SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1v5l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 1v5l ACTININ ALPHA 2
ASSOCIATED LIM
PROTEIN
PDZ AND LIM DOMAIN 3
(Mus
musculus) 		5 / 11 ALA A  55
LEU A  80
ILE A  33
LEU A  47
ILE A  84
 None
 1.08A 1dhiB-1v5lA:
undetectable		 1dhiB-1v5lA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1v5l PDZ AND LIM DOMAIN 3
ACTININ ALPHA 2
ASSOCIATED LIM
PROTEIN
(Mus
musculus) 		5 / 12 ALA A  55
LEU A  80
ILE A  33
LEU A  47
ILE A  84
 None
 0.91A 1rx7A-1v5lA:
undetectable		 1rx7A-1v5lA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQB_A_FOLA2001_0
(DIHYDROFOLATE
REDUCTASE)		 1v5l PDZ AND LIM DOMAIN 3
ACTININ ALPHA 2
ASSOCIATED LIM
PROTEIN
(Mus
musculus) 		5 / 11 ALA A  55
LEU A  80
ILE A  33
LEU A  47
ILE A  84
 None
 1.09A 3tqbA-1v5lA:
undetectable		 3tqbA-1v5lA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA802_1
(CATALASE-PEROXIDASE)		 1v5l ACTININ ALPHA 2
ASSOCIATED LIM
PROTEIN
PDZ AND LIM DOMAIN 3
(Mus
musculus) 		4 / 8 LEU A  80
ASN A   8
GLY A   7
ILE A  84
 None
 0.85A 3wxoA-1v5lA:
undetectable		 3wxoA-1v5lA:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX6_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1v5l PDZ AND LIM DOMAIN 3
ACTININ ALPHA 2
ASSOCIATED LIM
PROTEIN
(Mus
musculus) 		5 / 12 ALA A  55
LEU A  80
ILE A  33
LEU A  47
ILE A  84
 None
 1.12A 4nx6A-1v5lA:
undetectable		 4nx6A-1v5lA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX7_A_FOLA202_0
(DIHYDROFOLATE
REDUCTASE)		 1v5l PDZ AND LIM DOMAIN 3
ACTININ ALPHA 2
ASSOCIATED LIM
PROTEIN
(Mus
musculus) 		5 / 12 ALA A  55
LEU A  80
ILE A  33
LEU A  47
ILE A  84
 None
 1.13A 4nx7A-1v5lA:
undetectable		 4nx7A-1v5lA:
20.00