SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1v5x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_2_T442129_1
(TRANSTHYRETIN)		 1v5x PHOSPHORIBOSYLANTHRA
NILATE ISOMERASE
(Thermus
thermophilus) 		4 / 6 LEU A 189
GLU A 178
THR A   9
LEU A  16
 None
 1.27A 1etb2-1v5xA:
undetectable		 1etb2-1v5xA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		 1v5x PHOSPHORIBOSYLANTHRA
NILATE ISOMERASE
(Thermus
thermophilus) 		4 / 8 GLU A  47
LEU A  11
ALA A  14
LEU A  15
 None
 0.90A 1hwiD-1v5xA:
undetectable		 1hwiD-1v5xA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1v5x PHOSPHORIBOSYLANTHRA
NILATE ISOMERASE
(Thermus
thermophilus) 		3 / 3 GLU A 158
GLU A 161
LEU A 171
 None
 0.67A 1v8bB-1v5xA:
undetectable		 1v8bB-1v5xA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_A_ADNA252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1v5x PHOSPHORIBOSYLANTHRA
NILATE ISOMERASE
(Thermus
thermophilus) 		5 / 11 ARG A  34
SER A 130
GLY A 154
ILE A 155
HIS A  82
 None
 1.36A 1vhwA-1v5xA:
undetectable
1vhwD-1v5xA:
undetectable		 1vhwA-1v5xA:
20.08
1vhwD-1v5xA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_C_ADNC252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1v5x PHOSPHORIBOSYLANTHRA
NILATE ISOMERASE
(Thermus
thermophilus) 		5 / 11 ARG A  34
SER A 130
GLY A 154
ILE A 155
HIS A  82
 None
 1.37A 1vhwC-1v5xA:
undetectable
1vhwE-1v5xA:
undetectable		 1vhwC-1v5xA:
20.08
1vhwE-1v5xA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_D_ADND252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1v5x PHOSPHORIBOSYLANTHRA
NILATE ISOMERASE
(Thermus
thermophilus) 		5 / 11 HIS A  82
ARG A  34
SER A 130
GLY A 154
ILE A 155
 None
 1.37A 1vhwA-1v5xA:
undetectable
1vhwD-1v5xA:
undetectable		 1vhwA-1v5xA:
20.08
1vhwD-1v5xA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_E_ADNE252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1v5x PHOSPHORIBOSYLANTHRA
NILATE ISOMERASE
(Thermus
thermophilus) 		5 / 11 HIS A  82
ARG A  34
SER A 130
GLY A 154
ILE A 155
 None
 1.37A 1vhwC-1v5xA:
undetectable
1vhwE-1v5xA:
undetectable		 1vhwC-1v5xA:
20.08
1vhwE-1v5xA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_2
(CYTOCHROME P450 2R1)		 1v5x PHOSPHORIBOSYLANTHRA
NILATE ISOMERASE
(Thermus
thermophilus) 		3 / 3 MET A  71
VAL A  93
GLU A  66
 None
 0.66A 3c6gA-1v5xA:
undetectable		 3c6gA-1v5xA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB303_0
(DISULFIDE
INTERCHANGE PROTEIN)		 1v5x PHOSPHORIBOSYLANTHRA
NILATE ISOMERASE
(Thermus
thermophilus) 		4 / 4 LEU A  68
ALA A  79
VAL A  99
PRO A  98
 None
 1.17A 3gv1B-1v5xA:
undetectable		 3gv1B-1v5xA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_A_478A200_1
(HIV-1 PROTEASE)		 1v5x PHOSPHORIBOSYLANTHRA
NILATE ISOMERASE
(Thermus
thermophilus) 		4 / 6 GLU A  47
PRO A  39
ARG A  43
GLY A  46
 None
 1.33A 3oxvA-1v5xA:
undetectable		 3oxvA-1v5xA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1v5x PHOSPHORIBOSYLANTHRA
NILATE ISOMERASE
(Thermus
thermophilus) 		4 / 8 LEU A 105
TYR A 134
LEU A 166
LEU A 143
 None
 0.83A 4l1xA-1v5xA:
11.2		 4l1xA-1v5xA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 1v5x PHOSPHORIBOSYLANTHRA
NILATE ISOMERASE
(Thermus
thermophilus) 		4 / 7 VAL A  56
ARG A 148
ILE A 150
ALA A 170
 None
 0.79A 4lv9A-1v5xA:
2.4		 4lv9A-1v5xA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 1v5x PHOSPHORIBOSYLANTHRA
NILATE ISOMERASE
(Thermus
thermophilus) 		4 / 7 VAL A  56
ARG A 148
ILE A 150
ALA A 170
 None
 0.81A 4lv9B-1v5xA:
2.6		 4lv9B-1v5xA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA602_1
(SERUM ALBUMIN)		 1v5x PHOSPHORIBOSYLANTHRA
NILATE ISOMERASE
(Thermus
thermophilus) 		5 / 8 LYS A 140
ALA A 139
GLY A 107
LEU A 105
LEU A 123
 None
 1.41A 4po0A-1v5xA:
undetectable		 4po0A-1v5xA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_A_GLYA403_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		 1v5x PHOSPHORIBOSYLANTHRA
NILATE ISOMERASE
(Thermus
thermophilus) 		4 / 4 LEU A  11
LEU A  49
GLY A  46
GLU A  47
 None
 1.21A 5hhjA-1v5xA:
undetectable		 5hhjA-1v5xA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 1v5x PHOSPHORIBOSYLANTHRA
NILATE ISOMERASE
(Thermus
thermophilus) 		5 / 12 LEU A 173
ILE A   5
LEU A  49
LEU A  20
GLY A  21
 None
 1.21A 5j7wC-1v5xA:
undetectable		 5j7wC-1v5xA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1v5x PHOSPHORIBOSYLANTHRA
NILATE ISOMERASE
(Thermus
thermophilus) 		5 / 12 ILE A 150
VAL A  56
VAL A  54
ILE A 155
ALA A 152
 None
 1.06A 5n0sA-1v5xA:
undetectable		 5n0sA-1v5xA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1v5x PHOSPHORIBOSYLANTHRA
NILATE ISOMERASE
(Thermus
thermophilus) 		5 / 12 ILE A 150
VAL A  56
VAL A  54
ILE A 155
ALA A 152
 None
 1.10A 5n0sB-1v5xA:
undetectable		 5n0sB-1v5xA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1v5x PHOSPHORIBOSYLANTHRA
NILATE ISOMERASE
(Thermus
thermophilus) 		5 / 12 ILE A 150
VAL A  56
VAL A  54
ILE A 155
ALA A 152
 None
 1.07A 5n0tA-1v5xA:
undetectable		 5n0tA-1v5xA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_E_CHDE401_0
(BILE SALT HYDROLASE)		 1v5x PHOSPHORIBOSYLANTHRA
NILATE ISOMERASE
(Thermus
thermophilus) 		4 / 8 ILE A   5
ASN A 159
LEU A 189
LEU A 160
 None
 0.81A 5y7pE-1v5xA:
undetectable		 5y7pE-1v5xA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0C_D_TA1D502_1
(TUBULIN BETA CHAIN)		 1v5x PHOSPHORIBOSYLANTHRA
NILATE ISOMERASE
(Thermus
thermophilus) 		6 / 12 GLU A 158
LEU A  16
ALA A 191
LEU A  20
GLY A 176
LEU A 173
 None
 1.26A 6b0cD-1v5xA:
undetectable		 6b0cD-1v5xA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)		 1v5x PHOSPHORIBOSYLANTHRA
NILATE ISOMERASE
(Thermus
thermophilus) 		5 / 12 LEU A 173
ILE A   5
LEU A  49
LEU A  20
GLY A  21
 None
 1.24A 6qyaB-1v5xA:
undetectable		 6qyaB-1v5xA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 1v5x PHOSPHORIBOSYLANTHRA
NILATE ISOMERASE
(Thermus
thermophilus) 		5 / 12 LEU A 173
ILE A   5
LEU A  49
LEU A  20
GLY A  21
 None
 1.25A 6qyaD-1v5xA:
undetectable		 6qyaD-1v5xA:
23.53