SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1v6a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 1v6a L-LACTATE
DEHYDROGENASE A
CHAIN
(Cyprinus
carpio) 		5 / 9 VAL A  26
GLY A  27
ASP A  52
ALA A  96
ILE A 116
 None
TRE  A 334 ( 4.0A)
TRE  A 334 (-2.5A)
TRE  A 334 (-3.6A)
TRE  A 334 ( 4.6A)
 0.53A 1cetA-1v6aA:
38.5		 1cetA-1v6aA:
29.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 1v6a L-LACTATE
DEHYDROGENASE A
CHAIN
(Cyprinus
carpio) 		5 / 9 VAL A  26
GLY A  27
ASP A  52
TYR A  83
ALA A  96
 None
TRE  A 334 ( 4.0A)
TRE  A 334 (-2.5A)
None
TRE  A 334 (-3.6A)
 0.57A 1cetA-1v6aA:
38.5		 1cetA-1v6aA:
29.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_A_GBNA502_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 1v6a L-LACTATE
DEHYDROGENASE A
CHAIN
(Cyprinus
carpio) 		4 / 8 THR A 275
GLY A 162
THR A 163
VAL A 303
 None
 0.59A 2a1hA-1v6aA:
undetectable
2a1hB-1v6aA:
undetectable		 2a1hA-1v6aA:
21.61
2a1hB-1v6aA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_B_GBNB501_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 1v6a L-LACTATE
DEHYDROGENASE A
CHAIN
(Cyprinus
carpio) 		4 / 8 VAL A 303
THR A 275
GLY A 162
THR A 163
 None
 0.55A 2a1hA-1v6aA:
undetectable
2a1hB-1v6aA:
undetectable		 2a1hA-1v6aA:
21.61
2a1hB-1v6aA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_2
(PROTEASE)		 1v6a L-LACTATE
DEHYDROGENASE A
CHAIN
(Cyprinus
carpio) 		5 / 12 LEU A 134
GLY A 253
ALA A  35
VAL A  91
VAL A  93
 None
 0.91A 2ieoB-1v6aA:
undetectable		 2ieoB-1v6aA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_C_TPFC2471_1
(CYTOCHROME P450 121)		 1v6a L-LACTATE
DEHYDROGENASE A
CHAIN
(Cyprinus
carpio) 		4 / 8 THR A  95
VAL A 136
ASN A 164
ALA A 257
 None
 0.96A 2ij7C-1v6aA:
0.0		 2ij7C-1v6aA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_D_TPFD2473_1
(CYTOCHROME P450 121)		 1v6a L-LACTATE
DEHYDROGENASE A
CHAIN
(Cyprinus
carpio) 		5 / 10 THR A  95
VAL A 136
ASN A 164
ALA A 257
SER A  38
 None
 1.28A 2ij7D-1v6aA:
0.0		 2ij7D-1v6aA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_1
(PROTEASE)		 1v6a L-LACTATE
DEHYDROGENASE A
CHAIN
(Cyprinus
carpio) 		5 / 12 LEU A 134
GLY A 253
ALA A  35
VAL A  91
VAL A  93
 None
 0.90A 2nnkA-1v6aA:
undetectable		 2nnkA-1v6aA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_2
(PROTEASE)		 1v6a L-LACTATE
DEHYDROGENASE A
CHAIN
(Cyprinus
carpio) 		5 / 11 LEU A  48
VAL A  91
ILE A 263
VAL A  25
VAL A  23
 None
 1.04A 2nnpB-1v6aA:
undetectable		 2nnpB-1v6aA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 1v6a L-LACTATE
DEHYDROGENASE A
CHAIN
(Cyprinus
carpio) 		5 / 10 VAL A  91
SER A 262
ASN A 164
VAL A 273
GLY A 160
 None
 1.46A 2x2iD-1v6aA:
0.0		 2x2iD-1v6aA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_A_TMQA611_1
(DHFR-TS)		 1v6a L-LACTATE
DEHYDROGENASE A
CHAIN
(Cyprinus
carpio) 		5 / 11 VAL A  93
MET A  33
ILE A  77
LEU A  40
THR A  95
 None
 0.94A 3clbA-1v6aA:
undetectable		 3clbA-1v6aA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		 1v6a L-LACTATE
DEHYDROGENASE A
CHAIN
(Cyprinus
carpio) 		5 / 12 GLN A 315
GLY A 162
VAL A 189
ASP A 141
SER A 319
 None
 1.04A 3d91B-1v6aA:
undetectable		 3d91B-1v6aA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_B_FLPB701_1
(CYCLOOXYGENASE-2)		 1v6a L-LACTATE
DEHYDROGENASE A
CHAIN
(Cyprinus
carpio) 		5 / 11 VAL A  25
LEU A  50
VAL A  31
GLY A 253
ALA A  34
 None
 1.26A 3pghB-1v6aA:
undetectable		 3pghB-1v6aA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LJ0_A_ACTA505_0
(NAB2)		 1v6a L-LACTATE
DEHYDROGENASE A
CHAIN
(Cyprinus
carpio) 		3 / 3 LEU A  72
LYS A  73
THR A  74
 None
 0.59A 4lj0A-1v6aA:
undetectable		 4lj0A-1v6aA:
12.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OKN_B_KANB403_1
(L-LACTATE
DEHYDROGENASE A
CHAIN)		 1v6a L-LACTATE
DEHYDROGENASE A
CHAIN
(Cyprinus
carpio) 		8 / 9 ASP A  52
VAL A  53
TYR A  83
ALA A  96
ARG A  99
ARG A 112
ILE A 116
ILE A 120
 TRE  A 334 (-2.5A)
TRE  A 334 ( 4.9A)
None
TRE  A 334 (-3.6A)
TRE  A 334 (-4.6A)
None
TRE  A 334 ( 4.6A)
None
 1.04A 4oknB-1v6aA:
51.3		 4oknB-1v6aA:
75.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_A_BEZA1001_0
(BENZOATE-COENZYME A
LIGASE)		 1v6a L-LACTATE
DEHYDROGENASE A
CHAIN
(Cyprinus
carpio) 		5 / 8 ALA A 256
VAL A 136
GLY A 253
ALA A  34
GLY A  32
 None
 1.24A 4zjzA-1v6aA:
2.0		 4zjzA-1v6aA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_B_BEZB601_0
(BENZOATE-COENZYME A
LIGASE)		 1v6a L-LACTATE
DEHYDROGENASE A
CHAIN
(Cyprinus
carpio) 		5 / 8 ALA A 256
VAL A  93
GLY A 253
ALA A  34
GLY A  32
 None
 1.48A 4zjzB-1v6aA:
2.8		 4zjzB-1v6aA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_B_BEZB601_0
(BENZOATE-COENZYME A
LIGASE)		 1v6a L-LACTATE
DEHYDROGENASE A
CHAIN
(Cyprinus
carpio) 		5 / 8 ALA A 256
VAL A 136
GLY A 253
ALA A  34
GLY A  32
 None
 1.25A 4zjzB-1v6aA:
2.8		 4zjzB-1v6aA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DWK_C_ACTC207_0
(DIACYLGLYCEROL
KINASE)		 1v6a L-LACTATE
DEHYDROGENASE A
CHAIN
(Cyprinus
carpio) 		4 / 5 GLU A 321
ALA A 320
GLU A 285
ASN A 284
 None
 0.84A 5dwkC-1v6aA:
undetectable		 5dwkC-1v6aA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXM_A_SAMA402_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 1v6a L-LACTATE
DEHYDROGENASE A
CHAIN
(Cyprinus
carpio) 		5 / 12 GLY A 160
LEU A 109
VAL A 110
ILE A 142
ASP A 141
 None
 1.21A 6bxmA-1v6aA:
3.7		 6bxmA-1v6aA:
20.06