SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1v61'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_2
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 1v61 RAC/CDC42 GUANINE
NUCLEOTIDE EXCHANGE
FACTOR (GEF) 6
(Mus
musculus) 		3 / 3 LEU A 124
MET A 118
ASP A 113
 None
 0.85A 3v5wA-1v61A:
9.0		 3v5wA-1v61A:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1v61 RAC/CDC42 GUANINE
NUCLEOTIDE EXCHANGE
FACTOR (GEF) 6
(Mus
musculus) 		5 / 9 VAL A 106
GLY A  98
GLU A 102
GLY A  78
PRO A  75
 None
 1.39A 5zniA-1v61A:
undetectable		 5zniA-1v61A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 1v61 RAC/CDC42 GUANINE
NUCLEOTIDE EXCHANGE
FACTOR (GEF) 6
(Mus
musculus) 		4 / 8 MET A 118
GLN A 120
VAL A  28
SER A  54
 None
 1.17A 6fbvC-1v61A:
undetectable		 6fbvC-1v61A:
8.17