SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1v5w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 1v5w MEIOTIC
RECOMBINATION
PROTEIN DMC1/LIM15
HOMOLOG
(Homo
sapiens) 		4 / 5 ILE A 121
ILE A 156
ILE A 256
LEU A 135
 None
 0.84A 1zgyA-1v5wA:
undetectable		 1zgyA-1v5wA:
26.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA802_1
(TRANSPORTER)		 1v5w MEIOTIC
RECOMBINATION
PROTEIN DMC1/LIM15
HOMOLOG
(Homo
sapiens) 		4 / 6 ILE A 315
SER A 318
ILE A 116
PHE A 108
 None
 0.96A 2q72A-1v5wA:
undetectable		 2q72A-1v5wA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		 1v5w MEIOTIC
RECOMBINATION
PROTEIN DMC1/LIM15
HOMOLOG
(Homo
sapiens) 		5 / 10 ASP A 337
ILE A 116
LEU A 310
ILE A 221
GLY A 334
 None
 1.29A 2v0mA-1v5wA:
undetectable		 2v0mA-1v5wA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1v5w MEIOTIC
RECOMBINATION
PROTEIN DMC1/LIM15
HOMOLOG
(Homo
sapiens) 		4 / 8 THR A 267
GLN A 269
ASP A 223
SER A 136
 None
 1.09A 2xytE-1v5wA:
undetectable		 2xytE-1v5wA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_H_TC9H1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1v5w MEIOTIC
RECOMBINATION
PROTEIN DMC1/LIM15
HOMOLOG
(Homo
sapiens) 		4 / 7 THR A 267
GLN A 269
ASP A 223
SER A 136
 None
 1.16A 2xytI-1v5wA:
undetectable		 2xytI-1v5wA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1v5w MEIOTIC
RECOMBINATION
PROTEIN DMC1/LIM15
HOMOLOG
(Homo
sapiens) 		4 / 8 THR A 267
GLN A 269
ASP A 223
SER A 136
 None
 1.10A 2xz5C-1v5wA:
undetectable
2xz5D-1v5wA:
undetectable		 2xz5C-1v5wA:
20.00
2xz5D-1v5wA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1000_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1v5w MEIOTIC
RECOMBINATION
PROTEIN DMC1/LIM15
HOMOLOG
(Homo
sapiens) 		5 / 10 ILE A 335
GLY A 336
GLY A 333
PHE A 177
ILE A 173
 None
 1.39A 2y7pA-1v5wA:
undetectable		 2y7pA-1v5wA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_B_VD3B2001_1
(VITAMIN D
HYDROXYLASE)		 1v5w MEIOTIC
RECOMBINATION
PROTEIN DMC1/LIM15
HOMOLOG
(Homo
sapiens) 		5 / 11 ILE A 116
LEU A 220
LEU A 139
ILE A 221
THR A 267
 None
 1.33A 3a50B-1v5wA:
undetectable		 3a50B-1v5wA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 1v5w MEIOTIC
RECOMBINATION
PROTEIN DMC1/LIM15
HOMOLOG
(Homo
sapiens) 		5 / 11 LEU A 293
ARG A 242
PHE A 229
VAL A 264
LEU A 220
 None
 1.36A 3a9eB-1v5wA:
undetectable		 3a9eB-1v5wA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1v5w MEIOTIC
RECOMBINATION
PROTEIN DMC1/LIM15
HOMOLOG
(Homo
sapiens) 		5 / 12 ILE A 335
ALA A 124
ILE A 301
ILE A 101
PHE A 108
 None
 1.06A 3b2rA-1v5wA:
undetectable		 3b2rA-1v5wA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 1v5w MEIOTIC
RECOMBINATION
PROTEIN DMC1/LIM15
HOMOLOG
(Homo
sapiens) 		3 / 3 ARG A 166
THR A 142
THR A 267
 None
 0.56A 3k2hB-1v5wA:
2.6		 3k2hB-1v5wA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 1v5w MEIOTIC
RECOMBINATION
PROTEIN DMC1/LIM15
HOMOLOG
(Homo
sapiens) 		4 / 5 LEU A 135
GLY A 131
PHE A 328
PHE A 108
 None
 0.91A 3smtA-1v5wA:
undetectable		 3smtA-1v5wA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_A_IMNA201_1
(TRANSTHYRETIN)		 1v5w MEIOTIC
RECOMBINATION
PROTEIN DMC1/LIM15
HOMOLOG
(Homo
sapiens) 		4 / 7 LEU A 303
THR A 122
ALA A 124
THR A 267
 None
 0.78A 4ik7A-1v5wA:
undetectable		 4ik7A-1v5wA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_1
(CYTOCHROME P450 2D6)		 1v5w MEIOTIC
RECOMBINATION
PROTEIN DMC1/LIM15
HOMOLOG
(Homo
sapiens) 		5 / 12 PHE A 265
GLY A 114
LEU A 112
ALA A 263
PHE A 108
 None
 0.99A 4wnwB-1v5wA:
undetectable		 4wnwB-1v5wA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 1v5w MEIOTIC
RECOMBINATION
PROTEIN DMC1/LIM15
HOMOLOG
(Homo
sapiens) 		5 / 10 VAL A 266
GLU A 123
THR A 298
VAL A 264
LEU A 253
 None
 1.28A 4yb6A-1v5wA:
undetectable
4yb6E-1v5wA:
undetectable		 4yb6A-1v5wA:
21.79
4yb6E-1v5wA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 1v5w MEIOTIC
RECOMBINATION
PROTEIN DMC1/LIM15
HOMOLOG
(Homo
sapiens) 		5 / 10 VAL A 266
GLU A 123
THR A 298
VAL A 264
LEU A 253
 None
 1.27A 4yb6B-1v5wA:
undetectable
4yb6C-1v5wA:
undetectable		 4yb6B-1v5wA:
21.79
4yb6C-1v5wA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 1v5w MEIOTIC
RECOMBINATION
PROTEIN DMC1/LIM15
HOMOLOG
(Homo
sapiens) 		5 / 10 LEU A 253
VAL A 266
GLU A 123
THR A 298
VAL A 264
 None
 1.28A 4yb6B-1v5wA:
undetectable
4yb6F-1v5wA:
undetectable		 4yb6B-1v5wA:
21.79
4yb6F-1v5wA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 1v5w MEIOTIC
RECOMBINATION
PROTEIN DMC1/LIM15
HOMOLOG
(Homo
sapiens) 		4 / 5 GLY A 333
THR A 138
GLN A 134
THR A 331
 None
 1.30A 5h5fA-1v5wA:
undetectable		 5h5fA-1v5wA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1v5w MEIOTIC
RECOMBINATION
PROTEIN DMC1/LIM15
HOMOLOG
(Homo
sapiens) 		5 / 12 ILE A 101
GLY A 149
GLY A 114
LEU A 112
GLY A 153
 None
 1.12A 5i71A-1v5wA:
undetectable		 5i71A-1v5wA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 1v5w MEIOTIC
RECOMBINATION
PROTEIN DMC1/LIM15
HOMOLOG
(Homo
sapiens) 		5 / 12 ALA A 124
GLY A 126
LEU A 139
ASN A 268
PHE A 265
 None
 1.17A 5ybbA-1v5wA:
undetectable		 5ybbA-1v5wA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 1v5w MEIOTIC
RECOMBINATION
PROTEIN DMC1/LIM15
HOMOLOG
(Homo
sapiens) 		5 / 12 SER A 136
THR A 138
LEU A 303
PHE A 328
GLY A 334
 None
 1.11A 6drzA-1v5wA:
undetectable		 6drzA-1v5wA:
23.68