SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1v5f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Y_B_MK1B524_1
(PROTEIN (PROTEASE))		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 11 LEU A 276
ALA A 214
VAL A 236
GLY A 222
ILE A 212
 None
 0.86A 1c6yA-1v5fA:
undetectable		 1c6yA-1v5fA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Y_B_MK1B524_2
(PROTEIN (PROTEASE))		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.91A 1c6yB-1v5fA:
undetectable		 1c6yB-1v5fA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_1
(PROTEIN (PROTEASE))		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.94A 1c6zA-1v5fA:
undetectable		 1c6zA-1v5fA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_B_IPBB600_0
(ODORANT-BINDING
PROTEIN)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		4 / 4 ILE A 102
MET A  36
VAL A  51
GLY A 104
 None
 1.29A 1e06B-1v5fA:
undetectable		 1e06B-1v5fA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_2
(HIV-1 PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 9 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.91A 1hpvB-1v5fA:
undetectable		 1hpvB-1v5fA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_1
(HIV-1 PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 10 LEU A 276
ALA A 214
VAL A 236
GLY A 222
ILE A 212
 None
 0.85A 1hsgA-1v5fA:
undetectable		 1hsgA-1v5fA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_2
(HIV-1 PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.89A 1hsgB-1v5fA:
undetectable		 1hsgB-1v5fA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_D_D16D417_1
(THYMIDYLATE SYNTHASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ILE A  97
LEU A  89
LEU A  71
GLY A  72
ALA A 148
 None
 1.11A 1hvyD-1v5fA:
undetectable		 1hvyD-1v5fA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_3
(HIV-1 PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.89A 1hxbB-1v5fA:
undetectable		 1hxbB-1v5fA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_2
(HIV-1 PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 11 GLY A 390
ASP A 442
VAL A 466
GLY A 418
ILE A 419
 TPP  A1602 ( 3.9A)
MG  A1603 ( 2.8A)
None
None
None
 0.92A 1hxwB-1v5fA:
undetectable		 1hxwB-1v5fA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_C_NIOC225_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		4 / 6 SER A  77
PHE A  48
GLU A  54
GLY A  26
 None
 1.11A 1icuC-1v5fA:
undetectable
1icuD-1v5fA:
undetectable		 1icuC-1v5fA:
16.41
1icuD-1v5fA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_2
(POL POLYPROTEIN)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 GLY A 390
ASP A 442
VAL A 466
GLY A 418
ILE A 419
 TPP  A1602 ( 3.9A)
MG  A1603 ( 2.8A)
None
None
None
 0.98A 1k6cB-1v5fA:
undetectable		 1k6cB-1v5fA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ILE A 387
GLY A 423
ALA A  61
GLY A 418
LEU A  85
 None
 1.04A 1kiaC-1v5fA:
3.2		 1kiaC-1v5fA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVU_A_PRLA196_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		4 / 6 LEU A 550
GLU A 548
THR A 395
TYR A 565
 None
 1.45A 1qvuA-1v5fA:
1.2		 1qvuA-1v5fA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 10 ILE A 300
ALA A 214
LEU A 228
ILE A 298
THR A 218
 None
 1.26A 1rb3A-1v5fA:
undetectable		 1rb3A-1v5fA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ILE A 300
ALA A 214
LEU A 228
ILE A 298
THR A 218
 None
 1.12A 1re7A-1v5fA:
undetectable		 1re7A-1v5fA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_1
(PROTEASE RETROPEPSIN)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.88A 1rl8A-1v5fA:
undetectable		 1rl8A-1v5fA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.93A 1sdtB-1v5fA:
undetectable		 1sdtB-1v5fA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T3R_A_017A1200_2
(PROTEASE RETROPEPSIN)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 11 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.85A 1t3rB-1v5fA:
undetectable		 1t3rB-1v5fA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		3 / 3 PHE A 282
ARG A 409
ASN A 242
 FAD  A1601 (-4.1A)
None
None
 0.92A 1xzxX-1v5fA:
undetectable		 1xzxX-1v5fA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		4 / 7 THR A 448
VAL A 466
GLY A 441
THR A 393
 None
None
TPP  A1602 (-3.6A)
None
 0.96A 2a1mA-1v5fA:
undetectable		 2a1mA-1v5fA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQU_B_DR7B300_1
(HIV-1 PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 10 ALA A 324
ASP A 320
GLY A 279
VAL A 315
ILE A 317
 None
FAD  A1601 (-3.8A)
FAD  A1601 (-3.5A)
None
None
 0.99A 2aquA-1v5fA:
undetectable		 2aquA-1v5fA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_1
(POL POLYPROTEIN)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.87A 2avsA-1v5fA:
undetectable		 2avsA-1v5fA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_3
(POL POLYPROTEIN)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.89A 2avsB-1v5fA:
undetectable		 2avsB-1v5fA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 THR A 239
GLY A 217
GLY A 215
ASP A 303
ILE A 302
 FAD  A1601 (-2.8A)
FAD  A1601 (-3.4A)
FAD  A1601 (-2.9A)
None
FAD  A1601 (-3.9A)
 1.04A 2b25A-1v5fA:
undetectable		 2b25A-1v5fA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 THR A 239
SER A 280
GLY A 279
ASP A  91
ILE A  97
 FAD  A1601 (-2.8A)
FAD  A1601 (-2.6A)
FAD  A1601 (-3.5A)
None
None
 1.10A 2b25B-1v5fA:
undetectable		 2b25B-1v5fA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F81_A_017A302_1
(POL POLYPROTEIN)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 1.00A 2f81A-1v5fA:
undetectable		 2f81A-1v5fA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F81_A_017A302_2
(POL POLYPROTEIN)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.97A 2f81B-1v5fA:
undetectable		 2f81B-1v5fA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_1
(POL POLYPROTEIN)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.93A 2f8gA-1v5fA:
undetectable		 2f8gA-1v5fA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_2
(POL POLYPROTEIN)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		6 / 12 LEU A 276
GLY A 215
ALA A 214
VAL A 236
GLY A 222
ILE A 212
 None
FAD  A1601 (-2.9A)
None
None
None
None
 1.26A 2f8gB-1v5fA:
undetectable		 2f8gB-1v5fA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_1
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 11 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.97A 2idwA-1v5fA:
undetectable		 2idwA-1v5fA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_1
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		6 / 12 LEU A 276
GLY A 215
ALA A 214
VAL A 236
GLY A 222
ILE A 212
 None
FAD  A1601 (-2.9A)
None
None
None
None
 1.26A 2ienA-1v5fA:
undetectable		 2ienA-1v5fA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_2
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.89A 2ienB-1v5fA:
undetectable		 2ienB-1v5fA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_2
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 GLY A 390
ASP A 442
VAL A 466
GLY A 418
ILE A 419
 TPP  A1602 ( 3.9A)
MG  A1603 ( 2.8A)
None
None
None
 0.85A 2ienB-1v5fA:
undetectable		 2ienB-1v5fA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_1
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 GLY A 390
ASP A 442
VAL A 466
GLY A 418
ILE A 419
 TPP  A1602 ( 3.9A)
MG  A1603 ( 2.8A)
None
None
None
 0.92A 2ieoA-1v5fA:
undetectable		 2ieoA-1v5fA:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_A_TPFA2472_1
(CYTOCHROME P450 121)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 11 ASN A 344
THR A 268
ALA A 265
SER A 256
PHE A 243
 None
None
None
FAD  A1601 ( 4.6A)
None
 1.49A 2ij7A-1v5fA:
0.0		 2ij7A-1v5fA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		4 / 5 PRO A 189
PRO A 192
ILE A 317
GLY A 319
 None
 1.05A 2jkjD-1v5fA:
undetectable		 2jkjD-1v5fA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		4 / 5 PRO A 189
PRO A 192
ILE A 317
GLY A 319
 None
 1.06A 2jkjF-1v5fA:
undetectable		 2jkjF-1v5fA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_2
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 9 LEU A 276
ALA A 214
VAL A 236
GLY A 222
ILE A 212
 None
 0.93A 2o4pB-1v5fA:
undetectable		 2o4pB-1v5fA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4S_A_AB1A400_1
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.96A 2o4sA-1v5fA:
undetectable		 2o4sA-1v5fA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_1
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 9 ALA A 324
ASP A 320
GLY A 279
VAL A 315
ILE A 317
 None
FAD  A1601 (-3.8A)
FAD  A1601 (-3.5A)
None
None
 0.97A 2q5kA-1v5fA:
undetectable		 2q5kA-1v5fA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHC_B_AB1B9001_1
(PROTEASE RETROPEPSIN)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 11 ALA A 324
ASP A 320
GLY A 279
VAL A 315
ILE A 317
 None
FAD  A1601 (-3.8A)
FAD  A1601 (-3.5A)
None
None
 0.98A 2qhcA-1v5fA:
undetectable		 2qhcA-1v5fA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHC_B_AB1B9001_1
(PROTEASE RETROPEPSIN)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 11 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.83A 2qhcA-1v5fA:
undetectable		 2qhcA-1v5fA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHC_B_AB1B9001_2
(PROTEASE RETROPEPSIN)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.88A 2qhcB-1v5fA:
undetectable		 2qhcB-1v5fA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA502_0
(CHORISMATE SYNTHASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		3 / 3 GLY A 165
ASP A 166
SER A  34
 None
 0.53A 2qhfA-1v5fA:
undetectable		 2qhfA-1v5fA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 10 THR A 290
ILE A 237
GLY A 215
GLY A 240
THR A 257
 None
None
FAD  A1601 (-2.9A)
FAD  A1601 (-3.6A)
None
 1.28A 2wd9C-1v5fA:
5.2		 2wd9C-1v5fA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_1
(HIV-1 PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.88A 2z54A-1v5fA:
undetectable		 2z54A-1v5fA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_2
(HIV-1 PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.92A 2z54B-1v5fA:
undetectable		 2z54B-1v5fA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA607_1
(CHITINASE A)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		4 / 8 VAL A 225
GLY A 217
THR A 218
ALA A 321
 None
FAD  A1601 (-3.4A)
None
FAD  A1601 (-3.5A)
 0.69A 3aruA-1v5fA:
undetectable		 3aruA-1v5fA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYW_A_017A201_1
(HIV-1 PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.91A 3cywA-1v5fA:
undetectable		 3cywA-1v5fA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYW_A_017A201_2
(HIV-1 PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.93A 3cywB-1v5fA:
undetectable		 3cywB-1v5fA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Z_B_017B201_2
(HIV-1 PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.95A 3d1zB-1v5fA:
undetectable		 3d1zB-1v5fA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D20_A_017A201_1
(HIV-1 PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.99A 3d20A-1v5fA:
undetectable		 3d20A-1v5fA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D20_A_017A201_1
(HIV-1 PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 GLY A 390
ASP A 442
VAL A 466
GLY A 418
ILE A 419
 TPP  A1602 ( 3.9A)
MG  A1603 ( 2.8A)
None
None
None
 1.01A 3d20A-1v5fA:
undetectable		 3d20A-1v5fA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_1
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		6 / 8 LEU A 276
GLY A 215
ALA A 214
VAL A 236
GLY A 222
ILE A 212
 None
FAD  A1601 (-2.9A)
None
None
None
None
 1.25A 3ekpA-1v5fA:
undetectable		 3ekpA-1v5fA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_2
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 10 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.94A 3ekpB-1v5fA:
undetectable		 3ekpB-1v5fA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_2
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 10 LEU A 276
ALA A 214
VAL A 236
GLY A 222
ILE A 212
 None
 0.93A 3ekpB-1v5fA:
undetectable		 3ekpB-1v5fA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_1
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 10 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 1.01A 3ekpC-1v5fA:
undetectable		 3ekpC-1v5fA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_1
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 10 LEU A 276
ALA A 214
VAL A 236
GLY A 222
ILE A 212
 None
 0.90A 3ekpC-1v5fA:
undetectable		 3ekpC-1v5fA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_1
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 9 GLY A 390
ASP A 442
VAL A 466
GLY A 418
ILE A 419
 TPP  A1602 ( 3.9A)
MG  A1603 ( 2.8A)
None
None
None
 1.02A 3ektA-1v5fA:
undetectable		 3ektA-1v5fA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_2
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 9 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.98A 3ektB-1v5fA:
undetectable		 3ektB-1v5fA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_D_017D200_2
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 11 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.96A 3ektD-1v5fA:
undetectable		 3ektD-1v5fA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_D_017D200_2
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 11 GLY A 390
ASP A 442
VAL A 466
GLY A 418
ILE A 419
 TPP  A1602 ( 3.9A)
MG  A1603 ( 2.8A)
None
None
None
 0.97A 3ektD-1v5fA:
undetectable		 3ektD-1v5fA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_1
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		6 / 10 LEU A 276
GLY A 215
ALA A 214
VAL A 236
GLY A 222
ILE A 212
 None
FAD  A1601 (-2.9A)
None
None
None
None
 1.29A 3ekvA-1v5fA:
undetectable		 3ekvA-1v5fA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_2
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 9 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.84A 3ekvB-1v5fA:
undetectable		 3ekvB-1v5fA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_2
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 11 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.89A 3ekxB-1v5fA:
undetectable		 3ekxB-1v5fA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_1
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 10 ALA A 324
ASP A 320
GLY A 279
VAL A 315
ILE A 317
 None
FAD  A1601 (-3.8A)
FAD  A1601 (-3.5A)
None
None
 0.97A 3ekyA-1v5fA:
undetectable		 3ekyA-1v5fA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_1
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 10 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.88A 3em3A-1v5fA:
undetectable		 3em3A-1v5fA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_2
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 10 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.88A 3em3B-1v5fA:
undetectable		 3em3B-1v5fA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_2
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 10 LEU A 276
ALA A 214
VAL A 236
GLY A 222
ILE A 212
 None
 0.92A 3em3B-1v5fA:
undetectable		 3em3B-1v5fA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_1
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 11 ALA A 324
ASP A 320
GLY A 279
VAL A 315
ILE A 317
 None
FAD  A1601 (-3.8A)
FAD  A1601 (-3.5A)
None
None
 0.95A 3em4A-1v5fA:
undetectable		 3em4A-1v5fA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_2
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 9 ALA A 324
ASP A 320
GLY A 279
VAL A 315
ILE A 317
 None
FAD  A1601 (-3.8A)
FAD  A1601 (-3.5A)
None
None
 0.99A 3em4B-1v5fA:
undetectable		 3em4B-1v5fA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_2
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.89A 3em6B-1v5fA:
undetectable		 3em6B-1v5fA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JVY_B_017B401_1
(GAG-POL POLYPROTEIN)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.84A 3jvyA-1v5fA:
undetectable		 3jvyA-1v5fA:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_1
(HIV-1 PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.91A 3k4vC-1v5fA:
undetectable		 3k4vC-1v5fA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		4 / 8 ILE A 419
PRO A 422
GLY A 418
ASN A  87
 None
None
None
TPP  A1602 ( 4.8A)
 0.83A 3lslA-1v5fA:
2.3
3lslD-1v5fA:
undetectable		 3lslA-1v5fA:
19.06
3lslD-1v5fA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		4 / 8 ASN A  87
ILE A 419
PRO A 422
GLY A 418
 TPP  A1602 ( 4.8A)
None
None
None
 0.85A 3lslA-1v5fA:
2.3
3lslD-1v5fA:
undetectable		 3lslA-1v5fA:
19.06
3lslD-1v5fA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZS_A_017A200_1
(HIV-1 PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.89A 3lzsA-1v5fA:
undetectable		 3lzsA-1v5fA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZS_A_017A200_2
(HIV-1 PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.93A 3lzsB-1v5fA:
undetectable		 3lzsB-1v5fA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_1
(HIV-1 PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.95A 3lzuA-1v5fA:
undetectable		 3lzuA-1v5fA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_2
(HIV-1 PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.87A 3lzuB-1v5fA:
undetectable		 3lzuB-1v5fA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_2
(HIV-1 PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		6 / 12 LEU A 276
GLY A 215
ALA A 214
VAL A 236
GLY A 222
ILE A 212
 None
FAD  A1601 (-2.9A)
None
None
None
None
 1.29A 3lzuB-1v5fA:
undetectable		 3lzuB-1v5fA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MWS_B_017B201_1
(HIV-1 PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.83A 3mwsA-1v5fA:
undetectable		 3mwsA-1v5fA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MWS_B_017B201_1
(HIV-1 PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 GLY A 390
ASP A 442
VAL A 466
GLY A 418
ILE A 419
 TPP  A1602 ( 3.9A)
MG  A1603 ( 2.8A)
None
None
None
 0.86A 3mwsA-1v5fA:
undetectable		 3mwsA-1v5fA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MWS_B_017B201_2
(HIV-1 PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.97A 3mwsB-1v5fA:
undetectable		 3mwsB-1v5fA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_D_ROCD100_2
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.94A 3ndtD-1v5fA:
undetectable		 3ndtD-1v5fA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDW_A_RITA100_1
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.88A 3ndwA-1v5fA:
undetectable		 3ndwA-1v5fA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDW_A_RITA100_2
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 9 ALA A 324
ASP A 320
GLY A 279
VAL A 315
ILE A 317
 None
FAD  A1601 (-3.8A)
FAD  A1601 (-3.5A)
None
None
 0.95A 3ndwB-1v5fA:
undetectable		 3ndwB-1v5fA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU5_B_478B401_2
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.96A 3nu5B-1v5fA:
undetectable		 3nu5B-1v5fA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_1
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 10 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.91A 3nu6A-1v5fA:
undetectable		 3nu6A-1v5fA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_2
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 10 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.95A 3nu6B-1v5fA:
undetectable		 3nu6B-1v5fA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_2
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 9 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.93A 3nujB-1v5fA:
undetectable		 3nujB-1v5fA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_2
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 9 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.92A 3nuoB-1v5fA:
undetectable		 3nuoB-1v5fA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		3 / 3 TYR A 472
ASP A 442
ASP A 388
 TPP  A1602 ( 4.3A)
MG  A1603 ( 2.8A)
None
 0.99A 3ou7B-1v5fA:
undetectable		 3ou7B-1v5fA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 LEU A  32
ALA A 101
GLY A  76
LEU A 103
ALA A 159
 None
 1.34A 3ou7C-1v5fA:
undetectable		 3ou7C-1v5fA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_1
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.89A 3oxcA-1v5fA:
undetectable		 3oxcA-1v5fA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_1
(HIV-1 PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 9 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.88A 3oxvC-1v5fA:
undetectable		 3oxvC-1v5fA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_1
(HIV-1 PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 9 LEU A 276
ALA A 214
VAL A 236
GLY A 222
ILE A 212
 None
 0.94A 3oxvC-1v5fA:
undetectable		 3oxvC-1v5fA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_2
(HIV-1 PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 11 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.93A 3oxvD-1v5fA:
undetectable		 3oxvD-1v5fA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_2
(HIV-1 PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 10 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.94A 3oxwB-1v5fA:
undetectable		 3oxwB-1v5fA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_2
(HIV-1 PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 10 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.97A 3oxwD-1v5fA:
undetectable		 3oxwD-1v5fA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_2
(HIV-1 PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 10 LEU A 276
ALA A 214
VAL A 236
GLY A 222
ILE A 212
 None
 0.95A 3oxwD-1v5fA:
undetectable		 3oxwD-1v5fA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OY4_B_017B200_1
(HIV-1 PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 11 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.89A 3oy4A-1v5fA:
undetectable		 3oy4A-1v5fA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWM_B_017B402_1
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.95A 3pwmA-1v5fA:
undetectable		 3pwmA-1v5fA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWM_B_017B402_2
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.94A 3pwmB-1v5fA:
undetectable		 3pwmB-1v5fA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_3
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.88A 3pwrB-1v5fA:
undetectable		 3pwrB-1v5fA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL3_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ILE A 300
ALA A 214
LEU A 228
ILE A 298
THR A 218
 None
 1.23A 3ql3A-1v5fA:
undetectable		 3ql3A-1v5fA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_2
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 1.00A 3tkgD-1v5fA:
undetectable		 3tkgD-1v5fA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKW_B_017B401_1
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.95A 3tkwA-1v5fA:
undetectable		 3tkwA-1v5fA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_B_ADNB301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 10 ALA A 200
LEU A 228
LEU A 276
ASN A 296
ILE A 212
 None
 1.01A 3wdmB-1v5fA:
9.6		 3wdmB-1v5fA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_C_ADNC301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 9 ALA A 200
LEU A 228
LEU A 276
ASN A 296
ILE A 212
 None
 1.05A 3wdmC-1v5fA:
9.7		 3wdmC-1v5fA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_1
(ASPARTYL PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.92A 4dqbA-1v5fA:
undetectable		 4dqbA-1v5fA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_1
(ASPARTYL PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 10 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.92A 4dqcA-1v5fA:
undetectable		 4dqcA-1v5fA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_2
(ASPARTYL PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 9 GLY A 390
ASP A 442
VAL A 466
GLY A 418
ILE A 419
 TPP  A1602 ( 3.9A)
MG  A1603 ( 2.8A)
None
None
None
 1.07A 4dqcB-1v5fA:
undetectable		 4dqcB-1v5fA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_1
(ASPARTYL PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 11 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.93A 4dqeA-1v5fA:
undetectable		 4dqeA-1v5fA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQH_B_017B101_1
(WILD-TYPE HIV-1
PROTEASE DIMER)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 11 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.92A 4dqhA-1v5fA:
undetectable		 4dqhA-1v5fA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_F_ACTF402_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		3 / 3 PHE A 508
ASP A 515
ARG A 518
 None
 0.86A 4eahF-1v5fA:
undetectable		 4eahF-1v5fA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_G_ACTG401_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		3 / 3 PHE A 508
ASP A 515
ARG A 518
 None
 0.86A 4eahG-1v5fA:
undetectable		 4eahG-1v5fA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_2
(HIV-1 PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.85A 4jecB-1v5fA:
undetectable		 4jecB-1v5fA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_1
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 8 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 1.00A 4ll3A-1v5fA:
undetectable		 4ll3A-1v5fA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_2
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 9 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.97A 4ll3B-1v5fA:
undetectable		 4ll3B-1v5fA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_1
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 11 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.92A 4njtA-1v5fA:
undetectable		 4njtA-1v5fA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_1
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 11 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.90A 4njtC-1v5fA:
undetectable		 4njtC-1v5fA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_2
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 10 LEU A 276
ALA A 214
VAL A 236
GLY A 222
ILE A 212
 None
 0.91A 4njuB-1v5fA:
undetectable		 4njuB-1v5fA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_1
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.82A 4njvA-1v5fA:
undetectable		 4njvA-1v5fA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_1
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 GLY A 390
ASP A 442
VAL A 466
GLY A 418
ILE A 419
 TPP  A1602 ( 3.9A)
MG  A1603 ( 2.8A)
None
None
None
 0.95A 4njvA-1v5fA:
undetectable		 4njvA-1v5fA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_2
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 11 GLY A 390
ASP A 442
VAL A 466
GLY A 418
ILE A 419
 TPP  A1602 ( 3.9A)
MG  A1603 ( 2.8A)
None
None
None
 1.01A 4njvB-1v5fA:
undetectable		 4njvB-1v5fA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_2
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.84A 4njvD-1v5fA:
undetectable		 4njvD-1v5fA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_2
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 GLY A 390
ASP A 442
VAL A 466
GLY A 418
ILE A 419
 TPP  A1602 ( 3.9A)
MG  A1603 ( 2.8A)
None
None
None
 0.94A 4njvD-1v5fA:
undetectable		 4njvD-1v5fA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 11 ILE A 300
ALA A 214
LEU A 204
ILE A 298
THR A 218
 None
 1.19A 4p66A-1v5fA:
undetectable		 4p66A-1v5fA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P7N_A_GCSA702_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		3 / 3 ASP A 146
TYR A 178
TRP A  19
 None
 1.09A 4p7nA-1v5fA:
undetectable		 4p7nA-1v5fA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA601_1
(SERUM ALBUMIN)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASN A 344
PHE A 577
LEU A 581
VAL A 211
SER A 338
 None
 1.38A 4po0A-1v5fA:
undetectable		 4po0A-1v5fA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_2
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 11 LEU A 276
ALA A 214
VAL A 236
GLY A 222
ILE A 212
 None
 0.88A 4qgiB-1v5fA:
undetectable		 4qgiB-1v5fA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ARG A 150
ALA A 181
SER A  18
GLY A  20
ALA A 159
 None
 1.09A 4r29C-1v5fA:
undetectable		 4r29C-1v5fA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_2
(HIV-1 PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 9 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.92A 4rvjB-1v5fA:
undetectable		 4rvjB-1v5fA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_2
(HIV-1 PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 9 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.92A 4rvjD-1v5fA:
undetectable		 4rvjD-1v5fA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		4 / 5 TYR A 178
LYS A 143
PRO A 142
GLU A 147
 None
 1.39A 4w5tA-1v5fA:
2.0		 4w5tA-1v5fA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		4 / 6 TYR A 178
LYS A 143
PRO A 142
GLU A 147
 None
 1.41A 4z4cA-1v5fA:
4.4		 4z4cA-1v5fA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_2
(CYP51 VARIANT1)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		3 / 3 PRO A 544
ILE A 348
SER A 392
 None
None
TPP  A1602 (-2.7A)
 0.78A 5fsaA-1v5fA:
undetectable		 5fsaA-1v5fA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		4 / 5 GLY A 215
PRO A 404
THR A 218
THR A 239
 FAD  A1601 (-2.9A)
None
None
FAD  A1601 (-2.8A)
 1.07A 5h5fA-1v5fA:
undetectable		 5h5fA-1v5fA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_A_ADNA401_1
(ADENOSINE KINASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 GLY A 222
ALA A 214
GLY A 215
ALA A 278
ILE A 212
 None
None
FAD  A1601 (-2.9A)
None
None
 0.91A 5kb6A-1v5fA:
3.0		 5kb6A-1v5fA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_B_ADNB401_1
(ADENOSINE KINASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 GLY A 222
ALA A 214
GLY A 215
ALA A 278
ILE A 212
 None
None
FAD  A1601 (-2.9A)
None
None
 0.92A 5kb6B-1v5fA:
undetectable		 5kb6B-1v5fA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_2
(PROTEASE E35D-APV)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 9 GLY A 390
ASP A 442
VAL A 466
GLY A 418
ILE A 419
 TPP  A1602 ( 3.9A)
MG  A1603 ( 2.8A)
None
None
None
 1.05A 5kr0B-1v5fA:
undetectable		 5kr0B-1v5fA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_C_EPAC502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		4 / 8 ILE A 237
PHE A 282
ALA A 265
PRO A 412
 None
FAD  A1601 (-4.1A)
None
FAD  A1601 (-4.0A)
 0.82A 5m0oC-1v5fA:
undetectable		 5m0oC-1v5fA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_1
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 1.02A 5t2zA-1v5fA:
undetectable		 5t2zA-1v5fA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_1
(REGULATORY PROTEIN
TETR)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		4 / 8 ILE A 397
TYR A 369
TRP A 351
VAL A 547
 None
 1.05A 5vlmF-1v5fA:
0.0		 5vlmF-1v5fA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 9 ASP A  95
ALA A 129
PHE A 414
GLY A  88
GLY A 157
 None
 1.35A 6awoA-1v5fA:
undetectable		 6awoA-1v5fA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 9 ASP A  95
ALA A 129
PHE A 414
GLY A  88
GLY A 157
 None
 1.35A 6awqA-1v5fA:
undetectable		 6awqA-1v5fA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		6 / 12 GLY A 279
ASP A 301
ILE A 302
ASP A 303
ASP A 320
ALA A 321
 FAD  A1601 (-3.5A)
FAD  A1601 (-3.0A)
FAD  A1601 (-3.9A)
None
FAD  A1601 (-3.8A)
FAD  A1601 (-3.5A)
 0.68A 6bq4A-1v5fA:
3.8		 6bq4A-1v5fA:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		6 / 12 GLY A 279
ASP A 301
ILE A 302
ASP A 303
ASP A 320
ALA A 321
 FAD  A1601 (-3.5A)
FAD  A1601 (-3.0A)
FAD  A1601 (-3.9A)
None
FAD  A1601 (-3.8A)
FAD  A1601 (-3.5A)
 0.71A 6bq4B-1v5fA:
3.7		 6bq4B-1v5fA:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_0
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.94A 6dgxA-1v5fA:
undetectable		 6dgxA-1v5fA:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH3_A_017A101_0
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.95A 6dh3A-1v5fA:
undetectable		 6dh3A-1v5fA:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH6_A_017A104_0
(PROTEASE)		 1v5f PYRUVATE OXIDASE
(Aerococcus
viridans) 		5 / 12 ASP A 388
ALA A 444
ASP A 442
VAL A 466
ILE A 440
 None
TPP  A1602 (-3.7A)
MG  A1603 ( 2.8A)
None
None
 0.93A 6dh6A-1v5fA:
undetectable		 6dh6A-1v5fA:
8.56