SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1v5k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1WRK_B_TFPB203_1 (TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES)	1v5k	MICROTUBULE-ASSOCIAT ED PROTEIN, RP/EB FAMILY, MEMBER 1 (Mus musculus)	4 / 5	PHE A 108 LEU A 21 PHE A 104 SER A 33	None	1.22A	1wrkB-1v5kA: undetectable	1wrkB-1v5kA: 24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4P6X_G_HCYG900_2 (GLUCOCORTICOID RECEPTOR)	1v5k	MICROTUBULE-ASSOCIAT ED PROTEIN, RP/EB FAMILY, MEMBER 1 (Mus musculus)	3 / 3	LEU A 44 MET A 78 TYR A 37	None	0.73A	4p6xG-1v5kA: undetectable	4p6xG-1v5kA: 17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HIE_C_P06C801_2 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	1v5k	MICROTUBULE-ASSOCIAT ED PROTEIN, RP/EB FAMILY, MEMBER 1 (Mus musculus)	4 / 7	ILE A 28 VAL A 54 ASN A 18 PHE A 56	None	0.91A	5hieC-1v5kA: undetectable	5hieC-1v5kA: 18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VCE_A_RITA602_1 (CYTOCHROME P450 3A4)	1v5k	MICROTUBULE-ASSOCIAT ED PROTEIN, RP/EB FAMILY, MEMBER 1 (Mus musculus)	5 / 12	PHE A 75 ILE A 84 PHE A 104 ALA A 35 ALA A 50	None	1.07A	5vceA-1v5kA: undetectable	5vceA-1v5kA: 11.32

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1WRK_B_TFPB203_1","TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES","1v5k","MICROTUBULE-ASSOCIATED PROTEIN, RP\/EB FAMILY, MEMBER 1","Mus musculus",4,"PHE A 108;LEU A  21;PHE A 104;SER A  33","None","1.22A","1wrkB-1v5kA:undetectable","1wrkB-1v5kA:24.14"],["4P6X_G_HCYG900_2","GLUCOCORTICOID RECEPTOR","1v5k","MICROTUBULE-ASSOCIATED PROTEIN, RP\/EB FAMILY, MEMBER 1","Mus musculus",3,"LEU A  44;MET A  78;TYR A  37","None","0.73A","4p6xG-1v5kA:undetectable","4p6xG-1v5kA:17.96"],["5HIE_C_P06C801_2","SERINE\/THREONINE-PROTEIN KINASE B-RAF","1v5k","MICROTUBULE-ASSOCIATED PROTEIN, RP\/EB FAMILY, MEMBER 1","Mus musculus",4,"ILE A  28;VAL A  54;ASN A  18;PHE A  56","None","0.91A","5hieC-1v5kA:undetectable","5hieC-1v5kA:18.46"],["5VCE_A_RITA602_1","CYTOCHROME P450 3A4","1v5k","MICROTUBULE-ASSOCIATED PROTEIN, RP\/EB FAMILY, MEMBER 1","Mus musculus",5,"PHE A  75;ILE A  84;PHE A 104;ALA A  35;ALA A  50","None","1.07A","5vceA-1v5kA:undetectable","5vceA-1v5kA:11.32"]]