SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1v6t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_A_NIOA145_1
(LEGHEMOGLOBIN A)		 1v6t HYPOTHETICAL UPF0271
PROTEIN PH0986
(Pyrococcus
horikoshii) 		4 / 8 ILE A  87
HIS A 107
LEU A 141
VAL A 128
 None
 0.89A 1fslA-1v6tA:
undetectable		 1fslA-1v6tA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)		 1v6t HYPOTHETICAL UPF0271
PROTEIN PH0986
(Pyrococcus
horikoshii) 		5 / 12 GLU A  81
LEU A 133
GLY A 131
MET A 156
ALA A 153
 None
 1.09A 1hvyA-1v6tA:
undetectable		 1hvyA-1v6tA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)		 1v6t HYPOTHETICAL UPF0271
PROTEIN PH0986
(Pyrococcus
horikoshii) 		5 / 12 GLU A  81
LEU A 133
GLY A 131
MET A 156
ALA A 153
 None
 1.11A 1hvyB-1v6tA:
undetectable		 1hvyB-1v6tA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1v6t HYPOTHETICAL UPF0271
PROTEIN PH0986
(Pyrococcus
horikoshii) 		4 / 6 ASP A  21
ASP A   8
ASN A  32
GLU A  54
 None
 1.32A 1rjdA-1v6tA:
undetectable		 1rjdA-1v6tA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1v6t HYPOTHETICAL UPF0271
PROTEIN PH0986
(Pyrococcus
horikoshii) 		4 / 6 ASP A  21
ASP A   8
ASN A  32
GLU A  54
 None
 1.33A 1rjdB-1v6tA:
undetectable		 1rjdB-1v6tA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_B_ADNB2002_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 1v6t HYPOTHETICAL UPF0271
PROTEIN PH0986
(Pyrococcus
horikoshii) 		4 / 6 ARG A 168
GLU A 187
ASN A 226
ALA A 229
 None
 1.26A 2ejfB-1v6tA:
0.0		 2ejfB-1v6tA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_A_ADNA1501_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 1v6t HYPOTHETICAL UPF0271
PROTEIN PH0986
(Pyrococcus
horikoshii) 		4 / 7 ARG A 168
GLU A 187
ASN A 226
ALA A 229
 None
 1.17A 2ejgA-1v6tA:
undetectable		 2ejgA-1v6tA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A164_1
(BETA-LACTOGLOBULIN)		 1v6t HYPOTHETICAL UPF0271
PROTEIN PH0986
(Pyrococcus
horikoshii) 		4 / 5 ASP A 214
LEU A 215
LYS A 216
MET A 199
 None
 0.99A 2gj5A-1v6tA:
undetectable		 2gj5A-1v6tA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_B_FUAB2002_1
(SERUM ALBUMIN)		 1v6t HYPOTHETICAL UPF0271
PROTEIN PH0986
(Pyrococcus
horikoshii) 		4 / 9 ILE A 220
ALA A 193
VAL A 196
LYS A 201
 None
 1.06A 2vufB-1v6tA:
undetectable		 2vufB-1v6tA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 1v6t HYPOTHETICAL UPF0271
PROTEIN PH0986
(Pyrococcus
horikoshii) 		3 / 3 PHE A 253
SER A  30
LEU A   5
 None
 0.60A 2w1bA-1v6tA:
0.0		 2w1bA-1v6tA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FXR_A_ASCA3001_0
(LYSR TYPE REGULATOR
OF TSAMBCD)		 1v6t HYPOTHETICAL UPF0271
PROTEIN PH0986
(Pyrococcus
horikoshii) 		4 / 8 ALA A  83
ILE A  87
PRO A  63
PRO A 110
 None
 0.98A 3fxrA-1v6tA:
undetectable		 3fxrA-1v6tA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)		 1v6t HYPOTHETICAL UPF0271
PROTEIN PH0986
(Pyrococcus
horikoshii) 		4 / 8 GLU A 104
TYR A  95
PHE A 135
ILE A 132
 None
 1.07A 3jz0B-1v6tA:
undetectable		 3jz0B-1v6tA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_B_ACTB1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 1v6t HYPOTHETICAL UPF0271
PROTEIN PH0986
(Pyrococcus
horikoshii) 		4 / 5 ARG A  73
GLY A 112
ALA A 113
GLY A  64
 None
 0.90A 4u9uB-1v6tA:
undetectable		 4u9uB-1v6tA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 1v6t HYPOTHETICAL UPF0271
PROTEIN PH0986
(Pyrococcus
horikoshii) 		4 / 6 LEU A 141
LYS A 109
PRO A 110
GLU A 163
 None
 1.12A 4z4gA-1v6tA:
2.3		 4z4gA-1v6tA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 1v6t HYPOTHETICAL UPF0271
PROTEIN PH0986
(Pyrococcus
horikoshii) 		5 / 12 GLY A  60
ALA A  31
ILE A 132
LEU A 105
PRO A 110
 None
 1.02A 6iftA-1v6tA:
undetectable		 6iftA-1v6tA:
25.00