SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1v5v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4001_1
(SERUM ALBUMIN)		 1v5v AMINOMETHYLTRANSFERA
SE
(Pyrococcus
horikoshii) 		4 / 5 ARG A 162
ALA A 165
ASP A 172
GLY A 170
 None
 1.19A 1e7bA-1v5vA:
undetectable		 1e7bA-1v5vA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4003_1
(SERUM ALBUMIN)		 1v5v AMINOMETHYLTRANSFERA
SE
(Pyrococcus
horikoshii) 		5 / 9 LEU A 235
VAL A  47
GLY A  48
ALA A 161
LEU A 164
 None
 1.10A 1e7bA-1v5vA:
undetectable		 1e7bA-1v5vA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4001_1
(SERUM ALBUMIN)		 1v5v AMINOMETHYLTRANSFERA
SE
(Pyrococcus
horikoshii) 		4 / 5 ARG A 162
ALA A 165
ASP A 172
GLY A 170
 None
 1.19A 1e7cA-1v5vA:
undetectable		 1e7cA-1v5vA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_0
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 1v5v AMINOMETHYLTRANSFERA
SE
(Pyrococcus
horikoshii) 		5 / 12 PHE A 204
ALA A 161
GLY A  48
ILE A  49
LEU A 186
 None
 1.26A 1kglA-1v5vA:
undetectable		 1kglA-1v5vA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_0
(N,N-DIMETHYLGLYCINE
OXIDASE)		 1v5v AMINOMETHYLTRANSFERA
SE
(Pyrococcus
horikoshii) 		6 / 12 TYR A  87
PHE A 179
TYR A 198
TYR A 207
TYR A 260
PHE A 289
 None
 0.91A 1pj7A-1v5vA:
44.4		 1pj7A-1v5vA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VID_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 1v5v AMINOMETHYLTRANSFERA
SE
(Pyrococcus
horikoshii) 		4 / 5 GLU A  57
TYR A 207
SER A 117
ASP A  51
 None
 1.36A 1vidA-1v5vA:
0.0		 1vidA-1v5vA:
19.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WOP_A_FFOA2887_0
(AMINOMETHYLTRANSFERA
SE)		 1v5v AMINOMETHYLTRANSFERA
SE
(Pyrococcus
horikoshii) 		5 / 12 MET A  55
TYR A  87
TYR A 198
ARG A 251
TYR A 260
 None
 0.71A 1wopA-1v5vA:
49.3		 1wopA-1v5vA:
38.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)		 1v5v AMINOMETHYLTRANSFERA
SE
(Pyrococcus
horikoshii) 		5 / 9 ALA A 155
ALA A 161
GLY A 158
GLY A 203
ILE A 173
 None
 1.22A 2v7bA-1v5vA:
undetectable		 2v7bA-1v5vA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 1v5v AMINOMETHYLTRANSFERA
SE
(Pyrococcus
horikoshii) 		5 / 9 ALA A 155
ALA A 161
GLY A 158
GLY A 203
ILE A 173
 None
 1.19A 2v7bB-1v5vA:
undetectable		 2v7bB-1v5vA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8O_A_OINA1314_1
(CHOLINE-BINDING
PROTEIN F)		 1v5v AMINOMETHYLTRANSFERA
SE
(Pyrococcus
horikoshii) 		4 / 5 LYS A 220
ASP A 217
ARG A 221
GLU A 218
 None
 1.45A 2x8oA-1v5vA:
0.0		 2x8oA-1v5vA:
23.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A8I_A_C2FA401_0
(AMINOMETHYLTRANSFERA
SE)		 1v5v AMINOMETHYLTRANSFERA
SE
(Pyrococcus
horikoshii) 		6 / 12 MET A  55
TYR A  87
MET A 153
PHE A 179
TYR A 198
ARG A 251
 None
 0.83A 3a8iA-1v5vA:
43.5		 3a8iA-1v5vA:
37.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A8I_B_C2FB401_0
(AMINOMETHYLTRANSFERA
SE)		 1v5v AMINOMETHYLTRANSFERA
SE
(Pyrococcus
horikoshii) 		5 / 12 MET A  55
TYR A  87
PHE A 179
TYR A 198
ARG A 251
 None
 0.82A 3a8iB-1v5vA:
43.1		 3a8iB-1v5vA:
37.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A8I_C_C2FC401_0
(AMINOMETHYLTRANSFERA
SE)		 1v5v AMINOMETHYLTRANSFERA
SE
(Pyrococcus
horikoshii) 		5 / 12 MET A  55
TYR A  87
PHE A 179
TYR A 198
ARG A 251
 None
 0.84A 3a8iC-1v5vA:
43.2		 3a8iC-1v5vA:
37.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A8I_D_C2FD401_0
(AMINOMETHYLTRANSFERA
SE)		 1v5v AMINOMETHYLTRANSFERA
SE
(Pyrococcus
horikoshii) 		5 / 12 MET A  55
TYR A  87
PHE A 179
TYR A 198
ARG A 251
 None
 0.88A 3a8iD-1v5vA:
43.3		 3a8iD-1v5vA:
37.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		 1v5v AMINOMETHYLTRANSFERA
SE
(Pyrococcus
horikoshii) 		4 / 7 TYR A 198
ASN A 265
LEU A 262
ASP A 252
 None
 1.43A 3lslA-1v5vA:
undetectable
3lslD-1v5vA:
undetectable		 3lslA-1v5vA:
21.96
3lslD-1v5vA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_1
(YAEB-LIKE PROTEIN
RPA0152)		 1v5v AMINOMETHYLTRANSFERA
SE
(Pyrococcus
horikoshii) 		4 / 5 SER A 344
ARG A 251
ASP A 116
THR A 267
 None
 1.40A 3okxA-1v5vA:
0.4		 3okxA-1v5vA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_1
(YAEB-LIKE PROTEIN
RPA0152)		 1v5v AMINOMETHYLTRANSFERA
SE
(Pyrococcus
horikoshii) 		4 / 5 SER A 344
ARG A 251
ASP A 118
THR A 267
 None
 1.44A 3okxA-1v5vA:
0.4		 3okxA-1v5vA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_2
(YAEB-LIKE PROTEIN
RPA0152)		 1v5v AMINOMETHYLTRANSFERA
SE
(Pyrococcus
horikoshii) 		4 / 5 SER A 344
ARG A 251
ASP A 116
THR A 267
 None
 1.40A 3okxB-1v5vA:
1.9		 3okxB-1v5vA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_2
(YAEB-LIKE PROTEIN
RPA0152)		 1v5v AMINOMETHYLTRANSFERA
SE
(Pyrococcus
horikoshii) 		4 / 5 SER A 344
ARG A 251
ASP A 118
THR A 267
 None
 1.44A 3okxB-1v5vA:
1.9		 3okxB-1v5vA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIN_H_QI9H1226_0
(FAB 314.3)		 1v5v AMINOMETHYLTRANSFERA
SE
(Pyrococcus
horikoshii) 		5 / 12 THR A 343
GLY A 259
PHE A 318
GLY A 354
PRO A 326
 None
 1.19A 4uinH-1v5vA:
undetectable
4uinL-1v5vA:
undetectable		 4uinH-1v5vA:
17.89
4uinL-1v5vA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)		 1v5v AMINOMETHYLTRANSFERA
SE
(Pyrococcus
horikoshii) 		5 / 12 LEU A  91
PHE A 297
GLU A 288
PRO A 282
GLY A 312
 None
 1.32A 5f9zB-1v5vA:
undetectable		 5f9zB-1v5vA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_A_FUAA1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 1v5v AMINOMETHYLTRANSFERA
SE
(Pyrococcus
horikoshii) 		4 / 5 ILE A 325
LYS A  37
ILE A  36
HIS A  40
 None
 0.90A 5jmnA-1v5vA:
0.0		 5jmnA-1v5vA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_A_NCTA402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 1v5v AMINOMETHYLTRANSFERA
SE
(Pyrococcus
horikoshii) 		4 / 8 TYR A 390
THR A 199
TYR A 260
LEU A 397
 None
 1.48A 5kxiA-1v5vA:
undetectable
5kxiB-1v5vA:
undetectable		 5kxiA-1v5vA:
22.60
5kxiB-1v5vA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 1v5v AMINOMETHYLTRANSFERA
SE
(Pyrococcus
horikoshii) 		4 / 8 TYR A 390
THR A 199
TYR A 260
LEU A 397
 None
 1.46A 5kxiD-1v5vA:
undetectable
5kxiE-1v5vA:
undetectable		 5kxiD-1v5vA:
22.60
5kxiE-1v5vA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_A_CCSA14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 1v5v AMINOMETHYLTRANSFERA
SE
(Pyrococcus
horikoshii) 		4 / 6 PHE A  60
LEU A  66
ARG A  61
GLY A  62
 None
 1.01A 5o4yA-1v5vA:
undetectable		 5o4yA-1v5vA:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 1v5v AMINOMETHYLTRANSFERA
SE
(Pyrococcus
horikoshii) 		4 / 5 VAL A  52
ARG A 251
GLY A 197
TYR A 198
 None
 1.11A 5x80A-1v5vA:
0.0
5x80B-1v5vA:
0.0		 5x80A-1v5vA:
16.71
5x80B-1v5vA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_D_SALD201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 1v5v AMINOMETHYLTRANSFERA
SE
(Pyrococcus
horikoshii) 		4 / 5 GLY A 197
TYR A 198
VAL A  52
ARG A 251
 None
 1.20A 5x80C-1v5vA:
undetectable
5x80D-1v5vA:
undetectable		 5x80C-1v5vA:
16.71
5x80D-1v5vA:
16.71