BILE SALT HYDROLASE)		 1v5b 3-ISOPROPYLMALATE
DEHYDROGENASE
(Bacillus
coagulans) 		5 / 10 LEU A  29
ILE A 352
LEU A 351
LEU A 298
ALA A 301
 None
 1.18A 5y7pD-1v5bA:
0.0		 5y7pD-1v5bA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_H_CHDH401_0
(BILE SALT HYDROLASE)		 1v5b 3-ISOPROPYLMALATE
DEHYDROGENASE
(Bacillus
coagulans) 		5 / 10 LEU A  29
ILE A 352
LEU A 351
LEU A 298
ALA A 301
 None
 1.16A 5y7pH-1v5bA:
0.0		 5y7pH-1v5bA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_1
(CYTOCHROME P450 1A1)		 1v5b 3-ISOPROPYLMALATE
DEHYDROGENASE
(Bacillus
coagulans) 		3 / 3 SER A 299
SER A 264
ALA A  73
 None
 0.71A 6dwnC-1v5bA:
undetectable		 6dwnC-1v5bA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA604_0
(SERUM ALBUMIN)		 1v5b 3-ISOPROPYLMALATE
DEHYDROGENASE
(Bacillus
coagulans) 		4 / 8 ALA A 282
GLY A  14
ALA A 291
LYS A 290
 None
 0.76A 6mdqA-1v5bA:
undetectable		 6mdqA-1v5bA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_0
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 1v5b 3-ISOPROPYLMALATE
DEHYDROGENASE
(Bacillus
coagulans) 		5 / 12 VAL A 321
VAL A 324
ASP A  19
ASN A 292
ILE A 345
 None
 1.24A 6mxtA-1v5bA:
0.6		 6mxtA-1v5bA:
22.68