SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1v6c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1v6c ALKALINE SERINE
PROTEASE
(Pseudoalteromona
s
sp.
AS-11) 		5 / 12 ILE A 114
ALA A 113
TRP A 104
VAL A 174
LEU A 130
 None
None
None
CA  A 505 (-4.5A)
PMS  A 501 (-4.5A)
 0.90A 1fm6A-1v6cA:
undetectable		 1fm6A-1v6cA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_A_CAMA1420_0
(CYTOCHROME P450-CAM)		 1v6c ALKALINE SERINE
PROTEASE
(Pseudoalteromona
s
sp.
AS-11) 		5 / 10 THR A 352
LEU A 257
THR A 340
VAL A 231
VAL A 336
 None
 1.32A 1o76A-1v6cA:
undetectable		 1o76A-1v6cA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB8_0
(GRAMICIDIN A)		 1v6c ALKALINE SERINE
PROTEASE
(Pseudoalteromona
s
sp.
AS-11) 		4 / 5 VAL A 231
GLY A 230
VAL A 336
TRP A   6
 None
 1.37A 1tkqB-1v6cA:
undetectable		 1tkqB-1v6cA:
3.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1v6c ALKALINE SERINE
PROTEASE
(Pseudoalteromona
s
sp.
AS-11) 		3 / 3 MET A 370
ASN A 235
GLN A 285
 None
 1.05A 1xoqB-1v6cA:
undetectable		 1xoqB-1v6cA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_A_ACTA601_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 1v6c ALKALINE SERINE
PROTEASE
(Pseudoalteromona
s
sp.
AS-11) 		4 / 7 SER A 170
ALA A 169
SER A 176
SER A 166
 None
 0.99A 2i91A-1v6cA:
3.4		 2i91A-1v6cA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 1v6c ALKALINE SERINE
PROTEASE
(Pseudoalteromona
s
sp.
AS-11) 		4 / 7 SER A 170
ALA A 169
SER A 176
SER A 166
 None
 1.00A 2i91B-1v6cA:
3.7		 2i91B-1v6cA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1121_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 1v6c ALKALINE SERINE
PROTEASE
(Pseudoalteromona
s
sp.
AS-11) 		4 / 5 SER A 335
VAL A 232
SER A 310
VAL A 308
 None
 1.32A 2j9cA-1v6cA:
undetectable
2j9cB-1v6cA:
undetectable
2j9cC-1v6cA:
undetectable		 2j9cA-1v6cA:
12.84
2j9cB-1v6cA:
12.84
2j9cC-1v6cA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_1
(ESTROGEN RECEPTOR)		 1v6c ALKALINE SERINE
PROTEASE
(Pseudoalteromona
s
sp.
AS-11) 		5 / 12 ALA A 426
ASP A 429
LEU A 428
GLY A  12
LEU A  16
 None
 1.10A 2jfaB-1v6cA:
undetectable		 2jfaB-1v6cA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_B_ACTB141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 1v6c ALKALINE SERINE
PROTEASE
(Pseudoalteromona
s
sp.
AS-11) 		3 / 3 PRO A 332
ASN A 356
ARG A 215
 None
 1.10A 2qeuB-1v6cA:
undetectable		 2qeuB-1v6cA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0P_A_ADNA1607_1
(ALCALIGIN
BIOSYNTHESIS PROTEIN)		 1v6c ALKALINE SERINE
PROTEASE
(Pseudoalteromona
s
sp.
AS-11) 		4 / 8 GLY A  84
ILE A  93
ASN A  43
ALA A  13
 None
 0.73A 2x0pA-1v6cA:
undetectable		 2x0pA-1v6cA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1303_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1v6c ALKALINE SERINE
PROTEASE
(Pseudoalteromona
s
sp.
AS-11) 		4 / 7 PRO A 373
ILE A 154
PRO A 201
GLY A 200
 None
 0.99A 2y7kA-1v6cA:
undetectable		 2y7kA-1v6cA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_A_SALA1341_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1v6c ALKALINE SERINE
PROTEASE
(Pseudoalteromona
s
sp.
AS-11) 		4 / 8 LEU A 216
PHE A 227
THR A   3
VAL A  82
 None
None
None
CA  A 503 (-4.9A)
 0.94A 3ax9A-1v6cA:
undetectable		 3ax9A-1v6cA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 1v6c ALKALINE SERINE
PROTEASE
(Pseudoalteromona
s
sp.
AS-11) 		5 / 10 THR A 295
ASN A 356
VAL A 354
GLY A 305
ILE A 329
 None
 1.45A 3bexC-1v6cA:
undetectable
3bexD-1v6cA:
undetectable		 3bexC-1v6cA:
19.86
3bexD-1v6cA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 1v6c ALKALINE SERINE
PROTEASE
(Pseudoalteromona
s
sp.
AS-11) 		5 / 10 ASN A 356
VAL A 354
GLY A 305
ILE A 329
THR A 295
 None
 1.45A 3bexE-1v6cA:
undetectable
3bexF-1v6cA:
undetectable		 3bexE-1v6cA:
19.86
3bexF-1v6cA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 1v6c ALKALINE SERINE
PROTEASE
(Pseudoalteromona
s
sp.
AS-11) 		5 / 11 THR A 340
LEU A 344
ASN A 229
ASP A 218
ILE A 307
 None
 1.41A 3bf1E-1v6cA:
undetectable
3bf1F-1v6cA:
undetectable		 3bf1E-1v6cA:
19.86
3bf1F-1v6cA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1v6c ALKALINE SERINE
PROTEASE
(Pseudoalteromona
s
sp.
AS-11) 		3 / 3 SER A 369
GLY A 158
GLY A 131
 PMS  A 501 (-1.5A)
PMS  A 501 ( 4.6A)
PMS  A 501 (-4.3A)
 0.49A 3bogA-1v6cA:
undetectable
3bogC-1v6cA:
undetectable		 3bogA-1v6cA:
undetectable
3bogC-1v6cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_A_CAMA424_0
(CYTOCHROME P450)		 1v6c ALKALINE SERINE
PROTEASE
(Pseudoalteromona
s
sp.
AS-11) 		5 / 9 THR A 352
LEU A 257
LEU A 278
THR A 340
VAL A 231
 None
 1.44A 4c9kA-1v6cA:
undetectable		 4c9kA-1v6cA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_B_CAMB424_0
(CYTOCHROME P450)		 1v6c ALKALINE SERINE
PROTEASE
(Pseudoalteromona
s
sp.
AS-11) 		5 / 9 LEU A 257
LEU A 278
THR A 340
VAL A 231
VAL A 336
 None
 1.48A 4c9kB-1v6cA:
undetectable		 4c9kB-1v6cA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_A_CAMA1419_0
(CYTOCHROME P450)		 1v6c ALKALINE SERINE
PROTEASE
(Pseudoalteromona
s
sp.
AS-11) 		6 / 12 THR A 352
LEU A 257
LEU A 278
THR A 340
VAL A 231
VAL A 336
 None
 1.38A 4c9lA-1v6cA:
undetectable		 4c9lA-1v6cA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_B_CAMB1419_0
(CYTOCHROME P450)		 1v6c ALKALINE SERINE
PROTEASE
(Pseudoalteromona
s
sp.
AS-11) 		6 / 12 THR A 352
LEU A 257
LEU A 278
THR A 340
VAL A 231
VAL A 336
 None
 1.35A 4c9lB-1v6cA:
undetectable		 4c9lB-1v6cA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_A_CAMA423_0
(CYTOCHROME P450)		 1v6c ALKALINE SERINE
PROTEASE
(Pseudoalteromona
s
sp.
AS-11) 		6 / 12 THR A 352
LEU A 257
LEU A 278
THR A 340
VAL A 231
VAL A 336
 None
 1.37A 4c9oA-1v6cA:
undetectable		 4c9oA-1v6cA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_B_CAMB423_0
(CYTOCHROME P450)		 1v6c ALKALINE SERINE
PROTEASE
(Pseudoalteromona
s
sp.
AS-11) 		6 / 12 THR A 352
LEU A 257
LEU A 278
THR A 340
VAL A 231
VAL A 336
 None
 1.37A 4c9oB-1v6cA:
undetectable		 4c9oB-1v6cA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_A_CAMA423_0
(CYTOCHROME P450)		 1v6c ALKALINE SERINE
PROTEASE
(Pseudoalteromona
s
sp.
AS-11) 		5 / 9 THR A 352
LEU A 257
LEU A 278
VAL A 231
VAL A 336
 None
 1.40A 4c9pA-1v6cA:
0.0		 4c9pA-1v6cA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_A_ADNA401_1
(APH(2'')-ID)		 1v6c ALKALINE SERINE
PROTEASE
(Pseudoalteromona
s
sp.
AS-11) 		5 / 11 GLY A 305
ALA A 303
ILE A 292
LEU A 322
ILE A 329
 None
 1.01A 4dt8A-1v6cA:
undetectable		 4dt8A-1v6cA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_B_ADNB401_1
(APH(2'')-ID)		 1v6c ALKALINE SERINE
PROTEASE
(Pseudoalteromona
s
sp.
AS-11) 		5 / 10 GLY A 305
ALA A 303
ILE A 292
LEU A 322
ILE A 329
 None
 1.06A 4dt8B-1v6cA:
undetectable		 4dt8B-1v6cA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)		 1v6c ALKALINE SERINE
PROTEASE
(Pseudoalteromona
s
sp.
AS-11) 		5 / 9 ALA A 123
ILE A  95
GLY A  47
ILE A 114
VAL A 126
 None
 1.03A 4nptA-1v6cA:
undetectable		 4nptA-1v6cA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_A_SAMA401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 1v6c ALKALINE SERINE
PROTEASE
(Pseudoalteromona
s
sp.
AS-11) 		5 / 11 GLY A 377
THR A  72
LEU A 152
VAL A 125
ILE A 419
 None
 1.14A 4pghA-1v6cA:
undetectable		 4pghA-1v6cA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_1
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 1v6c ALKALINE SERINE
PROTEASE
(Pseudoalteromona
s
sp.
AS-11) 		5 / 12 THR A  72
VAL A  69
GLN A   8
ILE A  26
TYR A  33
 None
 1.39A 4s0vA-1v6cA:
3.8		 4s0vA-1v6cA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_B_CLQB1079_0
(SAPOSIN-B)		 1v6c ALKALINE SERINE
PROTEASE
(Pseudoalteromona
s
sp.
AS-11) 		3 / 3 MET A 175
GLU A 197
LEU A 398
 None
 0.75A 4v2oB-1v6cA:
0.0		 4v2oB-1v6cA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 1v6c ALKALINE SERINE
PROTEASE
(Pseudoalteromona
s
sp.
AS-11) 		4 / 8 GLY A  22
TYR A 385
SER A  17
ASN A  23
 None
 0.97A 4wryA-1v6cA:
undetectable		 4wryA-1v6cA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 1v6c ALKALINE SERINE
PROTEASE
(Pseudoalteromona
s
sp.
AS-11) 		4 / 8 GLY A  22
TYR A 385
SER A  17
ASN A  23
 None
 0.96A 4wrzA-1v6cA:
undetectable		 4wrzA-1v6cA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS1_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 1v6c ALKALINE SERINE
PROTEASE
(Pseudoalteromona
s
sp.
AS-11) 		4 / 8 GLY A  22
TYR A 385
SER A  17
ASN A  23
 None
 0.96A 4ws1A-1v6cA:
undetectable		 4ws1A-1v6cA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_B_MZMB303_1
(ALPHA-CARBONIC
ANHYDRASE)		 1v6c ALKALINE SERINE
PROTEASE
(Pseudoalteromona
s
sp.
AS-11) 		5 / 10 ASP A 218
VAL A 231
VAL A 336
LEU A 344
ALA A 343
 None
 1.24A 4yhaB-1v6cA:
undetectable		 4yhaB-1v6cA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1v6c ALKALINE SERINE
PROTEASE
(Pseudoalteromona
s
sp.
AS-11) 		5 / 8 VAL A  82
VAL A 375
ILE A  26
ILE A 154
ILE A  28
 CA  A 503 (-4.9A)
None
None
None
None
 1.30A 5hi2A-1v6cA:
undetectable		 5hi2A-1v6cA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_A_9CRA503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1v6c ALKALINE SERINE
PROTEASE
(Pseudoalteromona
s
sp.
AS-11) 		5 / 12 ILE A 114
ALA A 113
TRP A 104
VAL A 174
LEU A 130
 None
None
None
CA  A 505 (-4.5A)
PMS  A 501 (-4.5A)
 1.02A 5uanA-1v6cA:
undetectable		 5uanA-1v6cA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_C_SALC201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 1v6c ALKALINE SERINE
PROTEASE
(Pseudoalteromona
s
sp.
AS-11) 		4 / 7 VAL A 196
VAL A 375
GLY A 417
TYR A 416
 None
 0.95A 5x80C-1v6cA:
undetectable
5x80D-1v6cA:
undetectable		 5x80C-1v6cA:
16.55
5x80D-1v6cA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_C_9CRC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1v6c ALKALINE SERINE
PROTEASE
(Pseudoalteromona
s
sp.
AS-11) 		5 / 12 ILE A 114
ALA A 113
TRP A 104
VAL A 174
LEU A 130
 None
None
None
CA  A 505 (-4.5A)
PMS  A 501 (-4.5A)
 0.94A 5z12C-1v6cA:
undetectable		 5z12C-1v6cA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_1
(TUBULIN BETA CHAIN)		 1v6c ALKALINE SERINE
PROTEASE
(Pseudoalteromona
s
sp.
AS-11) 		5 / 12 GLU A   2
ASP A  34
HIS A  37
ALA A  75
LEU A 206
 CA  A 503 (-3.4A)
None
None
None
None
 1.24A 6ew0F-1v6cA:
undetectable		 6ew0F-1v6cA:
9.43